POCT full-automatic chemiluminescence equipment

Abstract

The invention belongs to the field of medical equipment, and provides POCT (Point of Care Testing) full-automatic chemiluminescence equipment, which comprises a mounting frame; the reaction bin assembly is arranged on the mounting frame, can reciprocate in the length direction of the mounting frame, and is used for loading reagent strips; the PMT assembly is arranged at the rear end of the mounting frame and located above the reaction bin assembly, the reaction bin assembly is used for moving the reagent strip to the PMT assembly, and the PMT assembly is used for conducting luminous value detection on the detection position of the reagent strip; the multi-channel parallel pretreatment device is arranged on the mounting frame and located in front of the PMT device, the multi-channel parallel pretreatment device is located above the reaction bin assembly and can reciprocate in the length direction of the mounting frame, and the multi-channel parallel pretreatment device is used for sucking and spitting samples from the reagent strips and transferring magnetic particles. According to the multi-channel parallel pretreatment device, the multi-channel parallel pretreatment device is movably arranged in the mounting frame and can move relative to the reaction bin assembly, so that the pretreatment speed of the multi-channel parallel pretreatment device is increased.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a POCT fully automatic chemiluminescence device. Background Art

[0002] As a rapidly developing non-radioactive immunoassay technology, chemiluminescent immunoassay technology has become one of the important directions of immunological detection. Its principle is to use chemiluminescent signals to directly measure immune reactions. Chemiluminescent equipment using chemiluminescent immunoassay technology has the advantages of high sensitivity, good repeatability, high accuracy, good specificity and wide linear range.

[0003] POCT (Point-Of-Care Testing) is a testing method that conducts clinical testing immediately at the sampling site, eliminating the complex processing procedures of specimens in laboratory tests, and quickly obtaining test results. It has the characteristics of instrument programming, simple operation, and fast reporting of results.

[0004] At present, POCT fully automatic chemiluminescence equipment has been manufactured by applying chemiluminescence immunoassay technology to POCT products. This equipment has the advantages of instant detection and rapid diagnosis results, and has been rapidly and widely promoted in the in vitro diagnostic industry. However, as the requirements for detection speed become higher and higher, how to further improve the detection speed of POCT fully automatic chemiluminescence equipment has become a problem that many manufacturers are committed to solving.

[0005] In addition, the POCT fully automatic chemiluminescence equipment generally includes a reaction chamber module and a pre-treatment module. The reaction chamber module is used to load the reagent strips containing various reagents, and the reagent strips are moved to the pre-treatment module for corresponding treatment. The length of the reagent strip is affected by the number of test items. As the number of test items increases, the reagents sealed in the reagent strip also need to increase accordingly, and the length of the reagent strip will also increase.

[0006] When the device is used for detection and analysis of multiple projects, the distance that the reaction chamber module needs to move with the reagent strip in the device will increase, so that the reagent strip can be moved to the pre-treatment module for corresponding treatment of each well position. However, this will cause the size of the device to increase, which is not conducive to the miniaturization and portability of the device, and will also prolong the time for detection and obtaining diagnostic results. Summary of the invention

[0007] The embodiment of the present invention provides a POCT fully automatic chemiluminescence device, aiming to solve the technical problems of how to further improve the detection speed of the POCT fully automatic chemiluminescence device, and how to control the device volume and ensure the detection speed when increasing the reagent strip to meet multiple detection requirements.

[0008] The embodiment of the present invention is implemented as follows: a POCT fully automatic chemiluminescence device, comprising:

[0009] Install the frame;

[0010] A reaction chamber assembly disposed on the mounting frame, the reaction chamber assembly being reciprocatable along the length direction of the mounting frame, and the reaction chamber assembly being used for loading a reagent strip;

[0011] a PMT assembly disposed at the rear end of the mounting frame and located above the reaction chamber assembly, the reaction chamber assembly being used to move the reagent strip to the PMT assembly, the PMT assembly being used to detect the luminescence value of the detection position of the reagent strip; and

[0012] A multi-channel parallel pre-processing device is arranged on the mounting frame and located in front of the PMT device. The multi-channel parallel pre-processing device is located above the reaction chamber assembly and can reciprocate along the length direction of the mounting frame. The multi-channel parallel pre-processing device is used to aspirate samples from the reagent strip and transfer magnetic particles.

[0013] Furthermore, a first driving element and a first guide rail are provided on the bottom plate of the mounting frame, the first driving element is located at the rear end of the mounting frame, the first guide rail extends along the length direction of the mounting frame, and the multi-channel parallel pre-processing device is transmission-connected to the first driving element and movably arranged with the first guide rail.

[0014] Furthermore, the multi-channel parallel pre-processing device comprises:

[0015] a gantry provided on the bottom plate of the mounting frame, the gantry and the first guide rail being movably arranged and being in driving connection with the first driving element, and a second driving element being provided on the top of the gantry;

[0016] a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the second driving element and being capable of rising and falling under the driving of the second driving element to suck and discharge the sample on the reagent strip; and

[0017] The sample pre-processing mechanism is arranged on the gantry, and is drivingly connected with the second driving element, and can be lifted and lowered under the driving of the second driving element to transfer the magnetic particles on the reagent strip.

[0018] Furthermore, a first driving pulley is provided on the transmission shaft of the first driving element, a first mounting seat is provided at the front end of the base plate of the mounting frame, a first driven pulley is provided on the first mounting seat, the first driving pulley is connected to the first driven pulley through a belt, and a first synchronous belt pressure plate connected to the belt is provided at the bottom of the gantry.

[0019] Furthermore, the first driving element is a screw motor, and the transmission screw of the first driving element is transmission-connected to the bottom end of the gantry.

[0020] Furthermore, the sample extraction mechanism includes:

[0021] A first mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the first mounting frame to rise and fall;

[0022] a third driving element disposed on the first mounting frame; and

[0023] An extraction component is arranged on the first mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to move in a vertical direction to suck and discharge samples.

[0024] Furthermore, the extraction component includes:

[0025] An injection device is arranged on the first mounting frame, wherein a syringe cavity is formed in the injection device, a first loading head for loading a tip head is arranged at the bottom of the injection device, and the first loading head is communicated with the syringe cavity;

[0026] a first push plate disposed above the injection device, the first push plate being drivingly connected to the third driving element; and

[0027] The piston rod is arranged on the first push plate, and the piston rod is movably and sealedly connected to the syringe cavity. The third driving element can drive the first push plate to drive the piston rod to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0028] Furthermore, the sample extraction mechanism also includes:

[0029] A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the first push plate;

[0030] an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and

[0031] A separation plate is arranged at the bottom of the injection device, the first loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the first loading head.

[0032] Furthermore, there are multiple syringe cavities, and the multiple syringe cavities are evenly distributed along the length direction of the injection device;

[0033] There are a plurality of first loading heads, and the plurality of first loading heads are evenly spaced and distributed along the length direction of the injection device;

[0034] There are multiple piston rods, and the multiple piston rods are evenly distributed along the length direction of the first push plate.

[0035] Furthermore, the sample pre-processing mechanism includes:

[0036] A second mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the second mounting frame to rise and fall;

[0037] a fourth driving element disposed on the second mounting frame; and

[0038] A pre-processing component is arranged on the second mounting frame and is transmission-connected to the fourth driving element. The fourth driving element can drive the pre-processing component to move in a vertical direction to transfer magnetic particles.

[0039] Furthermore, the pre-processing component includes:

[0040] A magnetic bar device is arranged on the second mounting frame, wherein an active through hole is formed in the magnetic bar device, and a second loading head for loading a disposable magnetic separation sleeve is arranged at the bottom of the magnetic bar device, and the second loading head is communicated with the active through hole;

[0041] a second push plate disposed above the magnetic bar device, the second push plate being drivingly connected to the fourth driving element; and

[0042] A connecting rod is arranged on the second pushing plate, and a magnetic bar is arranged on the free end of the connecting rod. The fourth driving element can drive the second pushing plate to drive the magnetic bar to rise and fall in the corresponding movable through hole so as to be separated from the second loading head or pass through the second loading head.

[0043] Furthermore, the magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly spaced and distributed on the second push plate along the width direction of the second push plate;

[0044] There are multiple magnetic bars in each row, and the multiple magnetic bars are evenly distributed on the second pushing plate along the length direction of the second pushing plate at intervals.

[0045] Furthermore, the sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the second driving element, the third driving element and the fourth driving element are linearly arranged on the top of the gantry.

[0046] Furthermore, the gantry is provided with an activity space, the transmission shaft of the second driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves;

[0047] A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

[0048] Furthermore, the reaction chamber assembly comprises:

[0049] A second guide rail disposed on the bottom plate of the mounting frame;

[0050] A reaction chamber body disposed on the second guide rail, wherein a slider slidably connected to the second guide rail is disposed at the bottom of the reaction chamber body, and a plurality of evenly spaced receiving grooves for loading reagent strips are disposed on the reaction chamber body, wherein the receiving grooves extend along the length direction of the reaction chamber body;

[0051] a fifth driving element disposed on the bottom plate of the mounting frame and located at the rear end of the second guide rail, wherein a second driving pulley is disposed on the transmission shaft of the fifth driving element;

[0052] a second mounting seat disposed on the bottom plate of the mounting frame and located at the front end of the second guide rail, the second mounting seat being provided with a second driven pulley, the second driving pulley being transmission-connected to the second driven pulley via a belt; and

[0053] A second synchronous belt pressure plate is arranged on one side of the reaction chamber body, and the second synchronous belt pressure plate is connected to the belt.

[0054] Furthermore, the PMT assembly comprises:

[0055] A mounting bracket disposed on the bottom plate of the mounting frame;

[0056] a third mounting bracket disposed on the mounting bracket;

[0057] a fourth mounting frame disposed at the bottom of the third mounting frame;

[0058] A PMT module disposed on the fourth mounting frame;

[0059] A sixth driving element disposed on the top of the third mounting frame and drivingly connected to the fourth mounting frame, the sixth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down;

[0060] A seventh driving element and a third driven pulley are respectively arranged on both sides of the top of the mounting bracket, a third driving pulley is arranged on the transmission shaft of the seventh driving element, and the third driving pulley is connected to the third driven pulley through a belt; and

[0061] A third synchronous belt pressure plate is arranged on the third mounting frame, and the third synchronous belt pressure plate is connected to the belt.

[0062] In the POCT fully automatic chemiluminescence equipment of the embodiment of the present invention, the multi-channel parallel pre-treatment device is movably arranged in the installation frame so that the multi-channel parallel pre-treatment device can move relative to the reaction chamber assembly, thereby accelerating the speed at which the reagent strip moves to the multi-channel parallel pre-treatment device, and further accelerating the pre-treatment speed of the reagent strip by the multi-channel parallel pre-treatment device, so as to achieve the purpose of improving the analysis efficiency of the POCT fully automatic chemiluminescence equipment.

[0063] In addition, when the reagent strip is used for multiple detection items and the length of the reagent strip becomes longer, in order to enable the multi-channel parallel pretreatment device to quickly pre-treat the reagent strip, the reaction chamber assembly does not need to move the reagent strip for a long distance, but can shorten the moving distance between the multi-channel parallel pretreatment device and the reagent strip through the relative movement of the multi-channel parallel pretreatment device, thereby facilitating the multi-channel parallel pretreatment device to perform pre-treatment between the various holes of the reagent strip, and realizing efficient detection of multiple detection items while controlling the volume of the POCT fully-automatic chemiluminescence equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0064] Figure 1 is a three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device according to an embodiment of the present invention;

[0065] Figure 2 It is another three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device which is part of an embodiment of the present invention;

[0066] Figure 3 It is another three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device which is part of an embodiment of the present invention;

[0067] Figure 4 is a three-dimensional schematic diagram of a mounting frame according to an embodiment of the present invention;

[0068] Figure 5 is another three-dimensional schematic diagram of a mounting frame according to an embodiment of the present invention;

[0069] Figure 6 is a three-dimensional schematic diagram of a multi-channel parallel pre-processing device according to an embodiment of the present invention;

[0070] Figure 7is another three-dimensional schematic diagram of a multi-channel parallel pre-processing device according to an embodiment of the present invention;

[0071] Figure 8 is a schematic structural diagram of a multi-channel parallel pre-processing device according to an embodiment of the present invention;

[0072] Fig. 9 is a three-dimensional disassembled schematic diagram of a multi-channel parallel pre-processing device according to an embodiment of the present invention;

[0073] Fig.10 is a three-dimensional schematic diagram of a gantry according to an embodiment of the present invention;

[0074] Fig.11 is a three-dimensional schematic diagram of a sample extraction mechanism according to an embodiment of the present invention;

[0075] Fig.12 is a three-dimensional schematic diagram of a sample pre-processing mechanism according to an embodiment of the present invention;

[0076] Fig.13 is a three-dimensional schematic diagram of a PMT assembly according to an embodiment of the present invention;

[0077] Fig.14 is a three-dimensional schematic diagram of a reaction chamber body according to an embodiment of the present invention;

[0078] Fig.15 Schematic diagram of a cross-section of a reagent strip according to an embodiment of the present invention.

[0079] Description of main component symbols:

[0080] Mounting frame-10; first mounting seat-11; first driven pulley-111; reaction chamber assembly-20; reaction chamber body-21; accommodating groove-211; reagent strip-30; handle-31; tip-32; disposable magnetic separation sleeve-33; PMT assembly-40; mounting bracket-41; third mounting frame-42; fourth mounting frame-43; PMT module-44; sixth driving element-45; seventh driving element-46; third driven pulley-47; multi-channel parallel pre-processing device-50; first driving element-51; first driving pulley-511; first guide rail-52; gantry-53; activity space-531; transmission plate-532 ; second driving element-54; sample extraction mechanism-55; first mounting bracket-551; third driving element-552; extraction assembly-553; injection device-5531; first loading head-5532; first push plate-5533; piston rod-5534; push rod-5535; elastic element-5536; separation plate-5537; sample pre-treatment mechanism-56; second mounting bracket-561; fourth driving element-562; pre-treatment assembly-563; magnetic rod device-5631; second loading head-5632; second push plate-5633; connecting rod-5634; magnetic rod-5635; POCT fully automatic chemiluminescence equipment-100. DETAILED DESCRIPTION

[0081] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. In addition, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0082] In the description of the present invention, it is necessary to understand that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0083] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0084] The disclosure below provides many different embodiments or examples to realize different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the examples of various specific processes and materials provided by the present invention, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0085] See also Figures 1 to 5 The POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention comprises:

[0086] Mounting frame 10;

[0087] A reaction chamber assembly 20 disposed on the mounting frame 10 , the reaction chamber assembly 20 can reciprocate along the length direction of the mounting frame 10 , and the reaction chamber assembly 20 is used to load a reagent strip 30 ;

[0088] A PMT assembly 40 disposed at the rear end of the mounting frame 10 and located above the reaction chamber assembly 20, the reaction chamber assembly 20 is used to move the reagent strip 30 to the PMT assembly 40, and the PMT assembly 40 is used to detect the luminescence value of the detection position of the reagent strip 30; and

[0089] A multi-channel parallel pre-processing device 50 is provided on the mounting frame 10 and is located at the front end of the PMT device. The multi-channel parallel pre-processing device 50 is located relatively above the reaction chamber assembly 20 and can reciprocate along the length direction of the mounting frame 10. The multi-channel parallel pre-processing device 50 is used to aspirate and discharge samples from the reagent strip 30 and transfer magnetic particles.

[0090] In the POCT fully automatic chemiluminescence equipment 100 of the embodiment of the present invention, the multi-channel parallel pre-treatment device 50 is movably arranged in the installation frame 10, so that the multi-channel parallel pre-treatment device 50 can move relative to the reaction chamber assembly 20, thereby accelerating the speed at which the reagent strip 30 moves to the multi-channel parallel pre-treatment device 50, and further accelerating the pre-treatment speed of the reagent strip 30 by the multi-channel parallel pre-treatment device 50, so as to achieve the purpose of improving the analysis efficiency of the POCT fully automatic chemiluminescence equipment 100.

[0091] In addition, when the reagent strip 30 is used for multiple detection items and the length of the reagent strip 30 becomes longer, in order to enable the multi-channel parallel pretreatment device 50 to quickly pre-treat the reagent strip 30, the reaction chamber assembly 20 does not need to move the reagent strip 30 for a long distance, but can shorten the moving distance between the multi-channel parallel pretreatment device 50 and the reagent strip 30 through the relative movement of the multi-channel parallel pretreatment device 50, thereby facilitating the multi-channel parallel pretreatment device 50 to perform pre-treatment between the various hole positions of the reagent strip 30, and can control the volume of the POCT fully-automatic chemiluminescence device 100 while achieving efficient detection of multiple detection items by the POCT fully-automatic chemiluminescence device 100.

[0092] Specifically, the POCT fully automatic chemiluminescent device 100 of the embodiment of the present invention is roughly rectangular in shape, and the mounting frame 10 is the basic structure of the POCT fully automatic chemiluminescent device 100. The mounting frame 10 may include a base plate, multiple side plates and a top plate arranged on the base plate, etc. The mounting frame 10 surrounded by the base plate, multiple side plates and top plate is also roughly rectangular in shape.

[0093] The mounting frame 10 is used to carry and install the above-mentioned reaction chamber assembly 20, PMT assembly 40 and multi-channel parallel pre-processing device 50 and other components, provide stable support for the above-mentioned components and protect the above-mentioned components from interference from external impurities, water vapor and the like.

[0094] In an embodiment of the present invention, the reaction chamber assembly 20 can be arranged on the bottom plate of the mounting frame 10, and driving elements such as a motor and a guide rail extending along the length direction of the mounting frame 10 can be arranged on the bottom plate. A slide corresponding to the guide rail can be arranged at the bottom of the reaction chamber assembly 20. Through the cooperation between the slide and the guide rail, the reaction chamber assembly 20 can be slidably arranged on the mounting frame 10 to realize reciprocating movement, and then the reagent strip 30 can be moved to the corresponding position for corresponding detection and analysis.

[0095] See also Fig.14 and Fig.15 A plurality of parallel accommodating grooves 211 may be formed on the reaction chamber assembly 20, and the accommodating grooves 211 extend along the length direction of the reaction chamber assembly 20. The reagent strips 30 are loaded in the accommodating grooves 211. The plurality of accommodating grooves 211 may accommodate a plurality of reagent strips 30, that is, the reaction chamber assembly 20 may drive the plurality of reagent strips 30 to move in the POCT fully automatic chemiluminescence device 100, so that the POCT fully automatic chemiluminescence device 100 may perform multi-channel detection and analysis on the plurality of reagent strips 30 in sequence.

[0096] The reagent strip 30 is generally in the shape of a long strip, and a handle 31 may be provided at one end thereof. The handle 31 may be provided with anti-slip patterns to increase the friction between the reagent strip 30 and the operator's fingers, so that the operator can hold it tightly. The reagent strip 30 is a disposable consumable and can be directly discarded and destroyed after use.

[0097] Taking the reagent strip 30 that can be used for multiplex testing as an example, a sample hole, a tip hole, one or more disposable magnetic separation sleeve holes, multiple magnetic labeled ligand holes, multiple enzyme labeled ligand holes, multiple cleaning liquid holes and multiple substrate reading holes (i.e., the above-mentioned detection positions) can be provided in sequence from one end of the handle 31 to the other end of the reagent strip 30.

[0098] Among them, the sample hole is used to add blood samples, such as whole blood or serum, the tip hole is provided with a tip head 32, the disposable magnetic separation sleeve hole is provided with a disposable magnetic separation sleeve 33, the magnetic labeling ligand hole contains a magnetic labeling ligand, the enzyme labeling ligand hole contains an enzyme labeling ligand, wherein the ligand includes but is not limited to a hapten, an antigen, a monoclonal antibody, a polyclonal antibody and a nucleic acid ligand, the cleaning liquid hole contains a cleaning liquid, and the substrate reading hole contains a substrate reading. In addition, after the corresponding reagents are encapsulated in the corresponding holes of the reagent strip 30, the surface of the reagent strip 30 can be heat-sealed with a film to prevent the reagents in each hole from volatilizing, leaking or being contaminated, and it is also convenient for the storage and transportation of the reagent strip 30.

[0099] The tip head 32 is a hollow structure with a sharp end for breaking the sealing film on each hole position. The end is provided with a perforation so that the tip head 32 can be used to transfer samples or reagents. The disposable magnetic separation sleeve 33 can be used for adsorption, mixing, cleaning and transfer of magnetic particles. The cleaning liquid hole can be used to clean the magnetic particles. The substrate reading hole is used for performing chemiluminescent reaction and supplying the PMT component 40 with the luminescence value.

[0100] Since the reaction chamber assembly 20 is arranged on the bottom plate of the mounting frame 10, the PMT assembly 40 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT assembly 40 is located relatively above the reaction chamber assembly 20. To ensure that the PMT assembly 40 can detect the luminescence values ​​of all reagent strips 30 in the reaction chamber assembly 20, the PMT assembly 40 can move up, down, left and right in the mounting frame 10, that is, it can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 10), so as to approach or move away from the reagent strip 30 and move back and forth between multiple reagent strips 30.

[0101] Similarly, the multi-channel parallel pretreatment device 50 can also be arranged above the bottom plate through a bracket or other structure, that is, the multi-channel parallel pretreatment device 50 is located relatively above the reaction chamber assembly 20. To ensure that the multi-channel parallel pretreatment device 50 can pre-treat all reagent strips 30 in the reaction chamber assembly 20, the multi-channel parallel pretreatment device 50 can also move up and down in the mounting frame 10, that is, move in the vertical direction, so as to approach or move away from the reagent strip 30 to transfer samples or reagents, break the sealing film on the holes of the reagent strip 30, and adsorb, mix, clean and transfer magnetic particles.

[0102] Multi-channel parallel processing can be understood as processing multiple reagent strips 30 in multiple channels at the same time, and the processing before the sample is transferred to the substrate reading hole for chemiluminescent reaction can be understood as pre-processing. In an embodiment of the present invention, the multi-channel parallel pre-processing device 50 may include two parts, one part of the structure is used to combine with the tip head 32 to transfer samples or reagents and break the sealing film of each hole, and the other part of the structure is used to combine with the disposable magnetic separation sleeve 33 to adsorb, mix, wash and transfer magnetic particles.

[0103] Please continue reading Figures 2 to 5 Furthermore, a first driving element 51 and a first guide rail 52 are provided on the bottom plate of the mounting frame 10. The first driving element 51 is located at the rear end of the mounting frame 10. The first guide rail 52 extends along the length direction of the mounting frame 10. The multi-channel parallel pre-processing device 50 is transmission-connected to the first driving element 51 and is movably arranged with the first guide rail 52.

[0104] Specifically, the first driving element 51 provides power for the reciprocating movement of the multi-channel parallel pre-processing device 50, and can be a driving element such as a lead screw motor or a stepper motor. The lead screw motor has high movement accuracy and the stepper motor has high transmission efficiency, and can be selected according to specific needs.

[0105] The first driving element 51 is arranged at the rear end of the mounting frame 10, and combined with the first guide rail 52 extending along the length direction of the mounting frame 10, so that the moving distance of the multi-channel parallel pre-processing device 50 in the mounting frame 10 is long enough, and it can stably reciprocate in the mounting frame 10, thereby ensuring that it can stably move relative to the reaction chamber assembly 20 a sufficiently long distance to speed up the pre-processing speed.

[0106] See also Figures 5 to 10 , further, the multi-channel parallel pre-processing device 50 includes:

[0107] A gantry 53 is disposed on the bottom plate of the mounting frame 10, the gantry 53 and the first guide rail 52 are movably disposed and are in transmission connection with the first driving element 51, and a second driving element 54 is disposed on the top of the gantry 53;

[0108] A sample extraction mechanism 55 is disposed on the gantry 53, and the sample extraction mechanism 55 is in driving connection with the second driving element 54, and can be raised and lowered under the driving of the second driving element 54 to suck and discharge the sample on the test strip 30;

[0109] The sample pre-processing mechanism 56 disposed on the gantry 53 is drivingly connected to the second driving element 54 and can be raised and lowered under the drive of the second driving element 54 to transfer the magnetic particles on the reagent strip 30 .

[0110] Specifically, the gantry 53 can be made of metal materials, such as stainless steel, iron, aluminum and various alloys, which have high strength and can increase the service life of the multi-channel pre-processing device. The gantry 53 spans the width direction of the mounting frame 10, so that the sample extraction mechanism 55 and the sample pre-processing mechanism 56 can span the top of the reaction chamber assembly 20 to achieve multi-channel parallel pre-processing.

[0111] A sliding seat may be provided at the bottom of the gantry 53 to cooperate with the first guide rail 52, so that the gantry 53 and the first guide rail 52 can be movably arranged, or a sliding groove may be provided at the bottom of the gantry 53 to cooperate with the first guide rail 52 to achieve movable arrangement. The gantry 53 is connected to the transmission shaft of the first driving element 51, and the gantry 53 can be driven by the first driving element 51 to realize the reciprocating movement of the multi-channel parallel pre-processing device 50 in the installation frame 10.

[0112] In an embodiment of the present invention, the second driving element 54 can be a screw motor, which has high movement accuracy and more accurate and stable position adjustment. The second driving element 54 arranged on the top of the gantry 53 drives the sample extraction mechanism 55 and the sample pre-treatment mechanism 56 to rise and fall on the gantry 53, so that the sample extraction mechanism 55 and the sample pre-treatment mechanism 56 are close to or away from the reagent strip 30, so that the sample extraction mechanism 55 cooperates with the tip head 32 on the reagent strip 30 to achieve functions such as breaking the membrane, transferring samples or transferring reagents, and the sample pre-treatment mechanism 56 cooperates with the disposable magnetic separation sleeve 33 on the reagent strip 30 to achieve the adsorption, mixing, cleaning and transfer of magnetic particles.

[0113] In addition, the sample pre-processing mechanism 56 and the sample extraction mechanism 55 are located on opposite sides of the gantry 53 , such as the sample pre-processing mechanism 56 is located on one side of the gantry 53 close to the PMT assembly 40 , and the sample extraction mechanism 55 is located on the other side of the gantry 53 .

[0114] In this way, it is possible to avoid placing the sample pretreatment mechanism 56 and the sample extraction mechanism 55 on the same side of the gantry 53, which would cause crowded space and heavy load on one side of the gantry 53, resulting in inconvenient operation and unstable structure of the gantry 53. In addition, the sample extraction mechanism 55 and the sample pretreatment mechanism 56 can be made to correspond to reagent holes with different functions on the reagent strip 30 respectively. For example, the front section of the reagent strip 30 requires more participation of the sample extraction mechanism 55, while the rear section requires more participation of the sample pretreatment mechanism 56, which can further improve the pretreatment speed of the reagent strip 30 by the multi-channel parallel pretreatment device 50.

[0115] See also Figure 4 and Figure 5 Furthermore, in one embodiment of the present invention, a first driving pulley 511 is provided on the transmission shaft of the first driving element 51, a first mounting seat 11 is provided at the front end of the bottom plate of the mounting frame 10, a first driven pulley 111 is provided on the first mounting seat 11, the first driving pulley 511 is connected to the first driven pulley 111 through a belt, and a first synchronous belt pressure plate connected to the belt is provided at the bottom of the gantry 53.

[0116] Specifically, the first driving element 51 is located at the rear end of the mounting frame 10, and the first mounting seat 11 is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the multi-channel parallel pre-processing device 50 in the mounting frame 10 can be long enough to better cooperate with the movement of the reaction chamber assembly 20.

[0117] The transmission structure composed of the first driving pulley 511, the belt, the first synchronous belt pressure plate and the first driven pulley 111 has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the first guide rail 52, it can ensure that the multi-channel parallel pre-processing device 50 moves stably and quickly in the installation frame 10, thereby accelerating the movement speed of the multi-channel parallel pre-processing device 50.

[0118] In the embodiment of the present invention, the first driving element 51 and the above-mentioned belt transmission structure are two groups, which are respectively arranged on the left and right sides of the installation frame 10 to ensure the smooth driving of the gantry 53.

[0119] Furthermore, in another embodiment of the present invention, the first driving element 51 is a screw motor, and the transmission screw of the first driving element 51 is transmission-connected to the bottom end of the gantry 53 .

[0120] Specifically, the screw motor has high movement accuracy and is more accurate and stable in position adjustment. The transmission connection between the first drive element 51 and the gantry 53 can be a threaded connection. For example, a thread is provided on the transmission screw of the first drive element 51, and a screw hole is provided at the bottom end of the gantry 53. The threaded connection between the first drive element 51 and the gantry 53 can be achieved by inserting the transmission screw into the screw hole. The threaded connection has better stability and is easy to disassemble and assemble.

[0121] Of course, in other embodiments, the transmission connection mode between the first driving element 51 and the gantry 53 can be other, not limited to the above-mentioned threaded connection, and can be specifically configured according to specific needs.

[0122] See also Figure 6 , Fig. 9 and Fig.11 , further, the sample extraction mechanism 55 includes:

[0123] A first mounting frame 551 is disposed on the gantry 53 and is in driving connection with the second driving element 54. The second driving element 54 can drive the first mounting frame 551 to rise and fall;

[0124] a third driving element 552 disposed on the first mounting frame 551; and

[0125] The extraction component 553 is disposed on the first mounting frame 551 and is drivingly connected to the third driving element 552. The third driving element 552 can drive the extraction component 553 to move in a vertical direction to suck and discharge samples.

[0126] Specifically, the second driving element 54 can drive the first mounting frame 551 to rise and fall, thereby driving the sample extraction mechanism 55 to rise and fall, so as to perform corresponding processing such as aspirating and discharging samples on the reagent strip 30. The first mounting frame 551 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The third driving element 552 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting and lowering of the extraction component 553.

[0127] The extraction component 553 is arranged on the vertical extension plate, and the third driving element 552 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the extraction component 553. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the third driving element 552 can make the extraction component 553 move smoothly and accurately in the vertical direction through threaded driving, so as to smoothly and accurately suck out the sample after contacting with the sample.

[0128] In addition, a photoelectric switch can be set on one side of the top of the gantry 53, and a baffle can be set on the corresponding side of the first mounting frame 551. When the first mounting frame 551 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the sample extraction mechanism 55 has moved to the set height. At this time, the power supply of the second driving element 54 can be disconnected to avoid overload and damage of the second driving element 54, thereby saving power consumption.

[0129] Furthermore, a slider may be provided on one side of the first mounting frame 551 facing the gantry frame 53, and a slide rail extending along the height direction of the gantry frame 53 may be provided on one side of the gantry frame 53 facing the first mounting frame 551, and the slider is slidably connected to the slide rail. The slider and the slide rail are in two groups, which are respectively provided on both sides of the gantry frame 53 and the first mounting frame 551. Through the cooperation of the two groups of sliders and the slide rails, the second driving element 54 can drive the first mounting frame 551 to rise and fall smoothly on the gantry frame 53, thereby ensuring that the sample extraction mechanism 55 rises and falls smoothly and accurately.

[0130] See also Figure 6 , Figure 8 and Fig.11 , further, the extraction component 553 includes:

[0131] An injection device 5531 is arranged on the first mounting frame 551, wherein a syringe cavity is formed in the injection device 5531, and a first loading head 5532 for loading the tip head 32 is arranged at the bottom of the injection device 5531, and the first loading head 5532 is communicated with the syringe cavity;

[0132] A first push plate 5533 disposed above the injection device 5531, the first push plate 5533 is drivingly connected to the third driving element 552; and

[0133] The piston rod 5534 is arranged on the first push plate 5533, and the piston rod 5534 is movably and sealedly connected to the syringe cavity. The third driving element 552 can drive the first push plate 5533 to drive the piston rod 5534 to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0134] Specifically, the injection device 5531 is roughly in the shape of a rectangular parallelepiped, and is distributed along the width direction of the first mounting frame 551, so that the injection cavity can be distributed in the width direction of the extraction component 553 to correspond to the location of the reagent strip 30. The injection device 5531 also has a certain height to ensure that the space of the injection cavity is large enough, so that the piston rod 5534 can generate a sufficiently large suction and discharge force when moving in the injection cavity.

[0135] The first loading head 5532 and the tip head 32 are interference fit, so as to ensure the stability of the tip head 32 loaded on the first loading head 5532. When the second driving element 54 drives the first mounting frame 551 to drive the extraction assembly 553 to descend, the corresponding sealing film on the reagent strip 30 can be broken by the tip head 32 loaded on the first loading head 5532. The first loading head 5532 is connected to the syringe cavity, so that the syringe cavity is connected to the tip head 32. When the piston rod 5534 is pushed up and down in the syringe cavity, the sample can be sucked and discharged through the tip head 32.

[0136] The transmission shaft of the third driving element 552 extends downward through the top of the first mounting frame 551 and the first push plate 5533. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the first push plate 5533 can be fixed on the fixing piece. When the transmission shaft of the third driving element 552 moves, the first push plate 5533 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the piston rod 5534.

[0137] Alternatively, a screw hole may be provided on the first push plate 5533, and a thread may be provided on the transmission shaft of the third driving element 552, so that the transmission shaft is threadedly connected to the first push plate 5533. This can ensure the stability of the connection between the two, and the third driving element 552 can also drive the first push plate 5533 to rise and fall by threaded driving.

[0138] In this embodiment, the end of the piston rod 5534 in the syringe cavity can be sealed with the syringe cavity by a sealing ring (such as a rubber ring or a plastic ring, etc.). When the piston rod 5534 is driven upward by the first push plate 5533 and rises in the syringe cavity, negative pressure is generated in the syringe cavity to make the tip head 32 absorb the sample, and when the piston rod 5534 is pushed downward by the first push plate 5533 and descends in the syringe cavity, positive pressure is generated in the syringe cavity to make the tip head 32 spit out the sample.

[0139] Please combine Figure 8 and Fig.11 In the embodiment of the present invention, there are multiple syringe cavities, and the multiple syringe cavities are evenly spaced along the length direction of the injection device 5531; there are multiple first loading heads 5532, and the multiple first loading heads 5532 are evenly spaced along the length direction of the injection device 5531; there are multiple piston rods 5534, and the multiple piston rods 5534 are evenly spaced along the length direction of the first push plate 5533; that is, the multiple piston rods 5534, the multiple syringe cavities and the multiple piston rods 5534 correspond one to one, thereby realizing multi-channel parallel processing of multiple reagent strips 30.

[0140] Furthermore, in order to ensure that the extraction component 553 can be lifted and lowered smoothly on the first mounting frame 551, two slide rails extending in the vertical direction can be set on the extraction component 553, and two sliders adapted to the slide rails can be set on the first push plate 5533. The two slide rails and the two sliders are respectively located on both sides of the extraction component 553. The stable movement of the extraction component 553 on the first mounting frame 551 is achieved through the cooperation of the two slide rails and the two sliders.

[0141] Furthermore, a photoelectric switch can be arranged on the top of the first mounting frame 551, and a baffle can be arranged on the corresponding side of the first push plate 5533. When the first push plate 5533 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the first push plate 5533 has moved to the set height, that is, it indicates that the piston rod 5534 has been reset. At this time, the power supply of the third driving element 552 can be disconnected to prevent the third driving element 552 from being overloaded and damaged.

[0142] See also Fig.11 Furthermore, the sample extraction mechanism 55 also includes:

[0143] A push rod 5535 is lifted and lowered to penetrate the injection device 5531, and a top end of the push rod 5535 is spaced apart from the first push plate 5533;

[0144] An elastic element 5536 is sleeved on a push rod 5535 located in the injection device 5531, and the elastic element 5536 is stretched or compressed simultaneously when the push rod 5535 is lifted or lowered relative to the injection device 5531; and

[0145] A separation plate 5537 is provided at the bottom of the injection device 5531 , and the first loading head 5532 passes through the separation plate 5537 . The bottom end of the push rod 5535 is connected to the separation plate 5537 , and the push rod 5535 can drive the separation plate 5537 to rise and fall relative to the first loading head 5532 .

[0146] In the embodiment of the present invention, a through hole is provided on the separation plate 5537, and the size of the through hole is smaller than the size of the connection between the tip head 32 and the first loading head 5532, so the tip head 32 loaded on the first loading head 5532 can be withdrawn by the setting of the separation plate 5537. Specifically, since the top end of the push rod 5535 is spaced from the first push plate 5533, when the first push plate 5533 is pushed down a certain height by the third driving element 552 to contact with the top end of the push rod 5535, the first push plate 5533 pushes the push rod 5535 to descend in the injection device 5531, thereby pushing the separation plate 5537 located at the bottom of the injection device 5531 to descend and abut against the tip head 32, so as to push the tip head 32 to separate from the first loading head 5532.

[0147] After the tip 32 is separated, the third driving element 552 stops driving, and the elastic element 5536 stretches to generate an upward thrust on the push rod 5535, driving the separation plate 5537 to reset. The compression of the elastic element 5536 can provide a certain buffer force for the descent of the push rod 5535, so as to prevent the push rod 5535 from descending too fast and causing the tip 32 to be pressed and damaged, or the tip 32 is pressed on the reagent strip 30, causing the reagent strip 30 to deviate and shake.

[0148] In the embodiment of the present invention, there are two push rods 5535 and two elastic elements 5536, which are respectively arranged on both sides of the injection device 5531 to ensure that the push rod 5535 pushes the separation plate 5537 smoothly, thereby ensuring the separation effect of the tip head 32, and ensuring the smooth resetting of the separation plate 5537 by the elastic element 5536.

[0149] Exemplarily, the process of the sample extraction mechanism 55 sucking and discharging the sample (and transferring / mixing the reagent) is roughly as follows:

[0150] The reaction chamber assembly 20 drives the reagent strip 30 to move, and at the same time the first driving element 51 drives the gantry 53 and the reaction chamber assembly 20 to move relative to each other. When the two move relative to each other to corresponding positions, that is, when the multi-channel parallel pre-processing device 50 (sample extraction mechanism 55) and the reaction chamber assembly 20 move relative to each other to corresponding positions, the second driving element 54 drives the first mounting frame 551 to descend to the first loading head 5532 to cooperate and fix with the tip head 32 on the reagent strip 30.

[0151] After the tip head 32 is loaded, the reaction chamber assembly 20 drives the reagent strip 30 to move and / or the first driving element 51 drives the multi-channel parallel pre-processing device 50 to move, until the tip head 32 moves to above the sample hole, and at the same time, the third driving element 552 first drives the piston rod 5534 to descend a certain height or to the lowest point in the syringe cavity, and then the second driving element 54 drives the first mounting frame 551 to descend a certain height until the tip of the tip head 32 extends into the sample, and the third driving element 552 drives the piston rod 5534 to rise to absorb the sample through the tip head 32, and then the second driving element 54 drives the first mounting frame 551 to rise to make the tip head 32 separate from the sample liquid surface, and the reaction chamber assembly 20 drives the reagent strip 30 to move and / or the first driving element 51 drives the multi-channel parallel pre-processing device 50 to move, until the tip head 32 with the sample absorbed moves to directly above the target hole position.

[0152] The second driving element 54 drives the first mounting frame 551 to descend, driving the tip head 32 with the sample absorbed to descend until its tip is inserted below the liquid surface of the reagent. The third driving element 552 drives the piston rod 5534 to descend to inject the sample in the tip head 32 into the reagent. Then, the second driving element 54 drives the first mounting frame 551 to rise until the tip head 32 is separated from the reagent. The third driving element 552 drives the piston rod 5534 to rise to its original position to realize the suction and transfer of the sample, and then the tip head 32 is retracted into the hole of the tip head 32.

[0153] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0154] If multiple transfers are required, the tip 32 can be repeatedly loaded and the suction and injection actions can be repeated. In addition, the sample extraction mechanism 55 can also be used to mix the reagents, and the third driving element 552 is controlled to drive the piston rod 5534 to rise and fall repeatedly in the syringe cavity, so that the tip 32 repeatedly sucks and discharges under the reagent liquid surface, so that the reagents or samples that need to react can be fully mixed and reacted.

[0155] See also Figures 7 to 9 and Fig.12 Furthermore, the sample pre-processing mechanism 56 includes:

[0156] A second mounting frame 561 is disposed on the gantry 53 and is in driving connection with the second driving element 54. The second driving element 54 can drive the second mounting frame 561 to rise and fall;

[0157] a fourth driving element 562 disposed on the second mounting frame 561; and

[0158] The pre-processing component 563 is disposed on the second mounting frame 561 and is transmission-connected to the fourth driving element 562 . The fourth driving element 562 can drive the pre-processing component 563 to move in a vertical direction to transfer the magnetic particles.

[0159] Specifically, the second driving element 54 can drive the second mounting frame 561 to rise and fall, thereby driving the sample pre-processing mechanism 56 to rise and fall, so as to perform corresponding treatments such as transferring magnetic particles on the reagent strip 30. The second mounting frame 561 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The fourth driving element 562 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting of the pre-processing component 563.

[0160] The pre-processing component 563 is arranged on the vertical extension plate, and the fourth driving element 562 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the pre-processing component 563. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the fourth driving element 562 can make the pre-processing component 563 move smoothly and accurately in the vertical direction through threaded drive, thereby smoothly and accurately adsorbing the magnetic particles and then transferring the magnetic particles.

[0161] Furthermore, in order to ensure that the pre-processing component 563 is smoothly raised and lowered on the second mounting frame 561, a slide rail extending in the vertical direction can be set on the second mounting frame 561, and a slider adapted to the slide rail can be set on the second push plate 5633. The stable movement of the pre-processing component 563 on the second mounting frame 561 is achieved through the cooperation of the slide rail and the slider.

[0162] A slider may also be provided on the other side of the second mounting frame 561, that is, the side of the second mounting frame 561 facing the gantry 53. A slide rail extending along the height direction of the gantry 53 may be provided on the side of the gantry 53 facing the second mounting frame 561. The slider is slidably connected to the slide rail, and the slider and the slide rail are two groups, which are respectively arranged on the left and right sides of the gantry 53 and the second mounting frame 561. Through the cooperation of the two groups of sliders and the slide rails, it can be ensured that the second driving element 54 drives the second mounting frame 561 on the gantry 53 to rise and fall smoothly, thereby ensuring that the sample pre-processing mechanism 56 rises and falls smoothly and accurately.

[0163] In addition, a photoelectric switch can be set on one side of the top of the gantry 53, and a baffle can be set on the corresponding side of the second mounting frame 561. When the second mounting frame 561 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the sample pre-processing mechanism 56 has moved to the set height. At this time, the power supply of the fourth driving element 562 can be disconnected to prevent the fourth driving element 562 from being overloaded and damaged.

[0164] In the embodiment of the present invention, the sample extraction mechanism 55 is opposite to the sample pre-processing mechanism 56 on the gantry 53, and the sample extraction mechanism 55 is located in front of the sample pre-processing mechanism 56. The second driving element 54, the third driving element 552 and the fourth driving element 562 are arranged linearly on the top of the gantry 53, so that the top structure of the multi-channel parallel pre-processing device 50 is regularly distributed, and the three driving elements are basically concentrated in the middle position of the gantry 53 when exerting force, so that the gantry 53 is evenly stressed and not prone to shaking or deviation.

[0165] See also Figure 8 , Fig. 9 and Fig.12 , further, the pre-processing component 563 includes:

[0166] A magnetic bar device 5631 is arranged on the second mounting frame 561, wherein an active through hole is formed in the magnetic bar device 5631, and a second loading head 5632 for loading the disposable magnetic separation sleeve 33 is arranged at the bottom of the magnetic bar device 5631, and the second loading head 5632 is communicated with the active through hole;

[0167] a second push plate 5633 disposed above the magnetic bar device 5631, the second push plate 5633 being drivingly connected to the fourth driving element 562; and

[0168] A connecting rod 5634 is arranged on the second pushing plate 5633, and a magnetic rod 5635 is arranged on the free end of the connecting rod 5634. The fourth driving element 562 can drive the second pushing plate 5633 to drive the magnetic rod 5635 to rise and fall in the corresponding movable through hole so as to be separated from the second loading head 5632 or pass through the second loading head 5632.

[0169] Specifically, the magnetic rod device 5631 is roughly in the shape of a rectangular parallelepiped and is distributed along the width direction of the second mounting frame 561, so that the active through holes therein can be distributed in the width direction of the pre-processing component 563 to correspond to the location of the reagent strip 30. When the disposable magnetic separation sleeve 33 needs to be loaded, the second driving element 54 drives the second mounting frame 561 to descend to the second loading head 5632 to contact and load the disposable magnetic separation sleeve 33, and the two are interference fit, thereby ensuring the stability of the disposable magnetic separation sleeve 33 loaded on the second loading head 5632 and facilitating separation.

[0170] The second loading head 5632 is connected to the movable through hole, so that the movable through hole is connected to the disposable magnetic separation sleeve 33. When the fourth driving element 562 drives the connecting rod 5634 to drive the magnetic rod 5635 to pass through the second loading head 5632 to extend into the disposable magnetic separation sleeve 33, the magnetic particles can be adsorbed by the disposable magnetic separation sleeve 33. When the disposable magnetic separation sleeve 33 needs to be separated, the fourth driving element 562 is controlled to drive the magnetic rod 5635 to descend to abut against the bottom end of the disposable magnetic separation sleeve 33, so that the disposable magnetic separation sleeve 33 can be withdrawn from the second loading head 5632. When the fourth driving element 562 drives the connecting rod 5634 to drive the magnetic rod 5635 to separate from the second loading head 5632 and the disposable magnetic separation sleeve 33, the magnetic particles can be separated from the disposable magnetic separation sleeve 33 and transferred.

[0171] In addition, based on the transfer of magnetic particles, the pre-treatment component 563 can also be used to transfer the magnetic particles to the reagent for reaction mixing, or to separate the magnetic particles in the reaction solution into the cleaning solution, or to transfer the magnetic particles to the substrate reading for reaction and complete luminescence detection.

[0172] The transmission shaft of the fourth driving element 562 extends downward through the top of the second mounting frame 561 and the second push plate 5633. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the second push plate 5633 can be fixed on the fixing piece. When the transmission shaft of the fourth driving element 562 moves, the second push plate 5633 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the magnetic rod 5635.

[0173] Alternatively, a screw hole may be provided on the second push plate 5633, and a thread may be provided on the transmission shaft of the fourth drive element 562, so that the transmission shaft is threadedly connected to the second push plate 5633. This can ensure the stability of the connection between the two, and the fourth drive element 562 can also drive the second push plate 5633 to rise and fall by threaded driving.

[0174] See also Figure 7 and Fig.12 Furthermore, the magnetic bars 5635 are arranged in multiple rows, and the multiple rows of magnetic bars 5635 are evenly spaced apart on the second push plate 5633 along the width direction of the second push plate 5633, and the number of rows of magnetic bars 5635 is equal to the number of substrate reading holes, so as to realize multiple item detection, that is, to realize multi-item detection; there are multiple magnetic bars 5635 in each row, and the multiple magnetic bars 5635 are evenly spaced apart on the second push plate 5633 along the length direction of the second push plate 5633, and the number of magnetic bars 5635 in each row is equal to the number of reagent strips 30, thereby realizing multi-channel parallel processing of multiple reagent strips 30.

[0175] In the embodiment of the present invention, there are three rows of magnetic rods 5635, which can realize the detection of three items. The space occupied by the three rows of magnetic rods 5635 is not too large, and three items of detection can be realized. Multiple detection can be realized while controlling the volume of the POCT fully automatic chemiluminescence device 100.

[0176] Of course, in other embodiments, the magnetic bars 5635 can also be arranged in 2 rows, 4 rows or even more rows to detect different numbers of items.

[0177] The sample pre-processing mechanism 56 of the embodiment of the present invention can reciprocate the magnetic attraction by driving the magnetic rod 5635 up and down through the fourth driving element 562, so that the efficiency of magnetic separation is higher, and the multi-channel parallel separation process further improves the separation and transfer efficiency of magnetic particles. At the same time, the reciprocating motion of the disposable magnetic separation sleeve 33 is realized through the fourth driving element 562, and the mixing of the reaction solution and the resuspension of the cleaning solution can also be completed.

[0178] Exemplarily, the process of transferring magnetic particles by the sample pre-processing mechanism 56 is roughly as follows:

[0179] After the sample is injected into the corresponding reagent hole of the reagent strip 30, the reaction chamber assembly 20 drives the reagent strip 30 to move, and at the same time the first driving element 51 drives the gantry 53 to move to the corresponding position relative to the reaction chamber assembly 20, so that the sample pre-treatment mechanism 56 is located directly above the disposable magnetic separation sleeve. At this time, the second driving element 54 drives the second mounting frame 561 to descend a certain height until the disposable magnetic separation sleeve is loaded on the second loading head 5632. The second driving element 54 drives the second mounting frame 561 to rise, and the disposable magnetic separation sleeve is driven by the second loading head 5632 to rise to a certain height.

[0180] Afterwards, the reaction chamber assembly 20 and / or the sample pre-treatment assembly 563 moves until the sample pre-treatment assembly 563 loaded with the disposable magnetic separation sleeve moves to above the corresponding hole position of the reagent strip 30, and the fourth driving element 562 drives the magnetic rod 5635 to descend until the magnetic rod 5635 contacts the bottom of the disposable magnetic separation sleeve 33. At this time, the second driving element 54 drives the second mounting bracket 561 to descend to a certain height, so that the disposable magnetic separation sleeve extends into the liquid containing magnetic particles (such as the magnetically labeled ligand mentioned above) until the disposable magnetic separation sleeve contacts the bottom of the magnetically labeled ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve 33, and the magnetic particles can be fully adsorbed by slowly lifting and lowering for multiple times.

[0181] After the adsorption of the magnetic particles is completed, the second driving element 54 is controlled to drive the second mounting frame 561 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation cover 33. The reaction chamber assembly 20 and / or the sample pre-treatment assembly 563 are controlled to move to the disposable magnetic separation cover 33 above the cleaning liquid. The second driving element 54 drives the second mounting frame 561 to descend until the disposable magnetic separation cover 33 extends into the cleaning liquid. Afterwards, the fourth driving element 562 drives the magnetic rod 5635 to rise from the disposable magnetic separation cover 33 to make the magnetic field disappear, and the magnetic particles are separated from the outer wall of the disposable magnetic separation cover 33 and fall off, and enter the cleaning liquid.

[0182] In order to speed up the separation process of the magnetic particles, the second driving element 54 can drive the second mounting frame 561 to rise and fall repeatedly at different frequencies so that the magnetic particles repeatedly move in the cleaning solution, thereby ensuring that the magnetic particles and the cleaning solution are fully mixed and suspended. After the magnetic particles are completely separated from the outer wall of the disposable magnetic separation sleeve 33, the second driving element 54 drives the second mounting frame 561 to rise to the initial height to complete the separation, cleaning and mixing operation of the magnetic particles. If multiple magnetic separation and cleaning are required, the above operation can be repeated.

[0183] Similarly, if it is necessary to transfer the magnetic particles to other hole positions, just control the second driving element 54 to drive the second mounting frame 561 to descend until the disposable magnetic separation sleeve 33 extends into the bottom of the corresponding liquid surface, and then control the fourth driving element 562 to drive the magnetic rod 5635 to descend until it contacts the bottom end of the disposable magnetic separation sleeve 33, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 33, and control the second driving element 54 to drive the second mounting frame 561 to rise.

[0184] Afterwards, the sample pretreatment mechanism 56 and / or the reaction chamber assembly 20 are controlled to move until the disposable magnetic separation sleeve 33 adsorbed with magnetic particles moves to the top of the target hole, and then the second driving element 54 is controlled to drive the second mounting frame 561 to descend until the disposable magnetic separation sleeve 33 extends into the target liquid. At this time, the fourth driving element 562 is controlled to drive the magnetic rod 5635 to rise to make the magnetic field disappear, and the magnetic particles can be gradually separated into the target liquid. The second driving element 54 can be controlled to repeatedly drive the second mounting frame 561 to rise and fall, so that the disposable magnetic separation sleeve 33 can be repeatedly moved in the target liquid to accelerate the separation of the magnetic particles.

[0185] See also Fig. 9 and Fig.10 Furthermore, a movable space 531 is provided on the gantry 53, a transmission shaft of the second driving element 54 passes through the movable space 531, a transmission plate 532 is sleeved on the transmission shaft, a thread is provided on the transmission shaft, and a screw hole is provided on the transmission plate 532. Therefore, when the transmission shaft moves, the transmission plate 532 can be synchronously raised and lowered in the movable space 531 by thread transmission.

[0186] In addition, a first connecting portion is provided on the side of the first mounting frame 551 facing the gantry 53, and the first connecting portion is formed by a vertical extension plate of the first mounting frame 551 extending toward the gantry 53. A second connecting portion is provided on the side of the second mounting frame 561 facing the gantry 53, and the second extension portion is formed by a vertical extension plate of the second mounting frame 561 extending toward the gantry 53. The first connecting portion and the second connecting portion are both connected to the transmission plate 532 by fasteners (such as screws). Therefore, when the transmission plate 532 is lifted or lowered along with the transmission shaft of the second driving element 54, the first mounting frame 551 and the second mounting frame 561 can be driven to lift or lower, thereby realizing the lifting or lowering of the sample extraction mechanism 55 and the sample pre-processing mechanism 56 on the gantry 53.

[0187] See also Figure 2 , Figure 3 , Fig.14 and Fig.15 , further, the reaction chamber assembly 20 includes:

[0188] A second guide rail provided on the bottom plate of the mounting frame 10;

[0189] A reaction chamber body 21 is arranged on the second guide rail, a slider is provided at the bottom of the reaction chamber body 21 and is slidably connected to the second guide rail, and a plurality of evenly spaced receiving grooves 211 for loading the reagent strips 30 are provided on the reaction chamber body 21, and the receiving grooves 211 extend along the length direction of the reaction chamber body 21;

[0190] A fifth driving element is disposed on the bottom plate of the mounting frame 10 and is located at the rear end of the second guide rail, and a second driving pulley is disposed on the transmission shaft of the fifth driving element;

[0191] A second mounting seat is disposed on the bottom plate of the mounting frame 10 and located at the front end of the second guide rail, the second mounting seat is provided with a second driven pulley, and the second driving pulley is connected to the second driven pulley through a belt; and

[0192] A second synchronous belt pressure plate is provided on one side of the reaction chamber body 21, and the second synchronous belt pressure plate is connected to the belt.

[0193] Specifically, the reaction chamber assembly 20 may include a carrying plate that carries the reaction chamber body 21, and a slider is disposed at the bottom of the carrying plate and is slidably connected to a second guide rail, and the second guide rail extends along the length direction of the mounting frame 10. Through the sliding connection between the second guide rail and the slider, the reaction chamber assembly 20 can move smoothly along the length direction of the mounting frame 10, and the shape of the accommodating groove 211 is adapted to the shape of the reagent strip 30, so that the reagent strip 30 can be stably loaded on the reaction chamber assembly 20, maintaining stability during the movement process and the pre-treatment process, avoiding displacement and shaking, and avoiding leakage of the reagent from the reagent strip 30, etc.

[0194] The fifth driving element is located at the rear end of the mounting frame 10, and the second mounting seat is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the reaction chamber assembly 20 in the mounting frame 10 can be long enough to better cooperate with the movement of the multi-channel parallel pre-processing device 50.

[0195] The transmission structure composed of the second driving pulley, the belt, the second synchronous belt pressure plate and the second driven pulley has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the second guide rail, it can ensure that the reaction chamber assembly 20 moves stably and quickly in the installation frame 10, thereby improving the movement efficiency of the reaction assembly 20.

[0196] Furthermore, a photoelectric switch for real-time detection of the position of the reaction chamber body 21 may be provided on the bottom plate of the mounting frame 10, and a baffle may be provided on the reaction chamber body 21. When the reaction chamber body 21 drives the baffle to move to the corresponding position and the baffle reaches the photoelectric switch, causing the photoelectric switch to disconnect the sensing, it indicates that the reaction chamber assembly 20 has reached the set position. At this time, the power supply of the fifth driving element can be disconnected to prevent the fifth driving element from continuing to work and causing overload and failure.

[0197] In addition, a heating module is also provided at the bottom of the reaction chamber body 21. The heating temperature of the heating module can be kept constant at human body temperature, i.e., 37°C. The temperature inside the reaction chamber body 21 is kept constant within a preset value range, thereby making the reagents in the reagent strip 30 meet the temperature conditions for chemiluminescence determination.

[0198] See also Figure 2 , Figure 3 and Fig.13 , further, the PMT assembly 40 comprises:

[0199] A mounting bracket 41 provided on the bottom plate of the mounting frame 10;

[0200] A third mounting bracket 42 disposed on the mounting bracket 41;

[0201] A fourth mounting frame 43 disposed at the bottom of the third mounting frame 42;

[0202] A PMT module 44 disposed on a fourth mounting frame 43;

[0203] A sixth driving element 45 is disposed on the top of the third mounting frame 42 and is transmission-connected to the fourth mounting frame 43. The sixth driving element 45 can drive the fourth mounting frame 43 to move up and down to drive the PMT module 44 to move up and down;

[0204] A seventh driving element 46 and a third driven pulley 47 are respectively arranged on both sides of the top of the mounting bracket 41, and a third driving pulley is arranged on the transmission shaft of the seventh driving element 46, and the third driving pulley is connected to the third driven pulley 47 through a belt; and

[0205] The third synchronous belt pressure plate is arranged on the third mounting frame 42, and the third synchronous belt pressure plate is connected to the belt.

[0206] In the embodiment of the present invention, the structure of the mounting bracket 41 can be similar to that of the gantry 53, and it also spans the width direction of the mounting frame 10, so that the PMT module 44 can move above the reaction chamber assembly 20 to achieve chemiluminescence detection. In addition, the mounting bracket 41 can also be made of metal materials, such as stainless steel, iron, aluminum, and various alloys, which have high strength and can increase the service life of the PMT assembly 40.

[0207] The third mounting frame 42 is used to mount the sixth driving element 45, and provides stable support for the sixth driving element 45, so that the sixth driving element 45 is stably located on the top of the mounting bracket 41. The fourth mounting frame 43 is used to mount the PMT module 44, which is in transmission connection with the sixth driving element 45, so that the PMT module 44 can realize lifting motion under the drive of the sixth driving element 45.

[0208] The third mounting frame 42 is connected to the belt drive, which can drive the fourth mounting frame 43 and the PMT module 44 thereon to move in the horizontal direction. The sixth driving element 45 and the seventh driving element 46 are combined to realize the up, down, left and right movement of the PMT module 44 on the mounting bracket 41.

[0209] In an embodiment of the present invention, the sixth driving element 45 can be a screw motor, which drives the fourth mounting frame 43 to rise and fall through the sixth driving element 45 arranged on the top of the mounting bracket 41, so as to drive the PMT module 44 to rise and fall, so that the PMT component 40 can be close to or away from the reagent strip 30, and the screw motor has high movement accuracy, and the position adjustment of the PMT module 44 is more accurate and stable, so that the PMT component 40 can accurately and stably detect the luminous value of the detection position on the reagent strip 30.

[0210] The seventh driving element 46 can be a stepper motor, which is located on one side of the top of the mounting bracket 41 (such as the right side), and the third driven pulley 47 is located on the other side of the top of the mounting bracket 41 (such as the left side), so that the connection between the two can cover the length direction of the mounting bracket 41, so that the movement of the PMT module 44 on the mounting bracket 41 can cover the width range of the mounting frame 10.

[0211] The transmission structure composed of the third active pulley, the belt, the third synchronous belt pressure plate and the third driven pulley 47 has high transmission efficiency, simple structure, sufficient power, and the belt can increase the moving speed of the PMT module 44 and thus improve the detection efficiency, so that the PMT component 40 can quickly move and switch between the various reagent strips 30 in the reaction chamber component 20 to perform luminescence value detection respectively.

[0212] Furthermore, the POCT fully automatic chemiluminescence device 100 may also include components such as a control module, an electrical module, a display module, an image acquisition module and an alarm module. The control module is electrically connected to the electrical module, the display module, the image acquisition module and the alarm module, and the electrical module is also electrically connected to the display module, the image acquisition module and the alarm module.

[0213] Among them, the electrical module can be used to realize power support for the entire equipment, and the control module is used to realize the operation control of the equipment, such as controlling the opening and closing of each driving element, the opening and closing of the heating module, the display of the display module, and the image acquisition and image conversion of the image acquisition module, etc. The display module can be used to display the operating parameters of the equipment and project analysis results and other data, and the image acquisition module can be used to shoot and monitor the pre-processing work of the multi-channel parallel pre-processing device 50. When an abnormal operation is monitored, the control module can control the alarm module (such as sound and light alarm, display alarm, etc.) to issue a corresponding warning.

[0214] The components such as the control module, the electrical module, the display module, the image acquisition module and the alarm module are not related to the invention of the present invention, so they are not described in detail here, but only their connection relationship and basic functions are simply described. If there are any unclear points, those skilled in the art can refer to the structure, position and function of the components such as the control module, the electrical module, the display module, the image acquisition module and the alarm module in the related art.

[0215] In the description of this specification, the description with reference to the terms "Example 1", "Example 2", etc. means that the specific features, structures, materials or characteristics described in conjunction with the implementation or example are included in at least one implementation or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same implementation or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more implementations or examples in a suitable manner.

[0216] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; A reaction chamber assembly disposed on the mounting frame, the reaction chamber assembly being reciprocatable along the length direction of the mounting frame, and the reaction chamber assembly being used for loading a reagent strip; a PMT assembly disposed at the rear end of the mounting frame and located above the reaction chamber assembly, the reaction chamber assembly being used to move the reagent strip to the PMT assembly, the PMT assembly being used to detect the luminescence value of the detection position of the reagent strip; and A multi-channel parallel pre-processing device is arranged on the mounting frame and located in front of the PMT device. The multi-channel parallel pre-processing device is located above the reaction chamber assembly and can reciprocate along the length direction of the mounting frame. The multi-channel parallel pre-processing device is used to aspirate samples from the reagent strip and transfer magnetic particles.

2. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: A first driving element and a first guide rail are provided on the bottom plate of the mounting frame, the first driving element is located at the rear end of the mounting frame, the first guide rail extends along the length direction of the mounting frame, and the multi-channel parallel pre-processing device is transmission-connected to the first driving element and movably arranged with the first guide rail.

3. The POCT fully automatic chemiluminescence device according to claim 2, characterized in that: The multi-channel parallel pre-processing device comprises: a gantry provided on the bottom plate of the mounting frame, the gantry and the first guide rail being movably arranged and being in driving connection with the first driving element, and a second driving element being provided on the top of the gantry; a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the second driving element and being capable of rising and falling under the driving of the second driving element to suck and discharge the sample on the reagent strip; and The sample pre-processing mechanism is arranged on the gantry, and is drivingly connected with the second driving element, and can be lifted and lowered under the driving of the second driving element to transfer the magnetic particles on the reagent strip.

4. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: A first driving pulley is provided on the transmission shaft of the first driving element, a first mounting seat is provided at the front end of the base plate of the mounting frame, a first driven pulley is provided on the first mounting seat, the first driving pulley is connected to the first driven pulley through a belt, and a first synchronous belt pressure plate connected to the belt is provided at the bottom of the gantry.

5. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The first driving element is a screw motor, and the transmission screw of the first driving element is transmission-connected to the bottom end of the gantry.

6. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The sample extraction mechanism comprises: A first mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the first mounting frame to rise and fall; a third driving element disposed on the first mounting frame; and An extraction component is arranged on the first mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to move in a vertical direction to suck and discharge samples.

7. The POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The extraction component comprises: An injection device is arranged on the first mounting frame, wherein a syringe cavity is formed in the injection device, a first loading head for loading a tip head is arranged at the bottom of the injection device, and the first loading head is communicated with the syringe cavity; a first push plate disposed above the injection device, the first push plate being drivingly connected to the third driving element; and The piston rod is arranged on the first push plate, and the piston rod is movably and sealedly connected to the syringe cavity. The third driving element can drive the first push plate to drive the piston rod to rise and fall in the syringe cavity to perform a suction and exhalation action.

8. The POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The sample extraction mechanism also includes: A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the first push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and A separation plate is arranged at the bottom of the injection device, the first loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the first loading head.

9. The POCT fully automatic chemiluminescence device according to claim 7, characterized in that: There are multiple syringe cavities, and the multiple syringe cavities are evenly distributed along the length direction of the injection device; There are a plurality of first loading heads, and the plurality of first loading heads are evenly spaced and distributed along the length direction of the injection device; There are multiple piston rods, and the multiple piston rods are evenly distributed along the length direction of the first push plate.

10. The POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The sample pre-processing mechanism comprises: A second mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the second mounting frame to rise and fall; a fourth driving element disposed on the second mounting frame; and A pre-processing component is arranged on the second mounting frame and is transmission-connected to the fourth driving element. The fourth driving element can drive the pre-processing component to move in a vertical direction to transfer magnetic particles.

11. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The pre-processing component comprises: A magnetic bar device is arranged on the second mounting frame, wherein an active through hole is formed in the magnetic bar device, and a second loading head for loading a disposable magnetic separation sleeve is arranged at the bottom of the magnetic bar device, and the second loading head is communicated with the active through hole; a second push plate disposed above the magnetic bar device, the second push plate being drivingly connected to the fourth driving element; and A connecting rod is arranged on the second pushing plate, and a magnetic bar is arranged on the free end of the connecting rod. The fourth driving element can drive the second pushing plate to drive the magnetic bar to rise and fall in the corresponding movable through hole so as to be separated from the second loading head or pass through the second loading head.

12. The POCT fully automatic chemiluminescence device according to claim 11, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed on the second push plate along the width direction of the second push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars are evenly distributed on the second pushing plate along the length direction of the second pushing plate at intervals.

13. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the second driving element, the third driving element and the fourth driving element are linearly arranged on the top of the gantry.

14. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The gantry is provided with an activity space, the transmission shaft of the second driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves; A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

15. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The reaction chamber assembly comprises: A second guide rail disposed on the bottom plate of the mounting frame; A reaction chamber body disposed on the second guide rail, wherein a slider slidably connected to the second guide rail is disposed at the bottom of the reaction chamber body, and a plurality of evenly spaced receiving grooves for loading reagent strips are disposed on the reaction chamber body, wherein the receiving grooves extend along the length direction of the reaction chamber body; a fifth driving element disposed on the bottom plate of the mounting frame and located at the rear end of the second guide rail, wherein a second driving pulley is disposed on the transmission shaft of the fifth driving element; a second mounting seat disposed on the bottom plate of the mounting frame and located at the front end of the second guide rail, the second mounting seat being provided with a second driven pulley, the second driving pulley being transmission-connected to the second driven pulley via a belt; and A second synchronous belt pressure plate is arranged on one side of the reaction chamber body, and the second synchronous belt pressure plate is connected to the belt.

16. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The PMT assembly includes: A mounting bracket disposed on the bottom plate of the mounting frame; a third mounting bracket disposed on the mounting bracket; a fourth mounting frame disposed at the bottom of the third mounting frame; A PMT module disposed on the fourth mounting frame; A sixth driving element disposed on the top of the third mounting frame and drivingly connected to the fourth mounting frame, the sixth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down; A seventh driving element and a third driven pulley are respectively arranged on both sides of the top of the mounting bracket, a third driving pulley is arranged on the transmission shaft of the seventh driving element, and the third driving pulley is connected to the third driven pulley through a belt; and A third synchronous belt pressure plate is arranged on the third mounting frame, and the third synchronous belt pressure plate is connected to the belt.

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