High-extension functional medicine controlled-release patch with viscous controlled-release control layer

Abstract

The invention discloses a high-extension functional medicine controlled release patch with a viscous slow release control layer. The high-extension functional medicine controlled release patch comprises a high-extension waterproof and moisture-permeable layer and a functional medicine storage layer arranged below the high-extension waterproof and moisture-permeable layer, and the viscous slow release control layer, the high-extension waterproof and moisture-permeable layer, the functional medicine storage layer and the viscous slow release control layer are connected in sequence. The invention has the following beneficial effects: the mask can be effectively applied to the skin surface; the drug loading capacity can be effectively improved, controllable drug release is achieved, the treatment process is noninvasive, the bioavailability of the drug is improved, the treatment safety is improved, and the treatment frequency is reduced; the invention has the advantages of simple preparation, convenient operation and good use effect.

Description

Technical Field

[0001] The invention relates to the field of medical technology, in particular to a highly ductile functional drug controlled-release patch with a sticky sustained-release control layer. Background Art

[0002] In recent years, portable and wearable drug delivery technology has also been developed, especially microneedle drug delivery systems, which enable molecules to penetrate the stratum corneum, have high bioavailability, and patients can self-administer drugs. However, microneedles are expensive and may cause inflammation to the skin; therefore, how to achieve precise drug release and efficient absorption is an urgent problem that technicians in this field need to solve.

[0003] In view of the above situation, it is necessary to improve the existing drug administration method so that it can adapt to the current needs of medical use. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a high-extensibility functional drug controlled-release patch with a viscous sustained-release control layer, comprising a high-extensibility waterproof and breathable layer, a functional drug storage layer arranged below the high-extensibility waterproof and breathable layer, a viscous sustained-release control layer, a high-extensibility waterproof and breathable layer, the functional drug storage layer, and the viscous sustained-release control layer are connected in sequence.

[0005] As a further supplement to the technical solution, the functional drug storage layer includes a storage body and a plurality of functional drug bodies uniformly distributed in the storage body.

[0006] As a further supplement to the present technical solution, the viscous sustained-release control layer includes a storage layer connecting surface, a viscous support body, and a sustained-release controlled drug release surface which are arranged in sequence, and sustained-release control channels are evenly arranged in the viscous support body. The sustained-release controlled channel is connected to the functional drug storage layer through the storage layer connecting through hole, and a sustained-release controlled drug release through hole is provided on the sustained-release controlled drug release surface for connecting the sustained-release control channel.

[0007] As a further supplement to the technical solution, a plurality of sustained-release control channels are evenly arranged in the adhesive support body.

[0008] As a further supplement to the technical solution, the sustained-release control channel is connected to the functional drug storage layer through a plurality of storage layer connecting holes.

[0009] As a further supplement to the technical solution, a plurality of sustained-release controlled-drug release through holes are provided on the sustained-release controlled-drug release surface for connecting the sustained-release controlled channels.

[0010] As a further supplement to the technical solution, the storage body is composed of fabric, cross-linked polyacrylate gel, silica gel, and polyurethane.

[0011] As a further supplement to the technical solution, the adhesive support is composed of cross-linked polyacrylate gel, silica gel, polyurethane, synthetic rubber, butyl rubber, natural rubber, and pressure-sensitive adhesive.

[0012] Its beneficial effects are that it can be effectively applied to the skin surface; it can effectively increase the drug loading therein and achieve controlled drug release, the treatment process is non-invasive, the bioavailability of the drug is improved, the safety of treatment is improved and the number of treatments is reduced; the invention is simple to prepare, easy to operate and has good use effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a schematic diagram of the structure of the present invention;

[0014] Figure 2 This is an electron micrograph of a slice of a functional ingredient through a viscous sustained-release control layer in the early stage of the release process of the present invention;

[0015] Figure 3 This is an electron microscope image of a section of a functional ingredient passing through a viscous sustained-release control layer during the middle stage of the release process of the present invention;

[0016] In the figure, 1000, affected part; 10, high-extensibility functional drug controlled-release patch; 100, high-extensibility waterproof and breathable layer; 200, functional drug storage layer; 201, functional drug body; 203, storage body; 300, adhesive sustained-release control layer; 301, storage layer connecting surface; 303, sustained-release controlled drug release surface; 305, sustained-release control channel; 307, storage layer connecting through hole; 309, sustained-release controlled drug release through hole; 311, adhesive support body. DETAILED DESCRIPTION

[0017] In order to make the technical solution more clear to those skilled in the art, Figure 1-3 The technical solution of the present invention is described in detail:

[0018] like Figure 1 As shown, a high-extensibility functional drug controlled-release patch with a viscous sustained-release control layer includes a high-extensibility waterproof and breathable layer 100, a functional drug storage layer 200 arranged below the high-extensibility waterproof and breathable layer 100, and a viscous sustained-release control layer 300. The high-extensibility waterproof and breathable layer 100, the functional drug storage layer 200, and the viscous sustained-release control layer 300 are connected in sequence.

[0019] like Figure 1 As shown, further, the functional drug storage layer 200 includes a storage body 203 and a plurality of functional drug bodies 201 uniformly distributed in the storage body 203, wherein the storage body 203 is composed of fabric, cross-linked polyacrylate gel, silica gel, and polyurethane.

[0020] like Figure 1-3 As shown, the viscous sustained-release control layer 300 includes a storage layer connection surface 301, a viscous support body 311, and a sustained-release control drug release surface 303 which are sequentially arranged. The viscous support body 311 is evenly provided with sustained-release control channels 305. The sustained-release control channels 305 are connected to the functional drug storage layer 200 through the storage layer connection through holes 307, so that the plurality of functional drug bodies 201 in the storage body 203 can be controlled by the size of the sustained-release control channels 305 to enter the sustained-release control channels 305;

[0021] like Figure 1-3 As shown, a sustained-release controlled drug release through hole 309 is provided on the sustained-release controlled drug release surface 303 for connecting the sustained-release controlled channel 305, so that the functional drug body 201 in the sustained-release controlled channel leaves the viscous sustained-release controlled layer 300 and enters the affected part 1000; further, a plurality of sustained-release controlled channels 305 are evenly arranged in the viscous support body 311; the sustained-release controlled channel 305 is connected to the functional drug storage layer 200 through a plurality of storage layer connecting through holes 307; a plurality of sustained-release controlled drug release through holes 309 are provided on the sustained-release controlled drug release surface 303 for connecting the sustained-release controlled channel 305; further, the viscous support body 311 is composed of cross-linked polyacrylate gel, silica gel, polyurethane, synthetic rubber, butyl rubber, natural rubber, and pressure-sensitive adhesive.

[0022] The above technical solutions only reflect the preferred technical solutions of the technical solutions of the present invention. Some changes that may be made to certain parts thereof by technicians in this technical field all reflect the principles of the present invention and fall within the protection scope of the present invention.

Claims

1. A highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer, characterized in that: The invention comprises a highly elongated waterproof and breathable layer (100), a functional drug storage layer (200) arranged below the highly elongated waterproof and breathable layer (100), and a viscous sustained-release control layer (300), wherein the highly elongated waterproof and breathable layer (100), the functional drug storage layer (200), and the viscous sustained-release control layer (300) are sequentially connected.

2. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 1, characterized in that: The functional drug storage layer (200) comprises a storage body (203) and a plurality of functional drug bodies (201) uniformly distributed in the storage body (203).

3. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 2, characterized in that: The viscous sustained-release control layer (300) comprises a storage layer connecting surface (301), a viscous support body (311), and a sustained-release controlled drug release surface (303) which are arranged in sequence. Sustained-release control channels (305) are evenly arranged in the viscous support body (311). The sustained-release controlled drug release channel (305) is connected to the functional drug storage layer (200) through the storage layer connecting through hole (307). The sustained-release controlled drug release surface (303) is provided with a sustained-release controlled drug release through hole (309) for connecting the sustained-release controlled channel (305).

4. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 3, characterized in that: A plurality of sustained-release control channels (305) are evenly arranged in the adhesive support (311).

5. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 3, characterized in that: The sustained-release control channel (305) is connected to the functional drug storage layer (200) through a plurality of storage layer connecting holes (307).

6. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 3, characterized in that: The sustained-release controlled-drug-release surface (303) is provided with a plurality of sustained-release controlled-drug-release through holes (309) for connecting to the sustained-release controlled channel (305).

7. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 2, characterized in that: The storage body (203) is composed of fabric, cross-linked polyacrylate gel, silica gel, and polyurethane.

8. The highly extensible functional drug controlled-release patch with an adhesive sustained-release control layer according to claim 4, characterized in that: The adhesive support (311) is composed of cross-linked polyacrylate gel, silica gel, polyurethane, synthetic rubber, butyl rubber, natural rubber, and pressure-sensitive adhesive.

Images