Traditional Chinese medicine composition for tonifying yang and kidney and repairing impotence and premature ejaculation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for tonifying Yang and kidney and repairing impotence and premature ejaculation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 12 to 18 parts of ginseng, 30 to 36 parts of rhizoma polygonati, 15 to 20 parts of radix rehmanniae, 10 to 15 parts of cortex lycii radicis, 25 to 35 parts of fructus lycii, 8 to 10 parts of modified shellac and 12 to 16 parts of poly whey protein. The traditional Chinese medicine microcapsule is prepared, so that the effective components are protected, the effective time of the medicine is prolonged, the contact between bitter substances and taste buds is reduced, meanwhile, the modified shellac is prepared, the compactness of the microcapsule is enhanced, and the protection of the effective components is enhanced.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically refers to a traditional Chinese medicine composition for strengthening yang, tonifying the kidney and repairing impotence and premature ejaculation and a preparation method thereof. Background Art

[0002] Modern medical research believes that kidney yang is closely related to the nervous, endocrine, immune and other systems, and is a comprehensive manifestation of multiple system and organ functions. The clinical symptoms of kidney yang deficiency syndrome are mainly clear and long urination, pale complexion, cold limbs, lack of energy, and soreness of waist and knees. Men often show loss of libido, spermatorrhea and frequent urination, while women often show thin vaginal discharge, cold uterus and infertility. With the increase of modern working hours and life pressure, the number of people with sexual dysfunction has further increased. Traditional Chinese medicine believes that rare sperm belongs to the category of deficiency and fatigue, which is mostly due to insufficient congenital endowment, or excessive damage to kidney essence, deficiency of qi and blood, and insufficient kidney essence, which ultimately leads to insufficient kidney essence. Tonic and aphrodisiac Chinese medicine is the main way to treat sexual dysfunction. Clinically, erectile dysfunction is mainly treated with sildenafil-like drugs, supplemented with a small amount of testosterone replacement therapy, and most of these methods can only play a short-term therapeutic role and cannot cure it. Aphrodisiac Chinese medicine tastes bitter, and the effective ingredients are difficult to preserve. The active substances are easily oxidized and destroyed. After taking, they are easily destroyed by gastric juice, and the effect is not good.

[0003] The existing technology currently has the following main problems: the effective ingredients of aphrodisiac Chinese medicines are easily ineffective and have a strong bitter taste. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a Chinese medicine composition for strengthening yang and tonifying the kidney and repairing impotence and premature ejaculation and a preparation method thereof. In order to solve the problem that the effective ingredients of aphrodisiac Chinese medicines are easily ineffective and have a strong bitter taste, the present invention proposes to prepare Chinese medicine microcapsules to achieve the protection of the effective ingredients, prolong the effective time of the medicine, reduce the contact between bitter substances and taste buds, and at the same time prepare modified shellac to enhance the density of the microcapsules, thereby enhancing the protection of the effective ingredients.

[0005] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: The present invention proposes a traditional Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, and the traditional Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation comprises the following components in parts by weight: 12-18 parts of ginseng, 30-36 parts of polygonatum, 15-20 parts of rehmannia root, 10-15 parts of lycium barbarum, 25-35 parts of wolfberry, 8-10 parts of modified shellac and 12-16 parts of polylactic acid.

[0006] Preferably, the modified shellac is prepared from the following components in parts by weight: 50-60 parts of shellac resin, 120-140 parts of double-terminated mercapto polyethylene glycol and 13-16 parts of azobisisobutyronitrile.

[0007] Preferably, the preparation method of the modified shellac specifically comprises the following steps:

[0008] (1) adding shellac resin, double-terminated thiol polyethylene glycol and azobisisobutyronitrile to 95 wt% anhydrous ethanol, mixing them evenly with magnetic stirring, and reacting them in a water bath under nitrogen atmosphere with stirring to obtain a reaction solution;

[0009] (2) The reaction solution obtained in step 1 is subjected to rotary evaporation, concentrated, filtered, washed with ethanol and deionized water, and vacuum dried to obtain modified shellac.

[0010] Preferably, in step (1), the water bath heating temperature is 60-70°C, the speed is 50-60 rpm, and the time is 20-30 hours.

[0011] The present invention also provides a method for preparing a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, which specifically comprises the following steps:

[0012] S1. Wash, dry and grind ginseng, polygonatum, rehmannia root, lycium bark and wolfberry through a 50-60 mesh sieve to obtain Chinese medicine powder;

[0013] S2, adding the Chinese medicine powder obtained in S1 to a 65-75wt% ethanol solution, adding 2% of cellulase and 1.5% of pectinase by weight of the Chinese medicine powder, stirring in a water bath, and filtering to obtain the medicine residue and alcohol extract;

[0014] S3, adding the residue obtained in S2 into deionized water, boiling for 35 minutes, and filtering while hot to obtain a filtrate;

[0015] S4, adding polylactic acid to water to prepare a 3-4wt% polylactic acid solution, adding shellac to a 2wt% ammonium bicarbonate solution to prepare a 4-5wt% modified shellac solution, mixing the polylactic acid solution and the modified shellac solution, and stirring to obtain a microcapsule wall material solution;

[0016] S5, adding the alcohol extract obtained in S2 to the microcapsule wall material solution, magnetically stirring, and spray drying to obtain alcohol extract microcapsules;

[0017] S6. Rotate and evaporate the filtrate obtained in S3 to obtain an ointment, add the alcohol extract microcapsules, and stir evenly to obtain a Chinese medicine composition for strengthening yang, tonifying the kidney, and repairing impotence and premature ejaculation.

[0018] Preferably, in S2, the water bath stirring temperature is 30-40°C, the speed is 60-80 rpm, and the time is 50-60 min.

[0019] Preferably, in S3, the amount of the medicinal residue added to deionized water is 30-50 mg / mL.

[0020] Preferably, in S5, the spray drying inlet temperature is 150-160°C, the outlet temperature is 60-70°C, and the gas flow rate is 30-35m 3 / h.

[0021] Preferably, in S6, the ointment has a solid content of 50-60 wt %.

[0022] The beneficial effects achieved by the present invention are as follows: the present invention modifies shellac by double-terminal thiol polyethylene glycol to prepare modified shellac, and prepares composite wall materials with polylactic acid to enhance the density of microcapsules, improve the protective effect of the wall materials on effective components, and wrap alcohol-soluble substances with bitter substances to reduce contact with taste buds and reduce the bitter feeling when taken; the thiol groups react with carbon-carbon double bonds in the shellac resin by anti-Markovnikov addition reaction, eliminate the double bonds and introduce thiol groups at the same time, and form disulfide bonds with polylactic acid during the cross-linking process, thereby enhancing the strength of the cross-linked wall materials, improving the density, reducing the oxidation of the effective components of the core materials by air during the storage process, and effectively resisting gastric juice digestion during the gastric juice digestion process, so that the effective components maintain the required activity before reaching the small intestine for absorption, thereby improving the use effect of the aphrodisiac Chinese medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The results of the preservation experiments of Examples 1-3 and Comparative Examples 1-3 of the present invention are shown in FIG.

[0024] Figure 2 The results of digestion experiments of Examples 1-3 and Comparative Examples 1-3 of the present invention are shown in FIG.

[0025] Figure 3 The results of the enteric coating experiments of Examples 1-3 of the present invention are shown in FIG.

[0026] Figure 4 It is a bitterness analysis test result diagram of Examples 1-3 of the present invention and Comparative Examples 1-3.

[0027] Figure 5 The figure is the result of the cytotoxicity test of Example 1-3. The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0029] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0030] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0031] Example 1

[0032] A traditional Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation comprises the following components in parts by weight: 18 parts of ginseng, 36 parts of polygonatum, 20 parts of rehmannia root, 15 parts of lycium bark, 35 parts of wolfberry, 10 parts of modified shellac and 16 parts of polylactic acid.

[0033] The modified shellac is prepared from the following components in parts by weight: 60 parts of shellac resin, 140 parts of double-terminated mercapto polyethylene glycol and 16 parts of azobisisobutyronitrile.

[0034] The preparation method of modified shellac specifically comprises the following steps:

[0035] (1) adding shellac resin, double-terminated thiol polyethylene glycol and azobisisobutyronitrile to 95 wt% anhydrous ethanol, mixing them evenly with magnetic stirring, and reacting them in a water bath at 70°C and 60 rpm under a nitrogen atmosphere for 30 h to obtain a reaction solution;

[0036] (2) The reaction solution obtained in step 1 is subjected to rotary evaporation, concentrated, filtered, washed with ethanol and deionized water, and vacuum dried to obtain modified shellac.

[0037] The present invention also provides a method for preparing a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, which specifically comprises the following steps:

[0038] S1. Wash, dry and grind ginseng, polygonatum, rehmannia root, lycium bark and wolfberry through a 60-mesh sieve to obtain Chinese medicine powder;

[0039] S2, adding the Chinese medicine powder obtained in S1 to a 75wt% ethanol solution, adding 2% of the mass of the Chinese medicine powder to the cellulase and 1.5% of the pectinase, stirring at 80 rpm in a 40°C water bath for 60 min, and filtering to obtain the drug residue and the alcohol extract;

[0040] S3, adding 50 mg / mL of the residue obtained in S2 into deionized water, boiling for 35 min, and filtering while hot to obtain a filtrate;

[0041] S4, adding polylactic acid to water to prepare a 4wt% polylactic acid solution, adding shellac to a 2wt% ammonium bicarbonate solution to prepare a 5wt% modified shellac solution, mixing the polylactic acid solution and the modified shellac solution, and stirring to obtain a microcapsule wall material solution;

[0042] S5, add the alcohol extract obtained in S2 to the microcapsule wall material solution, stir magnetically, and spray dry to obtain alcohol extract microcapsules, with an inlet temperature of 160°C, an outlet temperature of 70°C, and a gas flow rate of 35m 3 / h;

[0043] S6. The filtrate obtained in S3 is subjected to rotary evaporation to obtain an ointment with a solid content of 60 wt%, and the ethanol extract microcapsules are added and stirred evenly to obtain a Chinese medicine composition for strengthening yang, tonifying the kidney, and repairing impotence and premature ejaculation.

[0044] Example 2

[0045] A traditional Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation comprises the following components in parts by weight: 12 parts of ginseng, 30 parts of polygonatum, 15 parts of rehmannia root, 10 parts of lycium bark, 25 parts of wolfberry, 8-10 parts of modified shellac and 12-16 parts of polylactic acid.

[0046] The modified shellac is prepared from the following components in parts by weight: 50 parts of shellac resin, 12 parts of double-terminated mercapto polyethylene glycol and 13 parts of azobisisobutyronitrile.

[0047] The preparation method of modified shellac specifically comprises the following steps:

[0048] (1) adding shellac resin, double-terminated thiol polyethylene glycol and azobisisobutyronitrile to 95 wt% anhydrous ethanol, mixing them evenly with magnetic stirring, and reacting them in a water bath at 60°C and 50 rpm under a nitrogen atmosphere for 20 h to obtain a reaction solution;

[0049] (2) The reaction solution obtained in step 1 is subjected to rotary evaporation, concentrated, filtered, washed with ethanol and deionized water, and vacuum dried to obtain modified shellac.

[0050] The present invention also provides a method for preparing a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, which specifically comprises the following steps:

[0051] S1. Wash, dry and grind ginseng, polygonatum, rehmannia root, lycium bark and wolfberry through a 50-mesh sieve to obtain Chinese medicine powder;

[0052] S2, adding the Chinese medicine powder obtained in S1 to a 65wt% ethanol solution, adding 2% of the mass of the Chinese medicine powder to the cellulase and 1.5% of the pectinase, stirring at 60 rpm in a 30°C water bath for 50 min, and filtering to obtain the drug residue and the ethanol extract;

[0053] S3, adding the residue obtained in S2 into deionized water at an addition amount of 30 mg / mL, boiling for 35 min, and filtering while hot to obtain a filtrate;

[0054] S4, adding polylactic acid to water to prepare a 3wt% polylactic acid solution, adding shellac to a 2wt% ammonium bicarbonate solution to prepare a 4wt% modified shellac solution, mixing the polylactic acid solution and the modified shellac solution, and stirring to obtain a microcapsule wall material solution;

[0055] S5, add the alcohol extract obtained in S2 to the microcapsule wall material solution, stir magnetically, and spray dry to obtain alcohol extract microcapsules, with an inlet temperature of 150°C, an outlet temperature of 60°C, and a gas flow rate of 30m 3 / h;

[0056] S6. The filtrate obtained in S3 is subjected to rotary evaporation to obtain an ointment with a solid content of 50 wt%, and the ethanol extract microcapsules are added and stirred evenly to obtain a Chinese medicine composition for strengthening yang, tonifying the kidney, and repairing impotence and premature ejaculation.

[0057] Example 3

[0058] A traditional Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation comprises the following components in parts by weight: 16 parts of ginseng, 34 parts of polygonatum, 18 parts of rehmannia root, 12 parts of lycium bark, 30 parts of wolfberry, 9 parts of modified shellac and 14 parts of polylactic acid.

[0059] The modified shellac is prepared from the following components in parts by weight: 55 parts of shellac resin, 130 parts of double-terminated mercapto polyethylene glycol and 15 parts of azobisisobutyronitrile.

[0060] The preparation method of modified shellac specifically comprises the following steps:

[0061] (1) adding shellac resin, double-terminated thiol polyethylene glycol and azobisisobutyronitrile to 95 wt% anhydrous ethanol, mixing them evenly with magnetic stirring, and reacting them in a water bath at 65°C and 55 rpm under a nitrogen atmosphere for 25 h to obtain a reaction solution;

[0062] (2) The reaction solution obtained in step 1 is subjected to rotary evaporation, concentrated, filtered, washed with ethanol and deionized water, and vacuum dried to obtain modified shellac.

[0063] The present invention also provides a method for preparing a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, which specifically comprises the following steps:

[0064] S1. Wash, dry and grind ginseng, polygonatum, rehmannia root, lycium bark and wolfberry through a 55-mesh sieve to obtain Chinese medicine powder;

[0065] S2, adding the Chinese medicine powder obtained in S1 to a 70wt% ethanol solution, adding 2% of the mass of the Chinese medicine powder to the cellulase and 1.5% of the pectinase, stirring at 70rpm in a 35°C water bath for 55min, and filtering to obtain the drug residue and the ethanol extract;

[0066] S3, adding the residue obtained in S2 into deionized water at an addition amount of 40 mg / mL, boiling for 35 min, and filtering while hot to obtain a filtrate;

[0067] S4, adding polylactic acid to water to prepare a 3.5wt% polylactic acid solution, adding shellac to a 2wt% ammonium bicarbonate solution to prepare a 4.5wt% modified shellac solution, mixing the polylactic acid solution and the modified shellac solution, and stirring to obtain a microcapsule wall material solution;

[0068] S5, add the alcohol extract obtained in S2 to the microcapsule wall material solution, stir magnetically, and spray dry to obtain alcohol extract microcapsules, with an inlet temperature of 155°C, an outlet temperature of 65°C, and a gas flow rate of 32.5m 3 / h;

[0069] S6. The filtrate obtained in S3 is subjected to rotary evaporation to obtain an ointment with a solid content of 55 wt%, and the ethanol extract microcapsules are added and stirred evenly to obtain a Chinese medicine composition for strengthening yang, tonifying the kidney, and repairing impotence and premature ejaculation.

[0070] Comparative Example 1

[0071] This comparative example provides a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation. The difference between it and Example 1 is that the shellac is not modified in the components, and the other components and component contents are the same as those in Example 1.

[0072] Comparative Example 2

[0073] This comparative example provides a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation. The difference between the Chinese medicine composition and Example 1 is that the composition does not contain shellac, and the other components and component contents are the same as those in Example 1.

[0074] Comparative Example 3

[0075] This comparative example provides a Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation. The difference between the Chinese medicine composition and Example 1 is that the composition does not contain shellac and polylactate, and the other components and component contents are the same as those in Example 1.

[0076] Experimental example

[0077] 1. Save the experiment

[0078] The Chinese medicine compositions for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation obtained in Examples 1-3 and Comparative Examples 1-3 were subjected to accelerated oxidation at a constant temperature of 60° C. and 50W incandescent light. Samples were taken at 0d and 5d, and the flavonoid content was measured. The content at 0d was taken as the reference value and 5d was taken as the final value. The preservation rate of flavonoids was calculated by the following formula:

[0079] Preservation rate = final value / baseline value × 100%;

[0080] Figure 1 The results of the preservation experiment of Examples 1-3 and Comparative Examples 1-3 of the present invention are shown in the figure. As shown in the figure, after 5 days, the preservation rates of the flavonoids of Examples 1-3 and Comparative Examples 1-3 are 91.6%, 91.2%, 92.2%, 77.6%, 65.3% and 45.1%, respectively; the preservation rate of the flavonoids of Examples 1-3 is significantly higher than that of Comparative Examples 1-3, indicating that the modification of shellac and the preparation of microcapsules improve the preservation rate of the active ingredients and extend the shelf life of the product.

[0081] 2. Digestion Experiment

[0082] Artificial gastric juice was prepared by dissolving 3 g of pepsin in 1000 mL of 0.5% (w / v) NaCl solution and adjusting the pH to 2;

[0083] The Chinese medicine compositions for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation obtained in Examples 1-3 and Comparative Examples 1-3 were added to artificial gastric juice, and the gastric emptying time was 4 hours, and the mixture was shaken at 100 rpm under 37° C. water bath conditions. The flavonoid content was measured at 0 hours and 4 hours, respectively. The content at 0 hours was taken as the reference value, and 4 hours was taken as the final value. The preservation rate of flavonoids was calculated by the following formula:

[0084] Preservation rate = final value / baseline value × 100%.

[0085] Figure 2 The results of the digestion experiment of Examples 1-3 of the present invention and Comparative Examples 1-3 are shown in the figure. As shown in the figure, after 5 days, the preservation rates of flavonoids in Examples 1-3 and Comparative Examples 1-3 are 88.6%, 86.2%, 88.9%, 78.1%, 66.2% and 38.3%, respectively; the preservation rate of flavonoids in Examples 1-3 is significantly higher than that in Comparative Examples 1-3, indicating that the modification of shellac and the preparation of microcapsules reduce the damage of gastric juice to flavonoids and play a protective role.

[0086] 3. Enteric Coating Test

[0087] Artificial intestinal fluid was prepared by dissolving 10 g of trypsin and 3 g of ox bile salt in 1 L of 0.5% NaCl solution and adjusting the pH to 7.5 with 0.1 mol / L NaOH solution.

[0088] The Chinese medicine compositions for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation obtained in Examples 1-3 were respectively subjected to gastric juice digestion experiments, and then added to artificial intestinal juice, and shaken at 37°C and 100 rpm for 6 hours to simulate the intestinal digestion process. The flavonoid content was measured at 0 hours and 6 hours, and the content at 0 hours was taken as the reference value and 6 hours as the final value. The release rate of flavonoids was calculated by the following formula:

[0089] Release rate = (baseline value - final value) / baseline value × 100%.

[0090] Figure 3 The results of the enteric coating experiment of Examples 1-3 of the present invention are shown in the figure. As shown in the figure, after 5 days, the release rates of the flavonoids of Examples 1-3 are 96.1%, 96.5%, and 95.9%, respectively; the release rates of the flavonoids of Examples 1-3 are all greater than 95%, indicating that the microcapsules have good release performance in the intestine.

[0091] 4. Bitterness Analysis Experiment

[0092] Example 1-3 and Comparative Example 1-3 were added into water at an addition amount of 0.3 g / mL, and the bitterness level was analyzed by electronic tongue.

[0093] Figure 4 This is a bitterness analysis test result diagram of Examples 1-3 of the present invention and Comparative Examples 1-3. As shown in the figure, the bitterness levels of Examples 1-3 and Comparative Examples 1-3 are 3.1, 3.2, 2.9, 5.4, 6.3, and 9.2, respectively; the bitterness level of Examples 1-3 is significantly lower than that of Comparative Examples 1-3, indicating that the modification of shellac and the preparation of microcapsules effectively reduce the bitterness of aphrodisiac Chinese medicine.

[0094] 5. Cytotoxicity Assay

[0095] Human embryonic kidney cells (HEK293) were used as test cells for toxicity test. They were inoculated on 96-well plates with 5000 cells per well. 10uL of culture medium was added to each well and cultured in an incubator for 24 hours. The culture medium was removed. 10ug of the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation obtained in Examples 1-3 and 90uL of culture medium containing 1% dimethyl sulfoxide were added to the cells of the experimental group. 100uL of culture medium containing 1wt% dimethyl sulfoxide was added to the cells of the control group. After 12 hours, the culture medium was removed and dissolved with 1wt% dimethyl sulfoxide. The blank group was 100uL of culture medium containing 1% dimethyl sulfoxide. The absorbance of each group was detected at 570nm using an ELISA reader, and the survival rate was calculated using the following formula:

[0096] Survival rate = (absorbance of experimental group - absorbance of blank group) / (absorbance of control group - absorbance of blank group) × 100%.

[0097] Figure 5This is a result diagram of the cytotoxicity test of Examples 1-3. As shown in the figure, the survival rates of the Chinese herbal compositions for strengthening yang, tonifying the kidney and repairing impotence and premature ejaculation obtained in Examples 1-3 are 108%, 105% and 110%, respectively; the survival rates of Examples 1-3 are all 100% and above, which shows that the Chinese herbal compositions obtained in Examples 1-3 are non-toxic to cells and have no inhibitory effect on cell division, differentiation and growth.

[0098] While the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that many changes, modifications, substitutions and variations can be made to the embodiments without departing from the principles and spirit of the invention.

[0099] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation, characterized in that: The invention comprises the following components in parts by weight: 12-18 parts of ginseng, 30-36 parts of polygonatum, 15-20 parts of rehmannia root, 10-15 parts of lycium bark, 25-35 parts of wolfberry, 8-10 parts of modified shellac and 12-16 parts of polylactic acid; The modified shellac is prepared from the following components in parts by weight: 50-60 parts of shellac resin, 120-140 parts of double-terminated mercapto polyethylene glycol and 13-16 parts of azobisisobutyronitrile.

2. A method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 1, characterized in that: The specific steps include: S1. Wash, dry and grind ginseng, polygonatum, rehmannia root, lycium bark and wolfberry through a 50-60 mesh sieve to obtain Chinese medicine powder; S2, adding the Chinese medicine powder obtained in S1 to a 65-75wt% ethanol solution, adding 2% of cellulase and 1.5% of pectinase by weight of the Chinese medicine powder, stirring in a water bath, and filtering to obtain the medicine residue and the alcohol extract; S3, adding the residue obtained in S2 into deionized water, boiling for 35 minutes, and filtering while hot to obtain a filtrate; S4, adding polylactic acid to water to prepare a 3-4wt% polylactic acid solution, adding shellac to a 2wt% ammonium bicarbonate solution to prepare a 4-5wt% modified shellac solution, mixing the polylactic acid solution and the modified shellac solution, and stirring to obtain a microcapsule wall material solution; S5, adding the alcohol extract obtained in S2 to the microcapsule wall material solution, magnetically stirring, and spray drying to obtain alcohol extract microcapsules; S6. Rotate and evaporate the filtrate obtained in S3 to obtain an ointment, add the alcohol extract microcapsules, and stir evenly to obtain a Chinese medicine composition for strengthening yang, tonifying the kidney, and repairing impotence and premature ejaculation.

3. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 2, characterized in that: In S2, the water bath stirring temperature is 30-40°C, the speed is 60-80 rpm, and the time is 50-60 min.

4. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 3, characterized in that: In S3, the amount of the medicinal residue added to deionized water is 30-50 mg / mL.

5. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 4, characterized in that: In S5, the spray drying inlet temperature is 150-160°C, the outlet temperature is 60-70°C, and the gas flow rate is 30-35m 3 / h.

6. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 5, characterized in that: In S6, the ointment has a solid content of 50-60 wt %.

7. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 6, characterized in that: The preparation method of the modified shellac specifically comprises the following steps: (1) adding shellac resin, double-terminated thiol polyethylene glycol and azobisisobutyronitrile to 95 wt% anhydrous ethanol, mixing them evenly with magnetic stirring, and reacting them in a water bath under nitrogen atmosphere with stirring to obtain a reaction solution; (2) The reaction solution obtained in step 1 is subjected to rotary evaporation, concentrated, filtered, washed with ethanol and deionized water, and vacuum dried to obtain modified shellac.

8. The method for preparing the Chinese medicine composition for strengthening yang, tonifying kidney and repairing impotence and premature ejaculation according to claim 7, characterized in that: In step (1), the water bath heating temperature is 60-70°C, the speed is 50-60rpm, and the time is 20-30h.

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