Ion mobility separation transmission device and ion transmission method

Abstract

The application discloses an ion mobility separation transmission device and an ion transmission method, which comprise a focusing guide rod, a guide rod support, a mobility separation electrode sheet, a partition, a focusing electrode sheet, a first circuit board and a second connecting circuit board. The ions to be measured enter the mobility separation part of the ion mobility separation transmission device, and are subjected to electric field force and gas collision force. The ion separation method operates in a pipeline mode. In the first period, the ions enter the device, spatial arrangement is generated according to the collision cross section size, and the ions are enriched. In the second period, a reverse voltage is applied on the atmospheric pressure interface air curtain disc to prevent subsequent ions from entering the device. The application adds the dimension information of the collision cross section, the ions can be enriched in the ion mobility separation transmission device, the ions are always bound by the radio frequency quadrupole field in the channel from entering the ion mobility separation transmission device, are not easy to be lost, and the detection sensitivity can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to a mass spectrometry sampling technology, in particular to an ion mobility separation transmission device and an ion transmission method. BACKGROUND

[0002] The traditional liquid chromatography-mass spectrometer generally introduces the sample into the system through an electrospray ion source, an atmospheric pressure interface and an ion transmission device. The electrospray ion source atomizes the solvent containing the sample into small droplets and applies a high voltage. The sample forms a Taylor cone in the atomization process to generate an electrospray phenomenon. The solvent evaporates to generate charged ions through Coulomb explosion into the atmospheric pressure interface. The atmospheric pressure interface is generally composed of a gas curtain disc and a sampling cone. A protective backflush gas is introduced into the gap between the gas curtain disc and the sampling cone to prevent liquid droplets, neutral particles and the like from polluting the mass spectrometer. The ions enter the vacuum region after the sampling cone, are captured by the ion transmission device and are transmitted to a triple quadrupole or quadrupole time-of-flight mass analysis system for detection. The ion transmission device is generally composed of a quadrupole, an ion funnel and a capillary. The electrode sheets of the ion transmission device and the mobility separation device of the existing ion mobility spectrometer are generally made of stainless steel sheets, gold-plated copper sheets or printed circuit boards and are welded together by tin soldering. There are problems such as high difficulty in processing and assembly, difficulty in cleaning after pollution and the like. Moreover, the complex gas flow channel is easy to cause ion divergence, which reduces the detection sensitivity. The present application proposes a new type of ion mobility separation transmission device for ion mobility spectrometer to solve the above problems. SUMMARY

[0003] In order to solve the above problems in the prior art, the purpose of the present application is to provide an ion mobility separation transmission device and an ion transmission method, which can improve the detection sensitivity when transmitting ions.

[0004] The technical scheme adopted by the present application to solve its technical problems is as follows: an ion mobility separation transmission device, comprising two first circuit boards and two second circuit boards, a mobility separation electrode sheet connected between the two first circuit boards, so that the two first circuit boards and the mobility separation electrode sheet together constitute a first module, a focusing electrode sheet connected between the two second circuit boards, so that the two second circuit boards and the focusing electrode sheet together constitute a second module, one end of the first module connected to one end of the second module, and four focusing guide rods connected to the other end of the first module.

[0005] Among the four focusing guide rods, two adjacent ones are a first pair of focusing guide rods, and the other two are a second pair of focusing guide rods, wherein the first pair of focusing guide rods introduces a voltage U0, and the second pair of focusing guide rods introduces a voltage -U0.

[0006] In the first module, the number of the mobility separation electrode pieces is multiple, so that the thickness of the stacked mobility separation electrode pieces is adapted to the length of the first circuit board, and each adjacent two mobility separation electrode pieces is separated by a partition, and the center of each mobility separation electrode piece and the partition is provided with a first center hole; each mobility separation electrode piece has four electrodes, wherein opposite two electrodes constitute a pair of electrodes, and in the two pairs of electrodes, one pair of electrodes is introduced with voltage U1 through one of the first circuit boards, and the other pair of electrodes is introduced with voltage -U1 through the other first circuit board; and in the first module, the direction of the electric field is from the direction close to the second module to the direction close to the focusing guide rod;

[0007] In the second module, the number of the focusing electrode pieces is multiple, so that the length of the stacked focusing electrode pieces is adapted to the length of the second circuit board, and each focusing electrode piece is provided with a second center hole, and the aperture of the second center hole of the focusing electrode piece gradually decreases from one end close to the first module to one end away from the first module, so that the center hole of the focusing electrode piece in the second module forms a funnel shape; each focusing electrode piece has four electrodes, and in adjacent two focusing electrode pieces, the four electrodes of the first focusing electrode piece are introduced with voltage U2 through one of the second circuit boards, and the four electrodes of the second focusing electrode piece are introduced with voltage -U2 through the other second circuit board.

[0008] The first center hole is connected with a gas flow, and the flow direction of the gas flow is from one end close to the focusing guide rod to one end close to the second module.

[0009] Optionally, the mobility separation electrode piece and the focusing electrode piece are each provided with two introduction electrodes.

[0010] Optionally, in the first circuit board and the second circuit board, an isolation capacitor and a voltage dividing resistor are attached.

[0011] Optionally, the focusing guide rod is made of 316L stainless steel, and the diameter of the focusing guide rod is 4-5mm, and the electric field radius is 2-3mm.

[0012] Optionally, the focusing guide rod is connected with the first module through a guide rod support.

[0013] Optionally, the guide rod support is made of PEEK material or PEI material.

[0014] Based on the ion mobility separation and transmission device, the application further provides an ion transmission method, which comprises the following steps,

[0015] S1, a sample is ionized to generate ions to be tested;

[0016] S2, the ions to be measured enter the ion mobility separation transmission device through a sampling cone and a gas curtain disc;

[0017] S3, after the ions to be measured enter the first module of the ion mobility separation transmission device, the ions to be measured collide with the gas flow in the first central hole of the first module, and the ions to be measured are spatially arranged according to the size of the collision cross section and reach a balance position;

[0018] S4, after the spatial arrangement of the ions to be measured in the first central hole is completed, the gas curtain disc applies a reverse voltage to prevent subsequent ions from entering the ion mobility separation transmission device;

[0019] S5, a direct current voltage is applied to the mobility separation electrode sheet in the first module, and the amplitude of the direct current voltage is scanned;

[0020] S6, during the scanning of the amplitude of the direct current voltage, the amplitude of the direct current voltage gradually decreases, and when the collision force of the gas flow is greater than the electric field force, the ions to be measured lose balance and move towards the second module of the ion mobility separation transmission device;

[0021] S7, under the action of the gas flow, the ions to be measured enter the second module in turn and flow out from the second central hole of the second module, and then enter the mass analysis system.

[0022] Optionally, when the ions to be measured enter the ion mobility separation transmission device, the motion trajectory is bound by a focusing guide rod, so that the motion trajectory of the ions to be measured converges towards the axis of the first central hole.

[0023] Optionally, after the direct current voltage is applied to the mobility separation electrode sheet in the first module, the electric field force in the first central hole of the first module is gradient distributed.

[0024] Compared with the prior art, the present application has the following beneficial effects:

[0025] 1. The ions are separated by mobility, which increases the collision cross section dimension information and improves the separation and detection capability of complex compounds.

[0026] 2. The ions can be enriched in the ion mobility separation transmission device, improving the detection sensitivity.

[0027] 3. The ions are always bound by the radio frequency quadrupole field in the channel from entering the ion mobility separation transmission device, are not easy to lose, and can improve the detection sensitivity.

[0028] 4. In addition to being applicable to newly designed instruments, the present application can also be used for the modification of traditional liquid chromatography-mass spectrometry systems. The transmission part can be directly replaced with the ion mobility separation transmission device of the present application to realize the ion mobility function, thereby improving the expandability of the instrument.

[0029] 5. The structure complexity is reduced, the assembly difficulty is reduced, the pollution is convenient to disassemble and clean, and the purchase and use costs are reduced. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 is a schematic diagram of an ion mobility separation transmission device;

[0031] Figure 2 is a schematic diagram of a mobility separation electrode sheet;

[0032] Figure 3 is a specific implementation of a spacer plate;

[0033] Figure 4 is a schematic diagram of a first circuit board and a second circuit board;

[0034] Figure 5 is a schematic diagram of an ion mobility separation transmission device;

[0035] Figure 6 is a specific implementation of the application in a triple quadrupole ion mobility mass spectrometer;

[0036] Figure 7 is another specific implementation of the application in a quadrupole time-of-flight ion mobility mass spectrometer. DETAILED DESCRIPTION

[0037] The application will be further described below in conjunction with the drawings and examples. It can be understood that the specific examples described herein are only used to explain the related application, and are not a limitation on the application. In addition, it should be noted that only the parts related to the application are shown in the drawings for ease of description.

[0038] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The present application will be described in detail below with reference to the drawings and in conjunction with the embodiments.

[0039] The application discloses an ion mobility separation transmission device, as shown in the figure, the ion mobility separation transmission device comprises a focusing guide rod 31, a guide rod support 46, a mobility separation electrode sheet 41, a spacer plate 42, a focusing electrode sheet 49, a first circuit board 50 and a second circuit board 51. Figure 1

[0040] ​In one embodiment of the present application, the focusing guide rod 31 comprises four rods, and the focusing guide rod 31 is made of 316L material, with a diameter of 4-5mm and a field radius of 2-3mm. The focusing guide rod 31 is connected to the ion mobility separation transmission device through a guide rod support 46, and the guide rod support is made of PEEK or PEI material. In another embodiment of the present application, the number of the focusing guide rod 31 can be, for example, six rods or eight rods.

[0041] In the present application, the number of the mobility separation electrode sheet 41 and the focusing electrode sheet 49 is multiple, so that the thickness of the stacked multiple mobility separation electrode sheets 41 matches the length of the first circuit board 50, and the thickness of the stacked multiple focusing electrode sheets 49 matches the length of the second circuit board 51. The mobility separation electrode sheets 41 are separated by the partition plate 42. In one embodiment of the present application, the mobility separation electrode sheet 41 is made of a printed circuit board (PCB) with a thickness of 1.6mm, and the partition plate 42 is also made of a printed circuit board (PCB) with a thickness of 1.6mm.

[0042] In the present application, the first circuit board 50 and the second circuit board 51 are both made of a printed circuit board 418. As shown in Figure 4 the printed circuit board 418 comprises a spring contact connector 417, and the printed circuit board is attached with an isolation capacitor 44 and a voltage dividing resistor 45, which together constitute a resistance-capacitance network. The number of the first circuit board 50 is two, and the two first circuit boards 50 are respectively connected to the upper and lower sides of the mobility separation electrode sheet 41 to form a first module. The number of the second circuit board 51 is also two, and the two second circuit boards 51 are respectively connected to the upper and lower sides of the focusing electrode sheet 49 to form a second module. The first circuit board 50 and the second circuit board 51 are both installed in a plug-in manner, realizing the quick combination and replacement of the mobility separation electrode sheet 41 and the focusing electrode sheet 49.

[0043] In the present application, the mobility separation electrode sheet 41 is distributed with four electrodes, as shown in Figure 2 the four electrodes, i.e., electrode one 410, electrode two 411, electrode three 412 and electrode four 413, form a pure radio frequency quadrupole field after applying radio frequency voltage. The electrode one 410 and the electrode three 412 are a pair of electrodes connected to the first introduction electrode 414 to introduce radio frequency voltage U1 through the first introduction electrode 414, and the electrode two 411 and the electrode four 413 are another pair of electrodes connected to the second introduction electrode 415 to introduce radio frequency voltage -U1 through the second introduction electrode 415, forming a pure radio frequency quadrupole field. In addition, the four electrodes distributed on the mobility separation electrode sheet 41 are all made by gold plating process, and the first introduction electrode 414 and the second introduction electrode 415 are both made by gold finger process to introduce voltage on the two pairs of electrodes.

[0044] A first center hole is arranged at the center of the mobility separation electrode sheet 41, and the aperture of the first center hole of all the mobility separation electrode sheets 41 is consistent, for passing ions.

[0045] In the present application, a sealing ring mounting groove is arranged on the partition plate 42, as shown in the drawing, an FKM sealing ring is mounted in the groove, and the partition plate 42 is sealed with the mobility separation electrode sheet 41. Figure 3

[0046] In an embodiment of the present application, the focusing electrode sheet 49 is made of a printed circuit board (PCB), and the thickness is preferably 1.0mm-3.0mm.

[0047] Four electrodes are distributed on the focusing electrode sheet 49 of the present application, and a radio frequency voltage U2 is superimposed on the four electrodes of one focusing electrode sheet 49, and a radio frequency voltage -U2 is superimposed on the four electrodes of the adjacent focusing electrode sheet 49, and a second center hole is arranged at the center of the focusing electrode sheet 49, and the aperture of the second center hole gradually decreases from the end close to the mobility separation electrode sheet 41 to the end away from the mobility separation electrode sheet 41, so that the electric field of the focusing electrode sheet 49 realizes ion focusing in the radial direction in the form of a funnel.

[0048] Two lead-in electrodes are also arranged on the focusing electrode sheet 49, and a gold finger process is adopted to lead in voltage to the electrodes of the focusing electrode sheet 49.

[0049] The focusing guide rod 31 is connected with the mobility separation electrode sheet 41 through the guide rod support 46, the mobility separation electrode sheet 41 is connected through the connecting column 43 and the fastening screw 47, and the focusing electrode sheet 49 is connected through the focusing electrode sheet mounting frame 48.

[0050] The present application provides an ion transmission method, which comprises the following steps:

[0051] S1, sample is ionized to generate ions to be measured.

[0052] The sample is sprayed from the atomizer 101 of the ion source, and high voltage is applied, the sample forms a Taylor cone in the atomization process, generates an electrospray phenomenon, forms a small droplet spray 107 after atomization, and charged ions 108, i.e. ions to be measured, are generated through Coulomb explosion in the solvent evaporation process.

[0053] S2, the ions to be measured enter the ion mobility separation transmission device through the sampling cone and the air curtain disc.

[0054] ​The charged ions 108 enter the atmospheric pressure interface composed of the gas curtain disc 102 and the sampling cone 103, and the gap between the gas curtain disc 102 and the sampling cone 103 is provided with the protective backflush gas 109 to prevent liquid droplets, neutral particles and the like from entering the mass spectrometer.

[0055] S3, after the to-be-tested ions enter the first module of the ion mobility separation and transmission device, the to-be-tested ions collide with the airflow in the first central hole of the first module, and the to-be-tested ions are spatially arranged according to the size of the collision cross section and reach a balance position.

[0056] When the to-be-tested ions enter the ion mobility separation and transmission device, the focusing guide rods 31 bind the motion trajectory, so that the motion trajectory of the to-be-tested ions converges to the axis of the first central hole.

[0057] Among the four focusing guide rods 31, the two opposite electrodes form a pair, one pair of electrodes is applied with a U0 voltage, and the other pair of electrodes is applied with a -U0 voltage to form a pure radio frequency quadrupole field, which produces a binding effect on the motion trajectory of the ions, and the flight trajectory of the ions converges to the axis. The amplitude U0 is adjustable from 0 to 200 V, and the frequency is selectable from 800 kHz to 2000 kHz.

[0058] S4, after the spatial arrangement of the to-be-tested ions in the first central hole is completed, the gas curtain disc applies a reverse voltage to prevent subsequent ions from entering the ion mobility separation and transmission device.

[0059] The to-be-tested ions after being bound enter the mobility separation part of the ion mobility separation and transmission device, which includes the mobility separation electrode sheet 41, the partition plate 42, the focusing electrode sheet 49, the first circuit board 50 and the second circuit board 51. The to-be-tested ions are subjected to the action of electric field force and gas collision force in this part.

[0060] S5, a direct current voltage is applied to the mobility separation electrode sheet in the first module, and the amplitude of the direct current voltage is scanned.

[0061] In the first module, the electric field force is generated in the following manner:

[0062] The direct current voltage U1 is distributed to the above-mentioned mobility separation electrode sheet 41 through the resistance-capacitance elements on the first circuit board, the first mobility separation electrode sheet 41 close to the inlet is grounded or connected to a bias voltage, and the mobility separation electrode sheet 41 close to the outlet is applied with a voltage U1. According to the different voltages on each electrode sheet, a spatial gradient electric field distribution along the axial direction is generated, forming the axial electric field force required for mobility separation, which points from the outlet to the inlet. The formed electric field distribution is as follows: Figure 5As shown in the figure, the coordinate system represents the potential distribution along the axial direction, and the origin O represents the position of the coordinate origin at the entrance of the mobility separation part. The horizontal coordinate X represents the axial displacement, and the vertical coordinate E represents the electric field strength. The OA segment represents a linearly increasing gradient electric field strength in this part, and the AB segment represents an equal electric field strength in this part.

[0063] The magnitude of the axial electric field force experienced by the ions is related to the position of the ions on the axis. Ions of the same charge experience a smaller electric field force near the entrance and a larger electric field force near the exit.

[0064] In addition, a gas flow in the same direction as the flight direction of the ions to be measured is introduced into the ion mobility separation and transmission device, and the flow direction points from the entrance to the exit. The gas collision force experienced by the ions to be measured is related to the collision cross section. Ions with a larger collision cross section experience a larger force, and ions with a smaller collision cross section experience a smaller force. After the ions to be measured reach force balance, the ions with a larger collision cross section are close to the exit, and the ions with a smaller collision cross section are close to the entrance, and the distribution of the ions to be measured is spatially separated according to the size of the collision cross section.

[0065] A pair of radio frequency voltages U1 and -U1 are distributed to the above-mentioned mobility separation electrode sheet 41 through the resistance-capacitance elements on the first circuit board 50. The mobility separation electrode sheet 41 has four electrodes distributed thereon, and opposite electrodes form a pair. One pair of electrodes applies a voltage U1, and the other pair of electrodes applies a voltage -U1, forming a pure radio frequency quadrupole field, which binds the ions in the radial direction and causes the ions to be distributed to the space close to the axis. The amplitude of U1 is adjustable from 0 to 500 V, and the frequency is selectable from 800 kHz to 2000 kHz.

[0066] S6. During the scanning of the amplitude of the direct current voltage, the amplitude of the direct current voltage is gradually reduced. When the collision force of the gas flow is greater than the electric field force, the ions to be measured lose balance and move towards the second module of the ion mobility separation and transmission device.

[0067] S7. The ions to be measured enter the second module in turn under the action of the gas flow, flow out of the second center hole of the second module, and then enter the mass analysis system.

[0068] In the second module, the four electrodes of two adjacent focusing electrode sheets 49 are superimposed with radio frequency voltages. The four electrodes of the first focusing electrode sheet are simultaneously superimposed with a voltage U2, and the four electrodes of the second focusing electrode sheet are simultaneously superimposed with a voltage -U2, forming a funnel shape in the radial direction to focus the ions. The amplitude of U2 is adjustable from 0 to 500 V, and the frequency is selectable from 800 kHz to 2000 kHz, which can be selected to be equal to U1.

[0069] The transmission method of the ions to be measured in the device operates in a periodic pipeline manner.

[0070] In the first cycle, the ions to be detected enter the ion mobility separation transmission device, and spatial arrangement is generated according to the collision cross section size, so that the ions to be detected are enriched.

[0071] In the second cycle, a reverse voltage is applied to the atmospheric interface air curtain disc, so that the subsequent ions to be detected are prevented from entering the device.

[0072] The specific implementation mode of the ion mobility mass spectrometer in the application is shown in Figure 6 The sample is sprayed from the atomizer 101 of the ion source, and a high voltage is applied. The sample forms a Taylor cone in the atomization process, generates an electrospray phenomenon, forms a spray of atomized droplets 107, and generates charged ions 108 through Coulomb explosion in the solvent evaporation process to enter the atmospheric interface composed of the sampling cone 103. The gap between the air curtain disc 102 and the sampling cone 103 is provided with a protective backflush gas 109 to prevent droplets, neutral particles and the like from being polluted into the mass spectrometer. The ions to be detected are enriched in the first cycle and are subjected to mobility separation in the second cycle through the ion mobility separation transmission device 105, and then enter the next stage of vacuum region, are transmitted into the high vacuum region through the ion transmission quadrupole 111, are subjected to parent ion screening through the first-stage quadrupole 112, are subjected to fragmentation in the collision cell composed of the second-stage quadrupole 113 and the lens one 117, the lens two 118, the lens three 119, the lens four 120 and the shell, are subjected to daughter ion screening through the third-stage quadrupole 114, are subjected to deflection or secondary electron generation through the repeller 115, and are detected by the electron multiplier one 116. The system can obtain ion mobility information and mass spectrum information.

[0073] Another specific implementation mode of the application in a quadrupole time-of-flight ion mobility mass spectrometer is shown in Figure 7The sample is ejected from the atomizer 101 of the ion source and is given a high voltage. The sample forms a Taylor cone during atomization, generating an electrospray phenomenon, forming a spray of atomized droplets 107, and charged ions 108 are generated by Coulomb explosion during solvent evaporation into the gas curtain disc 102, the atmospheric pressure interface composed of the sampling cone 103, the gap between the gas curtain disc 102 and the sampling cone 103 is protected by the protective backflush gas 109 to prevent droplets, neutral particles and the like from entering the mass spectrometer, and the ions to be measured are enriched in the first cycle and undergo mobility separation in the second cycle through the ion mobility separation and transmission device 105, and then enter the next stage of vacuum area, are transmitted into the high vacuum area through the ion transmission quadrupole 111, are subjected to parent ion screening through the first-stage quadrupole 112, are fragmented in the collision cell composed of the second-stage quadrupole 113 and the lens one 117, the lens two 118, the lens three 119, the lens four 120 and the outer shell, are focused through the lens five 121, are accelerated into the time-of-flight flight tube by the vertical introduction device 122, are reflected by the reflector 123 to generate a V-shaped reflection flight trajectory, and are detected by the channel electron multiplier two 124. The system can obtain ion mobility information and high-resolution mass spectrum information.

[0074] The above description is only the preferred embodiment of the present application and the explanation of the applied technical principles. Those skilled in the art should understand that the scope of the invention involved in the present application is not limited to the technical solutions formed by the specific combination of the above technical features, and should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the inventive concept. For example, the above features can be replaced with the technical features disclosed in the present application (but not limited to) having similar functions to form technical solutions.

[0075] In addition to the technical features described in the specification, the remaining technical features are known to those skilled in the art, and in order to highlight the innovative features of the present application, the remaining technical features will not be described here.

Claims

1. An ion mobility separation and transmission apparatus, characterized by, The ion mobility separation and transmission device comprises two first circuit boards and two second circuit boards, a mobility separation electrode sheet is connected between the two first circuit boards, the two first circuit boards and the mobility separation electrode sheet jointly form a first module, a focusing electrode sheet is connected between the two second circuit boards, the two second circuit boards and the focusing electrode sheet jointly form a second module, one end of the first module is connected with one end of the second module, and the other end of the first module is connected with four focusing guide rods. Among the four focusing guide rods, two adjacent ones are a first pair of focusing guide rods, and the other two are a second pair of focusing guide rods, the first pair of focusing guide rods is introduced with a voltage U0, and the second pair of focusing guide rods is introduced with a voltage -U0. In the first module, the number of the mobility separation electrode sheets is multiple, so that the thickness of the stacked mobility separation electrode sheets is adapted to the length of the first circuit board, and each two adjacent mobility separation electrode sheets are separated by a partition, the center of each mobility separation electrode sheet and the partition is provided with a first center hole, each mobility separation electrode sheet has four electrodes, and opposite two electrodes form a pair of electrodes, and in the two pairs of electrodes, one pair of electrodes is introduced with a voltage U1 through one of the first circuit boards, and the other pair of electrodes is introduced with a voltage -U1 through the other first circuit board, and in the first module, the direction of the electric field is from the direction close to the second module to the direction close to the focusing guide rods. In the second module, the number of the focusing electrode sheets is multiple, so that the length of the stacked focusing electrode sheets is adapted to the length of the second circuit board, each focusing electrode sheet is provided with a second center hole, and the aperture of the second center hole of the focusing electrode sheet gradually decreases from one end close to the first module to one end away from the first module, so that the center hole of the focusing electrode sheet in the second module forms a funnel shape, each focusing electrode sheet has four electrodes, and in the two adjacent focusing electrode sheets, the four electrodes of the first focusing electrode sheet are introduced with a voltage U2 through one of the second circuit boards, and the four electrodes of the second focusing electrode sheet are introduced with a voltage -U2 through the other second circuit board. The first center hole is introduced with an airflow, and the flow direction of the airflow is from one end close to the focusing guide rods to one end close to the second module.

2. The ion mobility separation and transmission device of claim 1, wherein, The mobility separation electrode sheet and the focusing electrode sheet are each provided with two introduction electrodes.

3. The ion mobility separation and transmission device of claim 2, wherein, In the first circuit board and the second circuit board, an isolation capacitor and a voltage dividing resistor are attached.

4. The ion mobility separation and transmission apparatus of claim 3, wherein, The focusing guide rod is made of 316L stainless steel, and the diameter of the focusing guide rod is 4-5mm, and the electric field radius is 2-3mm.

5. The ion mobility separation and transmission apparatus of claim 4, wherein, The focusing guide rod is connected with the first module through a guide rod support.

6. The ion mobility separation and transmission apparatus of claim 5, wherein, The guide rod support is made of PEEK material or PEI material.

7. A method of ion transport, characterized by, The ion mobility separation and transmission device is used for transmitting ions, comprising the following steps, S1, a sample is ionized to generate test ions; S2, the test ions enter the ion mobility separation and transmission device through a sampling cone and an air curtain disc; S3, after the to-be-tested ions enter the first module of the ion mobility separation transmission device, the to-be-tested ions collide with the airflow in the first central hole of the first module, and the to-be-tested ions are spatially arranged according to the size of the collision cross section and reach a balance position; S4, after the spatial arrangement of the to-be-tested ions in the first central hole is completed, the gas curtain disc applies a reverse voltage to prevent subsequent ions from entering the ion mobility separation transmission device; S5, a direct current voltage is applied to the mobility separation electrode sheet in the first module, and the amplitude of the direct current voltage is scanned; S6, during the scanning of the amplitude of the direct current voltage, the amplitude of the direct current voltage gradually decreases, when the collision force of the airflow is greater than the electric field force, the to-be-tested ions lose balance and move to the direction of the second module of the ion mobility separation transmission device; S7, under the action of the airflow, the to-be-tested ions enter the second module in turn and flow out from the second central hole of the second module, and then enter the mass analysis system.

8. The ion transfer method according to claim 7, wherein, When the to-be-tested ions enter the ion mobility separation transmission device, the focusing guide rod binds the motion trajectory, so that the motion trajectory of the to-be-tested ions converges to the axis of the first central hole.

9. The ion transport method according to claim 7, wherein, After the direct current voltage is applied to the mobility separation electrode sheet in the first module, the electric field force in the first central hole of the first module is gradient distributed.

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