A prescription for treating chronic atrophic gastritis

Abstract

The present invention relates to the technical field of traditional Chinese medicine, and discloses a prescription for treating chronic atrophic gastritis, which is composed of the following raw materials: Fructus Aurantii 9-15 g, Magnolia officinalis 9-15 g, dried ginger 6-9 g, Codonopsis pilosula 15-30 g, Poria cocos 15-30 g, Pinellia ternata 9-15 g, Panax notoginseng powder 6-9 g, Hedyotis diffusa 15-30 g, Scutellaria barbata 9-15 g, and is composed of the following raw materials: Fructus Aurantii 12 g, dried ginger 6 g, Magnolia officinalis 12 g, Codonopsis pilosula 20 g, Poria cocos 15 g, Pinellia ternata preparata 12 g, Panax notoginseng powder 9 g, Scutellaria barbata 12 g, Hedyotis diffusa 15 g. The total effective rate of the treatment group (95.00%) was higher than that of the control group (72.50%) (P < 0.05); the levels of TNF-α, IL-2, and IL-6 in both groups after treatment were lower than those before treatment in the same group (P < 0.05); the levels of TNF-α, IL-2, and IL-6 in the treatment group after treatment were lower than those in the control group (P < 0.05).

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a prescription for treating chronic atrophic gastritis. Background Art

[0002] Chronic Atrophic Gastritis (CAG) is a type of chronic gastritis. It refers to a class of chronic gastric diseases in which the gastric mucosa epithelium suffers repeated injuries and then shows gland atrophy with a reduced number of glands, with or without intestinal metaplasia and pseudopyloric gland metaplasia. It is a common and difficult-to-treat disease in clinical practice. Research believes that Helicobacter pylori-induced chronic atrophic gastritis is related to the occurrence of gastric cancer. After Helicobacter pylori infection, the Correa cascade reaction may occur, that is, the development trend of chronic non-atrophic gastritis - chronic atrophic gastritis - intestinal metaplasia - dysplasia - gastric cancer. Among them, chronic atrophic gastritis and intestinal metaplasia (IM) are considered precancerous lesions, with an annual incidence rate of 10.9% globally. The annual incidence of gastric cancer in patients with atrophic gastritis within 5 years after diagnosis is 0.1%. And in the latest global cancer statistics data, the incidence rate and cancer-related mortality rate of gastric cancer rank fifth and third respectively. Therefore, how to reduce the incidence rate of gastric cancer and related mortality and block the "inflammation-cancer transformation" is crucial. At present, Western medicine lacks an ideal treatment method for chronic atrophic gastritis. The main treatment is to eliminate Helicobacter pylori and symptomatic treatment, such as inhibiting gastric acid secretion, protecting the gastric mucosa, and promoting gastrointestinal motility, but the effect is not good and it is easy to relapse.

[0003] Traditional Chinese medicine's traditional syndrome differentiation and treatment plan requires a high level of syndrome differentiation and treatment ability of doctors. One prescription for one person, and the prescription changes with the syndrome, resulting in poor generalizability of the treatment plan and poor patient compliance. This has affected the application of traditional Chinese medicine therapy in the treatment of chronic atrophic gastritis. Summary of the Invention

[0004] The present invention provides a prescription for treating chronic atrophic gastritis, which solves the problems raised in the above background art.

[0005] The present invention provides the following technical solution: A prescription for treating chronic atrophic gastritis, which is composed of the following raw materials: Fructus Aurantii 9 - 15 g, Magnolia officinalis 9 - 15 g, Dry Ginger 6 - 9 g, Codonopsis pilosula 15 - 30 g, Poria cocos 15 - 30 g, Pinellia ternata 9 - 15 g, Panax notoginseng powder 6 - 9 g, Hedyotis diffusa 15 - 30 g, Scutellaria barbata 9 - 15 g.

[0006] Preferably, it is composed of the following raw materials: Fructus Aurantii 12 g, Dry Ginger 6 g, Magnolia officinalis 12 g, Codonopsis pilosula 20 g, Poria cocos 15 g, Rhizoma Pinelliae Praeparatum 12 g, Panax notoginseng powder 9 g, Scutellaria barbata 12 g, Hedyotis diffusa 15 g.

[0007] Preferably, the decocting method of the decoction is:

[0008] Step S1: Before decocting, first put the above-mentioned traditional Chinese medicine decoction pieces into a ceramic vessel and soak them in cold water. It is appropriate that the liquid level submerges the decoction pieces by about 2 cm. After soaking for 30 minutes;

[0009] Bring to a rapid boil over high heat, and then switch to low heat and maintain for about 15 - 20 minutes;

[0010] After filtering the medicinal juice while it is hot, add water again and decoct 2 more times;

[0011] Finally, mix the 1000 ml of medicinal liquid obtained from the 3 decoctions and then it can be taken;

[0012] Administration method: Three times a day, 150 ml each time, warm it and take it after meals.

[0013] Preferably, the preparation method of the powder: Mix the above traditional Chinese medicines, crush them with a traditional Chinese medicine grinder, and pass through a 100-mesh sieve to obtain fine powder;

[0014] Administration method: Twice a day, 10 g each time, add about 100 ml of boiling water, soak for 10 minutes, and then take it warm.

[0015] Preferably, the preparation method of the pills:

[0016] Step S1: Mix the above traditional Chinese medicines, crush them with a traditional Chinese medicine grinder, and pass through a 100-mesh sieve to obtain fine powder;

[0017] Step S2: Heat the honey until it boils, its color darkens and it becomes viscous. Switch to low heat and heat until light red shiny foam appears. When it has strong viscosity when pinched by hand but no white filaments, turn off the heat. After cooling, it becomes refined honey;

[0018] Step S3: Make small honey pills with 30 g of refined honey for every 100 g of fine powder;

[0019] Administration method: Twice a day, about 8 g each time, take it with warm water after meals

[0020] The present invention has the following beneficial effects:

[0021] 1. For the prescription for treating chronic atrophic gastritis, Codonopsis pilosula is the monarch drug. It belongs to the spleen and lung meridians, can invigorate the spleen and benefit the lung, nourish blood and promote fluid production, and has the effect of tonifying both qi and blood;

[0022] Atractylodes macrocephala, Poria cocos, Pinellia ternata, Fructus Aurantii, Magnolia officinalis are the ministerial drugs.

[0023] Atractylodes macrocephala invigorates the spleen and dries dampness. It is used in combination with Codonopsis pilosula to enhance the effect of invigorating qi and strengthening the spleen.

[0024] Poria cocos invigorates the spleen and promotes diuresis, Pinellia ternata dries dampness and harmonizes the stomach to relieve fullness. The combination of the three can invigorate the spleen, harmonize the stomach and remove dampness, and assist the spleen and stomach in digestion and transportation;

[0025] Citrus aurantium can regulate qi, relieve fullness, and relieve bloating, while Magnolia officinalis can dry out dampness, relieve qi and relieve fullness. The combination of the two can strengthen the spleen and promote qi, and together regulate the qi of the middle jiao.

[0026] Panax notoginseng powder can dissipate blood stasis, relieve swelling and relieve pain, Scutellaria barbata can detoxify and dissipate blood stasis, and Hedyotis diffusa can clear away heat, detoxify, promote blood circulation and relieve pain. The combination of these three medicines can promote blood circulation and dissipate blood stasis, and also have the effects of clearing away heat, detoxifying, dissipating blood stasis and relieving pain.

[0027] The hot nature of dried ginger can not only warm and protect the spleen yang, but also neutralize the properties of other cold medicines, thus serving as an adjuvant.

[0028] All the medicines work together to invigorate the spleen and replenish qi, activate blood circulation and detoxify.

[0029] 2. The prescription for treating chronic atrophic gastritis, Yiqi Kangwei Decoction, has good therapeutic effects in the clinical practice of treating chronic atrophic gastritis. It has the advantages of few side effects, relatively low price, and long-term use, and has broad application prospects;

[0030] At the same time, it will help promote the research and transformation of preparations of traditional Chinese medicines with unique clinical efficacy, and has very important social and economic value.

[0031] 3. The total effective rate of the prescription for treating chronic atrophic gastritis was 95.00% in the treatment group, which was higher than 72.50% in the control group (P<0.05);

[0032] After treatment, the levels of TNF-α, IL-2, and IL-6 in the two groups were lower than those before treatment (P<0.05); after treatment, the levels of TNF-α, IL-2, and IL-6 in the treatment group were lower than those in the control group (P<0.05). BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a graph comparing the therapeutic effects of two groups of the present invention [n(%)];

[0034] Figure 2 Comparison of inflammatory factor levels in two groups of the present invention picture. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] See also Figure 1-2A prescription for treating chronic atrophic gastritis, composed of the following raw materials: 9-15g of Citrus aurantium, 9-15g of Magnolia officinalis, 6-9g of dried ginger, 15-30g of Codonopsis pilosula, 15-30g of Poria cocos, 9-15g of Pinellia ternata, 6-9g of Panax notoginseng powder (taken with water), 15-30g of Hedyotis diffusa, and 9-15g of Scutellaria barbata.

[0037] Among them, it is composed of the following raw materials: 12g of Citrus aurantium, 6g of dried ginger, 12g of Magnolia officinalis, 20g of Codonopsis pilosula, 15g of Poria cocos, 12g of Pinellia ternata, 9g of Panax notoginseng powder, 12g of Scutellaria barbata, and 15g of Hedyotis diffusa.

[0038] Among them, the decoction method is:

[0039] Step S1: before decocting, firstly put the above Chinese herbal medicine pieces into a ceramic vessel (such as a casserole or a clay pot) and soak them in cold water, preferably the liquid surface covers the pieces by about 2 cm, and soak for 30 minutes;

[0040] Step S2: boil rapidly over high heat, then switch to low heat and maintain for about 15 to 20 minutes;

[0041] Step S3: Filter the medicinal juice while it is hot, and then add water and boil it again for 2 times;

[0042] Step S4: finally, the 1000 ml medicinal solution obtained by decocting three times is mixed and then taken;

[0043] Dosage: 150ml three times a day, taken warm after meals.

[0044] The preparation method of the powder is as follows: the above Chinese medicines are mixed, crushed using a Chinese medicine crusher, and sieved through a 100-mesh sieve to obtain fine powder;

[0045] Dosage: Take twice a day, 10g each time, add about 100ml of boiling water, soak for 10 minutes and drink while warm.

[0046] Wherein, the preparation method of pills:

[0047] Step S1: Mix the above Chinese medicines, crush them using a Chinese medicine crusher, and sieve them through a 100-mesh sieve to obtain fine powder;

[0048] Step S2: heat the honey until it boils, becomes darker in color and sticky, then turn to low heat and heat until light red shiny foam appears. When it is sticky but no white threads are left when you pick it up with your hands, turn off the heat and let it cool to make refined honey.

[0049] Step S3: For every 100g of fine powder, 30g of refined honey is used to make small honey pills;

[0050] Dosage: Twice a day, about 8g each time, take with warm water after meals.

[0051] Yiqi Kangwei Decoction is modified from "Zhishi Xiaopi Pills" in "Secret Collection of the Orchid Chamber" and has the effects of supplementing qi and promoting the transportation of the spleen, clearing heat and detoxifying, regulating qi and activating blood circulation, and promoting diuresis.

[0052] Dangshen (Codonopsis pilosula) is the monarch drug. It enters the spleen and lung meridians, can invigorate the spleen and benefit the lung, nourish blood and promote the production of body fluid, and has the effect of supplementing both qi and blood.

[0053] Baizhu (Atractylodes macrocephala), Fuling (Poria cocos), Banxia (Pinellia ternata), Zhike (Citrus aurantium), and Houpo (Magnolia officinalis) are the ministerial drugs.

[0054] Baizhu invigorates the spleen and dries dampness. It synergizes with Dangshen to enhance the effect of supplementing qi and strengthening the spleen.

[0055] Fuling invigorates the spleen and promotes diuresis. Banxia dries dampness and harmonizes the stomach to relieve fullness. The combination of the three can invigorate the spleen and stomach, remove dampness, and assist the spleen and stomach in digestion and transportation.

[0056] Zhike can regulate qi and relieve fullness, promote qi movement and relieve distension. Houpo dries dampness and lowers qi to relieve fullness. The combination of the two strengthens the spleen and promotes qi movement, and jointly regulates the qi mechanism in the middle jiao.

[0057] Sanqi powder (Panax notoginseng powder) dispels stasis, relieves distension and pain. Banzhilian (Scutellaria barbata) detoxifies and dissipates stasis. Hedyotis diffusa detoxifies heat and activates blood circulation to relieve pain. The combination of the three drugs can activate blood circulation to remove stasis and also has the effects of clearing heat and detoxifying, dissipating stasis and relieving pain.

[0058] Ganjiang (Zingiber officinale) is warm in nature and can not only warm and protect the spleen yang but also neutralize the cold nature of other cold drugs. It is the adjuvant drug.

[0059] The combination of various drugs exerts the effects of promoting the transportation of the spleen, supplementing qi, activating blood circulation, and detoxifying.

[0060] The use of Yiqi Kangwei Decoction with modifications in the treatment of chronic atrophic gastritis of spleen-stomach yang deficiency type has achieved good therapeutic effects. While significantly relieving the clinical symptoms of patients, it can reverse the atrophy and intestinal metaplasia in some patients.

[0061] Yiqi Kangwei Decoction has good therapeutic effects in the clinical treatment of chronic atrophic gastritis. It has the advantages of few side effects, relatively low price, and can be taken for a long time, and has broad application prospects.

[0062] At the same time, it helps to promote the research on the preparation of traditional Chinese medicine formulas with unique clinical efficacy and the transformation of research results, and has very important social and economic value.

[0063] Now, cases are listed to illustrate the effect of Yiqi Kangwei Decoction in the treatment of chronic atrophic gastritis:

[0064] 1. General information

[0065] Eighty CAG patients admitted from January 2020 to January 2022 were selected and grouped by the random number table method. In the control group (40 cases), there were 26 males and 14 females, aged 30 to 69 years, with an average age of (49.29 ± 1.54) years; the disease course was 6 months to 6 years, with an average of (3.98 ± 1.21) years. In the treatment group (40 cases), there were 24 males and 16 females, aged 31 to 72 years, with an average age of (49.85 ± 1.65) years; the disease course was 4 months to 6 years, with an average of (3.59 ± 1.33) years. When comparing the data of the two groups, P > 0.05. The patients were informed about the content of this study and signed the consent form.

Claims

1. A prescription for treating chronic atrophic gastritis, characterized in that: It consists of the following raw materials: 9 - 15 g of Fructus Aurantii, 9 - 15 g of Magnolia officinalis, 6 - 9 g of dried ginger, 15 - 30 g of Codonopsis pilosula, 15 - 30 g of Poria cocos, 9 - 15 g of Pinellia ternata, 6 - 9 g of Panax notoginseng powder, 15 - 30 g of Hedyotis diffusa, 9 - 15 g of Scutellaria barbata.

2. A prescription for treating chronic atrophic gastritis according to claim 1, characterized in that: It consists of the following raw materials: 12 g of Fructus Aurantii, 6 g of dried ginger, 12 g of Magnolia officinalis, 20 g of Codonopsis pilosula, 15 g of Poria cocos, 12 g of Pinellia ternata prepared with Rhizoma Zingiberis Recens, 9 g of Panax notoginseng powder, 12 g of Scutellaria barbata, 15 g of Hedyotis diffusa.

3. A prescription for treating chronic atrophic gastritis according to claim 1, characterized in that: The decocting method of the decoction is as follows: Step S1: Before decocting, first put the above-mentioned traditional Chinese medicine pieces into a ceramic vessel and soak them in cold water. It is appropriate that the liquid level is about 2 cm higher than the pieces. After soaking for 30 minutes; Step S2: Bring to a rapid boil over high heat, then change to low heat and maintain for about 15 - 20 minutes; Step S3: Filter the medicinal juice while it is hot, and then add water to decoct again twice; Step S4: Finally, mix the 1000 ml of medicinal liquid obtained from the three decoctions and it can be taken; Administration method: Three times a day, 150 ml each time, warm taking after meals.

4. A prescription for treating chronic atrophic gastritis according to claim 1, characterized in that: Preparation method of the powder: Mix the above traditional Chinese medicines, pulverize them with a traditional Chinese medicine pulverizer, and pass through a 100 - mesh sieve to obtain fine powder; Taking method: Twice a day, 10 g each time, add about 100 ml of boiling water, soak for 10 minutes, and then take warm.

5. A prescription for treating chronic atrophic gastritis according to claim 1, characterized in that: Preparation method of the pills: Step S1: Mix the above traditional Chinese medicines, pulverize them with a traditional Chinese medicine pulverizer, and pass through a 100 - mesh sieve to obtain fine powder; Step S2: Heat the honey until it boils, the color turns dark, it becomes viscous, turn to low heat and heat until light red shiny foam appears. When it is sticky when pinched by hand but has no white filaments, turn off the fire. After cooling, it becomes refined honey; Step S3: Make small honey pills with 30 g of refined honey for every 100 g of fine powder; Taking method: Twice a day, about 8 g each time, take warm with warm water after meals.

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