Transcranial stimulation electrodes

Abstract

The present application discloses a transcranial collection stimulation electrode, which relates to the field of microelectrode technology. The transcranial collection stimulation electrode includes: an electrode terminal, a stimulation component, a collection component and a fixing agent. The stimulation component includes a stimulation wire and a stimulation contact, and the two ends of the stimulation wire are directly electrically connected to the electrode terminal and the stimulation contact respectively, and the stimulation contact is used to be directly connected to the target receptor. The collection component includes a collection wire, and the collection wire has a connected implantation part and a conductive part, and the end of the conductive part away from the implantation part is directly electrically connected to the electrode terminal, and the end of the implantation part away from the conductive part is used to be implanted in the target tissue. The fixing agent is located on the upper end surface of the electrode terminal, and is used to fix the relative position between the electrode terminal and the stimulation component and the collection component. The transcranial collection stimulation electrode provided by the present application can penetrate deep into the tissue to stimulate and collect EEG signals.

Description

Technical Field

[0001] The present invention relates to the technical field of microelectrodes, and in particular to a transcranial collection stimulation electrode. Background Art

[0002] Transcranial Stimulation (TCS) is a non-invasive brain stimulation technology that is widely used in the research and treatment of neurological diseases. In the field of mental health, TCS has shown good efficacy in the treatment of diseases such as depression, anxiety and post-traumatic stress disorder, especially for patients who do not respond well to traditional drug treatments. In terms of neurorehabilitation, this technology helps promote neural remodeling in patients with stroke and brain injury, thereby restoring motor and cognitive functions. In addition, TCS can regulate the brain's perception of pain and relieve chronic pain symptoms in pain management. More importantly, TCS shows potential application value in improving cognitive functions such as learning ability, memory and attention, especially in the fields of education and training.

[0003] At present, the research on transcranial electrical stimulation mainly applies electrical signals to detect target calcium signals to determine the inhibitory or excitation state of neurons. This method usually requires injecting the virus into the mouse, inserting the optical fiber after it recovers for several days, giving the corresponding stimulation in its awake state, and using calcium imaging technology to record neuronal signals in real time. This process significantly prolongs the experimental cycle. In contrast, the method of using electrical signals to monitor the activity state of the organism can significantly improve the experimental efficiency. However, there is currently a lack of electrodes on the market that can simultaneously achieve skull surface stimulation and deep intracranial monitoring of neuronal activity. Therefore, the invention of an electrode that can both implement transcranial electrical stimulation and collect target EEG signals has important research and application value. Summary of the invention

[0004] In view of the deficiencies of the prior art, one purpose of this specification is to provide a transcranial acquisition stimulation electrode that can penetrate deep into tissues to stimulate and acquire EEG signals.

[0005] To achieve the above-mentioned purpose, the embodiments of this specification provide a transcranial collection stimulation electrode, including:

[0006] Electrode terminal;

[0007] A stimulation component, comprising a stimulation wire and a stimulation contact, wherein two ends of the stimulation wire are directly electrically connected to the electrode terminal and the stimulation contact respectively, and the stimulation contact is used to directly connect to the target receptor;

[0008] A collection assembly, comprising a collection wire, wherein the collection wire has an implantation portion and a conductive portion connected to each other, an end of the conductive portion away from the implantation portion is directly electrically connected to the electrode terminal, and an end of the implantation portion away from the conductive portion is used for implantation into a target tissue;

[0009] The setting agent located on the upper end surface of the electrode terminal is used to fix the relative position between the electrode terminal, the stimulation component and the collection component.

[0010] As a preferred embodiment, the electrode terminal includes a multi-channel conductive contact, and each of the conductive contacts is directly connected to the corresponding stimulation wire or the collection wire.

[0011] As a preferred embodiment, the surface of the stimulation wire except the two ends is covered with an insulating layer; the surface of the conductive part of the collection wire except the two ends is covered with an insulating layer, and the surface of the implantation part of the collection wire except the two ends is covered with an insulating layer.

[0012] As a preferred embodiment, the stimulation contact is a spherical contact or a disc-shaped contact.

[0013] As a preferred embodiment, the stimulation component also includes an upper cover plate and a lower cover plate, the stimulation wire is located between the upper cover plate and the lower cover plate, and the upper cover plate and the lower cover plate are both provided with a first through hole corresponding to the stimulation contact and a second through hole corresponding to the collection component.

[0014] As a preferred implementation, the collection component further includes a protective layer film, and the conductive part is located between the protective layer film and the upper cover plate.

[0015] As a preferred embodiment, the collection component also includes a fixing part for fixing the implant part, and the material of the fixing part is polyethylene glycol; the upper end of the fixing part is connected to the lower cover plate, and the implant part extends from the lower end of the fixing part.

[0016] As a preferred implementation manner, the conducting part and the implanting part are vertically arranged, the conducting part is parallel to the upper end surface of the electrode terminal, and the conducting part and the implanting part are made of different materials.

[0017] As a preferred embodiment, the implant part is made of tungsten wire, stainless steel wire or nickel titanium wire, and the conductive part is made of platinum wire, silver wire or copper wire.

[0018] As a preferred embodiment, the implanted parts are arranged in a stepped array or an equal length array. Beneficial Effects

[0019] The transcranial collection stimulation electrode provided in this embodiment is provided with electrode terminals, stimulation components and collection components. The stimulation wire is directly electrically connected to the electrode terminal and the stimulation contact. The stimulation contact is directly connected to the target receptor. The electrical signal is transmitted from the electrode terminal to the stimulation wire, the stimulation contact and the target receptor in sequence, so that the electrical stimulation of the target receptor can be achieved. One end of the conductive part of the collection wire is directly electrically connected to the electrode terminal, and the other end is connected to the implant part. The other end of the implant part is implanted in the target tissue, so that the bioelectric signal is transmitted from the target tissue to the implant part, the conductive part and the electrode terminal in sequence, so that the target electrical signal can be collected. Therefore, the transcranial collection stimulation electrode can stimulate and collect brain electrical signals deep inside the tissue, and combine transcranial electrical stimulation with the collection of target electrical signals, so as to realize the visualization of the changes in the physiological electrical signals of animals, including the stages before, during and after stimulation.

[0020] By using the transcranial acquisition stimulation electrodes provided in this embodiment, not only can the dynamic changes of physiological electrical signals be monitored in real time, but also the effects of different stimulation conditions on neural activity can be accurately analyzed. Researchers can intuitively observe the immediate response of stimulation to the physiological state of animals, which is of great significance to scientific research, and can help scientists verify theoretical models, optimize experimental designs, and provide important basis for the development of new therapies. In addition, this technology also has broad potential in clinical applications, which can provide doctors with reference data, assist decision-making, and improve treatment plans for patients, thereby promoting research and development in the fields of neuroscience and medicine.

[0021] With reference to the following description and the accompanying drawings, the specific embodiments of the present invention are disclosed in detail, indicating the manner in which the principles of the present invention can be adopted. It should be understood that the embodiments of the present invention are not limited in scope thereby.

[0022] Features described and / or illustrated with respect to one embodiment may be used in the same or similar manner in one or more other embodiments, combined with features in other embodiments, or substituted for features in other embodiments.

[0023] It should be emphasized that the term “include / comprises” when used herein refers to the presence of features, integers, steps or components, but does not exclude the presence or addition of one or more other features, integers, steps or components. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without paying creative labor.

[0025] Figure 1 A schematic diagram of the three-dimensional structure of a transcranial collection stimulation electrode provided in this embodiment;

[0026] Figure 2 for Figure 1 Schematic diagram of the three-dimensional structure from another perspective.

[0027] Description of reference numerals:

[0028] 1. Electrode terminal; 2. Stimulation contact; 3. Collection wire; 4. Fixing agent; 5. Fixing part; 6. Protective layer film; 7. Upper cover plate; 8. Lower cover plate. DETAILED DESCRIPTION

[0029] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0030] It should be noted that when an element is referred to as being "disposed on" another element, it may be directly on the other element or there may be another element centered thereon. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be another element centered thereon at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and do not represent the only implementation method.

[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0032] See also Figure 1 and Figure 2 The embodiment of the present application provides a transcranial collection stimulation electrode, comprising: an electrode terminal 1 , a stimulation component, a collection component and a setting agent 4 .

[0033] Wherein, the stimulation component includes a stimulation wire (not shown) and a stimulation contact 2, and the two ends of the stimulation wire are directly electrically connected to the electrode terminal 1 and the stimulation contact 2 respectively, and the stimulation contact 2 is used to directly connect to the target receptor. The collection component includes a collection wire 3. The collection wire 3 has a connected implantation part and a conductive part, and the end of the conductive part away from the implantation part is directly electrically connected to the electrode terminal 1, and the end of the implantation part away from the conductive part is used to be implanted into the target tissue. The fixative 4 is located on the upper end surface of the electrode terminal 1, and is used to fix the relative position between the electrode terminal 1 and the stimulation component and the collection component.

[0034] The transcranial collection stimulation electrode provided in this embodiment is provided with an electrode terminal 1, a stimulation component and a collection component. The stimulation wire is directly electrically connected to the electrode terminal 1 and the stimulation contact 2. The stimulation contact 2 is directly connected to the target receptor. The electrical signal is transmitted from the electrode terminal 1 to the stimulation wire, the stimulation contact 2, and the target receptor in sequence, so that electrical stimulation of the target receptor can be achieved; one end of the conductive part of the collection wire 3 is directly electrically connected to the electrode terminal 1, and the other end is connected to the implant part. The other end of the implant part is implanted in the target tissue, so that the bioelectric signal is transmitted from the target tissue to the implant part, the conductive part, and the electrode terminal 1 in sequence, so that the target electrical signal can be collected. Therefore, the transcranial collection stimulation electrode can penetrate deep into the tissue to stimulate and collect brain electrical signals, and combine transcranial electrical stimulation with the collection of target electrical signals, so as to realize the visualization of changes in animal physiological electrical signals, including each stage before, during and after stimulation.

[0035] By using the transcranial acquisition stimulation electrodes provided in this embodiment, not only can the dynamic changes of physiological electrical signals be monitored in real time, but also the effects of different stimulation conditions on neural activity can be accurately analyzed. Researchers can intuitively observe the immediate response of stimulation to the physiological state of animals, which is of great significance to scientific research, and can help scientists verify theoretical models, optimize experimental designs, and provide important basis for the development of new therapies. In addition, this technology also has broad potential in clinical applications, which can provide doctors with reference data, assist decision-making, and improve treatment plans for patients, thereby promoting research and development in the fields of neuroscience and medicine.

[0036] In this embodiment, the electrode terminal 1 is designed as a multi-channel conductive contact, that is, the electrode terminal 1 has multiple independent channels, which are effectively isolated by insulating materials to prevent signal interference and cross-interference. Each of the conductive contacts is directly connected to the corresponding stimulation wire or collection wire 3 to ensure efficient transmission and precise stimulation of electrical signals. According to needs, the number of channels of the electrode terminal 1 can be flexibly expanded to support the use of two or more electrode terminals 1 to meet the complexity and diversity of different experimental or therapeutic applications. This design not only improves the functionality of the electrode terminal 1, but also enhances its application potential in multi-channel stimulation and monitoring, and can adapt to more complex neural stimulation schemes and data acquisition requirements. The transcranial collection stimulation electrode is placed in the body, and the input and output of electrical signals are realized through the electrode terminal 1.

[0037] Specifically, the setting agent 4 is arranged on the upper end surface of the electrode terminal 1, which can ensure that the relative position between the electrode terminal 1 and the stimulation component and the collection component is fixed. The setting agent 4 is made of a high-adhesion material, such as medical-grade silicone, polyimide, resin, etc., which can effectively firmly connect the electrode terminal 1 to the stimulation component and the collection component, thereby preventing displacement or loosening due to external force or movement during use. Through this stable connection, the setting agent 4 not only improves the overall reliability of the system, but also ensures the consistency and accuracy of the transmission of electrical signals. In order to further enhance its function, the setting agent 4 can also be designed to have a certain elasticity and flexibility to adapt to different experimental environments and operating conditions, thereby optimizing the performance of the electrode system in a variety of application scenarios.

[0038] In this embodiment, the stimulation wire is a conductor, which is designed to achieve efficient electrical stimulation. One end of the stimulation wire is directly connected to the conductive contact of the electrode terminal 1 to ensure lossless transmission of the electrical signal. The other end of the stimulation wire is connected to the stimulation contact 2, which is responsible for transmitting the electrical signal to the target neural tissue or cells. The surface of the stimulation wire is covered with a high-performance insulating layer, which is designed to prevent current leakage and ensure the concentration and effective transmission of the stimulation signal. At the same time, no insulating layer is applied to both ends of the stimulation wire to ensure direct contact between the stimulation wire and the electrode terminal 1 and the stimulation contact 2, thereby achieving optimal conductivity performance. This design not only improves the accuracy of the stimulation, but also helps to reduce the side effects that may occur during the stimulation process, thereby providing a more reliable and effective solution for clinical applications and research.

[0039] Specifically, the stimulation contact 2 is directly connected to the stimulation wire to ensure efficient transmission of the electrical signal. The stimulation contact 2 is designed as a spherical contact or a disc-shaped contact to meet different application needs and structural requirements.

[0040] Among them, the spherical contacts have a smaller contact area and are particularly suitable for precisely stimulating specific neurons or tissues. They can effectively concentrate the current and thus achieve higher stimulation accuracy. In contrast, the disc-shaped contacts provide a larger contact area and are suitable for situations that require extensive stimulation. Figure 1 and Figure 2 The stimulation contact 2 shown in the figure adopts a disc-shaped contact design, and a through hole is set in the center of the stimulation contact 2, so as to allow the stimulation contact 2 to be connected to the skull nail, thereby increasing the contact area, ensuring uniform distribution of current, and improving the coverage and effect of stimulation.

[0041] In addition, the stimulation contact 2 is directly connected to the target receptor, ensuring that the electrical signal can be efficiently transmitted to the receptor structure, thereby activating or inhibiting its neural activity. This direct connection design not only improves the response speed of the stimulation, but also significantly reduces the loss during signal transmission, enhancing the effectiveness and reliability of the overall system. By optimizing the shape and connection method of the stimulation contact 2, a more flexible and effective solution can be provided for different types of experiments and clinical applications to meet diverse needs.

[0042] like Figure 1 and Figure 2 As shown, the stimulation assembly also includes an upper cover plate 7 and a lower cover plate 8, and the stimulation wire is located between the upper cover plate 7 and the lower cover plate 8, and the upper cover plate 7 and the lower cover plate 8 can provide necessary protection and support for the stimulation wire. The upper cover plate 7 and the lower cover plate 8 are both provided with a first through hole corresponding to the stimulation contact 2 to ensure that the electrical signal can be smoothly transmitted to the stimulation contact 2 while avoiding any unnecessary interference. There are multiple first through holes, and the size and position of the first through holes are accurately calculated to achieve the best stimulation effect and ensure that the stimulation contact 2 can effectively contact the target receptor.

[0043] Furthermore, the upper cover plate 7 and the lower cover plate 8 are also provided with a second through hole corresponding to the acquisition component, which not only allows the acquisition component to effectively monitor neural activity during the stimulation process, but also ensures accurate acquisition and transmission of signals. Through this design, the upper cover plate 7 and the lower cover plate 8 provide support for the functionality of the entire system while protecting the stimulation wire, ensuring the synchronization and effectiveness of stimulation and monitoring. This structured design significantly improves the overall performance of the device, making it more suitable for complex neural stimulation and monitoring applications. Specifically, the second through hole is located at the connection between the implanted part and the conductive part of the acquisition wire 3, and the second through hole is provided for the passage of the connection.

[0044] The upper cover plate 7 and the lower cover plate 8 can not only be mass-produced to ensure uniform specifications and reduce production costs, but can also be individually adjusted according to the specific needs of different receptors. This flexibility enables the device to adapt to a variety of experimental conditions and biological models to meet the needs of different studies.

[0045] The design of the upper cover plate 7 and the lower cover plate 8 takes into account the stability and reliability of the stimulation wire, ensuring that the stimulation wire can be effectively fixed during the experiment to avoid affecting the experimental results due to movement or displacement. At the same time, the upper cover plate 7 and the lower cover plate 8 can be made of materials such as polyimide, polyester film, photosensitive resin, hydrogel, etc. to ensure that they have good mechanical strength and biocompatibility during use, thereby ensuring safe contact with the organism. This design not only improves the practicality of the equipment, but also enhances the repeatability and accuracy of the experiment.

[0046] In this embodiment, the collection component further includes a protective layer film 6, and the conductive part is located between the protective layer film 6 and the upper cover plate 7, that is, the protective layer film 6 is located above the conductive part of the collection wire 3, which can provide additional mechanical protection to prevent external forces from causing damage to the collection wire 3. At the same time, the conductive part is arranged above the upper cover plate 7, which can effectively utilize the space, miniaturize the stimulation electrode as a whole, and does not affect its function of realizing electrical signal stimulation and collection.

[0047] The protective layer membrane 6 is made of high-strength, lightweight material with excellent compression resistance and wear resistance to ensure that it can effectively resist impact and friction in various operating environments. At the same time, the thickness and flexibility of the membrane are precisely adjusted to maintain the flexibility of the collection silk 3 without affecting its signal collection and transmission performance. The surface treatment of the protective layer membrane 6 is also specially designed to prevent liquid penetration and contamination, thereby further improving the durability and reliability of the collection silk 3. Through the application of the protective layer membrane 6, the collection silk 3 can maintain its functionality in a complex biological environment, ensuring that the performance will not be reduced due to external factors during long-term use, thereby improving the stability and effectiveness of the overall system.

[0048] Specifically, the collection component further includes a fixing portion 5 for fixing the implanted portion, and the fixing portion 5 is made of polyethylene glycol. Figure 2 As shown, the upper end of the fixing part 5 is connected to the lower cover plate 8, and the implanted part extends from the lower end of the fixing part 5. The fixing part 5 made of polyethylene glycol is used to fix the collection silk 3 array, and has good water solubility, biocompatibility, low toxicity and adjustability.

[0049] In this embodiment, the collection wire 3 is a conductor specially designed for effectively collecting and transmitting bioelectric signals. The collection wire 3 is divided into two sections: an implantation part and a conduction part. The conduction part and the implantation part are arranged vertically, and the conduction part is parallel to the upper end surface of the electrode terminal 1. The conduction part and the implantation part are made of different materials, which can optimize the material selection under different functional requirements, improve the performance and reliability of the overall system, and ensure efficient and stable operation in a complex biological environment.

[0050] Specifically, the conductive part is made of conductive materials with good toughness, such as platinum wire, silver wire or copper wire. These materials not only have excellent conductive properties, but also have certain flexibility, so that the conductive part can adapt to different operating environments and dynamic changes in the body, ensuring the stability and accuracy of the signal during transmission.

[0051] The implant part is made of materials with high biocompatibility such as tungsten wire, stainless steel wire or nickel titanium wire. These materials have excellent hardness and toughness, can withstand the mechanical stress during the implantation process, and ensure long-term stability in the body. The design purpose of this part is to ensure that the collection wire 3 can be safely and effectively implanted into the target tissue and form a reliable electrical contact with the receptor structure, thereby improving the quality of signal collection.

[0052] It is worth noting that the surface of the implanted part is covered with an insulating layer to prevent unnecessary current leakage and signal interference, while there is no insulating layer at the connection and both ends of the implanted part to ensure good contact with the target tissue. The surface of the conductive part is also covered with an insulating layer to prevent external interference, but there is no insulating layer at the connection and both ends to ensure good electrical contact.

[0053] In this embodiment, the surfaces of the stimulation wire and the collection wire 3 are covered with an insulating layer, while the two ends are not covered with an insulating layer, so as to ensure that the head of the stimulation wire and the collection wire 3 can be smoothly connected, so as to effectively collect electrophysiological signals. This design can not only accurately target the stimulation target area, but also avoid stimulating non-target neurons, thereby significantly improving the precision and accuracy of the experiment.

[0054] Preferably, the collection wire 3 and the stimulation wire are made of metal materials with excellent corrosion resistance, including platinum, titanium, gold, platinum-iridium alloy, tungsten or iridium oxide. These materials not only have excellent biocompatibility, but also can effectively reduce the irritation and toxicity of the microneedle surface to the animal skin, thereby ensuring that the impact on the animal during the experiment is minimized. This design can achieve continuous, long-term and efficient collection of physiological electrical signals, ensure that the acquired data is accurate and reliable, and help to further study neurophysiological mechanisms and related biological reactions.

[0055] Preferably, the implanted portion of the collection wire 3 is arranged in a stepped array or an equal length array. Figure 1 and Figure 2The arrangement shown in the figure is an equal length array. In the equal length array arrangement, each collection wire 3 is of equal length, and the adjacent collection wires 3 are evenly spaced. In the step array arrangement, the adjacent collection wires 3 are evenly spaced, the collection wires 3 at the center are longer, and the lengths of the collection wires 3 at the periphery gradually decrease. The design of the two arrangement methods enables the collection results to be compared with both the longitudinal theoretical model and the horizontal experimental model. This not only improves the flexibility of the experiment, but also enhances the comprehensiveness and reliability of the data analysis.

[0056] Specifically, in the case of a stepped array arrangement, the design can effectively compare the difference between the longitudinal theoretical model and the actual stimulation results, so as to clearly evaluate the effect of the stimulation on the target area. This comparative analysis not only helps to verify the accuracy of the theoretical model, but also provides important reference data for practical applications. In the isometric array arrangement, the uniform spacing of the collection wire 3 enables researchers to systematically compare and verify the axial theoretical model with the actual stimulation results. This arrangement ensures the uniformity of the stimulation signal at different positions, which helps to deeply understand the mechanism of the impact of stimulation on neurons, and thus promote research progress in related fields.

[0057] Preferably, the microwires on the surface of the implanted part are of smaller size to ensure that the microwires can smoothly penetrate the stratum corneum of the animal skin without causing pain and bleeding.

[0058] The transcranial collection stimulation electrode provided in this embodiment is developed based on existing processing and assembly processes, can be applied in vivo in a minimally invasive manner, causes little damage, and can penetrate deep into tissues for long periods of time to stimulate and collect EEG signals.

[0059] In a specific application scenario, the transcranial acquisition stimulation electrode is placed in a biological body, and the stimulation contact 2 is directly connected to the target receptor (such as the surface of the skull). The electrical signal is transmitted from the electrode terminal 1 to the stimulation wire, the stimulation contact 2, and the target receptor in sequence, so that electrical stimulation of the target receptor can be achieved; the end of the implanted part away from the conductive part is implanted into the target tissue (such as the motor cortex, the pathological target in the brain), so that the bioelectrical signal is transmitted from the target tissue to the implanted part, the conductive part, and the electrode terminal 1 in sequence, so that the target electrical signal can be collected. Therefore, the transcranial acquisition stimulation electrode can penetrate deep into the tissue to stimulate and collect EEG signals, and the combination of transcranial electrical stimulation and the collection of target electrical signals can realize the visualization of changes in the physiological electrical signals of animals, including the stages before, during, and after stimulation.

[0060] It should be noted that, in the description of this specification, the terms "first", "second", etc. are only used for descriptive purposes and to distinguish similar objects. There is no order of precedence between the two, and they cannot be understood as indicating or implying relative importance. In addition, in the description of this specification, unless otherwise specified, the meaning of "plurality" is two or more.

[0061] All articles and references disclosed, including patent applications and publications, are incorporated herein by reference for all purposes. The term "consisting essentially of..." to describe a combination should include the identified elements, ingredients, parts or steps and other elements, ingredients, parts or steps that do not substantially affect the basic novel characteristics of the combination. The use of the terms "comprising" or "including" to describe a combination of elements, ingredients, parts or steps herein also contemplates embodiments that consist essentially of these elements, ingredients, parts or steps. By using the term "may", it is intended to indicate that any attribute described that "may" include is optional.

[0062] Multiple elements, ingredients, parts or steps can be provided by a single integrated element, ingredient, part or step. Alternatively, a single integrated element, ingredient, part or step can be divided into separate multiple elements, ingredients, parts or steps. The disclosure "one" or "an" used to describe an element, ingredient, part or step is not intended to exclude other elements, ingredients, parts or steps.

[0063] It should be understood that the above description is for illustration and not for limitation. Many embodiments and many applications beyond the examples provided will be apparent to those skilled in the art upon reading the above description. Therefore, the scope of the present teachings should not be determined with reference to the above description, but should be determined with reference to the appended claims and the full scope of equivalents possessed by such claims. For the purpose of comprehensiveness, all articles and references, including disclosures of patent applications and publications, are incorporated herein by reference. The omission of any aspect of the subject matter disclosed herein in the preceding claims is not intended to be a waiver of the subject matter, nor should it be considered that the inventors did not consider the subject matter to be part of the disclosed inventive subject matter.

Claims

1. A transcranial collection stimulation electrode, characterized in that: include: Electrode terminal; A stimulation component, comprising a stimulation wire and a stimulation contact, wherein two ends of the stimulation wire are directly electrically connected to the electrode terminal and the stimulation contact respectively, and the stimulation contact is used to directly connect to the target receptor; A collection assembly, comprising a collection wire, wherein the collection wire has an implantation portion and a conductive portion connected to each other, an end of the conductive portion away from the implantation portion is directly electrically connected to the electrode terminal, and an end of the implantation portion away from the conductive portion is used for implantation into a target tissue; A fixing agent located on the upper end surface of the electrode terminal, used to fix the relative position between the electrode terminal and the stimulation component and the collection component; The transcranial collection stimulation electrode is placed in a living body, and the input and output of electrical signals are realized through the electrode terminal; The stimulation component further comprises an upper cover plate and a lower cover plate, the stimulation wire is located between the upper cover plate and the lower cover plate, and the upper cover plate and the lower cover plate are both provided with a first through hole corresponding to the stimulation contact and a second through hole corresponding to the collection component; the second through hole is located at the connection between the implantation part and the conduction part of the collection wire; The collection assembly further includes a protective layer film, and the conductive part is located between the protective layer film and the upper cover plate; The conducting part and the implanting part are arranged vertically, the conducting part is parallel to the upper end surface of the electrode terminal, and the conducting part and the implanting part are made of different materials; The implantation part is made of tungsten wire, stainless steel wire or nickel titanium wire, and the conduction part is made of platinum wire, silver wire or copper wire.

2. The transcranial collection stimulation electrode according to claim 1, characterized in that: The electrode terminal includes a multi-channel conductive contact, and each of the conductive contacts is directly connected to the corresponding stimulation wire or the collection wire.

3. The transcranial collection stimulation electrode according to claim 1, characterized in that: The surface of the stimulation wire except the two ends is covered with an insulating layer; the surface of the conductive part of the collection wire except the two ends is covered with an insulating layer, and the surface of the implantation part of the collection wire except the two ends is covered with an insulating layer.

4. The transcranial collection stimulation electrode according to claim 1, characterized in that: The stimulation contact is a spherical contact or a disc-shaped contact.

5. The transcranial collection stimulation electrode according to claim 1, characterized in that: The collection component also includes a fixing part for fixing the implant part, and the material of the fixing part is polyethylene glycol; the upper end of the fixing part is connected to the lower cover plate, and the implant part extends from the lower end of the fixing part.

6. The transcranial collection stimulation electrode according to claim 1, characterized in that: The implanted parts are arranged in a stepped array or an equal length array.

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