Azelaic acid foam preparation for reducing stimulation effect in acne treatment process and preparation method of azelaic acid foam preparation

Abstract

The invention discloses an azelaic acid foam preparation for reducing stimulation in an acne treatment process and a preparation method thereof, and belongs to the field of cosmetic preparation. The azelaic acid foam preparation capable of reducing the stimulation effect in the acne treatment process is prepared from the functional components, the propellant, the humectant, the softening and moistening agent, the thickening agent, the emulsifying agent, the allergy relieving agent, the skin conditioning agent and the traditional Chinese medicine extract, and the azelaic acid foam preparation has a good treatment effect on acnes and is free of stimulation; the side effect probability is lower than that of other preparation methods and component compositions, and the treatment effect and the side effect occurrence probability are superior to those of existing products.

Description

Technical Field

[0001] The invention relates to an azelaic acid foam preparation for reducing irritation during acne treatment and a preparation method thereof, belonging to the field of cosmetic preparation. Background Art

[0002] Azelaic acid can effectively inhibit and kill aerobic and anaerobic bacteria including Propionibacterium acnes. Azelaic acid is also a competitive inhibitor of mitochondrial oxidoreductase and 5-α reductase, which can reduce the excessive secretion of sebum by sebaceous glands. In addition, azelaic acid can reduce the synthesis of filamentous keratin, prevent excessive keratinization of hair follicles, change the maturation and proliferation of hair follicles, act on the cells arranged on the hair follicles, thereby reducing the "blockage" of hair follicles and helping to prevent blackheads and whiteheads. At the same time, azelaic acid can also inhibit tyrosinase activity and pigment synthesis in abnormal pigment cells, inhibit DNA synthesis and mitochondrial enzyme activity in abnormal pigment cells, thereby fading acne marks. However, azelaic acid is somewhat irritating to the skin, so consider using it with repairing and anti-allergic ingredients to reduce the irritation of azelaic acid to the skin. The applicant has previously applied for a series of patents for cosmetic compositions involving azelaic acid. For example, CN116370327A relates to a cosmetic composition for external use, which comprises: azelaic acid, purslane extract, dipotassium glycyrrhizate, α-bisabolol, allantoin, butylene glycol, squalane and benzoic acid, and adopts a mousse cream dosage form, which reduces the irritation of azelaic acid to the skin to a certain extent, but still has a certain degree of irritation.

[0003] In order to reduce the irritation of azelaic acid to the skin, U.S. Patent US2018 / 0214558A1 discloses an azelaic acid foam preparation, which contains water, a hydrophobic solvent, a foam adjuvant, a surfactant and a hydrogelling agent. The cosmetic or medicinal foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. According to the effect of use, the number of inflammatory lesions and the total number of lesions of all subjects have decreased, and the number of non-inflammatory lesions of 89% of the subjects has decreased; the tolerance is good, and almost all side effects such as erythema, dryness, peeling, oiliness, itching and burning are mild, and most adverse reactions have been resolved. Therefore, the foam formulation of azelaic acid is called a new alternative to reduce the irritation of azelaic acid to the skin.

[0004] Although the azelaic acid foam mentioned in the above-mentioned US patent has good effects, considering that China is mainly populated by Asians, while Europe and the United States are mainly populated by Caucasians, and there are differences in skin structure and dietary culture between the two, it is unknown whether it can be used on Chinese skin and achieve the same acne-removing effect and have the same mild adverse reactions.

[0005] The applicant added a certain amount of natural extracts to the mousse cream previously applied for, mainly Chinese medicine components. In addition to the above-mentioned added components, the Chinese Pharmacopoeia records a large number of Chinese medicines suitable for acne removal and skin improvement. However, different Chinese medicine components have different properties and can be used in different scenarios.

[0006] Therefore, how to better utilize the extract to prepare azelaic acid foam preparation that reduces irritation during acne treatment is an urgent problem that needs to be solved. Summary of the invention

[0007] [Technical issues]

[0008] Cosmetics containing azelaic acid are highly irritating;

[0009] Azelaic acid has low solubility;

[0010] Cosmetics containing azelaic acid have poor stability;

[0011] The therapeutic effect of cosmetics containing azelaic acid on acne needs to be further improved.

[0012] [Technical solution]

[0013] In order to solve the above problems, the present invention prepares a nonanedioic acid foam preparation that reduces irritation during the treatment of acne through functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, allergic agents, skin conditioners, and Chinese medicine extracts. The nonanedioic acid foam preparation has good therapeutic effects on acne and is non-irritating, and its probability of side effects is lower than that of other preparation methods and ingredient compositions. Its therapeutic effect and the probability of side effects are better than those of existing products.

[0014] The first object of the present invention is to provide a nonanedioic acid foam preparation for reducing irritation during acne treatment, which is prepared from functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, soothing agents, skin conditioners, Chinese herbal medicine extracts and water; wherein the mass ratio of the functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, soothing agents, skin conditioners and Chinese herbal medicine extracts is 20-40: 5-10: 5-8: 5-10: 0.5-3: 1-3: 0.5-1: 5-8: 0.01-5, and the rest of the water is supplemented to 100 parts;

[0015] Wherein, the functional ingredient is one or more of azelaic acid, sodium hyaluronate, and salicylic acid;

[0016] The propellant is one or more of propane, butane, isobutane and carbon dioxide;

[0017] The moisturizer is one or more of butylene glycol, glycerin, propylene glycol, tocopherol, and 1,2-hexanediol;

[0018] The emollient is one or more of caprylic / capric triglyceride, dimethyl isosorbide, and polydimethylsiloxane;

[0019] The thickener is one or more of methylcellulose, carbomer and xanthan gum;

[0020] The emulsifier is one or more of steareth-21 and steareth-2 cetearyl alcohol;

[0021] The allergy-relief agent is one or more of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone, and golden chamomile extract;

[0022] The skin conditioning agent is one or more of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane, and benzoic acid;

[0023] The Chinese medicine extract is one or more of baicalin, Centella asiatica, asiatica glycoside, and olive;

[0024] The preparation method of the azelaic acid foam preparation is:

[0025] (1) mixing azelaic acid, sodium hyaluronate and salicylic acid in a mass ratio of 50-70:1-4:2-8, and treating at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component;

[0026] (2) stirring the thickener and the humectant at 100-1000 rpm and 20-30° C. for 10-20 min to form a mixture A;

[0027] (3) stirring the emulsifier and the emollient at 100-1000 rpm and 65-75° C. for 20-40 min to obtain a mixture B;

[0028] (4) Add water and soothing agent to mixture A, heat to 65-75° C., and stir at 100-1000 rpm for 20-40 min; then add mixture B, and stir at 100-1000 rpm for 10-20 min; cool to 20-35° C., add functional ingredients and skin conditioning agent, and homogenize at 10000-20000 rm for 1-5 min; fill and add propellant to obtain a nonanedioic acid foam preparation that reduces irritation during acne treatment.

[0029] In one embodiment, the preparation method of the functional ingredient is:

[0030] Mix azelaic acid, sodium hyaluronate and salicylic acid evenly, and process at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component;

[0031] The mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 50-70:1-4:2-8;

[0032] Preferably, the mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 55:2:4.

[0033] In one embodiment, it is characterized in that the mass ratio of butylene glycol, glycerol, propylene glycol and 1,2-hexanediol in the moisturizing agent is 1-2:1-2:1-2:1-2;

[0034] Preferably, the mass ratio of butylene glycol, glycerol, propylene glycol, tocopherol and 1,2-hexanediol is 2:1:1:1.

[0035] In one embodiment, the mass ratio of caprylic / capric triglyceride, dimethyl isosorbide, and polydimethylsiloxane in the softener is 1-5:1-5:1-2;

[0036] Preferably, the mass ratio of caprylic / capric triglyceride, dimethyl isosorbide and polydimethylsiloxane is 1:1:2.

[0037] In one embodiment, the mass ratio of steareth-21 to steareth-2 cetearyl alcohol in the emulsifier is 1-2:1-2;

[0038] Preferably, the mass ratio of steareth-21 to steareth-2 cetearyl alcohol is 1:1.

[0039] In one embodiment, the mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone, and golden chamomile extract in the allergy-relieving agent is 1-3:1-3:1-3:1-3;

[0040] Preferably, the mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone and golden chamomile extract is 3:3:3:1.

[0041] In one embodiment, the mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane, and benzoic acid in the skin conditioner is 1-3:1-2:1-2:1-2:1-3:1-3:1-3:1-3;

[0042] Preferably, the mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane and benzoic acid is 3:1:1:1:2:2:2:2.

[0043] In one embodiment, the mass ratio of baicalin, Centella asiatica, asiatica glycoside, and olive in the traditional Chinese medicine extract is 1-2:1-2:1-2:1-2;

[0044] Preferably, the mass ratio of baicalin, Centella asiatica, asiaticaoside and olive is 2:1:2:1.

[0045] In one embodiment, the propellant is isobutane.

[0046] In one embodiment, the thickening agent is methylcellulose.

[0047] The second object of the present invention is to provide a method for preparing azelaic acid foam preparation for reducing irritation during acne treatment, comprising the following steps:

[0048] (1) mixing azelaic acid, sodium hyaluronate and salicylic acid in a mass ratio of 50-70:1-4:2-8, and treating at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component;

[0049] (2) stirring the thickener and the humectant at 100-1000 rpm and 20-30° C. for 10-20 min to form a mixture A;

[0050] (3) stirring the emulsifier and the emollient at 100-1000 rpm and 65-75° C. for 20-40 min to obtain a mixture B;

[0051] (4) Add water and soothing agent to mixture A, heat to 65-75° C., and stir at 100-1000 rpm for 20-40 min; then add mixture B, and stir at 100-1000 rpm for 10-20 min; cool to 20-35° C., add functional ingredients and skin conditioning agent, and homogenize at 10000-20000 rpm for 1-5 min; fill and add propellant to obtain a nonanedioic acid foam preparation that reduces irritation during acne treatment.

[0052] In one embodiment, the preparation method of the functional ingredient is:

[0053] Mix azelaic acid, sodium hyaluronate and salicylic acid evenly, and process at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component;

[0054] The mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 50-70:1-4:2-8;

[0055] Preferably, the mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 55:2:4.

[0056] In one embodiment, it is characterized in that the mass ratio of butylene glycol, glycerol, propylene glycol and 1,2-hexanediol in the moisturizing agent is 1-2:1-2:1-2:1-2;

[0057] Preferably, the mass ratio of butylene glycol, glycerol, propylene glycol, tocopherol and 1,2-hexanediol is 2:1:1:1.

[0058] In one embodiment, the mass ratio of caprylic / capric triglyceride, dimethyl isosorbide, and polydimethylsiloxane in the softener is 1-5:1-5:1-2;

[0059] Preferably, the mass ratio of caprylic / capric triglyceride, dimethyl isosorbide and polydimethylsiloxane is 1:1:2.

[0060] In one embodiment, the mass ratio of steareth-21 to steareth-2 cetearyl alcohol in the emulsifier is 1-2:1-2;

[0061] Preferably, the mass ratio of steareth-21 to steareth-2 cetearyl alcohol is 1:1.

[0062] In one embodiment, the mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone, and golden chamomile extract in the allergy-relieving agent is 1-3:1-3:1-3:1-3;

[0063] Preferably, the mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone and golden chamomile extract is 3:3:3:1.

[0064] In one embodiment, the mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane, and benzoic acid in the skin conditioner is 1-3:1-2:1-2:1-2:1-3:1-3:1-3:1-3;

[0065] Preferably, the mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane and benzoic acid is 3:1:1:1:2:2:2:2.

[0066] In one embodiment, the mass ratio of baicalin, Centella asiatica, asiatica glycoside, and olive in the traditional Chinese medicine extract is 1-2:1-2:1-2:1-2;

[0067] Preferably, the mass ratio of baicalin, Centella asiatica, asiaticaoside and olive is 2:1:2:1.

[0068] The third object of the present invention is to provide a product, which contains any of the above-mentioned azelaic acid foam preparations; the product is a medicine or a cosmetic.

[0069] [Beneficial Effects]

[0070] The composition of the present invention is in the form of a foam preparation, which is easy to apply and evenly absorbed, and can effectively remove acne. A trace amount of a skin conditioning agent compound is added therein, which reduces the irritation of the azelaic acid foam preparation to the skin and greatly reduces erythema, itching and burning sensations.

[0071] Specific:

[0072] (1) The azelaic acid foam preparation prepared by the present invention has a good therapeutic effect on acne. On the 30th day, the pore count decreased by more than 60.8%, the blackhead area decreased by more than 55.9%, and the skin acne volume decreased by more than 78.3%, which is significantly better than the azelaic acid mousse cream in the prior art (CN116370327A);

[0073] (2) The azelaic acid foam preparation prepared by the present invention has a lower probability of side effects such as erythema, dryness, peeling, itching and burning, and is significantly better than the azelaic acid mousse cream in the prior art (CN116370327A). DETAILED DESCRIPTION

[0074] The preferred embodiments of the present invention are described below. It should be understood that the embodiments are for better explaining the present invention and are not used to limit the present invention.

[0075] Test method:

[0076] The acne-relieving effects of the azelaic acid foam preparations prepared in the examples and comparative examples were tested as follows:

[0077] Acne relief effect:

[0078] 160 acne patients aged 20-30 were selected as volunteers, without gender restrictions. The patients often suffered from acne and had a large acne area. They had no other skin diseases or other major diseases in the past six months, and had not taken any antibiotics or hormone drugs. The test site was the face. After shaking the sample, dip a cotton swab in the sample and apply it evenly on the acne. Use it once in the morning and evening for 30 consecutive days. Skin condition observation and skin basic data collection were performed before using the sample, on the 5th, 10th and 30th days after using the sample to evaluate the sample's soothing, pore shrinking, blackhead removal and acne removal effects.

[0079] Evaluation indicators:

[0080] Pore ​​counting: Use a skin imager to take pictures of the subject's facial skin, analyze the pictures to obtain the numerical value of the pores in the test area, and analyze the changes in the number of pores in the test area of ​​the subject at different time points.

[0081] Blackhead area value: Use a skin imager to take pictures of the subject's facial skin, obtain the blackhead area value of the nose area by analyzing the pictures, and analyze the changes in the blackhead area value of the nose area of ​​the subject at different time points.

[0082] Skin acne volume: Use a skin imager to take pictures of the subject's facial skin, obtain the subject's skin acne volume by analyzing the pictures, and analyze the changes in the subject's skin acne volume at different time points.

[0083] Side effect detection

[0084] The feeling of the foam composition of the present invention during use was tested, mainly focusing on whether there were erythema, dryness, peeling, itching, burning, etc., and the statistical results were averaged.

[0085] The raw materials used in the examples are:

[0086] The raw materials used in the examples are all commercially available.

[0087] Example 1: Azelaic acid foam formulation for reducing irritation during acne treatment

[0088] 1. Prepare functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, allergy-relieving agents, skin conditioners, and Chinese herbal medicine extracts. The components and preparation methods are shown in Table 1.

[0089] Table 1 Preparation methods of different components

[0090]

[0091]

[0092] The mass ratio of functional ingredients, propellant, moisturizer, emollient, thickener, emulsifier, allergic agent, skin conditioner and traditional Chinese medicine extract is 25:9:6:8:1:2:0.5:8:5, and deionized water is added to make up to 100 parts.

[0093] 2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment:

[0094] (1) Azelaic acid, sodium hyaluronate, and salicylic acid were uniformly mixed in a mass ratio of 55:2:4, and treated at 1000 rpm and 90° C. for 4 h to obtain a functional component;

[0095] (2) stirring the thickener and the humectant at 100 rpm and 30° C. for 20 min to form a mixture A;

[0096] (3) stirring the emulsifier and the emollient at 100 rpm and 75° C. for 20 min to obtain a mixture B;

[0097] (4) Add water and soothing agent to mixture A, heat to 65°C, and stir at 100 rpm for 40 min; then add mixture B and stir at 100 rpm for 20 min; cool to 35°C, add functional ingredients, Chinese herbal extracts and skin conditioners, and homogenize at 10,000 rm for 5 min; fill and add propellant to obtain azelaic acid foam preparation that reduces irritation during acne treatment.

[0098] Example 2: Azelaic acid foam formulation that reduces irritation during acne treatment

[0099] On the basis of Example 1, the weight ratio of functional ingredients, propellant, moisturizer, emollient, thickener, emulsifier, allergy-relieving agent, skin conditioner, and Chinese herbal medicine extract was changed to 30:8:6:8:1:2:1:6:0.5, and deionized water was supplemented to 100 parts;

[0100] Changes in the preparation of azelaic acid foam formulations to reduce irritation during acne treatment:

[0101] (1) Azelaic acid, sodium hyaluronate, and salicylic acid were uniformly mixed in a mass ratio of 55:2:4, and treated at 100 rpm and 70° C. for 8 h to obtain a functional component;

[0102] (2) stirring the thickener and the humectant at 1000 rpm and 20° C. for 10 min to form a mixture A;

[0103] (2) stirring the emulsifier and the emollient at 1000 rpm and 65° C. for 40 min to obtain a mixture B;

[0104] (3) Add water and soothing agent to mixture A, heat to 75°C, and stir at 1000rpm for 20min; then add mixture B and stir at 1000rpm for 10min; cool to 20°C, add functional ingredients, Chinese herbal extracts and skin conditioning agents, and homogenize at 20000rm for 1min; fill and add propellant to obtain azelaic acid foam preparation that reduces irritation during acne treatment.

[0105] Based on Example 1, step (1) in “2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment” is omitted, and the specific steps are as follows:

[0106] (1) stirring the thickener and the humectant at 100 rpm and 30° C. for 20 min to form a mixture A;

[0107] (2) stirring the emulsifier and the emollient at 100 rpm and 75° C. for 20 min to obtain a mixture B;

[0108] (3) Add water and soothing agent to mixture A, heat to 65°C, and stir at 100 rpm for 40 min; then add mixture B and stir at 100 rpm for 20 min; cool to 35°C, add functional ingredients (i.e., azelaic acid, sodium hyaluronate, salicylic acid; the total amount is consistent with that in Example 1), Chinese herbal extracts and skin conditioners, and homogenize at 10,000 rm for 5 min; fill and add propellant to obtain azelaic acid foam preparation that reduces irritation during acne treatment.

[0109] Comparative Example 2: Preparation method of changing functional components

[0110] Based on Example 1, step (1) in “2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment” is changed to:

[0111] Azelaic acid and hyaluronic acid were mixed evenly in a mass ratio of 55:2, and treated at 1000 rpm and 90°C for 4 hours to obtain a mixed solution. Hyaluronic acid was then added to the mixed solution, wherein the mass ratio of azelaic acid:salicylic acid was 55:4, and mixed evenly to prepare the functional ingredient.

[0112] The remaining steps were the same as those in Example 1 to prepare azelaic acid foam preparation.

[0113] Comparative Example 3: Changing the preparation temperature of functional ingredients

[0114] Based on Example 1, step (1) in “2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment” is changed to:

[0115] Azelaic acid, sodium hyaluronate and salicylic acid were uniformly mixed in a mass ratio of 55:2:4, and treated at 1000 rpm and 60° C. for 4 hours to obtain a functional component.

[0116] The remaining steps were the same as those in Example 1 to prepare azelaic acid foam preparation.

[0117] Comparative Example 4: Preparation of azelaic acid foam preparation by one-step method

[0118] Based on Example 1, change “2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment” to:

[0119] The thickener, moisturizer, emulsifier, propellant, softener, allergy-relieving agent, functional ingredient, Chinese herbal extract, skin conditioner and water were mixed, stirred at 100 rpm for 40 min at 65° C., and homogenized at 10000 rm for 5 min to prepare azelaic acid foam preparation.

[0120] The remaining steps were the same as those in Example 1 to prepare azelaic acid foam preparation.

[0121] Comparative Example 5: Preparation of azelaic acid foam preparation by two-step method

[0122] Based on Example 1, change “2. Preparation of azelaic acid foam preparation for reducing irritation during acne treatment” to:

[0123] (1) Azelaic acid, sodium hyaluronate, and salicylic acid were uniformly mixed in a mass ratio of 55:2:4, and treated at 1000 rpm and 90° C. for 4 h to obtain a functional component;

[0124] (2) stirring the thickener, humectant, emulsifier and emollient at 100 rpm and 30° C. for 20 min to form a mixture;

[0125] (3) Add water and allergy-relieving agent to the mixture, heat to 65° C., and stir at 100 rpm for 40 min; cool to 35° C., add functional ingredients, Chinese herbal extracts and skin conditioners, and homogenize at 10,000 rpm for 5 min; fill and add propellant to prepare azelaic acid foam preparation.

[0126] The remaining steps were the same as those in Example 1 to prepare azelaic acid foam preparation.

[0127] Comparative Example 6: Changing the composition of Chinese herbal medicine extract

[0128] On the basis of Example 1, the total amount of the Chinese herbal extract is kept unchanged, but the ingredients of the Chinese herbal extract are changed to Centella asiatica, asiatica glycoside, and olive in a mass ratio of 1:2:1. The remaining steps are consistent with Example 1 to prepare a nonanedioic acid foam preparation.

[0129] Example 3: Testing the effect of azelaic acid foam preparation

[0130] The azelaic acid foam preparations prepared in Examples 1-2 and Comparative Examples 1-6 were used to test the therapeutic effects on acne patients, and the azelaic acid mousse cream (CN116370327A) previously applied by the applicant for the same amount and capable of removing acne was used as a control.

[0131] 1. Treatment effect of acne

[0132] The therapeutic effects of the azelaic acid foam preparations prepared in Examples 1-2 and Comparative Examples 1-6 on 160 acne patients aged 20-30 years old were tested. The results are shown in Table 2.

[0133] By comparing Examples 1-2 and Comparative Examples 1-3, it can be seen that the step of preparing the functional ingredients is crucial. The therapeutic effects of the azelaic acid foam preparation prepared by mixing azelaic acid, sodium hyaluronate and salicylic acid together on acne are very different from those without treatment, separate treatment and low-temperature treatment. The azelaic acid foam preparation prepared by mixing together and treating at 70-90°C has the best therapeutic effect on acne. On the 30th day, the pore count decreased by more than 60.8%, the blackhead area decreased by more than 55.9%, and the skin acne volume decreased by more than 78.3%.

[0134] By comparing Examples 1-2 and Comparative Examples 4-5, it can be seen that the effect of the step-by-step preparation when mixing the components is worse than that of the one-step preparation and the two-step preparation. By comparing Examples 1-2 and Comparative Example 6, it can be seen that baicalin is an important component in the Chinese medicine extract. When baicalin is missing, the prepared azelaic acid foam preparation is also effective, but not as good as Example 1-2 with the addition of baicalin.

[0135] Comparing Examples 1-2 and the control (CN116370327A), it can be seen that the azelaic acid foam preparation prepared in Examples 1-2 has a better therapeutic effect on acne.

[0136] Table 2 Therapeutic effects of acne

[0137]

[0138]

[0139] 2. Side effect detection

[0140] The side effects of the azelaic acid foam preparations prepared in Examples 1-2 and Comparative Examples 1-6 on 160 acne patients aged 20-30 years old were tested. The results are shown in Table 3.

[0141] By comparing Example 1-2 and Comparative Example 1-3, it can be seen that the functional ingredients (zelaic acid, sodium hyaluronate, salicylic acid) are mixed together and prepared by treating at 70-90°C, which can significantly reduce the proportion of side effects in patients.

[0142] By comparing Examples 1-2 and Comparative Examples 4-5, it can be seen that when mixing the components, the step-by-step preparation can also reduce the proportion of side effects in patients compared to the one-step preparation and the two-step preparation.

[0143] Comparison of Example 1-2 and Comparative Example 6 shows that, in the absence of baicalin, the probability of side effects of the azelaic acid foam preparation is also lower, but still inferior to that of Example 1-2.

[0144] Comparing Example 1-2 and the control, it can be seen that the side effects of the two products are slightly different, but the side effect rate of the azelaic acid foam preparation prepared in Example 1-2 is lower.

[0145] Table 3 Side effects

[0146] erythema(%) dry(%) Peeling (%) Itch (%) Burning (%) Example 1 0％ 5％ 0％ 0％ 0％ Example 2 0％ 0％ 0％ 0％ 5％ Comparative Example 1 30％ 15％ 20％ 15％ 20％ Comparative Example 2 25％ 25％ 15％ 15％ 25％ Comparative Example 3 35％ 25％ 25％ 15％ 30％ Comparative Example 4 5％ 10％ 10％ 5％ 15％ Comparative Example 5 5％ 15％ 15％ 10％ 15％ Comparative Example 6 0％ 5％ 5％ 5％ 0％ Comparison 5％ 0％ 5％ 0％ 0％

[0147] In summary, the azelaic acid foam preparation prepared in Example 1-2 has a good therapeutic effect on acne and is non-irritating, and its probability of side effects is lower than that of other preparation methods and component compositions. Its therapeutic effect and probability of side effects are better than the prior art (CN116370327A).

[0148] Although the present invention has been disclosed as above in the form of a preferred embodiment, it is not intended to limit the present invention. Anyone familiar with this technology can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be based on the definition of the claims.

Claims

1. A nonanedioic acid foam preparation for reducing irritation during acne treatment, characterized in that: The azelaic acid foam preparation is prepared from functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, soothing agents, skin conditioners, Chinese herbal medicine extracts and water; wherein the mass ratio of the functional ingredients, propellants, moisturizers, emollients, thickeners, emulsifiers, soothing agents, skin conditioners and Chinese herbal medicine extracts is 20-30: 5-10: 5-8: 5-10: 0.5-3: 1-3: 0.5-1: 5-8: 0.01-5, and the rest of the water is used to make up 100 parts; Wherein, the functional ingredient is one or more of azelaic acid, sodium hyaluronate, and salicylic acid; The propellant is one or more of propane, butane, isobutane and carbon dioxide; The moisturizer is one or more of butylene glycol, glycerin, propylene glycol, and 1,2-hexanediol; The emollient is one or more of caprylic / capric triglyceride, dimethyl isosorbide, and polydimethylsiloxane; The thickener is one or more of methylcellulose, carbomer and xanthan gum; The emulsifier is one or more of steareth-21 and steareth-2 cetearyl alcohol; The allergy-relief agent is one or more of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone, and golden chamomile extract; The skin conditioning agent is one or more of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane, and benzoic acid; The Chinese medicine extract is one or more of baicalin, Centella asiatica, asiatica glycoside, and olive; The preparation method of the azelaic acid foam preparation is: (1) mixing azelaic acid, sodium hyaluronate and salicylic acid in a mass ratio of 50-70:1-4:2-8, and treating at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component; (2) stirring the thickener and the humectant at 100-1000 rpm and 20-30° C. for 10-20 min to form a mixture A; (3) stirring the emulsifier and the emollient at 100-1000 rpm and 65-75° C. for 20-40 min to obtain a mixture B; (4) Add water and soothing agent to mixture A, heat to 65-75° C., and stir at 100-1000 rpm for 20-40 min; then add mixture B, and stir at 100-1000 rpm for 10-20 min; cool to 20-35° C., add functional ingredients and skin conditioning agent, and homogenize at 10000-20000 rm for 1-5 min; fill and add propellant to obtain a nonanedioic acid foam preparation that reduces irritation during acne treatment.

2. The azelaic acid foam preparation according to claim 1, characterized in that The preparation method of the functional ingredient is: Mix azelaic acid, sodium hyaluronate and salicylic acid evenly, and process at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component; The mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 50-70:1-4:2-8; Preferably, the mass ratio of azelaic acid, sodium hyaluronate and salicylic acid is 55:2:

4.

3. The azelaic acid foam preparation according to claim 1, characterized in that The mass ratio of butylene glycol, glycerin, propylene glycol and 1,2-hexanediol in the moisturizer is 1-2:1-2:1-2:1-2; Preferably, the mass ratio of butylene glycol, glycerol, propylene glycol and 1,2-hexanediol is 2:1:1:

1.

4. The azelaic acid foam preparation according to claim 1, characterized in that: The mass ratio of caprylic / capric triglyceride, dimethyl isosorbide, and polydimethylsiloxane in the softener is 1-5:1-5:1-2; Preferably, the mass ratio of caprylic / capric triglyceride, dimethyl isosorbide and polydimethylsiloxane is 1:1:

2.

5. The azelaic acid foam preparation according to claim 1, characterized in that: The mass ratio of steareth-21 and steareth-2 cetearyl alcohol in the emulsifier is 1-2:1-2; Preferably, the mass ratio of steareth-21 to steareth-2 cetearyl alcohol is 1:

1.

6. The azelaic acid foam preparation according to claim 1, characterized in that: The mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone and golden chamomile extract in the allergy-relieving agent is 1-3:1-3:1-3:1-3; Preferably, the mass ratio of dipotassium glycyrrhizinate, bisabolol, p-hydroxyacetophenone and golden chamomile extract is 3:3:3:

1.

7. The azelaic acid foam preparation according to claim 1, characterized in that: The mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane and benzoic acid in the skin conditioning agent is 1-3:1-2:1-2:1-2:1-3:1-3:1-3:1-3; Preferably, the mass ratio of bergamot fruit oil, farnesol, purslane extract, allantoin, tocopherol, panthenol, squalane and benzoic acid is 3:1:1:1:2:2:2:

2.

8. The azelaic acid foam preparation according to claim 1, characterized in that: The mass ratio of baicalin, Centella asiatica, asiatica glycoside and olive in the Chinese medicine extract is 1-2:1-2:1-2:1-2; Preferably, the mass ratio of baicalin, Centella asiatica, asiaticaoside and olive is 2:1:2:

1.

9. A method for preparing an azelaic acid foam preparation for reducing irritation during acne treatment, characterized in that: The steps include: (1) mixing azelaic acid, sodium hyaluronate and salicylic acid in a mass ratio of 50-70:1-4:2-8, and treating at 100-1000 rpm and 70-90° C. for 4-8 hours to obtain a functional component; (2) stirring the thickener and the humectant at 100-1000 rpm and 20-30° C. for 10-20 min to form a mixture A; (3) stirring the emulsifier and the emollient at 100-1000 rpm and 65-75° C. for 20-40 min to obtain a mixture B; (4) Add water and soothing agent to mixture A, heat to 65-75° C., and stir at 100-1000 rpm for 20-40 min; then add mixture B, and stir at 100-1000 rpm for 10-20 min; cool to 20-35° C., add functional ingredients and skin conditioning agent, and homogenize at 10000-20000 rpm for 1-5 min; fill and add propellant to obtain a nonanedioic acid foam preparation that reduces irritation during acne treatment.

10. A product, characterized in that The product contains the azelaic acid foam preparation according to any one of claims 1 to 8; the product is a medicine or a cosmetic.

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