Pill with alcohol sobering and liver protecting effects and preparation method thereof

The pills prepared through the combination of Chinese medicinal materials and enzymatic decomposition technology solve the problem of poor results of existing bartender liver-relieving products, and achieve the effect of understanding the liver protection, promoting digestion, clearing heat and detoxification. They are suitable for before, after or in wine. Use significantly improves alcohol discomfort.

CN117797106BActive Publication Date: 2025-01-03CHONGQING ACAD OF CHINESE MATERIA MEDICA
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Patent Information

Application Number
CN202311827121.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-12-28
Publication Date
2025-01-03
Estimated Expiration
2043-12-28

AI Technical Summary

Technical Problem

The preparation materials of existing bartender liver-proofing products do not completely rely on Chinese medicinal materials, and most of them are in the form of drinks, which have poor results, and are unwilling to continue taking them because of drunkenness, so they cannot effectively cure the liver.

Method used

Use pills composed of Chinese herbal medicines such as hawthorn, tangerine peel, yam, cornus officinalis, atractylodes, ginseng, licorice, Codonopsis pilosula, Chuanxiong, Angelica sinensis, chrysanthemum, Luohan fruit, white peony, etc., through soaking, roasting, decoction, enzymatic decomposition and other steps Prepare to form easy-to-absorbing powder, combine it with the principle of homologous medicine and food to reduce toxicity and enhance therapeutic effect.

Benefits of technology

It can realize the effect of alcohol protecting the liver, relieve stomach discomfort after drinking, promote digestion, enhance physical strength, clear heat and detoxify, and is suitable for use before, after drinking or in wine, which is convenient and fast, and significantly improves discomfort after drinking.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention discloses a pill with alcohol-relief and liver-protection effects and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparation. The pill comprises, by weight, 5-8 parts of hawthorn, 8-12 parts of dried tangerine peel, 10-15 parts of yam, 8-12 parts of cornus fruit, 10-15 parts of atractylodes macrocephala, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of codonopsis pilosula, 10-15 parts of ligusticum chuanxiong, 4-7 parts of angelica, 6-10 parts of chrysanthemum, 5-8 parts of momordica grosvenori and 8-13 parts of white peony root. The raw medicinal materials used in the present invention are compatible with each other. Hawthorn, tangerine peel, yam, cornus fruit, atractylodes, ginseng, codonopsis, ligusticum chuanxiong and licorice are matched with each other through roasting and decocting, which can play the greatest role, can alleviate the toxicity of the drug, and can stimulate the original activity of the drug, enhance the efficacy of the drug, and change the performance of the drug; 3. The present invention crushes the decocted medicinal materials, and then adds the enzymatic stock solution to the powder, so that the macromolecules in the stock solution are decomposed into small molecules, so that the effective components are precipitated, and the combination with the powder can be more conducive to human body absorption and increase the efficacy.
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Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a pill with alcohol-resolving and liver-protecting effects and a preparation method thereof. Background Art

[0002] The liver and stomach are vital to our body and are important components of our internal organs. In daily interpersonal communication, drinking is inevitable, but many people feel burning in the spleen and stomach after drinking, and in severe cases, they will vomit continuously. This is mainly due to excessive drinking that causes damage to the liver, spleen, and stomach, causing blood stasis in the body and damaging the vitality, which leads to dysfunction of the body and triggers a series of adverse reactions.

[0003] There are some health products on the market that protect the liver and nourish the stomach, but the raw materials are not completely Chinese herbal medicines, and other chemical substances are added. This not only fails to protect the liver and nourish the stomach, but also burdens the body, which is counterproductive. Other alcohol-detoxifying drugs are generally taken in the form of drinks after drinking, but the effect is not good, and because the user is already drunk, he is not willing to continue to take too much drink products, which also fails to achieve the effect of detoxifying. Summary of the invention

[0004] In view of this, the object of the present invention is to provide a pill having the effects of sobering up and protecting the liver and a preparation method thereof.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a pill with alcohol sobering and liver protecting effects, which is composed of 5-8 parts of hawthorn, 8-12 parts of tangerine peel, 10-15 parts of yam, 8-12 parts of cornus fruit, 10-15 parts of atractylodes, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of codonopsis, 10-15 parts of ligusticum, 4-7 parts of angelica, 6-10 parts of chrysanthemum, 5-8 parts of momordica and 8-13 parts of white peony root.

[0006] Furthermore, the pills are composed of 6 parts of hawthorn, 10 parts of tangerine peel, 13 parts of yam, 10 parts of cornus fruit, 12 parts of atractylodes, 6 parts of ginseng, 14 parts of licorice, 13 parts of codonopsis, 13 parts of ligusticum, 8 parts of chrysanthemum, 6 parts of momordica, 6 parts of angelica and 10 parts of white peony root.

[0007] Furthermore, it also includes a method for preparing a pill having the effect of sobering up and protecting the liver, comprising the following steps:

[0008] S1. After removing impurities from the surface of the raw medicinal materials in the formula amount, except for licorice and chrysanthemum, the remaining raw medicinal materials are soaked in clean water respectively, and then dried, and the soaked raw medicinal materials are evenly divided into medicinal material portion 1 and medicinal material portion 2, and the soaking water of the soaked medicinal materials is mixed;

[0009] S2, roasting a portion of licorice and adding it to the soaking water for decocting to obtain the first licorice liquid;

[0010] S3, adding the medicinal material portion 1 to the first liquorice liquid, continuing to decoct, and then taking out the decoction of the medicinal material portion 1, stir-frying, and grinding to obtain a medicinal powder;

[0011] S4, crushing another portion of licorice and soaking it with chrysanthemum to obtain a second licorice liquid, and taking out the chrysanthemum; adding the medicinal material portion 2 to the second licorice liquid for decoction, and then taking out the decoction of the medicinal material portion 2, stir-frying it, and grinding it to obtain a medicinal powder;

[0012] S5, cooling the first licorice liquid and the second licorice liquid after decoction to 40-50 degrees Celsius respectively, and then adding a composite enzyme for enzymolysis, and then reflux extraction and purification;

[0013] S6, mixing the stir-fried medicinal materials of steps S3 and S4, and first adding the second liquorice solution after enzymolysis to the medicinal powder, mixing the medicinal powder into a dry paste, and then continuing to add the first liquorice solution after enzymolysis to the dry paste medicinal powder to prepare a pill

[0014] Furthermore, in step S1, the raw medicinal materials are soaked in 1.2-1.5 times the amount of clean water for 2 hours.

[0015] Furthermore, in step S2, the roasting temperature of the licorice is 110-120 degrees Celsius, the distance from the flame is 2-3 cm, and the roasting time is 8-12 minutes; the boiling temperature of the licorice after roasting is 60-80 degrees Celsius, and the boiling time is 10-20 minutes.

[0016] Furthermore, in step S3, the decoction temperature after adding the medicinal material portion 1 is 100-120 degrees Celsius, and the decoction time is 50-65 minutes.

[0017] Furthermore, in step S4, the licorice and chrysanthemum are soaked for 20-30 minutes, and after the second licorice solution is added to the medicinal material 2, the decoction temperature is 100-120 degrees Celsius, and the decoction time is 50-65 minutes.

[0018] Furthermore, in step S5, the compound enzyme is one or more of cellulase, protease and amylase, and the compound enzyme accounts for 0.13-0.17% of the total weight of the raw material.

[0019] The invention adopts hawthorn, and organic acids such as hawthorn acid and malic acid in hawthorn have the functions of promoting digestion, improving digestion and relieving stagnation, promoting the secretion of digestive juice, regulating gastrointestinal motility, and increasing appetite, and can also treat stomach pain, help decompose food, and reduce the burden on the stomach. At the same time, the pectin component in hawthorn can form a protective film with gastric acid to protect the gastric mucosa, relieve stomach pain, and prevent ulcers.

[0020] Tangerine peel has the effects of regulating qi and strengthening the spleen, harmonizing the middle, drying dampness and resolving phlegm. It can promote digestion, treat abdominal distension, improve conditions such as anorexia, vomiting and diarrhea, and food accumulation, and can also treat symptoms such as excessive phlegm and cough.

[0021] The combination of yam and cornus officinalis can nourish the body, replenish qi and strengthen the spleen, moisten the lungs and relieve coughs, and is beneficial for regulating digestive function, increasing appetite, enhancing physical strength, and improving fatigue. The combination of the two complements each other and can prevent fever from getting angry.

[0022] Atractylodes can replenish Qi and strengthen the spleen, dry dampness and promote diuresis, treat edema due to lung Qi deficiency and spleen deficiency, eliminate water and dampness that have been retained in the body, and can also treat nausea, loss of appetite, and physical fatigue.

[0023] Ginseng is a traditional Chinese medicine that replenishes qi and blood. It has the effects of replenishing vital energy, restoring the pulse and strengthening the body, nourishing the spleen and lungs, promoting the production of body fluids and nourishing blood, calming the mind and improving intelligence. It is suitable for improving symptoms such as profuse sweating, vomiting, diarrhea, and improving fatigue.

[0024] Licorice root is sweet, nourishing, and has a cooling effect. It has the effects of replenishing qi and tonifying the middle, relieving pain, and the "Illustrated Materia Medica" records that licorice can detoxify and relieve the toxicity and potency of drugs. Roasted licorice root has the effects of replenishing qi and restoring pulse, tonifying spleen and stomach, and can be used for symptoms such as spleen and stomach weakness, fatigue, palpitations, etc.

[0025] Codonopsis is sweet and mild, and can replenish the middle and benefit qi, harmonize the stomach and regulate the middle, without being dry or greasy. It is used to treat spleen and lung qi deficiency, and improve conditions such as poor appetite, fatigue, cough, weak wheezing, sallow complexion, and weakness in the limbs.

[0026] Chuanxiong and white peony root are used together to treat liver depression and flank pain, soothe the liver and promote qi circulation, promote blood circulation and relieve pain, and improve dry retching, insomnia, dreaminess, and irritability.

[0027] Angelica sinensis is sweet and nourishing, pungent and warm, and can strengthen the spleen and nourish the heart, and has a calming and liver-protecting effect.

[0028] Chrysanthemum has the effects of clearing away heat and detoxifying, clearing the liver and improving eyesight. Licorice can clear away heat and detoxify, and relieve sore throat. Chrysanthemum and licorice are cold in nature and can clear away heat, promote liver detoxification, clear liver fire, and treat red, swollen and painful eyes, blurred vision, etc. Monk fruit has the effects of clearing heat and moistening the lungs, treating sore throat, aphonia, and dry intestines and constipation.

[0029] The beneficial effects of the present invention are:

[0030] 1. The raw medicinal materials used in the present invention are compatible with each other. Hawthorn, tangerine peel, yam, cornus fruit, atractylodes, ginseng, etc. can play a role in regulating qi and spleen, promoting digestion, regulating digestive function, and regulating stomach discomfort; and the reasonable combination of codonopsis, chuanxiong, angelica, and white peony root can protect the liver, and chrysanthemum and momordica grosvenori have the effects of clearing away heat and detoxifying, clearing the lungs and relieving cough;

[0031] 2. During the preparation of the present invention, the licorice is roasted and boiled, and the decocted liquid is then combined with each other to play the greatest role, which can not only alleviate the toxicity of the drug, but also stimulate the original activity of the drug, enhance the efficacy of the drug, and change the performance of the drug;

[0032] 3. The present invention crushes the decocted medicinal materials, and then adds the enzymatic solution to the powder, so that the macromolecules in the solution are decomposed into small molecules, so that the effective components are separated out, and the combination with the powder can be more conducive to human absorption and increase the efficacy;

[0033] 4. The pills of the present invention are prepared by adopting the principle of medicine and food being of the same origin, which can reduce the toxicity of the drug to the maximum extent while maximizing the therapeutic effect of the drug itself. The finished product is fragrant and has no bitter taste, is convenient to carry and easy to use.

[0034] The edible tablets of the present invention are prepared by water and fire respectively. Other advantages, objectives and features of the present invention will be described in the subsequent description and will be obvious to a person skilled in the art to some extent, or can be taught by the practice of the present invention. The objectives and other advantages of the present invention can be achieved and obtained through the following description. DETAILED DESCRIPTION

[0035] The applicant provides the following examples to further illustrate the present invention, but the present invention is not limited to these examples.

[0036] Example 1

[0037] A pill with alcohol-resolving and liver-protecting effects:

[0038] S1. According to the weight ratio, 6 parts of hawthorn, 10 parts of dried tangerine peel, 13 parts of yam, 10 parts of cornus, 12 parts of atractylodes, 6 parts of ginseng, 14 parts of licorice, 13 parts of codonopsis, 13 parts of ligusticum, 8 parts of chrysanthemum, 6 parts of momordica, 4 parts of angelica and 10 parts of white peony root were weighed, and the surfaces of the above raw medicinal materials were cleaned. Except for licorice and chrysanthemum, the remaining raw medicinal materials were soaked in 1.2-1.5 times of clean water for 2 hours respectively. After drying, the soaked raw medicinal materials were evenly divided into medicinal material portion 1 and medicinal material portion 2, and the soaking water of the soaked medicinal materials was mixed;

[0039] S2, roast 7 parts of licorice at 110-120 degrees Celsius for 10 minutes, add them to the soaking water and boil them at 70 degrees Celsius for 15 minutes to obtain the first licorice liquid;

[0040] S3, after adding the medicinal material 1 to the first liquorice solution, the temperature is raised to 110 degrees Celsius, and the decocted medicinal material 1 is continued to be boiled for 60 minutes, and then the decocted medicinal material 1 is taken out, stir-fried, and ground to obtain a powder;

[0041] S4, crush the other 7 parts of licorice and soak them with chrysanthemum for 25 minutes to obtain a second licorice liquid, and take out the chrysanthemum; add the medicinal material part 2 to the second licorice liquid at 110 degrees Celsius, and boil for 60 minutes, then take out the boiled medicinal material part 2, stir-fry, and grind to obtain a powder;

[0042] S5, cooling the first licorice liquid and the second licorice liquid after decoction to 40-50 degrees Celsius respectively, and then adding cellulase, protease and amylase in a mass ratio of 1.5:1:2 for enzymolysis, and then reflux extraction and purification;

[0043] S6, mixing the stir-fried medicinal materials of steps S3 and S4, and adding the second liquorice solution after enzymolysis to the medicinal powder in small amounts and multiple times, mixing the medicinal powder into a dry paste, and then continuing to add the first liquorice solution after enzymolysis to the dry paste medicinal powder to prepare pills.

[0044] In the present invention, Momordica grosvenori can clear away heat and remove fire, is rich in vitamin C, can help iron absorption, promote alcohol metabolism, is conducive to improving the content of acetaldehyde dehydrogenase and alcohol dehydrogenase, promotes alcohol dissolution, achieves the effect of sobering up and protecting the liver, and the compatibility of Momordica grosvenori, chrysanthemum, liquorice, etc. can not only sober up and protect the liver, but also achieve the effect of clearing away heat and detoxifying, relieve the situation of sore throat and loss of voice, red and swollen eyes, and blurred vision after drinking. The compatibility of hawthorn, tangerine peel, yam, cornus fruit, etc. has the effect of protecting the stomach and regulating stomach discomfort, has the effect of promoting digestion, invigorating qi and strengthening the spleen, and can reduce stomach pantothenic acid at the same time, treat nausea and vomiting, loss of appetite, and abdominal diarrhea. The compatibility of ginseng, codonopsis, chuanxiong, white peony root, etc. has the effect of nourishing the kidney and liver, moistening the lung, and can also relieve consumptive cough, dry lung and thirst, and can be matched with each other to play the purpose of nourishing the liver and kidney, and can play a relieving role for the symptoms such as abdominal pain, bad mood, insomnia and dreaminess, depression and unhappiness caused by liver qi discomfort. Licorice is mild in nature and sweet in taste. It has the effects of tonifying the spleen and replenishing qi, relieving acute pain, and at the same time can alleviate the toxicity and strength of drugs. Therefore, roasted licorice can be used for symptoms such as weak spleen and stomach, fatigue, etc. Soaking, heating and stir-frying medicinal materials with licorice can alleviate the medicinal properties and remove the original bitterness in the medicinal materials.

[0045] The raw materials of the pills prepared by the present invention, wherein ginseng, codonopsis, chuanxiong and white peony root are matched to protect the liver and relieve liver discomfort, while hawthorn, tangerine peel, yam and cornus fruit are matched to protect and nourish the stomach, relieve liver and relieve depression, while monk fruit, chrysanthemum and liquorice are matched to clear away heat and detoxify, and relieve sore throat. The pills prepared by the formula of the present application can not only be eaten normally, but also protect the liver and nourish the stomach, and can be taken at any time, before, after or during drinking, and can relieve liver and stomach discomfort caused by drinking while relieving alcohol and protecting the stomach, and relieve the damage of thirst, sore throat and dizziness after drinking.

[0046] Example 2

[0047] A pill with alcohol sobering and liver protecting effects, the difference from Example 1 is that, by weight, it includes 8 parts of hawthorn, 8 parts of tangerine peel, 15 parts of yam, 8 parts of cornus, 10 parts of atractylodes, 8 parts of ginseng, 16 parts of liquorice, 10 parts of codonopsis, 15 parts of chuanxiong, 6 parts of chrysanthemum, 8 parts of momordica, 7 parts of angelica and 13 parts of white peony root. The preparation method of the pills in this embodiment is the same as that in Example 1, which will not be repeated here.

[0048] Example 3

[0049] A pill with alcohol sobering and liver protecting effects, the difference from Example 1 is that, by weight, it includes 5 parts of hawthorn, 11 parts of tangerine peel, 10 parts of yam, 11 parts of cornus fruit, 14.5 parts of atractylodes, 5 parts of ginseng, 12 parts of licorice, 15 parts of codonopsis, 10 parts of chuanxiong, 10 parts of chrysanthemum, 5 parts of momordica, 5 parts of angelica and 8 parts of white peony root. The preparation method of the pills in this embodiment is the same as that in Example 1, which will not be repeated here.

[0050] In order to demonstrate the superiority of the raw medicinal materials and the proportions of the present invention, Comparative Examples 1 to 4 are provided here.

[0051] Comparative Example 1

[0052] S1. According to the weight ratio, 5 parts of hawthorn, 6 parts of dried orange peel, 17 parts of yam, 7 parts of cornus, 8 parts of atractylodes, 10 parts of ginseng, 10 parts of licorice, 9 parts of codonopsis, 9 parts of chuanxiong, 5 parts of chrysanthemum, 5 parts of momordica, 9 parts of angelica and 7 parts of white peony root were weighed, and the surfaces of the above raw medicinal materials were cleaned. Except for licorice and chrysanthemum, the remaining raw medicinal materials were soaked in 1.2-1.5 times of clean water for 2 hours respectively. After drying, the soaked raw medicinal materials were evenly divided into medicinal material portion 1 and medicinal material portion 2, and the soaking water of the soaked medicinal materials was mixed;

[0053] S2, roast 5 parts of licorice at 110-120 degrees Celsius for 10 minutes, add them to the soaking water and boil them at 70 degrees Celsius for 15 minutes to obtain the first licorice liquid;

[0054] S3, after adding the medicinal material 1 to the first liquorice solution, the temperature is raised to 110 degrees Celsius, and the decocted medicinal material 1 is continued to be boiled for 60 minutes, and then the decocted medicinal material 1 is taken out, stir-fried, and ground to obtain a powder;

[0055] S4, crush the other 5 parts of licorice and soak them with chrysanthemum for 25 minutes to obtain a second licorice liquid, and take out the chrysanthemum; add the medicinal material part 2 to the second licorice liquid at 110 degrees Celsius, and boil for 60 minutes, then take out the boiled medicinal material part 2, stir-fry, and grind to obtain a powder;

[0056] S5, cooling the first licorice liquid and the second licorice liquid after decoction to 40-50 degrees Celsius respectively, and then adding cellulase, protease and amylase in a mass ratio of 1.5:1:2 for enzymolysis, and then reflux extraction and purification;

[0057] S6, mixing the stir-fried medicinal materials of steps S3 and S4, and adding the second liquorice solution after enzymolysis to the medicinal powder in small amounts and multiple times, mixing the medicinal powder into a dry paste, and then continuing to add the first liquorice solution after enzymolysis to the dry paste medicinal powder to prepare pills.

[0058] Comparative Example 2

[0059] S1. According to the weight ratio, 10 parts of hawthorn, 13 parts of dried orange peel, 8 parts of yam, 13 parts of cornus, 16 parts of atractylodes, 9 parts of ginseng, 18 parts of licorice, 16 parts of codonopsis, 16 parts of ligusticum, 11 parts of chrysanthemum, 11 parts of momordica, 2 parts of angelica and 14 parts of white peony root were weighed, and the surfaces of the above raw medicinal materials were cleaned. Except for licorice and chrysanthemum, the remaining raw medicinal materials were soaked in 1.2-1.5 times of clean water for 2 hours respectively. After drying, the soaked raw medicinal materials were evenly divided into medicinal material portion 1 and medicinal material portion 2, and the soaking water of the soaked medicinal materials was mixed;

[0060] S2, roast 9 parts of licorice at 110-120 degrees Celsius for 10 minutes, add them to the soaking water and boil them at 70 degrees Celsius for 15 minutes to obtain the first licorice liquid;

[0061] S3, after adding the medicinal material 1 to the first liquorice solution, the temperature is raised to 110 degrees Celsius, and the decocted medicinal material 1 is continued to be boiled for 60 minutes, and then the decocted medicinal material 1 is taken out, stir-fried, and ground to obtain a powder;

[0062] S4, crush the other 9 parts of licorice and soak them with chrysanthemum for 25 minutes to obtain a second licorice liquid, and take out the chrysanthemum; add the medicinal material part 2 to the second licorice liquid and boil it at 110 degrees Celsius for 60 minutes, then take out the boiled medicinal material part 2, stir-fry it, and grind it to obtain a powder;

[0063] S5, cooling the first licorice liquid and the second licorice liquid after decoction to 40-50 degrees Celsius respectively, and then adding cellulase, protease and amylase in a mass ratio of 1.5:1:2 for enzymolysis, and then reflux extraction and purification;

[0064] S6, mixing the stir-fried medicinal materials of steps S3 and S4, and adding the second liquorice solution after enzymolysis to the medicinal powder in small amounts and multiple times, mixing the medicinal powder into a dry paste, and then continuing to add the first liquorice solution after enzymolysis to the dry paste medicinal powder to prepare pills.

[0065] Comparative Example 3

[0066] A pill with alcohol-resolving and liver-protecting effects:

[0067] S1. Weigh 6 parts of hawthorn, 10 parts of dried orange peel, 13 parts of yam, 10 parts of cornus, 12 parts of atractylodes, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis, 13 parts of ligusticum, 8 parts of chrysanthemum, 6 parts of momordica, 6 parts of angelica and 10 parts of white peony root, and remove impurities from the surfaces of the above raw medicinal materials;

[0068] S2. Grind all the raw medicinal materials into powder, and then add water to make pills.

[0069] Comparative Example 4

[0070] S1. According to the weight ratio, weigh 6 parts of hawthorn, 10 parts of dried tangerine peel, 13 parts of yam, 10 parts of cornus, 12 parts of atractylodes, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis, 13 parts of ligusticum, 8 parts of chrysanthemum, 6 parts of momordica, 6 parts of angelica and 10 parts of white peony root, remove impurities from the surface of the above raw medicinal materials, add clean water and soak them for 2 hours respectively, and after drying, evenly divide the soaked raw medicinal materials into medicinal material portion 1 and medicinal material portion 2;

[0071] S2. Add licorice to water and boil at 40 degrees Celsius for 30 minutes.

[0072] S3, add raw medicinal materials to the liquorice solution and boil at 110 degrees Celsius for 60 minutes;

[0073] S4, taking out the medicinal materials, stir-frying them, and grinding them into medicinal powder;

[0074] S5. Pour the medicine juice into the medicine powder to prepare pills.

[0075] The proportions of Comparative Examples 1 and 2 are different from those of the present invention, and the preparation methods of Comparative Examples 3 and 4 are different from those of the present invention.

[0076] The pills of Examples 1-3 and Comparative Examples 1-4 were tested. 21 adult males with liver and stomach discomfort were selected, with 3 people in each group, and divided into 7 groups. Groups 1-7 took the pills of Examples 1-3 and Comparative Examples 1-4 respectively for 15 consecutive days. The results are shown in the following table:

[0077]

[0078]

[0079]

[0080] By comparing Examples 1-3 and Comparative Examples 1-4, it can be seen that after the subjects took the pills prepared by the raw material formulas of Examples 1-3 of the present invention, the alcohol sobering effect was obvious, and the burning, dizziness and discomfort after drinking were well relieved, and the liver and stomach discomfort themselves were improved, achieving the effects of soothing the liver and relieving depression, and nourishing the stomach. The pills of the present invention do not need to be taken in water, and the time of taking is not limited, which is convenient and fast, and has strong practicality.

[0081] After the subjects took the pills of Comparative Examples 1 and 2, since the raw material formulas of the two were different from the formula of the present invention, their liver and spleen discomfort and stomach bloating were slightly improved, but the effect was not obvious, and after drinking, there was no obvious hangover effect, and they were still drunk and dizzy. After the subjects took the pills of Comparative Examples 3 and 4, there was no obvious effect of soothing the liver and relieving depression, the discomfort after drinking was strong, there was no obvious improvement, and the pills had a bad taste.

[0082] In summary, it can be concluded from the above examples that the pills prepared by the raw material formula of the present invention and the preparation steps of the present application can not only nourish the stomach and treat liver and stomach discomfort after being taken by patients, but also improve the patients' bad mood, low interest, and easy fatigue. At the same time, they can also sober up and reduce hangovers, dizziness, and bloating after drinking.

[0083] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A pill with alcohol sobering and liver protecting effects, characterized in that: The pills are composed of 5-8 parts of hawthorn, 8-12 parts of tangerine peel, 10-15 parts of yam, 8-12 parts of cornus fruit, 10-15 parts of atractylodes, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of codonopsis, 10-15 parts of ligusticum, 4-7 parts of angelica, 6-10 parts of chrysanthemum, 5-8 parts of momordica and 8-13 parts of white peony root.

2. The pill with alcohol sobering and liver protecting effects according to claim 1, characterized in that: In terms of weight, the pills are composed of 6 parts of hawthorn, 10 parts of dried tangerine peel, 13 parts of yam, 10 parts of cornus fruit, 12 parts of atractylodes, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis, 13 parts of ligusticum, 8 parts of chrysanthemum, 6 parts of momordica, 6 parts of angelica and 10 parts of white peony root.

3. The pill with alcohol sobering and liver protecting effect according to any one of claims 1-2, further comprising a method for preparing the pill with alcohol sobering and liver protecting effect, characterized in that: The following steps are included: S1. After removing impurities from the surface of the raw medicinal materials in the formula amount, except for licorice and chrysanthemum, the remaining raw medicinal materials are soaked in clean water respectively, and then dried, and the soaked raw medicinal materials are evenly divided into medicinal material portion 1 and medicinal material portion 2, and the soaking water of the soaked medicinal materials is mixed; S2, roasting a portion of licorice and adding it to the soaking water for decocting to obtain the first licorice liquid; S3, adding the medicinal material portion 1 to the first liquorice liquid, continuing to decoct, and then taking out the decoction of the medicinal material portion 1, stir-frying, and grinding to obtain a medicinal powder; S4, crushing another portion of licorice and soaking it with chrysanthemum to obtain a second licorice liquid, and taking out the chrysanthemum; adding the medicinal material portion 2 to the second licorice liquid for decoction, and then taking out the decoction of the medicinal material portion 2, stir-frying it, and grinding it to obtain a medicinal powder; S5, cooling the first licorice liquid and the second licorice liquid after decoction to 40-50 degrees Celsius respectively, and then adding complex enzyme for enzymolysis, and then reflux extraction and purification; S6, mixing the stir-fried medicinal materials of steps S3 and S4, and first adding the second liquorice solution after enzymolysis to the medicinal powder, mixing the medicinal powder into a dry paste, and then continuing to add the first liquorice solution after enzymolysis to the dry paste medicinal powder to prepare pills.

4. The method for preparing the pills having the effects of sobering up and protecting the liver according to claim 3, characterized in that: In step S1, the raw medicinal materials are soaked in 1.2-1.5 times the amount of clean water for 2 hours.

5. The method for preparing a pill having alcohol sobering and liver protecting effects according to claim 3, characterized in that: In step S2, the roasting temperature of the licorice is 110-120 degrees Celsius, the distance from the flame is 2-3 cm, and the roasting time is 8-12 minutes; the boiling temperature of the licorice after roasting is 60-80 degrees Celsius, and the boiling time is 10-20 minutes.

6. The method for preparing a pill having alcohol sobering and liver protecting effects according to claim 3, characterized in that: In the step S3, the boiling temperature after adding the medicinal material 1 is 100-120 degrees Celsius, and the boiling time is 50-65 minutes.

7. The method for preparing a pill having alcohol sobering and liver protecting effects according to claim 3, characterized in that: In step S4, the licorice and chrysanthemum are soaked for 20-30 minutes, and after the second licorice solution is added to the medicinal material 2, the decoction temperature is 100-120 degrees Celsius, and the decoction time is 50-65 minutes.

8. The method for preparing a pill having alcohol sobering and liver protecting effects according to claim 3, characterized in that: In step S5, the compound enzyme is one or more of cellulase, protease and amylase, and the compound enzyme accounts for 0.13-0.17% of the total weight of the raw material.