Preparation for dispelling effects of alcohol and protecting liver

Abstract

The invention belongs to the technical field of biological medicine, and particularly discloses a hangover-alleviating and liver-protecting preparation which comprises a liver-protecting agent layer, a first coating layer, a hangover-alleviating layer and a second coating layer which are sequentially arranged from inside to outside, the component of the liver-protecting agent layer is a mixture A, the component of the hangover-alleviating layer is a mixture B, the component of the first coating layer is a mixture C, the component of the second coating layer is a mixture B, and the component of the third coating layer is a mixture C; the component of the coating layer II is a mixture D. The hangover-alleviating and liver-protecting preparation provided by the invention is of a multi-layer structure, and can continuously release active ingredients for a long time, so that the concentration of medicines in blood is kept stable; meanwhile, side effects caused by too high drug concentration in a short time can be avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a preparation for sobering up and protecting the liver. Background Art

[0002] The liver is an important metabolic organ in the body, and alcohol is one of its main "enemies". Long-term heavy drinking can lead to alcoholic liver disease, which may then develop into alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis, and even liver cancer.

[0003] Alcohol induces mitochondrial dysfunction and produces a large amount of reactive oxygen species, which can lead to lipid peroxidation, produce harmful substances such as malondialdehyde (MDA), and damage liver cells. At the same time, alcohol can also increase the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the blood and accumulate triglycerides (TG), further aggravating liver damage.

[0004] Alcohol poisoning and complications caused by long-term excessive or one-time large-scale alcohol intake have seriously affected people's normal life. my country is a major producer and consumer of alcohol, and the number of patients suffering from alcohol poisoning caused by alcohol is huge. Therefore, the development of effective preparations for preventing drunkenness, sobering up and protecting the liver has received widespread attention from the pharmaceutical and food industries. Summary of the invention

[0005] The purpose of the present invention is to overcome the above problems existing in the prior art and provide a hangover and liver protection preparation, which has a multi-layer structure and can continuously release active ingredients over a long period of time to maintain a stable drug concentration in the blood; at the same time, it can avoid the side effects caused by excessive drug concentration in a short period of time.

[0006] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0007] A hangover-relief and liver-protecting preparation, comprising a liver-protecting agent layer, a first coating layer, a hangover-relief layer and a second coating layer arranged in order from the inside to the outside, wherein the liver-protecting agent layer comprises a mixture A, the hangover-relief layer comprises a mixture B, the first coating layer comprises a mixture C, and the second coating layer comprises a mixture D;

[0008] The mixture A comprises the following components in terms of mass percentage: 30-50% of Tremella fuciformis extract, 25-35% of yam extract, 6-10% of peach gum extract, 5-15% of wolfberry extract, 1-6% of lotus leaf extract, and 1-6% of licorice extract;

[0009] The mixture B comprises the following components in terms of mass percentage: 25-35% of kudzu root extract, 20-30% of Hovenia dulcis extract, 10-25% of corn oligopeptide powder, 6-10% of turmeric extract, 2-8% of taurine, 3-10% of emblica extract, 1-6% of rice bran fatty alkyl alcohol, 0.1-0.5% of ammonium glycyrrhizate, 1-5% of mung bean, and 0.01-0.5% of small molecule citrus pectin;

[0010] According to mass percentage, the mixture C comprises the following components: 60-80% chitosan and 20-40% turmeric extract;

[0011] Calculated by mass percentage, the mixture D comprises the following components: 60-80% chitosan and 20-40% tremella extract.

[0012] Furthermore, in the alcohol sobering and liver protecting preparation, the mass ratio of the liver protecting agent layer, the coating layer 1, the alcohol sobering layer and the coating layer 2 is 1:(0.1-0.2):(1.2-1.6):(0.1-0.2).

[0013] Furthermore, the preparation process of the alcohol sobering and liver protecting preparation is as follows:

[0014] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0015] S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use;

[0016] S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use;

[0017] S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0018] S5: granulating the mixture A using a dry granulator to prepare mixture A particles;

[0019] S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II.

[0020] S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

[0021] Furthermore, the Pueraria root extract, Hovenia dulcis fruit extract, Curcuma longa extract and Phyllanthus emblica fruit extract are all ethanol extracts.

[0022] Furthermore, the extraction process of the kudzu root extract, the Hovenia dulcis extract, the turmeric extract, and the emblica extract comprises the following steps:

[0023] Pueraria root, Hovenia dulcis, Curcuma longa and Phyllanthus emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Phyllanthus emblica extract.

[0024] Furthermore, the extraction process of the Tremella extract, the Chinese yam extract, the peach gum extract, the wolfberry extract, the lotus leaf extract, and the licorice extract comprises the following steps:

[0025] Step (1): taking Tremella fuciformis, Chinese yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them respectively in water, ultrafine grinding them, and then subjecting them to multiple modification treatments to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution;

[0026] Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract;

[0027] Step (3): After the crude extract is deproteinized, desalted, separated and purified, Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract and liquorice extract are prepared.

[0028] Furthermore, the multiple modification treatments are specifically: ultrasonic treatment, vacuum freeze-drying treatment, and ultraviolet treatment in sequence.

[0029] Furthermore, the composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:(1-4):(1-4);

[0030] The mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:(0.1-1.0).

[0031] Furthermore, a coating layer 3 is provided outside the coating layer 2, the material of the coating layer 3 is an auxiliary agent, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:(0.2-0.8);

[0032] The preparation method of the auxiliary preparation is as follows:

[0033] Step 1: Preparation of microcapsule particles

[0034] Weighing gelatin, gum arabic, and maltodextrin, dissolving gelatin and gum arabic in distilled water, adding maltodextrin, stirring at high speed with a magnetic stirrer, adding functional auxiliary additives, continuing to stir and emulsify, homogenizing with a high-pressure homogenizer, and immediately spray drying to prepare microcapsule particles one;

[0035] Step 2: Preparation of microcapsule particles 2

[0036] Weigh gelatin, gum arabic, and maltodextrin, dissolve gelatin and gum arabic in distilled water, add maltodextrin, stir at high speed with a magnetic stirrer, add flavor auxiliary additives, continue stirring and emulsifying, homogenize with a high-pressure homogenizer, and immediately spray dry to prepare microcapsule particles one;

[0037] Step 3: Preparation of auxiliary preparations

[0038] The microcapsule particles 1 and the microcapsule particles 2 are uniformly mixed in a mass ratio of 1:(0.1-1.0) to prepare an auxiliary preparation.

[0039] Furthermore, in step 1 and step 2, the mass ratio of gelatin, gum arabic and maltodextrin is independently 1:(1-1.5):(0.1-1.0);

[0040] In step 1, the mass ratio of the amount of the functional auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8);

[0041] In step 2, the mass ratio of the amount of flavor auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8);

[0042] The functional auxiliary additive is vitamin C and / or vitamin E;

[0043] The fragrance auxiliary additive is natural plant essential oil.

[0044] Compared with the prior art, the present invention has the following beneficial effects:

[0045] 1. In the present invention, the components work synergistically to increase the activity of liver alcohol dehydrogenase and acetaldehyde dehydrogenase, accelerate the decomposition and metabolism of alcohol in the body, avoid the damage of alcohol to liver tissue, enhance the liver's metabolic capacity, regulate lipid metabolism and oxidative stress response, protect liver cell membranes, improve liver function, thereby playing the role of sobering up and protecting the liver, and can also act as a diuretic and detoxifying agent.

[0046] 2. In the present invention, the preparation has a multi-layer structure, which can continuously release active ingredients for a long time and maintain the stability of the drug concentration in the blood. Specifically, the inner layer of the preparation is a liver protective agent layer, which mainly plays a role in protecting the liver. A coating layer is provided between the liver protective agent layer and the alcohol detoxification layer to separate the liver protective agent layer from the alcohol detoxification layer, thereby playing a sustained release role and avoiding the side effects caused by excessive drug concentration in a short period of time.

[0047] 3. In the present invention, the coating layer 1 and the coating layer 2 are mixed with chitosan and functional additives to form a coating layer outside the liver protective agent layer and the alcohol detoxification layer respectively, which not only plays a role of sustained release, but also can cooperate with the effective ingredients in the liver protective agent layer and the alcohol detoxification layer to play the effect of alcohol detoxification and liver protection.

[0048] 4. In the present invention, a coating layer 3 is arranged outside the coating layer 2, and the coating layer 3 is used to provide fragrance for the alcohol sobering and liver protecting preparation and also has the effect of anti-oxidation. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0050] Figure 1 It is a schematic diagram of the structure of the alcohol sobering and liver protecting preparation provided by the present invention.

[0051] Among them, the figures are marked as: 1. liver protecting agent layer; 2. coating layer one; 3. alcohol sobering layer; 4. coating layer two. DETAILED DESCRIPTION

[0052] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0053] In the description of the present invention, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inside", "all around" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0054] like Figure 1 As shown, a hangover-relieving and liver-protecting preparation comprises a liver-protecting agent layer 1, a coating layer 1 2, a hangover-relieving layer 3 and a coating layer 2 4 which are sequentially arranged from the inside to the outside, wherein the liver-protecting agent layer 1 comprises a mixture A, the hangover-relieving layer 3 comprises a mixture B, the coating layer 1 2 comprises a mixture C, and the coating layer 2 4 comprises a mixture D;

[0055] According to mass percentage, mixture A includes the following components: 30-50% of Tremella fuciformis extract, 25-35% of yam extract, 6-10% of peach gum extract, 5-15% of wolfberry extract, 1-6% of lotus leaf extract, and 1-6% of licorice extract;

[0056] According to the mass percentage, the mixture B comprises the following components: 25-35% of kudzu root extract, 20-30% of Hovenia dulcis extract, 10-25% of corn oligopeptide powder, 6-10% of turmeric extract, 2-8% of taurine, 3-10% of emblica extract, 1-6% of rice bran fatty alkyl alcohol, 0.1-0.5% of ammonium glycyrrhizinate, 1-5% of mung bean, and 0.01-0.5% of small molecule citrus pectin; wherein the small molecule citrus pectin is a natural ingredient extracted from the peel, pulp or orange pith of citrus (such as citrus, lemon, orange and grapefruit, etc.), is a polysaccharide complex with galactose as the main component, has uniform chemical composition, can be orally absorbed, has the effect of regulating gastrointestinal function, improving symptoms such as constipation and diarrhea, and also has the effects of controlling blood sugar, blood lipids and blood pressure, protecting the stomach, and sobering up;

[0057] In terms of mass percentage, mixture C includes the following components: chitosan 60-80%, turmeric extract 20-40%;

[0058] Calculated by mass percentage, mixture D includes the following components: 60-80% chitosan and 20-40% tremella extract.

[0059] In the alcohol-detoxifying and liver-protecting preparation, the mass ratio of the liver-protecting agent layer 1, the coating layer 1 2, the alcohol-detoxifying layer 3 and the coating layer 2 4 is 1:(0.1-0.2):(1.2-1.6):(0.1-0.2).

[0060] The preparation process of the alcohol-detoxifying and liver-protecting preparation is as follows:

[0061] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0062] S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use;

[0063] In step S2, in the turmeric extract solution, the mass ratio of turmeric extract to deionized water is 1:(20-60);

[0064] In the chitosan solution, the mass ratio of chitosan to acetic acid solution is 1:(30-60);

[0065] S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use;

[0066] In step S3, in the Tremella fuciformis extract solution, the mass ratio of Tremella fuciformis extract to deionized water is 1:(20-60);

[0067] In the chitosan solution, the mass ratio of chitosan to acetic acid solution is 1:(30-60);

[0068] S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0069] S5: granulating the mixture A using a dry granulator to prepare mixture A particles;

[0070] S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II.

[0071] S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

[0072] Among them, the kudzu root extract, the Hovenia dulcis extract, the turmeric extract, and the emblica fruit extract are all ethanol extracts; specifically, the extraction process of the kudzu root extract, the Hovenia dulcis extract, the turmeric extract, and the emblica fruit extract comprises the following steps:

[0073] Pueraria root, Hovenia dulcis, Curcuma longa and Phyllanthus emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Phyllanthus emblica extract.

[0074] Wherein, during the ultrasonic-assisted extraction process, the ratio of the weight of each of Puerariae Radix, Hovenia Dulcis Fruit, Curcuma Longa, and Phyllanthus Emblica to the volume of ethanol is independently selected from 1:(10-40);

[0075] Among them, the extraction process of Tremella extract, Chinese yam extract, peach gum extract, wolfberry extract, lotus leaf extract and licorice extract includes the following steps:

[0076] Step (1): taking Tremella fuciformis, yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them in water respectively, ultrafine grinding them, and then sequentially subjecting them to ultrasonic treatment, vacuum freeze drying treatment and ultraviolet treatment to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution;

[0077] Among them, after ultrafine grinding, the particle sizes of Tremella, Chinese yam, peach gum, wolfberry, lotus leaf and licorice are independently 1-40 μm;

[0078] Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract;

[0079] The composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:(1-4):(1-4);

[0080] Wherein, the mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:(0.1-1.0);

[0081] Step (3): after the crude extract is deproteinized, desalted, separated and purified, a Tremella extract, a Chinese yam extract, a peach gum extract, a wolfberry extract, a lotus leaf extract and a liquorice extract are prepared;

[0082] In addition, a coating layer 3 is provided outside the coating layer 2. The material of the coating layer 3 is an auxiliary agent. The coating layer 3 is coated on the outside of the coating layer 2 by passing water vapor. The mass ratio of the coating layer 2 to the coating layer 3 is 1:(0.2-0.8);

[0083] The preparation method of the auxiliary preparation is as follows:

[0084] Step 1: Preparation of microcapsule particles

[0085] Weighing gelatin, gum arabic, and maltodextrin, dissolving gelatin and gum arabic in distilled water, adding maltodextrin, stirring at high speed with a magnetic stirrer, adding functional auxiliary additives, continuing to stir and emulsify, homogenizing with a high-pressure homogenizer, and immediately spray drying to prepare microcapsule particles one;

[0086] Step 2: Preparation of microcapsule particles 2

[0087] Weigh gelatin, gum arabic, and maltodextrin, dissolve gelatin and gum arabic in distilled water, add maltodextrin, stir at high speed with a magnetic stirrer, add flavor auxiliary additives, continue stirring and emulsifying, homogenize with a high-pressure homogenizer, and immediately spray dry to prepare microcapsule particles one;

[0088] Step 3: Preparation of auxiliary preparations

[0089] The microcapsule particles 1 and the microcapsule particles 2 are uniformly mixed in a mass ratio of 1:(0.1-1.0) to prepare an auxiliary preparation;

[0090] In step 1 and step 2, the mass ratio of gelatin, gum arabic and maltodextrin is independently 1:(1-1.5):(0.1-1.0);

[0091] In step 1, the mass ratio of the amount of the functional auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8);

[0092] In step 2, the mass ratio of the amount of flavor auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8);

[0093] The functional auxiliary additives are vitamin C and / or vitamin E;

[0094] The fragrance auxiliary additive is natural plant essential oil.

[0095] The following are specific preparation examples, embodiments and comparative examples. In the following preparation examples, embodiments and comparative examples, each raw material can be obtained from commercial sources; specifically:

[0096] Preparation Examples 1-3 provide preparation methods for Pueraria lobata extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract, and Preparation Examples 4-6 provide extraction methods for Tremella fuciformis extract, Chinese yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract.

[0097] Preparation Example 1

[0098] This preparation example provides a preparation method of Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract, which is as follows:

[0099] Pueraria root, Hovenia dulcis, Curcuma longa and Emblica emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added at a mass volume ratio of 1:25 for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Emblica emblica extract.

[0100] Preparation Example 2

[0101] This preparation example provides a preparation method of Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract, which is as follows:

[0102] Pueraria root, Hovenia dulcis, Curcuma longa and Emblica emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added in a mass-to-volume ratio of 1:10 for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Emblica emblica extract.

[0103] Preparation Example 3

[0104] This preparation example provides a preparation method of Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract, which is as follows:

[0105] Pueraria root, Hovenia dulcis, Curcuma longa and Emblica emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added at a mass-to-volume ratio of 1:40 for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Emblica emblica extract.

[0106] Preparation Example 4

[0107] This preparation example provides a method for extracting Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, which specifically comprises the following steps:

[0108] Step (1): taking Tremella fuciformis, yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them in water respectively, ultrafine grinding them, and then sequentially subjecting them to ultrasonic treatment, vacuum freeze drying treatment and ultraviolet treatment to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution;

[0109] Among them, after ultrafine grinding, the particle sizes of Tremella, Chinese yam, peach gum, wolfberry, lotus leaf and licorice are independently 1-40 μm;

[0110] Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract;

[0111] The composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:2:2;

[0112] The mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:0.5;

[0113] Step (3): After the crude extract is deproteinized, desalted, separated and purified, Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract and liquorice extract are prepared.

[0114] Preparation Example 5

[0115] This preparation example provides a method for extracting Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, which specifically comprises the following steps:

[0116] Step (1): taking Tremella fuciformis, yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them in water respectively, ultrafine grinding them, and then sequentially subjecting them to ultrasonic treatment, vacuum freeze drying treatment and ultraviolet treatment to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution;

[0117] Among them, after ultrafine grinding, the particle sizes of Tremella, Chinese yam, peach gum, wolfberry, lotus leaf and licorice are independently 1-40 μm;

[0118] Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract;

[0119] The composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:4:1;

[0120] The mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:0.1;

[0121] Step (3): After the crude extract is deproteinized, desalted, separated and purified, Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract and liquorice extract are prepared.

[0122] Preparation Example 6

[0123] This preparation example provides a method for extracting Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, which specifically comprises the following steps:

[0124] Step (1): taking Tremella fuciformis, yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them in water respectively, ultrafine grinding them, and then sequentially subjecting them to ultrasonic treatment, vacuum freeze drying treatment and ultraviolet treatment to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution;

[0125] Among them, after ultrafine grinding, the particle sizes of Tremella, Chinese yam, peach gum, wolfberry, lotus leaf and licorice are independently 1-40 μm;

[0126] Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract;

[0127] The composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:1:4;

[0128] The mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:1.0;

[0129] Step (3): After the crude extract is deproteinized, desalted, separated and purified, Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract and liquorice extract are prepared.

[0130] Preparation Example 7

[0131] This preparation example provides an auxiliary preparation, and the preparation method of the auxiliary preparation is as follows:

[0132] Step 1: Preparation of microcapsule particles

[0133] Weigh gelatin, gum arabic, and maltodextrin, dissolve gelatin and gum arabic in distilled water, add maltodextrin, stir at high speed with a magnetic stirrer, add functional auxiliary additives, wherein the mass ratio of gelatin, gum arabic, and maltodextrin is 1:1.2:0.2, and the mass ratio of the added amount of the functional auxiliary additive to the total added amount of gelatin, gum arabic, and maltodextrin is 1:0.45, continue to stir and emulsify, homogenize with a high-pressure homogenizer, and immediately spray dry to prepare microcapsule particles one;

[0134] The functional auxiliary additive is prepared by mixing vitamin C and vitamin E in a mass ratio of 1:1;

[0135] Step 2: Preparation of microcapsule particles 2

[0136] Weigh gelatin, gum arabic, and maltodextrin, dissolve gelatin and gum arabic in distilled water, add maltodextrin, stir at high speed with a magnetic stirrer, add flavor auxiliary additives, wherein the mass ratio of gelatin, gum arabic, and maltodextrin is 1:1.2:0.2, and the mass ratio of the added amount of the flavor auxiliary additive to the total added amount of gelatin, gum arabic, and maltodextrin is 1:0.45, continue to stir and emulsify, homogenize with a high-pressure homogenizer, and immediately spray dry to prepare microcapsule particles one;

[0137] The fragrance auxiliary additive is peppermint oil;

[0138] Step 3: Preparation of auxiliary preparations

[0139] The microcapsule particles 1 and the microcapsule particles 2 were uniformly mixed in a mass ratio of 1:0.5 to prepare an auxiliary preparation.

[0140] Example 1

[0141] This embodiment provides a hangover-relieving and liver-protecting preparation, comprising a liver-protecting agent layer, a coating layer 1, a hangover-relieving layer and a coating layer 2 arranged in sequence from the inside to the outside, the liver-protecting agent layer is composed of a mixture A, the hangover-relieving layer is composed of a mixture B, the coating layer 1 is composed of a mixture C, and the coating layer 2 is composed of a mixture D; a coating layer 3 is further arranged outside the coating layer 2, the material of the coating layer 3 is an auxiliary preparation, and the coating layer 3 is coated on the outside of the coating layer 2 by passing water vapor; the auxiliary preparation is prepared by the preparation example 7, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:0.4;

[0142] In terms of mass percentage, mixture A includes the following components: 42% of Tremella fuciformis extract, 30% of yam extract, 8% of peach gum extract, 10% of wolfberry extract, 5% of lotus leaf extract, and 5% of licorice extract;

[0143] Mixture B includes the following components in terms of mass percentage: 30% of kudzu root extract, 25% of Hovenia dulcis extract, 8% of turmeric extract, 4% of taurine, 8% of emblica extract, 20% of corn oligopeptide powder, 2% of rice bran fatty alkyl alcohol, 0.4% of ammonium glycyrrhizate, 2.5% of mung bean, and 0.1% of small molecule citrus pectin;

[0144] In terms of mass percentage, mixture C includes the following components: chitosan 70%, turmeric extract 30%;

[0145] In terms of mass percentage, mixture D includes the following components: 70% chitosan and 30% tremella extract.

[0146] In the alcohol-detoxifying and liver-protecting preparation, the mass ratio of the liver-protecting agent layer, the first coating layer, the alcohol-detoxifying layer and the second coating layer is 1:0.15:1.4:0.15;

[0147] Among them, the Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract were prepared by Preparation Example 1; the Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract were prepared by Preparation Example 4.

[0148] This embodiment also provides a method for preparing a hangover-relieving and liver-protecting preparation, the preparation method comprising the following steps:

[0149] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0150] S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use;

[0151] In step S2, in the turmeric extract solution, the mass ratio of turmeric extract to deionized water is 1:40;

[0152] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:40;

[0153] S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use;

[0154] In step S3, in the Tremella fuciformis extract solution, the mass ratio of the Tremella fuciformis extract to deionized water is 1:40;

[0155] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:40;

[0156] S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0157] S5: granulating the mixture A using a dry granulator to prepare mixture A particles;

[0158] S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II.

[0159] S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

[0160] Example 2

[0161] This embodiment provides a hangover-relieving and liver-protecting preparation, comprising a liver-protecting agent layer, a coating layer 1, a hangover-relieving layer and a coating layer 2 arranged in sequence from the inside to the outside, the liver-protecting agent layer is composed of a mixture A, the hangover-relieving layer is composed of a mixture B, the coating layer 1 is composed of a mixture C, and the coating layer 2 is composed of a mixture D; a coating layer 3 is further arranged outside the coating layer 2, the material of the coating layer 3 is an auxiliary preparation, and the coating layer 3 is coated on the outside of the coating layer 2 by passing water vapor; the auxiliary preparation is prepared by the preparation example 7, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:0.2;

[0162] In terms of mass percentage, mixture A includes the following components: 30% Tremella extract, 35% Chinese yam extract, 10% peach gum extract, 15% wolfberry extract, 6% lotus leaf extract, and 4% licorice extract;

[0163] Mixture B includes the following components in terms of mass percentage: 35% of kudzu root extract, 20% of Hovenia dulcis extract, 10% of turmeric extract, 8% of taurine, 10% of emblica extract, 10% of corn oligopeptide powder, 1.49% of rice bran fatty alkyl alcohol, 0.5% of ammonium glycyrrhizate, 5% of mung bean, and 0.01% of small molecule citrus pectin;

[0164] In terms of mass percentage, mixture C includes the following components: chitosan 60%, turmeric extract 40%;

[0165] In terms of mass percentage, mixture D includes the following components: 80% chitosan and 20% tremella extract.

[0166] In the alcohol-detoxifying and liver-protecting preparation, the mass ratio of the liver-protecting agent layer, the first coating layer, the alcohol-detoxifying layer and the second coating layer is 1:0.1:1.6:0.2;

[0167] Among them, the Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract were prepared by Preparation Example 2; the Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract were prepared by Preparation Example 5.

[0168] This embodiment also provides a method for preparing a hangover-relieving and liver-protecting preparation, the preparation method comprising the following steps:

[0169] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0170] S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use;

[0171] In step S2, in the turmeric extract solution, the mass ratio of turmeric extract to deionized water is 1:20;

[0172] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:60;

[0173] S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use;

[0174] In step S3, in the Tremella fuciformis extract solution, the mass ratio of Tremella fuciformis extract to deionized water is 1:20;

[0175] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:60;

[0176] S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0177] S5: granulating the mixture A using a dry granulator to prepare mixture A particles;

[0178] S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II.

[0179] S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

[0180] Example 3

[0181] This embodiment provides a hangover-relieving and liver-protecting preparation, comprising a liver-protecting agent layer, a coating layer 1, a hangover-relieving layer and a coating layer 2 arranged in sequence from the inside to the outside, the liver-protecting agent layer is composed of a mixture A, the hangover-relieving layer is composed of a mixture B, the coating layer 1 is composed of a mixture C, and the coating layer 2 is composed of a mixture D; a coating layer 3 is further arranged outside the coating layer 2, the material of the coating layer 3 is an auxiliary preparation, and the coating layer 3 is coated on the outside of the coating layer 2 by passing water vapor; the auxiliary preparation is prepared by the preparation example 7, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:0.8;

[0182] In terms of mass percentage, mixture A includes the following components: 50% Tremella extract, 32% Chinese yam extract, 6% peach gum extract, 5% wolfberry extract, 1% lotus leaf extract, and 6% licorice extract;

[0183] Mixture B includes the following components by mass percentage: 31.4% of kudzu root extract, 30% of Hovenia dulcis extract, 6% of turmeric extract, 2% of taurine, 3% of emblica extract, 25% of corn oligopeptide powder, 1% of rice bran fatty alkyl alcohol, 0.1% of ammonium glycyrrhizate, 1% of mung bean, and 0.5% of small molecule citrus pectin;

[0184] In terms of mass percentage, mixture C includes the following components: chitosan 80%, turmeric extract 20%;

[0185] In terms of mass percentage, mixture D includes the following components: 60% chitosan and 40% tremella extract.

[0186] In the alcohol-detoxifying and liver-protecting preparation, the mass ratio of the liver-protecting agent layer, the first coating layer, the alcohol-detoxifying layer and the second coating layer is 1:0.2:1.2:0.1;

[0187] Among them, Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract, and Phyllanthus emblica extract were prepared by Preparation Example 3; Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract were prepared by Preparation Example 6.

[0188] This embodiment also provides a method for preparing a hangover-relieving and liver-protecting preparation, the preparation method comprising the following steps:

[0189] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0190] S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use;

[0191] In step S2, in the turmeric extract solution, the mass ratio of turmeric extract to deionized water is 1:60;

[0192] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:30;

[0193] S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use;

[0194] In step S3, in the Tremella fuciformis extract solution, the mass ratio of the Tremella fuciformis extract to deionized water is 1:60;

[0195] In the chitosan solution, the mass ratio of chitosan to acetic acid solution was 1:30;

[0196] S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0197] S5: granulating the mixture A using a dry granulator to prepare mixture A particles;

[0198] S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II.

[0199] S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

[0200] Example 4

[0201] This embodiment provides a hangover-relieving and liver-protecting preparation, comprising a liver-protecting agent layer, a coating layer 1, a hangover-relieving layer and a coating layer 2 arranged in sequence from the inside to the outside, the liver-protecting agent layer is composed of a mixture A, the hangover-relieving layer is composed of a mixture B, the coating layer 1 is composed of a mixture C, and the coating layer 2 is composed of a mixture D; a coating layer 3 is further arranged outside the coating layer 2, the material of the coating layer 3 is an auxiliary preparation, and the coating layer 3 is coated on the outside of the coating layer 2 by passing water vapor; the auxiliary preparation is prepared by the preparation example 7, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:0.4;

[0202] In terms of mass percentage, mixture A includes the following components: 49% Tremella extract, 25% Chinese yam extract, 10% peach gum extract, 10% wolfberry extract, 5% lotus leaf extract, and 1% licorice extract;

[0203] Mixture B includes the following components by mass percentage: 25% of kudzu root extract, 30% of Hovenia dulcis extract, 10% of turmeric extract, 2% of taurine, 10% of emblica extract, 11.6% of corn oligopeptide powder, 6% of rice bran fatty alkyl alcohol, 0.3% of ammonium glycyrrhizate, 5% of mung bean, and 0.1% of small molecule citrus pectin;

[0204] In terms of mass percentage, mixture C includes the following components: chitosan 70%, turmeric extract 30%;

[0205] In terms of mass percentage, mixture D includes the following components: 70% chitosan and 30% tremella extract.

[0206] In the alcohol-detoxifying and liver-protecting preparation, the mass ratio of the liver-protecting agent layer, the first coating layer, the alcohol-detoxifying layer and the second coating layer is 1:0.15:1.4:0.15.

[0207] This embodiment also provides a method for preparing a hangover-relieving and liver-protecting preparation, and the preparation method is carried out with reference to the preparation method for the hangover-relieving and liver-protecting preparation provided in Example 1.

[0208] Comparative Example 1

[0209] This comparative example provides a hangover-relieving and liver-protecting preparation, which is different from Example 1 in that, in this comparative example, the second coating layer and the third coating layer are removed, and the remaining raw materials are the same as those in Example 1.

[0210] This comparative example also provides a method for preparing a hangover-relieving and liver-protecting preparation, which is different from Example 1 in that, in this comparative example, step S6 is removed, and the rest is carried out with reference to Example 1.

[0211] Comparative Example 2

[0212] This comparative example provides a hangover and liver protection preparation, comprising a mixture A and a mixture B, wherein the mass ratio of the mixture A to the mixture B is 1:1.4; specifically, the mixture A comprises the following components, measured by mass percentage: 42% of Tremella fuciformis extract, 30% of yam extract, 8% of peach gum extract, 10% of wolfberry extract, 5% of lotus leaf extract, and 5% of licorice extract;

[0213] In terms of mass percentage, mixture B includes the following components: 30% kudzu root extract, 25% hovenia dulcis extract, 8% turmeric extract, 4% taurine, 8% emblica extract, 20% corn oligopeptide powder, 2% rice bran fatty alkyl alcohol, 0.4% ammonium glycyrrhizate, 2.5% mung bean, and 0.1% small molecule citrus pectin.

[0214] This comparative example also provides a preparation method of a hangover-relieving and liver-protecting preparation, and the preparation method is as follows:

[0215] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0216] S2: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0217] S3: After uniformly mixing mixture A and mixture B in a mass ratio of 1:1.4, granulation is performed using a dry granulator to prepare a hangover-relief and liver-protecting preparation.

[0218] Comparative Example 3

[0219] The comparative example provides a hangover and liver protection preparation, comprising mixture A, mixture C, mixture B, and mixture D, wherein the mass ratio of mixture A, mixture C, mixture B, and mixture D is 1:0.15:1.4:0.15; specifically, in terms of mass percentage, mixture A comprises the following components: 42% of tremella extract, 30% of yam extract, 8% of peach gum extract, 10% of wolfberry extract, 5% of lotus leaf extract, and 5% of licorice extract;

[0220] Mixture B includes the following components in terms of mass percentage: 30% of kudzu root extract, 25% of Hovenia dulcis extract, 8% of turmeric extract, 4% of taurine, 8% of emblica extract, 20% of corn oligopeptide powder, 2% of rice bran fatty alkyl alcohol, 0.4% of ammonium glycyrrhizate, 2.5% of mung bean, and 0.1% of small molecule citrus pectin;

[0221] In terms of mass percentage, mixture C includes the following components: chitosan 70%, turmeric extract 30%;

[0222] In terms of mass percentage, mixture D includes the following components: 70% chitosan and 30% tremella extract.

[0223] This comparative example also provides a preparation method of a hangover-relieving and liver-protecting preparation, and the preparation method is as follows:

[0224] S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A;

[0225] S2: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B;

[0226] S3: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed and mixed evenly to prepare mixture C;

[0227] S4: according to the raw material composition of mixture D, chitosan and Tremella fuciformis extract are weighed and mixed evenly to prepare mixture C;

[0228] S3: Mixture A, mixture C, mixture B and mixture D in a mass ratio of 1:0.15:1.4:0.15, and granulate them using a dry granulator to prepare a hangover and liver protection preparation.

[0229] Experimental example

[0230] The alcohol sobering and liver protecting preparations prepared in Examples 1-4 and Comparative Examples 1-2 were used to conduct relevant experiments, and the relevant experimental procedures are as follows:

[0231] Experiment 1: Alcohol sobering effect experiment

[0232] Experimental method: mice were randomly divided into 8 groups, 10 mice in each group, and the 8 groups were respectively Example 1, Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, Comparative Example 3 and blank control. The experimental mice were treated as follows: after fasting for 12 hours, the blank control group was gavaged with 0.1g / 10g body weight of distilled water; the Example 1-4 and Comparative Example 1-2 groups were gavaged with 0.1g / 10g body weight of alcohol detoxifier, and all 7 groups were gavaged with alcohol at a dose of 0.1mL / 10g body weight after 30 minutes, and the drunkenness (disappearance of righting reflex) and sobering up (recovery of righting reflex) time of each group were recorded (starting from the time of drinking), and the results are shown in Table 1;

[0233] Table 1

[0234] Group Experimental mice / Drunk latency time / s Drunk duration / min Example 1 10 594.1±10.09 170.4±4.36 Example 2 10 529.9±13.27 184.5±4.13 Example 3 10 558.7±7.17 195.5±5.84 Example 4 10 573.7±7.29 189.1±6.27 Comparative Example 1 10 622.8±8.16 246.6±6.31 Comparative Example 2 10 679.4±6.47 262.6±8.64 Comparative Example 3 10 700.8±6.225 281.6±8.36 Blank control group 10 380.5±9.73 556.9±4.53

[0235] From the results in Table 2, it can be seen that in terms of the latent time of drunkenness, Examples 1-4 are shorter than Comparative Examples 1-3. This is because the alcohol-detoxifying and liver-protecting preparations provided by the present invention used in Examples 1-3 have a sustained-release effect. Therefore, relative to the Comparative Examples, the drunkenness latent time of the mice in the Examples is shorter. From the drunkenness maintenance time, it can be seen that the drunkenness maintenance time in Examples 1-4 is shorter than that in Comparative Examples 1-3. Similarly, since the alcohol-detoxifying and liver-protecting preparations have a sustained-release effect, the alcohol-detoxifying effect time of the preparations can be prolonged. After feeding the alcohol-detoxifying preparations first and then drinking the alcohol, the drunkenness maintenance time can be effectively shortened.

[0236] Experiment 2: Determination of various indicators in liver tissue

[0237] Experimental method: Mice were selected and divided into 7 groups, each with 10 mice. The 8 groups were specifically Example 1, Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, Comparative Example 3 and blank control. The mice in the other groups were fed normally after 30 minutes of administration and oral drinking of wine (wherein the medicine used is the alcohol detoxification and liver protection preparation provided in Example 1, Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, and Comparative Example 3, the injection amount of the medicine is 0.50 mg / g, injected once a day; drinking The mice in the blank control group were fed normally and given an equal amount of distilled water. The experiment lasted for 15 days. After the experiment, the mice in each group were weighed and anesthetized by intraperitoneal injection of 10% hydrated chloric acid. The mice were immediately dissected and their livers were removed. Under sterile conditions, 1-2 g of liver tissue was taken and manually homogenized with ice saline at a weight-to-volume ratio of 1:9. After centrifugation, the supernatant was taken to detect the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. The test results are shown in Table 2.

[0238] Table 2

[0239] Group Liver ADH (U / mgprot) Liver ALDH (U / mgprot) Example 1 40.15±3.24 62.31±2.33 Example 2 38.18±3.12 60.92±4.11 Example 3 37.52±4.86 59.51±2.45 Example 4 39.65±3.44 59.01±4.13 Comparative Example 1 40.01±5.74 61.25±6.88 Comparative Example 2 39.44±6.91 54.21±10.25 Comparative Example 3 38.47±4.21 51.32±11.32 Blank control group 22.34±4.22 38.76±2.41

[0240] It can be seen from the data in Table 2 that the alcohol detoxification and liver protection preparations provided in the embodiments and comparative examples are used for alcohol detoxification and liver protection, and the detected alcohol dehydrogenase and acetaldehyde dehydrogenase activities are higher than those of the blank control group, indicating that the raw materials provided by the present application can increase the activity of liver alcohol dehydrogenase and acetaldehyde dehydrogenase, accelerate the decomposition and metabolism of alcohol in the body, avoid the damage of alcohol to liver tissue, and enhance the liver's metabolic capacity, regulate lipid metabolism and oxidative stress response, protect liver cell membranes, and improve liver function, thereby achieving the effect of alcohol detoxification and liver protection;

[0241] Experiment 3: A number of drinkers were selected for the experiment and divided into 6 large groups, each of which was divided into two small groups, namely Group A and Group B, each of which had 5 people. The 6 large groups were specifically Example 1, Example 2, Example 3, Example 4, Comparative Example 1, and Comparative Example 2. Among them, the drinkers in Group A in each large group drank the same amount of drinking wine, and then took the same amount of alcohol detoxification and liver protection preparations prepared in Example 1, Example 2, Example 3, Example 4, and Comparative Example 1, and the symptoms of the drinkers in each group were counted; the drinkers in Group B in each large group drank the same amount of drinking water, and then took the same amount of alcohol detoxification and liver protection preparations prepared in Example 1, Example 2, Example 3, Example 4, and Comparative Example 1, and the symptoms of the drinkers in each group were counted. The statistical results of the experiment are shown in Table 3;

[0242] Specifically, in Table 4, in the sobering time index, * indicates that the sobering time is 0-30 minutes; ** indicates that the sobering time is 30-60 minutes, and *** indicates that the sobering time is more than 1 hour;

[0243] Among the symptoms after drinking, * indicates no nausea, vomiting, dizziness, unsteady gait and other discomfort symptoms; ** indicates any one of nausea, vomiting, dizziness, unsteady gait; *** indicates at least two of nausea, vomiting, dizziness, unsteady gait symptoms;

[0244] In the stomach feeling, * indicates no stomach discomfort or poor appetite symptoms; ** indicates any one of stomach discomfort or poor appetite symptoms; *** indicates both stomach discomfort and poor appetite symptoms;

[0245] Table 3

[0246]

[0247] It can be seen from the data in Table 4 that the alcohol-detoxifying and liver-protecting preparation prepared by the embodiment of the present invention can exert its effect continuously and stably over a long period of time due to its sustained-release effect, and thus, taking the alcohol-detoxifying and liver-protecting preparation without drinking alcohol will not cause discomfort to the body.

[0248] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0249] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.

Claims

1. A preparation for sobering up and protecting the liver, characterized in that: It comprises a liver-protecting agent layer, a coating layer 1, a hangover-relieving layer and a coating layer 2 which are arranged in sequence from the inside to the outside, wherein the liver-protecting agent layer is composed of a mixture A, the hangover-relieving layer is composed of a mixture B, the coating layer 1 is composed of a mixture C, and the coating layer 2 is composed of a mixture D; The mixture A comprises the following components in terms of mass percentage: 30-50% of Tremella fuciformis extract, 25-35% of yam extract, 6-10% of peach gum extract, 5-15% of wolfberry extract, 1-6% of lotus leaf extract, and 1-6% of licorice extract; The mixture B comprises the following components in terms of mass percentage: 25-35% of kudzu root extract, 20-30% of Hovenia dulcis extract, 10-25% of corn oligopeptide powder, 6-10% of turmeric extract, 2-8% of taurine, 3-10% of emblica extract, 1-6% of rice bran fatty alkyl alcohol, 0.1-0.5% of ammonium glycyrrhizate, 1-5% of mung bean, and 0.01-0.5% of small molecule citrus pectin; In terms of mass percentage, the mixture C comprises the following components: 60-80% chitosan and 20-40% turmeric extract; Calculated by mass percentage, the mixture D comprises the following components: 60-80% chitosan and 20-40% tremella extract.

2. The alcohol sobering and liver protecting preparation according to claim 1, characterized in that: In the alcohol sobering and liver protecting preparation, the mass ratio of the liver protecting agent layer, the first coating layer, the alcohol sobering layer and the second coating layer is 1:(0.1-0.2):(1.2-1.6):(0.1-0.2).

3. The alcohol sobering and liver protecting preparation according to claim 1, characterized in that: The preparation process of the alcohol-relieving and liver-protecting preparation is as follows: S1: According to the raw material composition of mixture A, weigh tremella extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract, and licorice extract, mix them evenly, and prepare mixture A; S2: according to the raw material composition of mixture C, chitosan and turmeric extract are weighed, the turmeric extract is dissolved in deionized water to prepare a turmeric extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the turmeric extract solution and the chitosan solution are mixed, glycerol is added, and after constant temperature magnetic stirring and homogenization, and then microwave treatment, a mixed solution 1 is obtained for standby use; S3: according to the raw material composition of mixture D, chitosan and tremella extract are weighed, the tremella extract is dissolved in deionized water to prepare a tremella extract solution, chitosan is dissolved in acetic acid solution to prepare a chitosan solution, the tremella extract solution and the chitosan solution are mixed, glycerol is added, and the mixture is stirred and homogenized by constant temperature magnetic stirring, and then subjected to microwave treatment to obtain a second mixed solution for standby use; S4: according to the raw material composition of mixture B, kudzu root extract, Hovenia dulcis extract, turmeric extract, taurine, emblica fruit extract, corn oligopeptide powder, rice bran fatty alkyl alcohol, ammonium glycyrrhizate, mung bean, and small molecular citrus pectin were weighed and mixed evenly to prepare mixture B; S5: granulating the mixture A using a dry granulator to prepare mixture A particles; S6: placing the particles of mixture A in a bottom spray coating boiling fluidized bed, and coating the mixture A with the bottom spray coating boiling fluidized bed to prepare coated particles A. After the coating is completed, the coated particles A are placed in mixture B under an inert atmosphere, and the mixture B is adhered to the outside of the coated particles A to prepare coated particles II. S7: After the coated particles are dried, they are placed in a bottom spray coating boiling fluidized bed, and the mixed solution 2 is coated on the outside of the coated particles 2 by using the bottom spray coating boiling fluidized bed. After drying, a hangover and liver protection preparation is prepared.

4. The alcohol sobering and liver protecting preparation according to claim 1, characterized in that: The kudzu root extract, the Hovenia dulcis fruit extract, the turmeric extract and the emblica fruit extract are all ethanol extracts.

5. The alcohol sobering and liver protecting preparation according to claim 4, characterized in that: The extraction process of the kudzu root extract, the Hovenia dulcis extract, the turmeric extract, and the emblica extract comprises the following steps: Pueraria root, Hovenia dulcis, Curcuma longa and Phyllanthus emblica were weighed respectively, crushed and sieved by a crusher, and then ethanol was added for ultrasonic-assisted extraction. The precipitate was discarded by centrifugation, and the supernatant was concentrated and vacuum freeze-dried to obtain Pueraria root extract, Hovenia dulcis extract, Curcuma longa extract and Phyllanthus emblica extract.

6. The alcohol sobering and liver protecting preparation according to claim 1, characterized in that: The extraction process of the Tremella extract, Chinese yam extract, peach gum extract, wolfberry extract, lotus leaf extract and licorice extract comprises the following steps: Step (1): taking Tremella fuciformis, Chinese yam, peach gum, wolfberry, lotus leaf and liquorice, crushing them respectively by a crusher, dissolving them respectively in water, ultrafine grinding them, and then subjecting them to multiple modification treatments to obtain multiple processed extracts, and re-dissolving the multiple processed extracts to obtain a primary reconstituted solution; Step (2): adding the complex enzyme to the first reconstitution solution, placing it in a constant temperature water bath, heating it to inactivate the enzyme, centrifuging it again, discarding the supernatant, washing it with ethanol, centrifuging it again, and re-dissolving it to prepare a crude extract; Step (3): After the crude extract is deproteinized, desalted, separated and purified, Tremella fuciformis extract, yam extract, peach gum extract, wolfberry extract, lotus leaf extract and liquorice extract are prepared.

7. The alcohol sobering and liver protecting preparation according to claim 7, characterized in that: The multiple modification treatments specifically include: ultrasonic treatment, vacuum freeze drying treatment, and ultraviolet treatment in sequence.

8. The alcohol sobering and liver protecting preparation according to claim 7, characterized in that: The composite enzyme is prepared by mixing protease, cellulase and pectinase in a mass ratio of 1:(1-4):(1-4); The mass ratio of the treated extract to the complex enzyme in the first reconstitution solution is 100:(0.1-1.0).

9. The alcohol sobering and liver protecting preparation according to claim 1, characterized in that: A coating layer 3 is further provided outside the coating layer 2, the material of the coating layer 3 is an auxiliary agent, and the mass ratio of the coating layer 2 to the coating layer 3 is 1:(0.2-0.8); The preparation method of the auxiliary preparation is as follows: Step 1: Preparation of microcapsule particles Weighing gelatin, gum arabic, and maltodextrin, dissolving gelatin and gum arabic in distilled water, adding maltodextrin, stirring at high speed with a magnetic stirrer, adding functional auxiliary additives, continuing to stir and emulsify, homogenizing with a high-pressure homogenizer, and immediately spray drying to prepare microcapsule particles one; Step 2: Preparation of microcapsule particles 2 Weigh gelatin, gum arabic, and maltodextrin, dissolve gelatin and gum arabic in distilled water, add maltodextrin, stir at high speed with a magnetic stirrer, add flavor auxiliary additives, continue stirring and emulsifying, homogenize with a high-pressure homogenizer, and immediately spray dry to prepare microcapsule particles one; Step 3: Preparation of auxiliary preparations The microcapsule particles 1 and the microcapsule particles 2 are uniformly mixed in a mass ratio of 1:(0.1-1.0) to prepare an auxiliary preparation.

10. The alcohol sobering and liver protecting preparation according to claim 9, characterized in that: In step 1 and step 2, the mass ratio of gelatin, gum arabic and maltodextrin is independently 1:(1-1.5):(0.1-1.0); In step 1, the mass ratio of the amount of the functional auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8); In step 2, the mass ratio of the amount of flavor auxiliary additive added to the total amount of gelatin, gum arabic, and maltodextrin added is 1:(0.4-0.8); The functional auxiliary additive is vitamin C and / or vitamin E; The fragrance auxiliary additive is natural plant essential oil.

Images