Broad-spectrum anticancer traditional Chinese medicine composition as well as preparation method and application thereof

Abstract

The invention provides a broad-spectrum anticancer traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The broad-spectrum anti-cancer traditional Chinese medicine composition is composed of a basic formula and an additive formula, and the basic formula is composed of rhizoma smilacis glabrae, piper cubeba, trichosanthes kirilowii maxim, fritillaria cirrhosa, exocarpium citri grandis, fructus citri sarcodactylis, citrus chachiensis hortorum, coix seeds, spina date seeds, herba epimedii, cistanche, morinda officinalis, codonopsis pilosula, astragalus membranaceus, Chinese yam and rehmannia. The traditional Chinese medicine composition has the advantages of conventional and easily available materials, quick effect, stable effect, no toxic or side effect, simple application and operation, alleviation of the medical workload of patients and family members, reduction of the fear of the patients, enhancement of the nutrition state of each internal organ, acceleration of the metabolism speed in vivo, acceleration of the cleaning of toxins in vivo, improvement of the survival ability of the patients and improvement of the life quality; the traditional Chinese medicine composition can be used for curing and treating various cancers and various stages in the cancer treatment process, and can effectively prevent relapse and metastasis of the cancers.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a broad-spectrum anti-cancer Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] Cancer is a general term for more than 100 related diseases. When a cell in the body mutates, it will continue to divide, out of the body's control, and eventually form cancer. All organs in the human body are made up of cells. Cell growth and differentiation can meet the needs of the body, and this orderly process can keep people healthy. However, if the cells continue to divide, these extra large numbers of cells form tumors. Cells in malignant tumors can invade and destroy nearby tissues and organs. In addition, cancer cells can break out of the tumor and enter the blood or lymphatic system. This is how cancer spreads from the original site to other organs to form new tumors. This process is called cancer metastasis. Most cancers are named according to the organ or cell type in which they start.

[0003] At present, the methods of Western medicine intervention in malignant tumors have made three leaps since 1809. The first leap was to clean up the body's cancerous tissue mainly through surgery, radiotherapy, and chemotherapy; the second leap was molecular targeted tumor therapy, which brought tumor treatment into the era of "precision medicine". The third leap was immune checkpoint blockade therapy that makes cancer cells nowhere to hide. However, because Western medicine surgical intervention methods and various drugs will bring many adverse reactions to patients, especially gastrointestinal reactions are the strongest, which will cause nausea, vomiting, anorexia, etc. in patients, thereby greatly reducing the quality of life of patients, and even worse, it will induce worsening of the disease.

[0004] Cancer is called The main cause of the disease is physical weakness. The weakness of the righteousness leads to the invasion of the six evil toxins, which forms a mass over time. It can also be seen in the seven emotions, emotional discomfort, qi stagnation, blood stasis, phlegm and turbidity, and gradually forming a mass, or in eating disorders, eating spicy, stimulating, greasy, sweet and fatty foods. Traditional Chinese medicine often takes regulating qi, removing blood stasis and promoting dampness as the main method, and assists with dispersing the knot and eliminating symptoms. For those with new diseases and strong bodies, they can be attacked and broken; for those with long-term diseases and weak bodies, when attacking evil, they must protect the righteousness and should follow the principle of "stopping when most of it is weakened", and should not be too harsh. Compared with the intervention methods of Western medicine, traditional Chinese medicine treatment can relieve the pain of patients and improve their quality of life. However, ordinary traditional Chinese medicine treatment lacks certain accuracy and clarity. Therefore, it is hoped that a traditional Chinese medicine formula that can effectively prevent and treat various types of tumors and tumor recurrence can be found. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine formula which can effectively prevent and treat various types of tumors and tumor recurrence.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a broad-spectrum anti-cancer Chinese medicine composition, which consists of a basic formula and an additional formula. The basic formula consists of the following raw materials in parts by weight: 15-25 parts of smilax glabra, 15-25 parts of cubeb, 15-25 parts of trichosanthes, 5-15 parts of fritillaria cirrhosa, 15-25 parts of tangerine peel, 15-25 parts of citron, 15-25 parts of citron, 15-25 parts of coix seeds, 10-20 parts of spiny jujube seeds, 10-20 parts of epimedium, 10-20 parts of cistanche, 10-20 parts of morinda officinalis, 5-15 parts of codonopsis pilosula, 5-15 parts of astragalus, 5-15 parts of yam and 5-15 parts of rehmannia root.

[0008] The additive is selected from the following raw materials in parts by weight: 10-20 parts of bupleurum, 10-20 parts of scutellaria, 10-20 parts of atractylodes, 10-20 parts of angelica, 10-20 parts of white peony, 10-20 parts of dandelion, 10-20 parts of houttuynia, 10-20 parts of loquat leaves, 5-15 parts of coltsfoot flowers, 5-15 parts of cassia twig, 5-15 parts of salvia miltiorrhiza, 5-15 parts of lithospermum, 5-15 parts of agrimony, 5-15 parts of eucommia, 5-15 parts of patrinia herb, 5-15 parts of ophiopogon, 5-15 parts of cornus, 10-20 parts of yam, and 10-20 parts of epimedium.

[0009] The preparation method of the broad-spectrum anti-cancer Chinese medicine composition comprises the following steps: taking each raw material medicine by weight, adding water 3 to 5 times the total volume of the raw material medicine, soaking for 25 to 35 minutes, heating, boiling and decocting on medium heat for 15 to 25 minutes, separating the solid and the liquid, and obtaining a first medicine soup and wet medicine residue; adding water 2 to 3 times the volume of the wet medicine residue to the wet medicine residue, heating, boiling and decocting on medium heat for 15 to 25 minutes, separating the solid and the liquid, and obtaining a second medicine soup, and mixing the first medicine soup and the second medicine soup.

[0010] Application of the broad-spectrum anti-cancer Chinese medicine composition in preparing medicine for treating cancer.

[0011] Preferably, the cancer includes liver cancer, lung cancer, stomach cancer, breast cancer, thyroid cancer, kidney cancer or colorectal cancer.

[0012] Preferably, the Chinese medicine composition is in the form of decoction, tablet or tea bag.

[0013] Preferably, when the cancer type is liver cancer or lung cancer, the additive prescription is composed of the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of scutellaria, 15 parts of cornus, 10 parts of lithospermum, 15 parts of salvia miltiorrhiza, 10 parts of angelica, and 10 parts of white peony root;

[0014] When the cancer type is gastric cancer, the supplementary prescription is composed of the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of scutellaria, 15 parts of atractylodes, 10 parts of angelica, 10 parts of white peony root, 15 parts of cornus, 15 parts of eucommia, or 15 parts of houttuynia, 15 parts of dandelion, 10 parts of bupleurum, 10 parts of salvia miltiorrhiza, 10 parts of lithospermum, 10 parts of angelica, and 10 parts of white peony root;

[0015] Preferably, when the cancer is breast cancer, the additive prescription consists of the following raw materials in parts by weight: 15 parts of dandelion, 15 parts of houttuynia cordata, 15 parts of loquat leaves, 10 parts of cassia twig, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum officinale.

[0016] Preferably, when the cancer is squamous cell carcinoma, the additive formula is composed of the following raw materials in parts by weight: 10 parts of Lithospermum officinale, 15 parts of Salvia miltiorrhiza, 15 parts of Agrimoniae, 15 parts of Patrinia scabra, 15 parts of Taraxacum officinale, 15 parts of Eucommia ulmoides, 15 parts of Cornus officinalis, 15 parts of Angelica sinensis, and 15 parts of Dioscorea opposita;

[0017] Preferably, when the cancer is thyroid cancer, the additive prescription consists of the following raw materials in parts by weight: 15 parts of Patrinia scabra, 15 parts of Agrimoniae, 15 parts of loquat leaves, 15 parts of Houttuynia cordata, 15 parts of Taraxacum officinale, 10 parts of Coltsfoot Flos, 10 parts of Ophiopogon japonicus, and 10 parts of Lithospermum officinale.

[0018] Preferably, when the cancer is renal cancer, the additive is composed of the following raw materials in parts by weight: 15 parts of epimedium, 15 parts of cornus officinalis, 15 parts of eucommia bark, 15 parts of agrimony, 15 parts of patrinia herba, and 15 parts of dandelion;

[0019] When the cancer is rectal cancer, the additive prescription is composed of the following raw materials in parts by weight: 10 parts of angelica sinensis, 10 parts of white peony root, 10 parts of atractylodes macrocephala, 10 parts of eucommia bark, 15 parts of patrinia herb, 15 parts of agrimony, 10 parts of cassia twig, and 10 parts of salvia miltiorrhiza;

[0020] Or it may be composed of 15 parts of bupleurum, 15 parts of cinnamon twig, 15 parts of scutellaria, 10 parts of angelica, 10 parts of white peony root, 10 parts of atractylodes, 15 parts of dandelion, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum.

[0021] In the present invention, Rhizoma Smilacis Glabrae, Rhizoma Cuscutae, Rhizoma Trichosanthis and Rhizoma Fritillariae Chuanxiong are main medicines for clearing away heat and detoxifying, softening and resolving lumps; Rhizoma Citrus Grandis, Rhizoma Citri Reticulatae and Rhizoma Coix are assistant medicines for resolving phlegm and dispersing lumps; Semen Ziziphi Spinosae, Herba Epimedii, Herba Cistanches and Herba Morindae Officinalis are adjuvant medicines for tonifying the kidney and nourishing the body; Radix Codonopsis Pilosulae, Herba Astragali, Rhizoma Dioscoreae and Rhizoma Rehmanniae are guiding medicines for tonifying qi and nourishing blood, strengthening the spleen and promoting qi; and then, on the basis of the basic prescription, additions and subtractions are made according to different cancer types, and Radix Bupleuri, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Herba Taraxaci, Herba Houttuyniae, Leaf of Eriobotrya japonicae, Flos Coltsfoot, Twig of Cinnamon, Radix Salviae Miltiorrhizae, Herba Lithospermi, Herba Agrimoniae, Herba Eucommiae, Herba Patriniae, Radix Ophiopogonis, Fructus Corni, Rhizoma Dioscoreae and Herba Epimedii are added.

[0022] The materials of the present invention are conventionally easy to obtain, have a rapid effect, a stable effect, no toxic side effects, are simple to apply and operate, reduce the workload of patients and their families in seeking medical treatment, and reduce the fear of patients. The Chinese medicine composition provided by the present invention is dominant in enhancing the nutritional status of various internal organs, accelerating the metabolic rate in the body, accelerating the cleaning of toxins in the body, restoring the ability to eat, drink, defecate, urinate and sleep in daily life, improving the survival ability of patients, and improving the quality of life of patients. It can be used for the maintenance and treatment of various cancers and various stages in the process of cancer treatment. In addition, the longer the time of taking this prescription, the more stable the improvement effect, and the effective rate is more than 70%. In addition, those who insist on taking the Chinese medicine composition of this application for more than 1 year have an effective survival rate of more than 3 years, and those who can insist on taking it for more than 2 years have an effective survival rate of more than 5 years. After two years, those who can use this prescription for regular maintenance for 3 months every year can stay away from cancer and effectively prevent the recurrence and metastasis of cancer. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is the discharge record of the patient in Example 1.

[0024] Figure 2 This is the blood routine test report of the patient in Example 1 in April 2015.

[0025] Figure 3 This is the blood routine test report of the patient in Example 1 in October 2015.

[0026] Figure 4 This is the routine blood test report of the patient in Example 1 in January 2023.

[0027] Figure 5 This is the routine blood test report of the patient in Example 2 in February 2020.

[0028] Figure 6 This is the routine blood test report of the patient in Example 2 in February 2021.

[0029] Figure 7 This is the routine blood test report of the patient in Example 3 in November 2019.

[0030] Figure 8 This is the routine blood test report of the patient in Example 3 in November 2020.

[0031] Fig. 9 This is the routine blood test report of the patient in Example 3 in January 2021.

[0032] Fig.10 This is the routine blood test report of the patient in Example 3 in August 2022.

[0033] Fig.11 This is the pathological diagnosis report of the patient in Example 4 in May 2022.

[0034] Fig.12This is the routine blood test report of the patient in Example 4 in March 2022.

[0035] Fig.13 This is the routine blood test report of the patient in Example 4 in November 2022.

[0036] Fig.14 This is the discharge record of the patient in Example 5 in March 2020.

[0037] Fig.15 This is the routine blood test report of the patient in Example 5 in April 2020.

[0038] Fig.16 This is the routine blood test report of the patient in Example 5 in November 2021.

[0039] Fig.17 This is the routine blood test report of the patient in Example 6 when the maintenance ends in 2022.

[0040] Fig.18 This is the routine blood test report of the patient in Example 6 in June 2024.

[0041] Fig.19 This is the radiological diagnosis report of the patient in Example 7 in April 2020.

[0042] Fig. 20 This is the routine blood test report of the patient in Example 7 in April 2020.

[0043] Fig.21 This is the routine blood test report of the patient in Example 7 in April 2021.

[0044] Fig. 22 This is the discharge record of the patient in Example 8 in March 2021.

[0045] Fig.23 This is the routine blood test report of the patient in Example 8 in March 2022.

[0046] Fig.24 This is the routine blood test report of the patient in Example 9 in March 2022.

[0047] Fig.25 This is the routine blood test report of the patient in Example 9 in August 2022.

[0048] Fig.26 This is the routine blood test report of the patient in Example 9 in December 2022. DETAILED DESCRIPTION

[0049] In the present invention, Rhizoma Smilacis Glabrae, Rhizoma Cuscutae, Rhizoma Trichosanthis and Rhizoma Fritillariae Chuanxiong are the main drugs for clearing away heat and detoxifying, softening and dissolving lumps, Rhizoma Citrus Grandis, Rhizoma Citri Reticulatae and Rhizoma Coix are the assistant drugs for dissolving phlegm and dispersing lumps, Semen Ziziphi Spinosae, Herba Epimedii, Herba Cistanches and Rhizoma Morindae Officinalis are the adjuvant drugs for tonifying kidney and nourishing body, and Radix Codonopsis Pilosulae, Radix Astragali, Rhizoma Dioscoreae and Radix Rehmanniae are the guiding drugs for tonifying Qi and nourishing blood, strengthening spleen and promoting Qi circulation. Together, they constitute the basic prescription, and on this basis, the prescription is further added or subtracted according to the symptoms.

[0050] The judgment criteria for maintenance of the present invention are:

[0051] 1. When the number or percentage of neutrophils and lymphocytes in the peripheral blood leukocytes is within the reference range and remains stable for 2 to 3 months, it can be judged that an inflection point has occurred.

[0052] 2. The number of peripheral blood white blood cells and red blood cells returns to the indicators before surgery or one year before surgery, or the number or percentage of neutrophils, lymphocytes, monocytes, eosinophils and basophils under the white blood cells is within the reference range and basically close to the middle value of the reference range. It can be basically evaluated as "various physical indicators are gradually stabilizing". Preferably, "various physical indicators are gradually stabilizing" for more than half a year before the maintenance is terminated.

[0053] 3. The above evaluations are based on data after stopping the use of Western medicine and can only be used as a reference (except for antihypertensive and hypoglycemic drugs).

[0054] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0055] Example 1

[0056] Name: Zhou, Gender: Male, Age when maintenance started: 53 years old;

[0057] Surgery time: twice in 2011 and 2013; Surgery location: Hangzhou, Shanghai;

[0058] Western medicine treatment plan: (Case analysis / left evidence information): Resection of ileocecal malignant tumor in 2011. Surgery for left lung metastasis in 2013. Suspected left liver metastasis in December 2014. Figure 1 This indicates that the patient has undergone multiple tumor surgeries and has a high risk of cancer metastasis.

[0059] The starting time and plan of taking this prescription: From April 2015 to January 2023, non-continuous comprehensive care, a total of 40 months. Comprehensive care refers to making the prescription into a decoction for drinking.

[0060] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0061] Then take 15 parts of Bupleurum, 15 parts of Scutellaria, 15 parts of Cornus, 10 parts of Lithospermum, 15 parts of Salvia miltiorrhiza, 10 parts of Angelica sinensis, and 10 parts of White Peony Root and add them to the basic formula.

[0062] Preparation method: Take the raw materials according to the above prescription, add water 4 times the total volume of the above raw materials, soak for 30 minutes, heat, boil and then boil on medium heat for 20 minutes, pour out the medicine soup as the first medicine soup, take the wet medicine residue, add water 3 times the volume of the wet medicine residue to the wet medicine residue, heat, boil and then boil on medium heat for 20 minutes, pour out the medicine soup as the second medicine soup, mix the first medicine soup and the second medicine soup, and then concentrate to 1000mL as the daily dosage, take it in four times, and the time interval between each dose is 3h.

[0063] Current work and life status: April 2015 (blood routine test results as Figure 2 Maintenance was started. In the first half year, the data were followed up once a week. After the Mid-Autumn Festival in 2015, the blood routine test on October 19, 2015 showed ( Figure 3 ) The number of neutrophils and lymphocytes was basically within the reference range, and the overall immunity showed an inflection point, so the data was followed up once a month. After the Spring Festival in 2016, the overall condition was basically stable, and by August, the health level was in a state where the autoimmunity could defeat the disease. During the comprehensive care period, Mr. Zhou continued to work as usual, adjusted his living habits to a reasonable state, and successfully completed the first stage of care.

[0064] 2020 to 2023 (if the blood routine test results are as follows in January 2023 Figure 4 As shown in the figure, compared with the number and percentage of neutrophils before January, there has been significant progress. The relationship between the percentage of neutrophils and lymphocytes has changed from the original inverted to the positive, and various physical indicators have gradually stabilized. During the three years, Mr. Zhou worked in Xuzhou, Jiangsu. In order to further improve his health level and better devote himself to work, he took comprehensive maintenance tea bags (crushed the raw materials in the prescription into 30mm, wrapped them in cloth into tea bags, and soaked in water for daily drinking) during the three years to further repair various systems. The symptoms of the new crown infection are very mild, and the recovery is relatively fast, and work is normal. From 2015 to now, it has been more than 9 years, and Mr. Zhou's quality of life has remained at the level of normal peers.

[0065] Example 2

[0066] Name: Luo Moumou, Gender: Male, Age: 73 years old;

[0067] Surgery time: December 2018, surgery location: Shanghai;

[0068] Western medicine treatment plan: (Case analysis / evidence information): Gastric cancer, antral MT surgery.

[0069] The starting time and plan of taking this prescription: From January 2019 to March 2022, non-continuous maintenance, a total of 29 months of comprehensive maintenance and 7 months of tablet maintenance were carried out during the above period.

[0070] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0071] Then add 15 parts of Houttuynia cordata, 15 parts of Taraxacum mongolicum, 10 parts of Bupleurum chinense, 10 parts of Salvia miltiorrhiza, 10 parts of Lithospermum officinale, 10 parts of Angelica sinensis, and 10 parts of White Peony Root.

[0072] The preparation method of the comprehensive maintenance prescription is the same as that of Example 1; the tablet maintenance medication is the same as the comprehensive maintenance prescription, and the tablet preparation method is the same as the conventional tablet candy process. After each raw material is crushed to 100 mesh, it is mixed and placed in a tablet press for tableting (the same below), and the tablet is 0.8g / tablet.

[0073] Comprehensive care involves taking Chinese herbal decoctions, which need to be boiled. For ease of taking, after the patient's physical condition stabilizes or recovers, the prescription can be made into tablets and taken 3 times a day, 9 tablets each time. The care effect of tablets is equivalent to 50-60% of the comprehensive care effect.

[0074] Treatment status: Routine blood test on February 20, 2020 (such as Figure 5 As shown): white blood cell count 4.5, neutrophil percentage 68.5%, lymphocyte percentage 21.5%, red blood cell count 4.15, the above data are basically within the reference range. It can be seen that after 12 months of intraoperative and postoperative care, the fundamentals are stable and have entered the healthy inflection point stage. The patient has gastric cancer and the lymphocyte count is still low. Due to his older age, he still needs to continue to maintain for a long time to achieve a stable state. Blood routine examination on February 5, 2021 ( Figure 6 ): White blood cell count 5.39, neutrophil percentage 63.2%, lymphocyte percentage 28.0%, red blood cell count 4.34, compared with before the operation, has been steadily improved and basically close to the middle value. In the absence of external infection, blood routine data tends to be ideal and health level improves.

[0075] Current work and life status: After completing 3 years of care in April 2022, all physical indicators are stable. Living conditions are no different from those of 78-year-olds. PCT rechecked in 2024 showed no abnormalities.

[0076] Example 3

[0077] Name: Jiang Moumou, Gender: Female, Age: 67 years old;

[0078] Surgery time: After neoadjuvant chemotherapy for right breast cancer in August 2019, surgery was performed on October 31, 2019. Surgery location: Shanghai;

[0079] Western medicine treatment plan: (Case analysis / evidence information): Invasive cancer of the right breast. Modified radical mastectomy for right breast cancer.

[0080] The starting time and plan for taking this prescription: Comprehensive care will be implemented from August 2019 to January 2021, and tablet care will be implemented from March 2021 to September 2022.

[0081] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0082] Then add 15 parts of dandelion, 15 parts of houttuynia, 15 parts of loquat leaf, 10 parts of cinnamon twig, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum. The preparation method of the comprehensive maintenance decoction is the same as that of Example 1, and the preparation method of the tablet is the same as that of Example 2.

[0083] Treatment status: On November 15, 2019, blood routine test after surgery showed ( Figure 7 ): White blood cell count 6.6, the number and percentage of neutrophils and lymphocytes are basically in the median of the reference range, red blood cell count 3.6, hemoglobin 108 is low, and platelets 285 are high. Because of the 3-month preoperative care, the white blood cell data is better than that of patients of the same age undergoing similar surgeries. On November 24, 2020, after 12 months of continuous care, the blood routine showed ( Figure 8 ): The percentage of neutrophils and lymphocytes is in the median of the reference range, entering the healthy inflection point stage. In addition, the red blood cell count is 4.03, hemoglobin is 124, and platelets are 209, which are also relatively ideal. The blood routine test on January 23, 2021 showed ( Fig. 9 ): Routine blood test indicators are basically in the median of the reference range, tending to be in a relatively ideal state (the ideal percentage of eosinophils is 2-2.5%), and the health level is stable.

[0084] Current work and life status: From August 2019 to January 2021, I implemented the comprehensive care of our prescription, which lasted before, during and after surgery. From March 2021 to September 2022 (before the end of care, that is, the blood routine test in August 2022 was as follows: Fig.10 ) Implement tablet maintenance. During the 3 years, the rhythm of life was stable, no different from that of ordinary people. No infection during the COVID-19 period. There was no abnormality in the comprehensive physical examination in 2024.

[0085] Embodiment 4:

[0086] Name: Wu, Gender: Male, Age: 53 years old;

[0087] Surgery time: May 25, 2022, surgery location: Shanghai;

[0088] Western medicine treatment plan: (Case analysis / evidence information): Cirrhosis: (esophageal ESD) squamous cell carcinoma, moderately differentiated (such as Fig.11 ).

[0089] The starting time and plan for taking this prescription: March 2022 to November 2022, a total of 9 months of comprehensive care.

[0090] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0091] Then add 10 parts of lithospermum officinale, 15 parts of salvia miltiorrhiza, 15 parts of agrimony, 15 parts of patrinia herba, 15 parts of dandelion, 15 parts of eucommia bark, 15 parts of cornus officinalis, 15 parts of angelica sinensis and 15 parts of yam. The preparation method is the same as that of Example 1.

[0092] Treatment status: Blood routine test results on March 19, 2022 showed ( Fig.12 ) White blood cell count 4.27, neutrophil percentage 52.0%, lymphocyte percentage 36.3%, red blood cell count 3.72, hemoglobin 103, white blood cell count is acceptable, red blood cell is below the lower limit of the reference range. On November 7, 2022, the blood routine showed ( Fig.13 ) The white blood cell count was 4.9, and compared with before the operation, the physical indicators were significantly improved, the percentage of neutrophils and lymphocytes tended to the middle value of the reference range, the red blood cell count was 4.61, the hemoglobin was 143, and the red blood cells achieved the ideal value. The preparation method is the same as in Example 1.

[0093] Embodiment 5:

[0094] Name: Yu Moumou, Gender: Female, Age: 55 years old;

[0095] Surgery time: March 20, 2020, surgery location: Zhejiang;

[0096] Western medicine treatment plan: (Case analysis / left evidence information): Thyroid cancer, "laparoscopic-assisted right thyroid cancer radical resection + left thyroid partial resection + fascia tissue flap plasty" ( Fig.14 ).

[0097] The starting time and plan of taking this prescription: From April 2020 to November 2022, non-continuous maintenance, a total of 22 months of comprehensive maintenance and 5 months of tablet maintenance.

[0098] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0099] Then add 15 parts of Patrinia scabra, 15 parts of Agrimoniae, 15 parts of Eriobotrya japonica, 15 parts of Houttuynia cordata, 15 parts of Taraxacum officinale, 10 parts of Coltsfoot Flos, 10 parts of Ophiopogon japonicus, and 10 parts of Lithospermum officinale. The preparation method is the same as that of Example 1.

[0100] Maintenance status: This regimen was used for maintenance in April 2020. The blood routine test on April 7 showed (such as Fig.15 As shown): White blood cell count 3.40, lower than the lower limit, red blood cell count 4.62, hemoglobin 141, the count is slightly high, the individual's white blood cell count has been low for many years, the red blood cell and hemoglobin are high, and the blood routine has obvious personalized characteristics. A week after being discharged from the hospital on April 17, the blood routine was rechecked, the white blood cell count was 11.9, and it was obvious that the response to chemotherapy was strong. Chemotherapy was not completed until July. During this period, this plan was defined as intraoperative maintenance. The blood routine on July 23, 2020 showed: white blood cell count 4.04, red blood cell count 3.84, hemoglobin 110. Compared with the data before the operation, combined with personal characteristics, after using this plan, the damage caused by chemotherapy is controllable, the white blood cell count is stable, the red blood cell count decreases rapidly, and the patient's physical condition is relatively responsible. The blood routine on November 26, 2021 showed ( Fig.16 ): White blood cell count 4.2, neutrophil and lymphocyte percentages tend to the median of the reference range, and the health inflection point is achieved. Subsequent maintenance will continue until November 2022, and all physical indicators will be basically stable. There will be no abnormalities in the physical examination in 2024.

[0101] Embodiment 6:

[0102] Name: Lou Moumou, Gender: Male, Age: 30 years old;

[0103] Surgery time: February 2021, surgery location: Shanghai;

[0104] Western medicine treatment plan: (Case analysis / evidence information): Malignant tumor of the right kidney.

[0105] The starting time and plan of taking this prescription: From February 2021 to November 2022, non-continuous maintenance, a total of 11 months of comprehensive maintenance.

[0106] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0107] Then add 15 parts of Epimedium, 15 parts of Cornus officinalis, 15 parts of Eucommia ulmoides, 15 parts of Agrimoniae, 15 parts of Patrinia scabra and 15 parts of Taraxacum officinale. The preparation method is the same as that of Example 1.

[0108] Maintenance: The goal of maintenance for young people with kidney cancer is to restore kidney functions and prevent intestinal metastasis. After 11 months of maintenance ( Fig.17 This is the blood routine test report when the maintenance ends in 2022). All blood routine test indicators are stable and close to the middle value of the reference range.

[0109] Current work and life status: Postoperative care in 2021, simultaneous preparation for pregnancy care, and a little princess was born in February 2023. Work is ongoing. Continued care for 8 months in 2021, and 3 months in the winter of 2022. While stabilizing the kidney condition, focus on preventing intestinal damage. No abnormalities in the 2024 reexamination (blood routine test results are as follows Fig.18 ).

[0110] Embodiment 7:

[0111] Name: Dai, Gender: Female, Age: 54;

[0112] Surgery time: October 2019, surgery location: Shanghai;

[0113] Western medicine treatment plan: (Case analysis / evidence information): Gastric malignant tumor, gastric MT surgery ( Fig.19 ).

[0114] The starting time and plan for taking this prescription: April 2020 to April 2021, a total of 12 months of comprehensive care.

[0115] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0116] Then add 15 parts of bupleurum, 15 parts of scutellaria, 15 parts of atractylodes, 10 parts of angelica, 10 parts of white peony root, 15 parts of cornus officinalis, and 15 parts of eucommia. The preparation method is the same as that of Example 1.

[0117] Maintenance status: As of April 2020, I have been in poor spirits for half a year after the operation, with great mental and physical stress. At the same time, I am in the menopausal age group. Look at the blood routine test on April 7 ( Fig. 20 ), white blood cell count 3.8, neutrophil count and percentage are both below the lower limit. After one month of care, both white blood cell count and neutrophil count were improved. In April 2021, the patient ended the one-year care on his own, but all physical indicators were relatively stable ( Fig.21 ), no physical abnormalities. So far, he is in good condition.

[0118] Embodiment 8:

[0119] Name: Zhang, Gender: Female, Age: 47;

[0120] Surgery time: March 8, 2021, surgery location: Hunan;

[0121] Western medicine treatment plan: (Case analysis / evidence information): Rectal cancer ( Fig. 22 ).

[0122] Starting time and plan for taking this prescription: Started in October 2021, currently under continuous maintenance.

[0123] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0124] Then add 10 parts of Chinese Angelica, 10 parts of white peony root, 10 parts of Atractylodes macrocephala, 10 parts of Eucommia bark, 15 parts of Patrinia scabra, 15 parts of Agrimoniae, 10 parts of Cinnamomum cassia, and 10 parts of Salvia miltiorrhiza. The preparation method is the same as that of Example 1.

[0125] Maintenance status: On November 3, 2021, the white blood cell count was 5.79, the lymphocyte percentage was 40.4%, the reference range exceeded the upper limit, and the red blood cell count was 3.94. The overall situation was not bad. The maintenance goal is to achieve overall recovery after surgery, prevent metastasis, and return to normal work and life in society. On March 8, 2022, the blood routine showed ( Fig.23 ), white blood cell count 6.76, neutrophil and lymphocyte count and percentage are within the reference range, red blood cell count 4.07, and the health inflection point is basically achieved. After entering social work, the work intensity and virus damage will be affected, but the data will not fluctuate much, and it can be controlled and adjusted at any time. The degree of recovery is relatively satisfactory, and it can be re-entered into social work without interruption. In December 2022, the symptoms of the new crown were not serious and the recovery was relatively fast. There were no abnormalities in the comprehensive physical examination in October 2023.

[0126] Embodiment 9:

[0127] Name: Zhou Moumou, Gender: Female, Age: 37 years old;

[0128] Surgery time: March 4, 2022, surgery location: Zhejiang;

[0129] Western medicine treatment plan: (Case analysis / evidence information): "Rectal" adenocarcinoma, perform rectal resection.

[0130] The starting time and plan for taking this prescription: March 2022 to December 2022, a total of 9 months of comprehensive care.

[0131] Prescription: by weight, take 20 parts of Smilax glabra, 20 parts of Solanum cumini, 20 parts of Trichosanthes, 10 parts of Fritillaria cirrhosa, 20 parts of Citrus grandis, 20 parts of Citrus grandis, 20 parts of Coix seeds, 15 parts of Ziziphus jujuba seeds, 15 parts of Epimedium, 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 10 parts of Codonopsis pilosula, 10 parts of Astragalus, 10 parts of Dioscorea opposita, and 10 parts of Rehmannia root as the basic prescription;

[0132] Then add 15 parts of bupleurum, 15 parts of cinnamon twig, 15 parts of scutellaria, 10 parts of angelica, 10 parts of white peony root, 10 parts of atractylodes, 15 parts of dandelion, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum. The preparation method is the same as that of Example 1.

[0133] Maintenance status: March 2022 (if Fig.24 ) White blood cell count 4.3, slightly low, blood routine test on August 13, 2022 (such as Fig.25 ), the white blood cell count recovered and approached the middle value of the reference range in December 2022 ( Fig.26), and the subsequent results were relatively stable. In addition, after rectal resection and chemotherapy, multiple indicators of biochemical test results exceeded the reference range when maintenance began, indicating that the function of the internal organs was damaged. They were gradually repaired and stabilized during the maintenance process, indicating that the function of the internal organs was restored. In December 2022, the symptoms of the new crown were not serious, and the recovery was relatively fast. The spirit gradually recovered, and he returned to social work after the Spring Festival in 2023.

[0134] In summary, the Chinese medicine composition provided by the present invention can be used for the maintenance and treatment of various cancers and various stages of their treatment, and no recurrence occurs in patients after treatment, which can effectively prevent cancer recurrence.

[0135] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A broad-spectrum anticancer Chinese medicine composition, characterized in that: The Chinese medicine composition consists of a basic formula and an additional formula. The basic formula consists of the following raw materials in parts by weight: 15-25 parts of Smilax glabra, 15-25 parts of Solanum tuberosum, 15-25 parts of Trichosanthes, 5-15 parts of Fritillaria cirrhosa, 15-25 parts of Citrus aurantium, 15-25 parts of Foetida citrifolia, 15-25 parts of Citrus reticulatae, 15-25 parts of Coix seeds, 10-20 parts of Ziziphus jujuba seeds, 10-20 parts of Epimedium, 10-20 parts of Cistanche deserticola, 10-20 parts of Morinda officinalis, 5-15 parts of Codonopsis pilosula, 5-15 parts of Astragalus, 5-15 parts of Dioscorea opposita and 5-15 parts of Rehmannia root.

2. The broad-spectrum anticancer Chinese medicine composition according to claim 1, characterized in that: The additive is selected from the following raw materials in parts by weight: 10-20 parts of bupleurum, 10-20 parts of scutellaria, 10-20 parts of atractylodes, 10-20 parts of angelica, 10-20 parts of white peony, 10-20 parts of dandelion, 10-20 parts of houttuynia, 10-20 parts of loquat leaves, 5-15 parts of coltsfoot flowers, 5-15 parts of cassia twig, 5-15 parts of salvia miltiorrhiza, 5-15 parts of lithospermum, 5-15 parts of agrimony, 5-15 parts of eucommia, 5-15 parts of patrinia herb, 5-15 parts of ophiopogon, 5-15 parts of cornus, 10-20 parts of yam, and 10-20 parts of epimedium.

3. A method for preparing the broad-spectrum anticancer Chinese medicine composition as claimed in claim 1 or 2, comprising the following steps: Take each raw material medicine according to weight, add water 3 to 5 times the total volume of the raw material medicine, soak for 25 to 35 minutes, heat, boil and then cook on medium heat for 15 to 25 minutes, separate the solid and liquid, and obtain the first medicinal soup and wet medicinal residue; add water 2 to 3 times the volume of the wet medicinal residue to the wet medicinal residue, heat, boil and then cook on medium heat for 15 to 25 minutes, separate the solid and liquid, and obtain the second medicinal soup, and mix the first medicinal soup and the second medicinal soup.

4. Use of the broad-spectrum anti-cancer Chinese medicine composition according to claim 1 or 2 or the broad-spectrum anti-cancer Chinese medicine composition prepared by claim 3 in the preparation of drugs for treating cancer.

5. The use according to claim 4, characterized in that: The cancer includes liver cancer, lung cancer, stomach cancer, breast cancer, thyroid cancer, kidney cancer or colorectal cancer.

6. The use according to claim 5, characterized in that The Chinese medicine composition is in the form of decoction, tablet or tea bag.

7. The use according to claim 5, characterized in that When the cancer type is liver cancer or lung cancer, the additive prescription is composed of the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of scutellaria, 15 parts of cornus, 10 parts of lithospermum, 15 parts of salvia miltiorrhiza, 10 parts of angelica, and 10 parts of white peony root; When the type of cancer is gastric cancer, the additional prescription is composed of the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of scutellaria, 15 parts of atractylodes, 10 parts of angelica, 10 parts of white peony, 15 parts of cornus, and 15 parts of eucommia, or 15 parts of houttuynia, 15 parts of dandelion, 10 parts of bupleurum, 10 parts of salvia miltiorrhiza, 10 parts of lithospermum, 10 parts of angelica, and 10 parts of white peony.

8. The use according to claim 5, characterized in that When the cancer is breast cancer, the additional prescription is composed of the following raw materials in parts by weight: 15 parts of dandelion, 15 parts of houttuynia cordata, 15 parts of loquat leaves, 10 parts of cassia twig, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum officinale.

9. The use according to claim 5, characterized in that: When the cancer is squamous cell carcinoma, the added prescription is composed of the following raw materials in parts by weight: 10 parts of lithospermum officinale, 15 parts of salvia miltiorrhiza, 15 parts of agrimony, 15 parts of patrinia scabra, 15 parts of dandelion, 15 parts of eucommia bark, 15 parts of cornus officinalis, 15 parts of angelica sinensis, and 15 parts of yam; When the cancer is thyroid cancer, the additional prescription is composed of the following raw materials in parts by weight: 15 parts of Patrinia scabra, 15 parts of Agrimoniae, 15 parts of loquat leaves, 15 parts of Houttuynia cordata, 15 parts of Taraxacum officinale, 10 parts of Coltsfoot Flos, 10 parts of Ophiopogon japonicus, and 10 parts of Lithospermum officinale.

10. The use according to claim 5, characterized in that: When the cancer is kidney cancer, the additive formula is composed of the following raw materials in parts by weight: 15 parts of epimedium, 15 parts of cornus officinalis, 15 parts of eucommia bark, 15 parts of agrimony, 15 parts of patrinia herba, and 15 parts of dandelion; When the cancer is rectal cancer, the additive prescription is composed of the following raw materials in parts by weight: 10 parts of angelica sinensis, 10 parts of white peony root, 10 parts of atractylodes macrocephala, 10 parts of eucommia bark, 15 parts of patrinia herb, 15 parts of agrimony, 10 parts of cassia twig, and 10 parts of salvia miltiorrhiza; Or it may be composed of 15 parts of bupleurum, 15 parts of cinnamon twig, 15 parts of scutellaria, 10 parts of angelica, 10 parts of white peony root, 10 parts of atractylodes, 15 parts of dandelion, 10 parts of salvia miltiorrhiza, and 10 parts of lithospermum.

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