The invention relates to a rapid sectioning method for a high-level radioactive waste repository 3D mesh model, belonging to the technical field of 3D modeling. The 3D rapid sectioning of any cross section of the high-level radioactive waste repository 3D mesh model based on tetrahedron construction can be supported. According to the method, through establishing the minimum bounding box of the high-level radioactive waste repository 3D mesh model, the mesh model is subjected to adaptive regional division, the rapid search of the divided areas of the repository model is carried out according to section information, the divided areas are determined, in mesh sectioning, the space information and topology information of the sectioned mesh are subjected to synchronous processing, and thus the geometric integrity of the model is maintained. According to the method, any times of sectioning of any cross section of the high-level radioactive waste repository 3D mesh model can be supported, the cross section area generation speed is rapid, when the tetrahedron quantity in the high-level radioactive waste repository 3D mesh model is larger than 1 million and is smaller than 5 million, the cross section generation time is smaller than three seconds, and the repository model can be dynamically refreshed in real time.