Pediatric breathing plaster traditional Chinese medicine composition and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a pediatric breathing plaster traditional Chinese medicine composition and a preparation method thereof, and the technical scheme is characterized in that the traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 80-120g of radix peucedani, 80-120g of pericarpium citri reticulatae viride, 80-120g of roasted aster, 40-60g of mint and 25-35g of asarum. According to the breathing plaster, the medicine with the spicy moving property is applied to the corresponding acupuncture point, and the overall function of the internal organs of the human body is adjusted through the stimulation effect of the medicine, the skin permeation effect and the channel tropism property of the acupuncture point, so that the treatment purpose is achieved. The traditional Chinese medicine composition has a good treatment effect on cough and asthma and asthma in the remission period and is suitable for children of all ages.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and more particularly to a pediatric respiratory plaster traditional Chinese medicine composition and a preparation method thereof. Background Art

[0002] Cough and asthma are the main symptoms of lung diseases. The causes of cough and asthma can be divided into external infection and internal injury, and the pathogenesis can be divided into cold, heat, deficiency and excess. Cough and asthma are closely related to sputum. Cough and asthma are often accompanied by sputum, and sputum often leads to cough and asthma. The ancients believed that cough with sound but no sputum, cough with no sound and sputum, and cough with sound and sputum. The occurrence of this disease is mainly due to the adverse upward movement of lung qi. The lung is the canopy, which controls breathing and opens to the nose, and is connected to the skin and fur. The cause of cough is nothing more than external infection and internal injury. External evil wind, cold, heat and dampness attack the skin and fur, invade the lungs, hinder the normal function of the lungs, and cause cough. The evil of the five internal organs (seven emotions, hunger and satiety) goes up to the lungs, which can also cause illness. Therefore, the cough theory of "Suwen" says: "All the five internal organs make people cough, not just the lungs." Asthma and panting are often mentioned together. The ancients believed that asthma is caused by phlegm blocking the qi, breathing is audible, the throat is like a saw, and even panting and unable to lie down. Panting is also divided into qi, phlegm, fire, water and other deficiency and excess. Panting syndrome is often accompanied by phlegm, so the ancients believed that asthma is caused by phlegm and fluid. But phlegm and fluid are the result of pathological changes and not the root cause of the disease.

[0003] Children's organs, tissues and physiological functions are in the process of continuous development. Their nervous system, endocrine system and many organs are not fully developed. The detoxification and excretion functions of the liver and kidneys and the blood-brain barrier are not sound, making them more vulnerable to drug damage. Oral administration has the disadvantages of few drug options, poor drug compliance, and strong drug toxicity and side effects. External patches are a good treatment method.

[0004] External patches are controlled-release preparations that are administered through the skin to achieve local or systemic therapeutic effects. Their advantages include avoiding the first-pass effect of the liver and the degradation of drugs in the gastrointestinal tract, reducing irritation to the gastrointestinal tract; maintaining steady-state blood drug concentrations, avoiding the peaks and valleys of blood drug concentrations caused by oral administration, and reducing toxic side effects; and exerting long-term effects, extending the dosing interval, reducing the number of dosing times, and making it convenient for patients to use.

[0005] Therefore, the present invention provides a pediatric respiratory plaster Chinese medicine composition and a preparation method thereof. Summary of the invention

[0006] The purpose of the present invention is to provide a pediatric respiratory plaster Chinese medicine composition.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is:

[0008] A Chinese medicine composition for pediatric respiratory plaster, which is composed of the following raw medicinal materials in parts by weight: 80-120g of Peucedanum chinense, 80-120g of Citrus aurantium, 80-120g of Radix Astragali, 40-60g of Menthus officinalis, and 25-35g of Asarum.

[0009] Preferably, the Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 90-110g of Peucedanum chinense, 90-110g of Citrus aurantium, 90-110g of Radix Asteris, 45-55g of Menthus fragrans, and 28-32g of Asarum.

[0010] Preferably, the Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 100g of Peucedanum chinense, 100g of Citrus aurantium, 100g of Radix Asteris, 50g of Menthus fragrans, and 30g of Asarum.

[0011] Another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition.

[0012] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0013] S1: Grind the prescribed amount of Peucedanum chinense, Citrus aurantium, Mentha arvense and Asarum sieboldii into powder to obtain medicinal powder;

[0014] S2: adding the medicinal powder to a suitable matrix, stirring evenly to a paste, and obtaining a paste of a traditional Chinese medicine composition;

[0015] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0016] Preferably, in step S1, the medicinal powder is an extremely fine powder.

[0017] Ultrafine powder refers to powder that can completely pass through the No. 8 sieve and contains no less than 95% of powder that can pass through the No. 9 sieve; the mesh number of the No. 8 sieve is 150 mesh, and the mesh number of the No. 9 sieve is 200 mesh.

[0018] Preferably, in step S2, the matrix is ​​any one or more of rubber, thermoplastic rubber, rosin, rosin derivatives, vaseline, lanolin and zinc oxide.

[0019] Preferably, the matrix is ​​vaseline.

[0020] Preferably, the mass ratio of the drug powder to the matrix is ​​1:1.

[0021] Another object of the present invention is to provide the use of the above-mentioned pediatric respiratory patch Chinese medicine composition in the preparation of medicines for treating chronic cough, sputum, rhinitis or chronic bronchitis.

[0022] It should be noted that the pharmacological effects of some of the raw materials in the formula of the present invention are as follows:

[0023] Peucedanum chinense: It is the dried root of Peucedanum chinense of the Apiaceae family. Nature and flavor and meridians: bitter, pungent, slightly cold. It enters the lung meridian. Functions and indications: It lowers qi and resolves phlegm, dispels wind and clears heat. It is used for wheezing due to phlegm-heat, yellow and thick sputum, and cough with wind-heat and excessive sputum.

[0024] Green peel: It is the dried young or immature fruit peel of Citrus reticulata Blanco and its cultivars. Nature and flavor and meridians: bitter, pungent, warm. It enters the liver, gallbladder, and stomach meridians. Functions and indications: It can relieve cold, dispel wind and relieve pain, clear the nasal passages, dry dampness and stop leukorrhea, reduce swelling and discharge pus. It can soothe the liver and resolve qi, eliminate stagnation and resolve stagnation. It is used for chest and flank distension and pain, hernia pain, breast lumps, breast abscesses, food accumulation and qi stagnation, and abdominal distension and pain.

[0025] Aster: The root and rhizome of Astertataricus Lf. Roasted Aster is a Chinese herbal medicine obtained by processing the root of Aster. Nature and flavor: warm in nature, pungent and bitter in taste. It enters the lung meridian. Functions and indications: warms the lungs, lowers qi, eliminates phlegm, and relieves cough. It treats cough and asthma due to wind and cold, cough and spitting of pus and blood due to asthenia, throat numbness, and urination difficulties.

[0026] Mint: The dried aerial part of Menthahaplocalyx Briq., a plant of the Lamiaceae family. Nature and flavor and meridians: pungent, cool. Enter the lung and liver meridians. Functions and indications: dissipate wind-heat, clear the head and eyes, relieve sore throat, clear rashes, soothe the liver and promote qi. Used for wind-heat cold, initial onset of wind-heat, headache, red eyes, throat paralysis, mouth sores, rubella, measles, chest and flank distension.

[0027] Asarum: The dried root and rhizome of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag., Asarum sieboldii Miq. var. seoulense Nakai or Asarum sieboldii Miq. of the Aristolochiaceae family. Nature and flavor and meridians: pungent, warm. It enters the heart, lung and kidney meridians. Functions and indications: dispel cold, dispel wind and relieve pain, open the orifices, warm the lungs and transform fluid. It is used for colds caused by wind and cold, headaches, toothaches, nasal congestion and runny nose, allergic rhinitis, sinusitis, rheumatic pain, phlegm and cough.

[0028] It should also be noted that the breathing patch prepared by the present invention has the effect of dispersing exogenous pathogens and promoting and descending lung qi, and its use method is: apply the breathing patch to the patient's Dazhui, Feishu, Tiantu and other acupoints, once a day, 2-4 hours each time, and a course of treatment for 5 days. Among them, Zhongdazhui is mainly used to treat exogenous diseases; bilateral Feishu is the place where the essence of the lung is infused, and it is the acupoint where the qi and blood of the lung meridians are infused on the back, which can regulate the function of the lungs and relieve cough and asthma; Tiantu is mainly used to treat phlegm congestion, shortness of breath, cough and asthma, and uncomfortable coughing; Tanzhong is mainly used to treat chest tightness, shortness of breath, phlegm and asthma cough.

[0029] The present invention has the following beneficial effects:

[0030] 1. In the Chinese medicine composition of the present invention, Peucedanum chinense promotes lung function and regulates qi, Citrus aurantium promotes qi and resolves phlegm, Rhizoma Asteris moistens the lung and relieves cough, Mentha dispels wind and expels evil, and Asarum unblocks the orifices and opens and closes. All the medicines are used together to play the role of dispersing exogenous evil and promoting and descending lung qi.

[0031] 2. The breathing plaster of the present invention applies the drug with pungent and fragrant properties to the corresponding acupuncture points, and adjusts the overall function of the human organs to achieve the purpose of treatment through the stimulation of the drug itself, the skin penetration effect, and the meridian properties of the acupuncture points. It has a good therapeutic effect on cough and asthma remission period, and is suitable for children of all ages. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0033] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0034] Embodiment 1:

[0035] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0036] S1: Grind 100g of Peucedanum chinense, 100g of Citrus aurantium, 100g of Radix Asteris, 50g of Mentha, and 30g of Asarum into very fine powder to obtain medicinal powder;

[0037] S2: adding the drug powder to an equal amount of vaseline, stirring evenly to a paste state, to obtain a paste of the Chinese medicine composition;

[0038] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0039] Embodiment 2:

[0040] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0041] S1: Grind 80g of Peucedanum chinense, 80g of Citrus aurantium, 80g of Radix Asteris, 40g of Mentha arvense, and 35g of Asarum into very fine powder to obtain medicinal powder;

[0042] S2: adding the medicinal powder to an equal amount of lanolin, stirring evenly to a paste, and obtaining a paste of the Chinese medicine composition;

[0043] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0044] Embodiment three:

[0045] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0046] S1: Grind 120g of Peucedanum chinense, 120g of Citrus aurantium, 120g of Radix Astragali, 60g of Mentha arvense, and 25g of Asarum into very fine powder to obtain medicinal powder;

[0047] S2: adding the medicinal powder to an equal amount of rosin, stirring evenly to a paste, and obtaining a paste of the Chinese medicine composition;

[0048] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0049] Embodiment 4:

[0050] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0051] S1: Grind 90g of Peucedanum chinense, 90g of Citrus aurantium, 90g of Radix Asteris, 45g of Mentha, and 28g of Asarum into very fine powder to obtain medicinal powder;

[0052] S2: adding the drug powder to an equal amount of rubber, stirring evenly to a paste, and obtaining a paste of the Chinese medicine composition;

[0053] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0054] Embodiment five:

[0055] A method for preparing a pediatric respiratory patch Chinese medicine composition comprises the following steps:

[0056] S1: Grind 110 g of Peucedanum chinense, 110 g of Citrus aurantium, 110 g of Radix Astragali, 55 g of Mentha arvense, and 32 g of Asarum into very fine powder to obtain medicinal powder;

[0057] S2: adding the drug powder to an equal amount of vaseline, stirring evenly to a paste state, to obtain a paste of the Chinese medicine composition;

[0058] S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

[0059] Clinical trial cases:

[0060] To prove that the respiratory plaster prepared by the Chinese medicine composition of the present invention has the positive effects of dispelling exogenous pathogens and promoting the descending of lung qi, the inventors conducted a large number of clinical trials on the respiratory plaster prepared in Example 1, and now select some clinical trials to report as follows.

[0061] Case 1: Shao Yuhan, female, 4 years and 1 month old, had an allergic constitution, and was prone to coughing and expectoration. The symptoms worsened in spring and autumn. When the symptoms occurred, acupoints were selected: Tiantu, Dazhui, and Feishu. After 1 course of application, the symptoms were alleviated. In combination with the breathing patch, the Sanfu (Nine) patch was applied. After 1 year, there was no recurrence in spring and autumn.

[0062] Case 2: Yang Zinuo, male, 6 years and 9 months old. The child developed phlegm in the throat due to respiratory tract infection more than a month ago. He took oral medication intermittently, but the effect was not good. Later, he used respiratory patch to apply on Tiantu acupoint. After 2 courses of treatment, the symptom of phlegm in the throat disappeared.

[0063] Case 3: Hang Wenxi, female, 5 years old, had a history of chronic rhinitis. She had nasal congestion, runny nose, and forehead headache in the past week. She used breathing plaster applied to the Dazhui and Feishu points, and the symptoms disappeared after one course of treatment.

[0064] Case 4: Li Zihan, 8 years and 3 months old, had intermittent cough for more than 2 months. The symptoms worsened after activities and cold. Chest X-ray and lung function were normal. Intermittent oral medication had poor effect. After 2 courses of treatment with breathing plaster applied to Tiantu, Feishu and Dingchuan points, the cough symptoms were relieved.

[0065] Case 5: Wang Chanyu, female, 5 years and 1 month old, had intermittent cough and wheezing for more than 2 years. She was diagnosed with bronchial asthma in a higher-level hospital and treated with standardized nebulized inhalation of fluticasone propionate. During this period, she still had asthma attacks. After 4 courses of treatment with breathing plaster on Tiantu, Tanzhong, Feishu and Dingchuan points, combined with Sanfu / Jiu plaster, the number of attacks was significantly reduced.

[0066] Case 6: Liu Renjie, male, 3 years and 11 months old, had intermittent cough and sputum due to chronic bronchitis for more than a month. Intermittent oral medication treatment was ineffective. The child still had intermittent cough and difficulty in expectoration, and the symptoms were obvious in the morning. After applying breathing plaster on the Dazhui, Feishu and Tiantu points for 2 courses of treatment, the cough symptoms were relieved compared with before.

[0067] Case 7: Lan Yuze, male, 6 years and 3 months old, had paroxysmal cough and sputum for more than a week. A chest X-ray showed bronchopneumonia. After anti-infection treatment, he still had intermittent cough and sputum symptoms. After two courses of treatment with breathing plaster on Tiantu, Feishu, Dingchuan and Tanzhong points, the symptoms were relieved.

[0068] Case 8: Lan Mingzhe, male, 3 years and 6 months old, had intermittent cough for 1 year. The symptoms worsened after exposure to cold air and irritating odors. Intermittent oral medication had poor efficacy. He was given 4 courses of respiratory plaster and his cough was relieved compared to before.

[0069] Case 9: Zhao Boyue, a 5-year-old and 3-month-old boy, had intermittent cough and sputum production for more than half a month. Oral medication was ineffective, and the sputum was too much and difficult to cough. After two courses of treatment with breathing patches, the symptoms were relieved.

[0070] Case 10: Yang Yitong, male, 1 year and 8 months old, had intermittent nasal congestion, runny nose and snoring for more than a year. He was diagnosed with adenoids hypertrophy at the ENT clinic. After oral medication, the snoring symptoms were relieved, but he still had intermittent nasal congestion and runny nose. He was given breathing plaster applied to the Dazhui, Feishu and Tanzhong points for 2 courses of treatment, combined with Sanfu / Jiutie, and the symptoms were relieved.

[0071] In summary, the breathing plaster prepared by the present invention has the effects of dispersing exogenous pathogens and promoting the descending of lung qi, and is mainly used to treat pediatric diseases such as chronic cough, sputum, rhinitis, chronic bronchitis, etc.

[0072] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A pediatric respiratory patch Chinese medicine composition, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 80-120g of Peucedanum chinense, 80-120g of Citrus aurantium, 80-120g of Radix Astragali, 40-60g of Mentha, and 25-35g of Asarum.

2. A pediatric respiratory patch Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 90-110g of Peucedanum chinense, 90-110g of Citrus aurantium, 90-110g of Radix Astragali, 45-55g of Menthus officinalis, and 28-32g of Asarum.

3. A pediatric respiratory patch Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 100g of Peucedanum chinense, 100g of Citrus aurantium, 100g of Radix Astragali, 50g of Mentha, and 30g of Asarum.

4. A method for preparing the Chinese medicine composition of the pediatric respiratory patch according to any one of claims 1 to 3, characterized in that: The steps include: S1: Grind the prescribed amount of Peucedanum chinense, Citrus aurantium, Mentha arvense and Asarum sieboldii into powder to obtain medicinal powder; S2: adding the medicinal powder to a suitable matrix, stirring evenly to a paste, and obtaining a paste of a traditional Chinese medicine composition; S3: The paste of the Chinese medicine composition is made into a medicine cake with a diameter of 2 cm and a thickness of 0.5 cm, and placed in a blank non-woven plaster to obtain a respiratory plaster.

5. The method for preparing the pediatric respiratory patch Chinese medicine composition according to claim 4, characterized in that: In step S1, the medicinal powder is an extremely fine powder.

6. The method for preparing the pediatric respiratory patch Chinese medicine composition according to claim 4, characterized in that: In step S2, the matrix is ​​any one or more of rubber, thermoplastic rubber, rosin, rosin derivatives, vaseline, lanolin and zinc oxide.

7. The method for preparing the pediatric respiratory patch Chinese medicine composition according to claim 4, characterized in that: The matrix is ​​vaseline.

8. The method for preparing the pediatric respiratory patch Chinese medicine composition according to claim 4, 6 or 7, characterized in that: The mass ratio of the drug powder to the matrix is ​​1:

1.

9. Use of the Chinese medicine composition of the pediatric respiratory patch according to any one of claims 1 to 3 in the preparation of medicines for treating chronic cough, sputum, rhinitis or chronic bronchitis.