Non-adhesive application for skin wounds as well as preparation method and application of non-adhesive application

Abstract

The invention provides a non-adhesive hydrogel patch for skin wounds as well as a preparation method and application of the non-adhesive hydrogel patch, and belongs to the technical field of medical dressings. The non-adhesive hydrogel application comprises a wound contact layer and an absorption layer which are sequentially arranged in a stacked mode. Wherein the wound contact layer is composed of a bacteriostatic hydrogel cushion layer and a reinforcing layer, and the bacteriostatic hydrogel cushion layer is composed of poly (sodium acrylate-co-acrylamide) composite hydrogel and a bacteriostatic agent; the reinforcing layer is a non-woven fabric composed of carboxymethyl cellulose or alginate fibers; the absorption layer is formed by combining a semi-permeable membrane and a substrate, and the semi-permeable membrane is a cellulose acetate semi-permeable membrane coated with anionic polyacrylamide hydrogel. The non-adhesive hydrogel application disclosed by the invention has a bacteriostatic agent three-stage slow-release effect, has more stable and lasting bacteriostatic performance, and has the effects of unidirectional water passing and wound seepage absorption, and realizes rapid and efficient repair of wound surfaces such as skin erosion, debonding, necrosis, blisters, skin trauma and the like in a wet surface environment.

Description

Technical Field

[0001] The invention belongs to the technical field of medical dressings and relates to a dressing material, in particular to a non-adhesive dressing for skin wounds and a preparation method and application thereof. Background Art

[0002] In the wound management of skin erosion, loosening, necrosis, blister bullae and skin trauma, it is crucial to prevent infection, provide a moist environment and minimize scar formation. Secondary infection of large-area wounds throughout the body is the main cause of death in such patients, and infection will delay the healing process of the wound. Appropriate dressings will provide a safe environment for the healing process of skin wounds. With the improvement of science and technology, the theory of wound healing has also changed from early dry healing to wet healing. The wet healing theory points out that a moist and sterile environment is conducive to wound healing. When the wound is in a moist and sterile environment, it can promote epithelial regeneration, enhance the activity of macrophages and fibroblasts, and reduce discomfort such as pain and itching caused by dryness.

[0003] Hydrogel is a non-adhesive soothing material that is easy to place or remove with minimal pain or trauma to the skin. Hydrogel can form a moist wound environment, which is particularly suitable for extremely dry necrotic wounds. Hydrocolloid dressings have certain absorption properties, which help to achieve painless debridement. Therefore, new moist antibacterial dressings have attracted much attention in the medical field at home and abroad, especially the application of antibacterial hydrogel dressings in wounds of skin erosion, loosening, necrosis, blisters and bullae, as well as skin trauma, showing a booming market prospect.

[0004] Antibacterial hydrogel dressings are hydrogels formed by cross-linking biomacromolecules with antibacterial properties, or dressings formed by adding active antibacterial components to ordinary medical hydrogels. They are currently commonly used to treat postoperative wounds, scalds, burns, abrasions and other diseases. The antibacterial agent in the antibacterial hydrogel dressing can effectively kill common pathogens and reduce the growth and reproduction of bacteria on the wound surface, thereby keeping the wound clean, promoting the growth and repair of new tissues, accelerating wound healing, and reducing the risk of scar formation.

[0005] For example, CN112891614A discloses a hydrogel wound dressing composed of a mixed system of ethylenediamine, sodium carboxymethylcellulose, pectin and sodium alginate. CN113925684A discloses a special dressing for preventing fistula infection, which comprises release paper, anti-infection drug absorption pad, sticky water-proof material and adhesive backing, wherein the type B anti-infection drug absorption pad is a gel absorption pad containing 2% chlorhexidine glucose or 5% iodine or 75% alcohol. CN110743082A discloses an antibacterial gel dressing comprising a printing layer, a flexible layer, an adhesive layer, a dressing layer and a protective layer, wherein the dressing layer gel contains chlorhexidine gluconate and is coated with nano silver particles on the surface.

[0006] Although the above-mentioned developed hydrogel dressings or patches are gradually developing towards antibacterial types, most of them do not have sufficient sustained-release function of antibacterial agents, especially the shaped hydrogel dressings or patches currently available on the market, which cannot create a clean, sterile or low-bacteria healing environment for the wound for a long time, especially for wounds with skin erosion, loosening, necrosis, blisters and bullae, as well as wounds after skin trauma. The long-lasting antibacterial performance in a wet surface environment is insufficient, thereby reducing the efficiency of wound healing and prolonging the care cycle.

[0007] In addition, the antibacterial hydrogel dressings that have been further developed are basically added with organic antibacterial agents or inorganic metal ions or particles. The addition of organic antibacterial agents or metal ions often has the problem of rapid and unstable release, and a large amount of accumulation on the wound surface in a short period of time can easily have an adverse effect on the wound. At the same time, the dressing cannot meet the needs of long-term and lasting antibacterial and needs to be replaced frequently. It is not only complicated, but also causes a waste of medical resources; and the addition of metal particles is easy to fall off and float on the wound surface and enter the body fluids, which is more harmful than the former.

[0008] Therefore, how to provide a non-adhesive antibacterial dressing with excellent sustained-release function of antibacterial agents, as well as stable and long-lasting antibacterial performance, which can maintain long-term rapid repair of large-area erosions, loosening, necrosis, blisters and bullae throughout the body, as well as skin trauma wounds, has become a technical problem that needs to be solved urgently. Summary of the invention

[0009] The present invention is to solve the above technical problems, thereby providing a non-adhesive dressing for skin wounds and its preparation method and application. The technical purpose of the present invention is to provide a non-adhesive hydrogel dressing with excellent antibacterial properties on the one hand to prevent secondary infection of wounds; on the other hand, to provide a long-lasting wet antibacterial dressing with good sustained release performance and good stability to promote the rapid healing of large-area skin erosion, loosening, necrosis, blisters or skin trauma.

[0010] In order to achieve the above technical objectives, the technical solution adopted by the present invention is as follows:

[0011] One of the purposes of the present invention is to provide a non-adhesive hydrogel dressing for skin wounds, the non-adhesive hydrogel dressing for skin wounds comprising a wound contact layer and an absorption layer stacked in sequence; wherein the wound contact layer is composed of an antibacterial hydrogel cushion layer and a reinforcing layer, the antibacterial hydrogel cushion layer is composed of a poly (sodium acrylate-co-acrylamide) composite hydrogel and an antibacterial agent; the reinforcing layer is a non-woven fabric composed of carboxymethyl cellulose or alginate fiber; the absorption layer is composed of a semi-permeable membrane and a substrate, the semi-permeable membrane is a cellulose acetate semi-permeable membrane coated with anionic polyacrylamide hydrogel.

[0012] The non-adhesive hydrogel dressing for skin wounds provided by the present invention adopts a multilayer composite structure, wherein a large number of hydrophilic carboxyl groups and amino groups are present in the poly (sodium acrylate-co-acrylamide) composite hydrogel system, and when absorbing alkaline wound exudate, it is easier to deprotonate to form an anionic structure, and the cationic antibacterial substances (such as chlorhexidine acetate) contained in the system form anion and cation pairing due to electrostatic attraction, so as to achieve the fixation of the antibacterial agent in the system, so as to be able to exert the antibacterial performance more stably and for a long time. Therefore, the antibacterial agent is loaded in the three-dimensional network of the above-mentioned hydrogel, which can effectively slow down the rate of release of the antibacterial agent to the wound.

[0013] On the other hand, the reinforcing layer composed of carboxymethyl cellulose or alginate nonwoven fabric has a high rate of liquid absorption performance, and can produce a gelation effect after absorbing wound exudate, in which a large number of carboxyl groups are deprotonated to form an anionic structure, which has a better effect on the fixation and sustained release of cations. When the antibacterial agent diffuses into the gelled reinforcing layer, the deprotonated carboxymethyl cellulose or alginate anion can fix the antibacterial agent cation for a second time, slowing down its diffusion into the wound again.

[0014] In addition, the cellulose acetate membrane modified by coating anionic polyacrylamide hydrogel is used as the absorption layer of the present invention, and the anionized semi-permeable membrane can be pulled in the reverse direction by electrostatic attraction, thereby further slowing down the diffusion rate of the antibacterial agent into the wound.

[0015] When the dressing is used for wound repair (one side of the reinforcement layer is attached to the wound), the reinforcement layer, as a highly absorbent carboxymethyl cellulose or alginate non-woven fabric, can absorb wound exudate, allowing the wound exudate to enter the antibacterial hydrogel pad layer of the wound contact layer. The exudate absorbed in the wound contact layer reaches the anionized semi-permeable membrane, and only water molecules diffuse unidirectionally through the semi-permeable membrane to the absorption layer for storage. The moisture of the wound exudate is transferred unidirectionally in multiple layers, avoiding the accumulation of a large amount of exudate at the wound, soaking the wound, and causing bacterial growth. At the same time, due to its anionization, the "temporary storage-re-release" effect of the antibacterial agent is achieved, extending the longer-term antibacterial effect of the dressing.

[0016] In summary, the composite multilayer dressing structure composed of the deprotonable reinforcing layer and the antibacterial hydrogel cushion layer, and the anionized semipermeable membrane in the present invention effectively realizes the three-level sustained release of the antibacterial agent, so that the antibacterial agent in the dressing achieves a three-level sustained release effect, and solves the problems of the existing antibacterial dressings that the antibacterial agent is easy to release quickly, the stability is poor after loading the antibacterial agent, and long-term and lasting antibacterial effect cannot be achieved, thereby preventing secondary infection of the wound and accelerating wound repair to a great extent.

[0017] Furthermore, the antibacterial hydrogel cushion layer comprises the following components by weight: 20 to 45 parts of acrylamide + acrylic acid, 0.05 to 0.2 parts of N,N'-methylenebisacrylamide, 0.05 to 0.5 parts of antibacterial agent, 20 to 50 parts of glycerol, 20 to 50 parts of water, 3 to 5 parts of sodium carboxymethyl cellulose, and 0.05 to 0.2 parts of photoinitiator.

[0018] Furthermore, the antibacterial agent is one or more of chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate.

[0019] Furthermore, the photoinitiator used in the present invention may be photoinitiator 2959.

[0020] Furthermore, the substrate of the absorption layer is a foam layer or a hydrogel layer.

[0021] Furthermore, the non-adhesive hydrogel patch is in the form of a sheet or a strip.

[0022] The second object of the present invention is to provide a method for preparing the non-adhesive hydrogel dressing for skin wounds as described above, comprising the following steps:

[0023] (1) first preparing an antibacterial hydrogel cushion layer, and then compounding a reinforcing layer on the transverse end surface of the antibacterial hydrogel cushion layer to form a wound contact layer of the dressing;

[0024] (2) An absorbent layer is stacked on the longitudinal end surface of the wound contact layer to form a non-adhesive hydrogel dressing.

[0025] Specifically, the preparation method of the wound contact layer as described above is as follows:

[0026] a) weighing an antibacterial agent according to weight, dissolving it in water to form a transparent solution A;

[0027] b) adding acrylamide, acrylic acid, N,N'-methylenebisacrylamide, sodium carboxymethyl cellulose and glycerol in the formulated amount to the above solution A, and stirring or homogenizing to form a mixture B;

[0028] c) adding a formulated amount of photoinitiator to the mixture B, stirring or homogenizing to form a mixture C;

[0029] d) Pour the mixture C into the mold, and after leveling, cover the surface with a reinforcement layer so that it floats above the mixture C;

[0030] e) sending the mold containing the mixture into a UV curing machine to obtain a wound contact layer.

[0031] The third object of the present invention is to provide the use of the above non-adhesive hydrogel patch in the preparation of medical materials for treating wound infection and wound repair. For example, the non-adhesive hydrogel patch of the present invention can be used for the rapid repair and healing of wounds such as skin erosion, loosening, necrosis, blister bullae and skin trauma.

[0032] The beneficial effects of the present invention are as follows:

[0033] (1) The present invention adopts a multi-layer composite structure (a deprotonable reinforcing layer and a hydrogel matrix, and an anionized semipermeable membrane) so that the antibacterial agent (chlorhexidine) in the dressing achieves a three-level sustained-release effect, thereby solving the problem of insufficient long-term antibacterial performance due to the rapid release of the antibacterial agent.

[0034] (2) The anionized semipermeable membrane used in the present invention can pass water in one direction, achieving the effect of liquid exudation and avoiding the risk of wound maceration. At the same time, due to its anionization, the "temporary storage-re-release" effect of the antibacterial agent is achieved, extending the longer-term antibacterial effect of the dressing.

[0035] (3) The non-adhesive hydrogel dressing of the present invention has a better three-level sustained-release effect of the antibacterial agent, more stable and lasting antibacterial performance, and the effect of unidirectional water passage and wound exudate absorption, thereby achieving rapid and efficient wound repair in a wet surface environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 It is a schematic diagram of the structure of the non-adhesive hydrogel dressing of the present invention;

[0037] Figure 2 Drug (chlorhexidine acetate) release profile from non-adhesive hydrogel patch. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is described in detail below in conjunction with the embodiments. It is necessary to point out that the following embodiments are only used to explain and illustrate the present invention and are not used to limit the present invention. Some non-essential improvements and adjustments made by those skilled in the art based on the above invention content still belong to the protection scope of the present invention.

[0039] Example 1

[0040] A non-adhesive antibacterial hydrogel dressing, such as Figure 1As shown, it includes a wound contact layer and an absorption layer stacked in sequence, and the wound contact layer is composed of an antibacterial hydrogel cushion layer and a reinforcement layer. Among them, the wound contact layer is an antibacterial hydrogel cushion layer composed of poly (sodium acrylate-co-acrylamide) + antibacterial agent (chlorhexidine), and the reinforcement layer is a non-woven fabric composed of carboxymethyl cellulose or alginate fiber. The absorption layer is a foam layer composed of a semi-permeable membrane and a substrate, wherein the semi-permeable membrane is a cellulose acetate semi-permeable membrane coated with anionic polyacrylamide hydrogel, and the substrate is a hydrogel layer. The non-adhesive antibacterial hydrogel patch is prepared in sheet form.

[0041] The antibacterial hydrogel system is a poly (sodium acrylate-co-acrylamide) composite hydrogel system: by weight, it includes the following components: 35 parts of acrylamide, 10 parts of acrylic acid, 0.1 parts of N,N'-methylenebisacrylamide, 0.15 parts of antibacterial agent, 30 parts of glycerol, 40 parts of water, 4 parts of sodium carboxymethyl cellulose, and 0.14 parts of photoinitiator. Chlorhexidine acetate is selected as the antibacterial agent, and the photoinitiator is photoinitiator 2959.

[0042] The preparation method of the non-adhesive antibacterial hydrogel patch comprises the following steps:

[0043] (1) first preparing an antibacterial hydrogel cushion layer, and then compounding a reinforcing layer on the transverse end surface of the antibacterial hydrogel cushion layer to form a wound contact layer of the dressing;

[0044] (2) An absorbent layer is stacked on the longitudinal end surface of the wound contact layer to form a composite antibacterial hydrogel dressing.

[0045] The preparation method of the wound contact layer is as follows:

[0046] a) weighing an antibacterial agent according to weight, dissolving it in water to form a transparent solution A;

[0047] b) adding acrylamide, acrylic acid, N,N'-methylenebisacrylamide, sodium carboxymethyl cellulose and glycerol in the formulated amounts to the above solution A, and stirring to form a mixture B;

[0048] c) adding a formulated amount of photoinitiator to the mixture B and stirring to form a mixture C;

[0049] d) Pour the mixture C into the mold, and after leveling, cover the surface with a reinforcement layer so that it floats above the mixture C;

[0050] e) sending the mold containing the mixture into a UV curing machine to obtain a wound contact layer.

[0051] Example 2

[0052] According to the method of Example 1, the difference is that the antibacterial hydrogel cushion layer includes the following components by weight: 10 parts of acrylamide, 10 parts of acrylic acid, 0.05 parts of N,N'-methylenebisacrylamide, 0.05 parts of antibacterial agent, 20 parts of glycerol, 50 parts of water, 3 parts of sodium carboxymethyl cellulose, and 0.05 parts of photoinitiator. Among them, the antibacterial agent is chlorhexidine hydrochloride, and the reinforcing layer is a non-woven fabric composed of alginate fibers. The non-adhesive antibacterial hydrogel patch is prepared in a strip shape.

[0053] Example 3

[0054] According to the method of Example 1, the difference is that the antibacterial hydrogel cushion layer includes the following components by weight: 25 parts of acrylamide, 20 parts of acrylic acid, 0.2 parts of N,N'-methylenebisacrylamide, 0.5 parts of antibacterial agent, 50 parts of glycerol, 50 parts of water, 5 parts of sodium carboxymethyl cellulose, and 0.2 parts of photoinitiator. Among them, the antibacterial agent is chlorhexidine gluconate, and the reinforcing layer is a non-woven fabric composed of carboxymethyl cellulose. The non-adhesive antibacterial hydrogel patch is prepared into a long strip.

[0055] Comparative Example 1

[0056] The poly(sodium acrylate-co-acrylamide) composite hydrogel in Example 1 is replaced by polyvinyl alcohol (PVA), polyethylene oxide (PEO) or polyvinyl pyrrolidone (PVP) and their composite system hydrogels.

[0057] Experiments have found that a large number of hydrophilic carboxyl groups and amino groups exist in the poly (sodium acrylate-co-acrylamide) hydrogel system of the present invention, which are more easily deprotonated to form anionic structures when absorbing alkaline wound exudate. The cationic antibacterial substance chlorhexidine contained in the system forms anion-cation pairing due to electrostatic attraction, thereby achieving the fixation of chlorhexidine in the system and longer retention.

[0058] In the parallel substitution system listed above, polyvinyl alcohol (PVA), polyoxyethylene (PEO), polyvinyl pyrrolidone (PVP) and its composite system, there are a large number of hydrophilic hydroxyl groups in the system, and the electronegativity of hydroxyl groups is much greater than that of carboxyl groups and amino groups. In the same weakly alkaline wound exudate environment, the higher the difficulty of deprotonation, the more stable the structure, the easier it is to maintain its original hydroxyl structure, and it is more difficult to form anionic structures than carboxyl groups and amino groups, so the fixing effect on chlorhexidine cations is weaker. Considering the system, its sustained release effect on chlorhexidine is significantly worse, and the three-level sustained release effect in the present invention cannot be achieved.

[0059] Comparative Example 2

[0060] The carboxymethyl cellulose or alginate nonwoven fabric reinforcement layer in Example 2 is replaced with cotton woven fabric or polyester mesh.

[0061] Experimental findings show that the carboxymethyl cellulose or alginate nonwoven fabrics in the present invention have high rate of liquid absorption performance, and can produce gelation effect after absorbing wound exudate, wherein a large amount of carboxyl groups rich in them are deprotonated to form anionic structures, which are better for the fixed sustained release effect of cationic chlorhexidine. The cotton fabric or polyester mesh in the parallel replacement layer has conventional or worse liquid absorption performance, and its components cannot form anionic structures in wound exudate. As a reinforcing layer, it is only used to improve the mechanics and mechanical properties of the hydrogel cushion layer, without other additional functions, and therefore the three-level sustained release effect in the present invention cannot be achieved.

[0062] Comparative Example 3

[0063] The semipermeable membrane in Example 3 is a cellulose acetate membrane modified by coating anionic polyacrylamide hydrogel and replaced with an unmodified cellulose acetate semipermeable membrane.

[0064] The experimental results show that after the cellulose acetate membrane in the present invention is modified by anionic polyacrylamide hydrogel, not only its surface hydrophilicity is improved, the permeability of exudate water is improved, and a faster exudate precipitation effect is achieved. The anionized semi-permeable membrane can achieve a reverse traction effect on the chlorhexidine cation, and further achieve a sustained release effect. At the same time, the temporary storage effect of the chlorhexidine cation can also be achieved, and finally it is released under the pressure difference at a later stage, and the drug release time is longer.

[0065] Experimental Example 1

[0066] Take a non-adhesive patch sample of the present invention (taking Example 1 as an example) with a mass of about 4 g, an area of ​​10 cm×10 cm, and an added amount of chlorhexidine acetate of 2 wt %.

[0067] The absorbance of chlorhexidine acetate was determined by UV-visible spectrophotometry. The sample was placed in 200 mL PBS (pH = 7.4, 0.1 mol / L), and then placed in a 37 ° C constant temperature shaker. 2 mL of the solution was taken out every 1d (24h), and 2 mL of PBS was added again. The absorbance was measured at a wavelength of 254nm. At the same time, a series of standard concentrations of chlorhexidine acetate-PBS solutions were prepared to measure the absorbance to draw a standard curve. The cumulative release of chlorhexidine acetate in the sample at the corresponding days was calculated according to the standard curve equation. The results are shown in Table 1 and Figure 2 .

[0068] Table 1 Cumulative release rate = pre-added amount / cumulative release amount × %

[0069]

[0070] From Table 1 and Figure 2 It can be seen that the non-adhesive antibacterial hydrogel dressing provided by the present invention has an excellent sustained-release effect of the antibacterial agent, and its cumulative release time can reach 15 days.

[0071] Experimental Example 2

[0072] The non-adhesive hydrogel dressings of the embodiments of the present invention (using embodiment 1 as an example, the effects of other embodiments are similar) and comparative examples 1-3 are used for repairing chronic wound infection (for example, wounds with erosion, loosening, necrosis, and blister bullae). The experimental method is as follows: a mouse type 2 diabetes difficult-to-heal wound model is established according to the method in YY / T 1477.6-2022. Further reference is made to the method in Advanced Functional Materials, 2019, 29(12): 11846-11865. / Colloids&SurfacesBiointerfaces, 2023, 65(7): 222-245. The wound is inoculated with 50 μL of Staphylococcus aureus (1.0×10 5 CFU / mL) suspension was inoculated and infected to obtain an infected wound model. The prepared hydrogel sample was then fitted to the wound, and the wound healing rate was calculated according to YY / T 1477.6-2022 at 0, 3, 7, 11, and 14 days (Table 2). In addition, the infected skin tissue of the wound was excised and then diluted 1000 times with normal saline. Subsequently, 50 μL of the dilution was dispersed on an LB agar plate, and the number of colonies at the infected wound was statistically calculated (Table 3).

[0073] Table 2

[0074] Wound healing rate / % 3d 5d 7d 11d 14d Test Example 1 42.1 57.7 74.5 100 100 Comparative Example 1 39.9 58.7 70.1 80.1 94.8 Comparative Example 2 45.6 54.2 71.2 80.6 96.1 Comparative Example 3 42.8 59.1 73.9 86.3 98.7

[0075] Table 3

[0076]

[0077] From the experimental results in Table 2 and Table 3, it is found that the wound of the non-adhesive antibacterial hydrogel dressing of the present invention can be healed and repaired in only 7-11 days; while the wound of the comparative example takes 11-14 days to heal.

Claims

1. A non-adhesive hydrogel dressing for skin wounds, characterized in that: The non-adhesive hydrogel dressing comprises a wound contact layer and an absorption layer which are stacked in sequence; wherein the wound contact layer is composed of an antibacterial hydrogel cushion layer and a reinforcing layer, wherein the antibacterial hydrogel cushion layer is composed of a poly(sodium acrylate-co-acrylamide) composite hydrogel and an antibacterial agent; the reinforcing layer is a non-woven fabric composed of carboxymethyl cellulose or alginate fiber; the absorption layer is composed of a semipermeable membrane and a substrate, wherein the semipermeable membrane is a cellulose acetate semipermeable membrane coated with anionic polyacrylamide hydrogel.

2. The non-adhesive hydrogel dressing for skin wounds according to claim 1, characterized in that: The antibacterial hydrogel cushion layer comprises the following components by weight: 20-45 parts of acrylamide+acrylic acid, 0.05-0.2 parts of N,N'-methylenebisacrylamide, 0.05-0.5 parts of antibacterial agent, 20-50 parts of glycerol, 20-50 parts of water, 3-5 parts of sodium carboxymethyl cellulose, and 0.05-0.2 parts of photoinitiator.

3. The non-adhesive hydrogel dressing for skin wounds according to claim 1 or 2, characterized in that: The antibacterial agent is one or more of chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate.

4. The non-adhesive hydrogel dressing for skin wounds according to claim 2, characterized in that: The photoinitiator is 2959.

5. The non-adhesive hydrogel dressing for skin wounds according to claim 1 or 2, characterized in that: The substrate of the absorption layer is a foam layer or a hydrogel layer.

6. The non-adhesive hydrogel dressing for skin wounds according to claim 1 or 2, characterized in that: The composite antibacterial hydrogel patch is in the form of a sheet or a strip.

7. The method for preparing the non-adhesive hydrogel dressing for skin wounds according to any one of claims 1 to 6, characterized in that: The following steps are involved: (1) first preparing an antibacterial hydrogel cushion layer, and then compounding a reinforcing layer on the transverse end surface of the antibacterial hydrogel cushion layer to form a wound contact layer of the dressing; (2) An absorbent layer is stacked on the longitudinal end surface of the wound contact layer to form a composite antibacterial hydrogel dressing.

8. The preparation method according to claim 7, characterized in that: The preparation method of the wound contact layer is as follows: a) weighing an antibacterial agent according to weight, dissolving it in water to form a transparent solution A; b) adding acrylamide, acrylic acid, N,N'-methylenebisacrylamide, sodium carboxymethyl cellulose and glycerol in the formulated amount to the above solution A, and stirring or homogenizing to form a mixture B; c) adding a formulated amount of photoinitiator to the mixture B, stirring or homogenizing to form a mixture C; d) Pour the mixture C into the mold, and after leveling, cover the surface with a reinforcement layer so that it floats above the mixture C; e) sending the mold containing the mixture into a UV curing machine to obtain a wound contact layer.

9. Use of the non-adhesive hydrogel patch according to any one of claims 1 to 6 or the non-adhesive hydrogel patch prepared by the method according to any one of claims 7 to 8 as a medical material for treating skin wound infection and repairing wound surface.

10. The use according to claim 9, characterized in that: The types of skin wound infection wounds include skin erosion, loosening, necrosis, blisters and bullae and skin trauma.

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