Medicine raw material detection equipment for improving purity of raw materials

Abstract

The invention relates to the technical field of medicine detection, and discloses medicine raw material detection equipment for improving the purity of raw materials, the medicine raw material detection equipment comprises a base and a supporting box, the bottom of the supporting box is fixedly connected to the outer side of the base, the top of the base is fixedly connected with a detection mechanism, and the top of the detection mechanism is fixedly connected with a detection plate; the top end of the supporting box is fixedly connected with a driving box, multiple filtering and impurity removing can be conducted on medicine raw materials through the impurity removing assembly, impurities in the raw materials can be screened out while the caked raw materials are screened out, the purity of the medicine raw materials is improved, the content of invalid or harmful ingredients in medicine can be reduced by removing the impurities, and therefore the medicine raw materials can be conveniently taken out. The purity and quality of the medicine are improved, the raw materials with higher purity can be used for preparing the medicine which is more efficient, safer and more stable, the treatment effect and the satisfaction degree of a patient are improved, and the content of active ingredients of the medicine can be improved by removing impurities, so that the curative effect of the medicine is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of drug detection, and in particular to a drug raw material detection device for improving the purity of the raw material. Background Art

[0002] APIs refer to the raw materials used to produce various preparations. They are the active ingredients in the preparations. They are various powders, crystals, extracts, etc. prepared by chemical synthesis, plant extraction or biotechnology for medicinal use, but are substances that patients cannot take directly. In the process of drug production, the purity of the raw materials is crucial to the quality and safety of the final product. Therefore, it is necessary to use a detector to test the purity of the APIs before producing the drugs.

[0003] However, before the detection equipment detects the raw materials, the raw materials themselves contain impurities. Even if the purity of the raw materials is very high, there are still trace amounts of impurities that are transferred and accumulated in the subsequent synthesis steps. In addition, various chemical reagents, catalysts, and solvents are used in the synthesis process of the raw materials. These reagents and solvents will remain in the reaction or react with the target compound, thereby introducing impurities. The impurities contained in the raw materials of the drugs have adverse effects on human health. Some impurities may also be toxic, irritating, or allergic, leading to drug side effects and adverse reactions in people. Some impurities have similar structures and activities to the target drugs, thereby interfering with the drug's mechanism of action and reducing the therapeutic effect. Impurities in the raw materials of the drugs may also reduce the purity of the drugs. Therefore, when the detection equipment detects the raw materials of the drugs, the impurities in the raw materials of the drugs are likely to reduce the accuracy of the purity detection of the raw materials of the drugs. Therefore, it is necessary to provide a drug raw material detection device that improves the purity of the raw materials, aiming to solve the above problems. Summary of the invention

[0004] The main purpose of the present invention is to provide a drug raw material detection device for improving the purity of raw materials, which can effectively solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a drug raw material detection device for improving the purity of raw materials, comprising a base and a support box, the bottom of the support box is fixedly connected to the outside of the base, the top of the base is fixedly connected to a detection mechanism, the top of the detection mechanism is fixedly connected to a detection plate, the top of the support box is fixedly connected to a driving box, the driving box and the support box are provided with impurity removal components for removing and purifying impurities in the drug raw materials to improve the purity of the drug raw materials, the support box is provided with a leveling component for leveling the drug raw materials and removing the drug raw materials leveled on the detection plate, the impurity removal component is provided with an anti-blocking component for preventing the drug raw materials from being blocked and a vibration component for improving the screening efficiency of the drug raw materials;

[0006] The impurity removal component includes a driving motor fixedly connected to the top of the driving box, the output shaft of the driving motor is fixedly connected to a reciprocating screw rod 1, the outer sides of the supporting box are respectively fixedly connected to a fixed box and a placement box, the interior of the fixed box is rotatably connected to a impurity removal cylinder, the impurity removal cylinder is provided with filtering holes arranged in a circumferential array, the outer wall of the impurity removal cylinder is fixedly connected to a gear ring, the reciprocating screw rod 1 is fixedly connected to an adjusting gear, the gear ring and the adjusting gear are meshed with each other, the reciprocating screw rod 1 is slidably connected to a moving block, the outer side of the moving block is fixedly connected to an extension rod, the end of the extension rod away from the moving block is fixedly connected to a fixed rod, the bottom end of the fixed rod is fixedly connected to a screening frame, the bottom of the impurity removal cylinder is fixedly connected to a fixed pipe 1, the bottom of the fixed box is fixedly connected to a fixed pipe 2, the interior of the placement box is fixedly connected to a mixing cylinder, the bottom end of the fixed pipe 2 is fixedly connected to the mixing cylinder, the interior of the fixed pipe 2 is fixedly connected to a purification net, the purification net is rotatably connected to the fixed pipe 1, and the outer side of the purification net is fixedly connected to.

[0007] As a further improvement of the above scheme, the leveling assembly includes a rotating rod 1 rotatably connected to the inside of the support box, the bottom end of the reciprocating screw rod 1 is fixedly connected to a bevel gear 1, the rotating rod 1 is fixedly connected to a bevel gear 2, the bevel gear 2 and the bevel gear 1 are meshed with each other, the inside of the support box is fixedly connected to a micro electric cylinder 1, the top of the micro electric cylinder 1 is fixedly connected to a fixed frame, the inside of the fixed frame is rotatably connected to a reciprocating screw rod 2, the inside of the fixed frame is fixedly connected to a limiting rod, the limiting rod and the reciprocating screw rod 2 are slidably connected to A slider, the outer wall of the slider is fixedly connected to a mounting frame, both sides of the mounting frame are fixedly connected to a connecting plate 1, the bottom of the connecting plate 1 is fixedly connected to a micro electric cylinder 2, the telescopic ends of the micro electric cylinder 2 are fixedly connected to the connecting frame, the interior of the connecting frame is rotatably connected to a leveling roller, the bottom of the mounting frame is fixedly connected to a cleaning scraper and a cleaning roller 1, the rotating rod 1 and the reciprocating screw rod 2 are respectively fixedly connected to a mounting gear and a moving gear, the mounting gear and the moving gear are meshed with each other, and the interior of the cleaning roller 1 contains disinfectant.

[0008] As a further improvement of the above scheme, the anti-blocking component includes two groups of mounting cylinders symmetrically fixedly connected to the inner wall of the fixed box, the two groups of mounting cylinders having a total of four, the interior of each mounting cylinder is fixedly connected with a compression spring 1, the end of each compression spring 1 close to the filter hole is fixedly connected with a slide plate, the side of each slide plate away from the compression spring 1 is fixedly connected with a push rod, the end of each push rod away from the slide plate is fixedly connected with a connecting plate 2, the side of each connecting plate 2 away from the push rod is fixedly connected with conical clearing heads arranged in an equidistant linear array, and the conical end of each conical clearing head is inserted into the filter hole.

[0009] As a further improvement of the above scheme, the vibration assembly includes four arc-shaped protrusions symmetrically fixedly connected to the inner wall of the fixed tube 2, four push plates are symmetrically slidably connected inside the fixed ring, the tops of the push plates are fixedly connected to conical protrusions, the bottoms of the push plates are fixedly connected to moving rods, the bottom ends of the moving rods are fixedly connected to connecting plates 3, the moving rods are provided with compression springs 2 fixedly connected to the push plates, the connecting plates 3 are fixedly connected to vibration heads arranged in an equidistant linear array, and the tops of the vibration heads are in contact with the bottom of the purification net.

[0010] As a further improvement of the above scheme, the impurity removal component also includes a connecting rod 1 which is symmetrically fixedly connected to the bottom of a fixed tube 1, the ends of the two connecting rods 1 that are close to each other are fixedly connected to a conical discharge tube 1, the bottom of the conical discharge tube 1 is symmetrically fixedly connected to a connecting rod 2, the ends of the two connecting rods 2 that are far away from each other are fixedly connected to a conical discharge tube 2, the bottom end of the conical discharge tube 2 passes through the interior of the mixing barrel, the conical discharge tube 2 is fixedly connected to stirring blades in an equidistant circular array, the bottom of the mixing barrel is fixedly connected to a solution tube, and the fixed tube 1 is located inside the fixed tube 2.

[0011] As a further improvement of the above solution, a sliding opening is provided on one side of the support box close to the detection plate, the mounting frame is slidably connected inside the sliding opening, a fixing opening is provided on the drive box, and the extension rod is slidably connected inside the fixing opening.

[0012] As a further improvement of the above scheme, the apertures of the screening frame, the filter holes and the purification net decrease from top to bottom, the fixed tube 1, the fixed tube 2, the conical feed tube 1, the conical feed tube 2 and the solution tube are all provided with solenoid valves, the support box is provided with an external power supply, and the drive motor, the micro electric cylinder 1 and the solenoid valve are all electrically connected to the controller.

[0013] A method for detecting a pharmaceutical raw material to improve the purity of the raw material comprises the following steps:

[0014] Step 1: Obtain the drug raw material sample to be tested and perform appropriate sample preparation as needed, such as grinding, dissolving or extraction;

[0015] Step 2: Pre-treat the drug raw material sample by screening and filtering the drug raw material sample multiple times to remove impurities or interfering substances contained in the drug raw material sample, and simultaneously screen out the agglomerated drug raw material sample;

[0016] Step 3: The drug raw material samples after the removal of impurities or interfering substances can be discharged in two states;

[0017] Step 4: First, drop the powdered drug raw material sample with impurities or interfering substances removed onto the test plate;

[0018] Step 5: Level the powdered pharmaceutical raw material sample that has fallen on the testing plate, and test the purity of the powdered pharmaceutical raw material sample through a testing mechanism;

[0019] Step 6: Scrape away the powdered drug raw material sample after purity testing and wipe it clean;

[0020] Step 7: Then mix the drug raw material sample with impurities or interfering substances removed with the standard solution and flow it onto the test plate;

[0021] Step 8: The liquid drug raw material sample is dropped onto the detection plate by the detection mechanism, and the purity of the liquid drug raw material sample is re-detected by the detection mechanism;

[0022] Step 9: Finally, scrape the liquid pharmaceutical raw material sample off the test plate and wipe it clean.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The impurity removal component can realize multiple filtration and impurity removal of pharmaceutical raw materials. The agglomerated raw materials can be screened out, and the impurities in the raw materials can be screened out to improve the purity of the pharmaceutical raw materials. Removing impurities can reduce the content of invalid or harmful ingredients in the medicine, improve the purity and quality of the medicine, and higher purity raw materials can prepare more efficient, safer and more stable medicines, improve the treatment effect and patient satisfaction. By removing impurities, the content of active ingredients in the medicine can be increased, thereby enhancing the efficacy of the medicine. Compared with the gravity screening and impurity removal in the prior art, this impurity removal component can separate the powdered raw materials adhered to the impurities from the impurities through centrifugal force, and can disperse the agglomerated powdered raw materials, which is more conducive to the removal of impurities in the powdered raw materials and improves the impurity removal efficiency.

[0025] 2. The leveling component can be used to level the powdered pharmaceutical raw materials that fall on the test plate. The leveled pharmaceutical raw materials can provide a more uniform surface, allowing the testing instrument to more accurately obtain sample information. Uniform material distribution can reduce the deviation of the test results and improve the accuracy and repeatability of the test. After the powdered pharmaceutical raw materials and solution-like pharmaceutical raw materials are tested, they can be scraped off and the solution-like pharmaceutical raw materials remaining on the test plate can be wiped clean to remove impurities, residues or contaminants on the test plate, ensuring that the test results are not affected by these interference factors, which can improve the accuracy and reliability of the test.

[0026] 3. The anti-blocking component can continuously clear the drug raw materials blocked in the rotating filter holes, which can effectively improve the impurity removal efficiency of the drug raw materials. The vibration force of the vibration component can further quickly screen the drug raw materials on the purification net, while preventing the purification net from being blocked. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0028] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0029] Figure 2 It is a cross-sectional view of the internal structure of the support box of the present invention;

[0030] Figure 3 For the present invention Figure 2 A schematic diagram of the structure enlargement in the middle;

[0031] Figure 4 For the present invention Figure 2 A magnified schematic diagram of the structure at B in the middle;

[0032] Figure 5 For the present invention Figure 2 A magnified schematic diagram of the structure at C in the middle;

[0033] Figure 6 It is a schematic diagram of the structure of a gear of the present invention;

[0034] Figure 7 It is a schematic diagram of the structure of the leveling assembly of the present invention;

[0035] Figure 8 For the present invention Figure 7 A magnified schematic diagram of the structure at D in the middle;

[0036] Fig. 9 It is a cross-sectional view of the internal structure of the second fixed pipe of the present invention;

[0037] Fig.10 For the present invention Fig. 9 The enlarged schematic diagram of the structure at E in the middle;

[0038] Fig.11 For the present invention Fig. 9 Enlarged schematic diagram of the structure at F in the middle.

[0039] In the figure: 1. base; 2. support box; 3. detection mechanism; 4. detection board; 5. drive box;

[0040] The impurity removal component includes: 601, driving motor; 602, reciprocating screw rod 1; 603, fixed box; 604, impurity removal cylinder; 605, filter hole; 606, gear ring; 607, adjusting gear; 608, moving block; 609, extension rod; 610, fixed rod; 611, screening frame; 612, fixed tube 1; 613, fixed tube 2; 614, purification net; 615, connecting rod 1; 616, conical discharge tube 1; 617, connecting rod 2; 618, conical discharge tube 2; 619, mixing cylinder; 620, solution tube; 621, stirring blade; 622, placement box; 623, fixed ring;

[0041] The leveling assembly includes: 701, a rotating rod; 702, a bevel gear; 703, a bevel gear; 704, a micro electric cylinder; 705, a fixed frame; 706, a limit rod; 707, a reciprocating screw rod; 708, a mounting gear; 709, a moving gear; 710, a slider; 711, a mounting frame; 712, a connecting plate; 713, a micro electric cylinder; 714, a connecting frame; 715, a leveling roller; 716, a cleaning scraper; 717, a cleaning wipe roller;

[0042] The anti-blocking assembly includes: 801, a mounting tube; 802, a compression spring 1; 803, a slide plate; 804, a push rod; 805, a connecting plate 2; 806, a conical clearing plug;

[0043] The vibration assembly includes: 901, an arc-shaped protrusion; 902, a push plate; 903, a conical protrusion; 904, a moving rod; 905, a second compression spring; 906, a third connecting plate; 907, a vibration head; 10, a sliding opening; and 11, a fixing opening. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] See also Figures 1 to 11As shown, the present invention provides an embodiment: a drug raw material detection device for improving the purity of raw materials, comprising a base 1 and a support box 2, the bottom of the support box 2 is fixedly connected to the outside of the base 1, the top of the base 1 is fixedly connected with a detection mechanism 3, the top of the detection mechanism 3 is fixedly connected with a detection plate 4, the top of the support box 2 is fixedly connected with a driving box 5, the driving box 5 and the support box 2 are provided with an impurity removal component for removing and purifying impurities in the drug raw materials to improve the purity of the drug raw materials, the support box 2 is provided with a leveling component for leveling the drug raw materials and removing the leveled drug raw materials on the detection plate 4, the impurity removal component is provided with an anti-blocking component for preventing the drug raw materials from being blocked and a vibration component for improving the screening efficiency of the drug raw materials;

[0046] The impurity removal component includes a driving motor 601 fixedly connected to the top of the driving box 5, the output shaft of the driving motor 601 is fixedly connected to a reciprocating screw rod 602, the outer sides of the supporting box 2 are respectively fixedly connected to a fixed box 603 and a placement box 622, the interior of the fixed box 603 is rotatably connected to an impurity removal cylinder 604, the impurity removal cylinder 604 is provided with filter holes 605 arranged in a circular array, the outer wall of the impurity removal cylinder 604 is fixedly connected to a gear ring 606, the reciprocating screw rod 602 is fixedly connected to an adjusting gear 607, the gear ring 606 and the adjusting gear 607 are meshed with each other, the reciprocating screw rod 602 is slidably connected to a moving block 608, and the moving block 608 is An extension rod 609 is fixedly connected to the outside, and one end of the extension rod 609 away from the moving block 608 is fixedly connected to a fixing rod 610, and the bottom end of the fixing rod 610 is fixedly connected to a screening frame 611, the bottom of the impurity removal cylinder 604 is fixedly connected to a fixing pipe 1 612, and the bottom of the fixing box 603 is fixedly connected to a fixing pipe 2 613, and the inside of the placement box 622 is fixedly connected to a mixing cylinder 619, and the bottom end of the fixing pipe 2 613 is fixedly connected to the mixing cylinder 619, and the inside of the fixing pipe 2 613 is fixedly connected to a purification net 614, and the purification net 614 is rotatably connected to the fixing pipe 1 612, and the outside of the purification net 614 is fixedly connected to a fixing ring 623;

[0047] The impurity removal component also includes a connecting rod 1 615 symmetrically fixedly connected to the bottom of the fixed tube 1 612, the ends of the two connecting rods 1 615 close to each other are fixedly connected to a conical feeding tube 1 616, the bottom of the conical feeding tube 1 616 is symmetrically fixedly connected to a connecting rod 2 617, the ends of the two connecting rods 2 617 far away from each other are fixedly connected to a conical feeding tube 2 618, the bottom end of the conical feeding tube 2 618 passes through the interior of the mixing barrel 619, the conical feeding tube 2 618 is fixedly connected to stirring blades 621 in an equidistant circular array, the bottom of the mixing barrel 619 is fixedly connected to a solution tube 620, and the fixed tube 1 612 is located inside the fixed tube 2 613;

[0048] The apertures of the screening frame 611, the filter hole 605, and the purification net 614 decrease from top to bottom. The fixed tube 1 612, the fixed tube 2 613, the conical feed tube 1 616, the conical feed tube 2 618, and the solution tube 620 are all provided with solenoid valves. The support box 2 is provided with an external power supply. The driving motor 601, the micro electric cylinder 1 704, and the solenoid valve are all electrically connected to the controller.

[0049] Specifically, the impurities in the raw medicine can be removed multiple times through the impurity removal component, and the purity of the raw medicine can be further improved through multiple removals.

[0050] The leveling assembly includes a rotating rod 701 rotatably connected to the inside of the support box 2, a bevel gear 702 is fixedly connected to the bottom end of the reciprocating screw rod 602, a bevel gear 703 is fixedly connected to the rotating rod 701, and the bevel gear 703 and the bevel gear 702 are meshed with each other. A micro electric cylinder 704 is fixedly connected to the inside of the support box 2, and a fixing frame 705 is fixedly connected to the top of the micro electric cylinder 704. The inside of the fixing frame 705 is rotatably connected to the reciprocating screw rod 707, and the inside of the fixing frame 705 is fixedly connected to a limiting rod 706. The limiting rod 706 and the reciprocating screw rod 707 are slidably connected to a slider 710. The outer surface of the slider 710 A mounting frame 711 is fixedly connected to the wall, and connecting plates 1 712 are fixedly connected to both sides of the mounting frame 711. A micro electric cylinder 2 713 is fixedly connected to the bottom of the connecting plate 1 712. The telescopic ends of the micro electric cylinder 2 713 are fixedly connected to a connecting frame 714. A leveling roller 715 is rotatably connected inside the connecting frame 714. A cleaning scraper 716 and a cleaning roller 1 717 are fixedly connected to the bottom of the mounting frame 711. A mounting gear 708 and a moving gear 709 are fixedly connected to the rotating rod 1 701 and the reciprocating screw rod 2 707, respectively. The mounting gear 708 and the moving gear 709 are meshed with each other, and the interior of the cleaning roller 1 717 contains disinfectant.

[0051] Specifically, the leveling component can be used to level the fallen powdered pharmaceutical raw materials first, thereby improving the uniformity of the pharmaceutical raw materials during detection. At the same time, the pharmaceutical raw materials on the detection plate 4 can be scraped and wiped clean at the same time, thereby effectively preventing cross-infection between pharmaceutical raw materials.

[0052] The anti-blocking assembly includes two groups of mounting tubes 801 symmetrically fixedly connected to the inner wall of the fixed box 603, the two groups of mounting tubes 801 are four in total, the interior of the mounting tubes 801 is fixedly connected with a compression spring 1 802, one end of the compression spring 1 802 close to the filter hole 605 is fixedly connected with a slide plate 803, the side of the slide plate 803 away from the compression spring 1 802 is fixedly connected with a push rod 804, the end of the push rod 804 away from the slide plate 803 is fixedly connected with a connecting plate 2 805, the side of the connecting plate 2 805 away from the push rod 804 is fixedly connected with a conical clearing plug 806 arranged in an equidistant linear array, and the conical end of the conical clearing plug 806 is inserted into the filter hole 605;

[0053] Specifically, the anti-blocking component can be used to clear the drug raw materials blocked in the filter hole 605, thereby preventing the drug raw materials from being blocked, and effectively improving the efficiency of removing impurities from the drug raw materials.

[0054] The vibration assembly includes four arc-shaped protrusions 901 symmetrically fixedly connected to the inner wall of the second fixed tube 613, and four push plates 902 are symmetrically slidably connected inside the fixed ring 623. The tops of the push plates 902 are fixedly connected to conical protrusions 903, and the bottoms of the push plates 902 are fixedly connected to moving rods 904. The bottom ends of the moving rods 904 are fixedly connected to connecting plates 3 906. The moving rods 904 are provided with compression springs 2 905 fixedly connected to the push plates 902. The connecting plates 3 906 are fixedly connected to vibration heads 907 arranged in an equidistant linear array, and the tops of the vibration heads 907 are in contact with the bottom of the purification net 614.

[0055] Specifically, the purification net 614 can be vibrated and struck by the vibration component, and the material on the purification net 614 can be quickly discharged by the vibration force, and the vibration force can effectively prevent the drug raw materials from being blocked.

[0056] Reference Figure 1 As shown, a sliding opening 10 is provided on one side of the support box 2 close to the detection plate 4, and the mounting frame 711 is slidably connected inside the sliding opening 10. A fixing opening 11 is provided on the drive box 5, and the extension rod 609 is slidably connected inside the fixing opening 11;

[0057] Specifically, the sliding opening 10 can facilitate the sliding of the mounting frame 711, and the fixing opening 11 can facilitate the sliding of the extension rod 609.

[0058] A method for detecting a pharmaceutical raw material to improve the purity of the raw material comprises the following steps:

[0059] Step 1: Obtain the drug raw material sample to be tested and perform appropriate sample preparation as needed, such as grinding, dissolving or extraction;

[0060] Step 2: Pre-treat the drug raw material sample by screening and filtering the drug raw material sample multiple times to remove impurities or interfering substances contained in the drug raw material sample, and simultaneously screen out the agglomerated drug raw material sample;

[0061] Step 3: The drug raw material samples after the removal of impurities or interfering substances can be discharged in two states;

[0062] Step 4: First, drop the powdered drug raw material sample from which impurities or interfering substances have been removed onto the detection plate 4;

[0063] Step 5: Level the powdered drug raw material sample that has fallen on the testing plate 4, and test the purity of the powdered drug raw material sample through the testing mechanism 3;

[0064] Step 6: Scrape away the powdered drug raw material sample after purity testing and wipe it clean;

[0065] Step 7: Then, the drug raw material sample from which impurities or interfering substances have been removed is mixed evenly with the standard solution and then flows onto the detection plate 4;

[0066] Step 8: The liquid drug raw material sample is dropped onto the detection plate 4 by the detection mechanism 3, and the purity of the liquid drug raw material sample is re-detected by the detection mechanism 3;

[0067] Step 9: Finally, scrape the liquid drug raw material sample off the detection plate 4 and wipe it clean.

[0068] In combination with the above preferred embodiments, the working principle of the present invention is as follows:

[0069] In the initial state, compression spring 1 802 is in an uncompressed state, micro electric cylinder 1 704 is in a closed state, mounting gear 708 and moving gear 709 are in a separated state, compression spring 2 905 is in an uncompressed state, and arc-shaped protrusion 901 and conical protrusion 903 are in a non-contact state.

[0070] When working:

[0071] First, the staff places the pharmaceutical raw materials in the screening frame 611, and then the staff controls the driving motor 601 through the controller to start, thereby driving the fixed reciprocating screw rod 602 to rotate, and the rotation of the reciprocating screw rod 602 drives the moving block 608 to slide back and forth, and the reciprocating sliding of the moving block 608 drives the fixed extension rod 609 to slide back and forth synchronously, and the reciprocating sliding of the extension rod 609 drives the fixed fixing rod 610 to slide back and forth, and the reciprocating sliding of the fixing rod 610 drives the fixed screening frame 611 and the pharmaceutical raw materials placed inside to slide back and forth, and the reciprocating sliding force can provide a rapid force, and through the screening The reciprocating sliding force of the frame 611 will cause the screening frame 611 to generate a shaking force, and the shaking force can cause the pharmaceutical raw materials inside the screening frame 611 to be shaken and screened, thereby effectively removing impurities in the powdered pharmaceutical raw materials, and separating the impurities from the raw materials, thereby improving the purity of the medicine. The reciprocating sliding can create more contact surface areas between the powdered pharmaceutical raw materials and the processing medium, which helps to improve the interaction between the impurities and the processing medium and promote the removal of impurities. The reciprocating motion can help break up the lumps or agglomerations in the powdered raw materials, reduce the residual impurities in the powdered raw materials, and help improve the purity and quality of the powdered medicine.

[0072] While the reciprocating screw 602 continuously rotates, it drives the fixed adjusting gear 607 to rotate synchronously. The rotation of the adjusting gear 607 drives the meshing ring gear 606 to rotate. The rotation of the ring gear 606 drives the fixed impurity removal cylinder 604 to rotate. When the impurity removal cylinder 604 rotates, the powdered raw medicine after the initial screening can be screened for the second time through the centrifugal force of the impurity removal cylinder 604. The impurities in the powdered raw medicine can be quickly separated from the target components through the centrifugal force, and the solid impurities can be effectively removed. The centrifugal force can separate the impurities from the powdered raw medicine, thereby improving the purity of the raw materials. The centrifugal force can effectively remove impurities without affecting the target components. , and a part of the powdered pharmaceutical raw materials filtered for the second time is screened into the fixed box 603 through the filter hole 605, and a part of the powdered pharmaceutical raw materials filtered for the second time continues to fall onto the purification net 614 through the fixed tube 2 613, and a part of the powdered pharmaceutical raw materials filtered inside the impurity removal cylinder 604 can directly fall into the fixed tube 1 612, and the powdered pharmaceutical raw materials that have been screened for the third time to remove impurities are filtered again through the purification net 614 and fall, and a part of the powdered pharmaceutical raw materials that have been filtered and fallen fall into the mixing cylinder 619, and the other part falls into the conical discharge tube 2 618, and at this time, when the impurity removal cylinder 604 rotates, it drives the fixed fixed tube 1 612 to rotate synchronously, and the rotation of the fixed tube 1 612 The rotation of the conical discharge tube 616 drives the fixed conical discharge tube 618 to rotate synchronously, and the rotation of the conical discharge tube 618 drives the fixed stirring blade 621 to rotate continuously, so that the powdered pharmaceutical raw materials after multiple filtrations can be evenly mixed with the solution, and the evenly mixed solution raw materials are discharged to the detection plate 4 through the solution tube 620, while the powdered pharmaceutical raw materials not mixed with the solution are discharged to the surface of the detection plate 4 through the conical discharge tube 618. Since the conical discharge tube 618 is provided with an electromagnetic valve, the powdered and solution pharmaceutical raw materials can be double-detected by the detection mechanism 3, thereby further improving the pharmaceutical raw materials. The accuracy of the detection of raw materials, and the powdered or solution-like pharmaceutical raw materials can ensure the uniformity of the samples during the detection. The uniform samples can provide more accurate and repeatable test results and reduce the errors caused by the uneven samples. The powdered pharmaceutical raw materials have a larger surface area, which helps to improve the sensitivity and accuracy of the detection. After the powdered pharmaceutical raw materials are discharged through the conical discharge pipe 618, the impurities remaining in 604 after being sieved out fall into the conical discharge pipe 616 through the fixed pipe 612, and the impurities fall into the conical discharge pipe 618 through the conical discharge pipe 616, and are discharged through the conical discharge pipe 618, thereby realizing the discharge of impurities.

[0073] At the same time, when the reciprocating screw rod 1 602 rotates, it drives the fixed bevel gear 1 702 to rotate synchronously, and the rotation of the bevel gear 1 702 drives the meshing bevel gear 2 703 to rotate synchronously, and the rotation of the bevel gear 2 703 drives the fixed rotating rod 1 701 to rotate, and the rotation of the rotating rod 1 701 drives the fixed installation gear 708 to rotate synchronously. After the powder and solution pharmaceutical raw materials are tested respectively, the staff can start the micro electric cylinder 1 704. When the micro electric cylinder 1 704 is started, the telescopic end pushes the fixed fixing frame 705 to slide up, and the sliding of the fixing frame 705 pushes the reciprocating screw rod 2 707 and the limit rod 706 to slide up synchronously, and the sliding of the reciprocating screw rod 2 707 drives the fixed moving gear 709 to slide, so that the moving gear 709 and the installation gear 708 are in meshing. The cleaning scraper 716 is in a closed state, so that the bottom of the cleaning scraper 716 contacts the medicine on the detection plate 4, and then the slider 710 slides back and forth when the reciprocating screw rod 707 rotates, and the reciprocating sliding of the slider 710 drives the fixed mounting frame 711 to slide back and forth, and the reciprocating sliding of the mounting frame 711 drives the fixed connecting plate 1 712 to slide back and forth, and the reciprocating sliding of the connecting plate 1 712 drives the internal micro electric cylinder 2 713 to slide back and forth, and the reciprocating sliding of the micro electric cylinder 2 713 drives the fixed leveling roller 715 and the cleaning scraper 716 to slide back and forth synchronously, and the reciprocating sliding of the cleaning scraper 716 can level the powdered medicine raw materials on the detection plate 4, and the leveled medicine raw materials can provide a more uniform surface, and the sample is spectrally analyzed by ultraviolet-visible spectrophotometry (UV-Vis), infrared spectroscopy (IR) or mass spectrometry (MS) and other technologies in the detection mechanism 3, so that the detection mechanism 3 provides information about the sample. Chemical The information of structure and composition enables the detection mechanism 3 to obtain the information of the sample more accurately. The uniform material distribution can reduce the deviation of the test results and improve the accuracy and repeatability of the test. The flattened drug raw materials can provide more consistent shapes and sizes, which is conducive to the detection mechanism 3 to perform accurate measurement and analysis. By testing the flattened raw materials, it is easier to find impurities, lumps, and discolored particles in the raw materials, and take timely measures to solve them, thereby ensuring the quality and safety of the drugs.

[0074] After the pharmaceutical raw materials are leveled, the staff controls the telescopic end of the micro electric cylinder 2 713 through the controller to retract, and the retracted end of the micro electric cylinder 2 713 drives the fixed connecting frame 714 to slide up, and the upward sliding of the connecting frame 714 drives the rotating leveling roller 715 to slide up, so that the bottom of the cleaning roller 1 717 and the cleaning scraper 716 can be in contact with the detection plate 4, and then the reciprocating sliding of the mounting frame 711 can drive the cleaning scraper 716 and the cleaning roller 1 717 to scrape away the raw materials on the detection plate 4 and wipe them clean at the same time, so that the detection plate 4 can be wiped clean to remove impurities, residues or contaminants on the plate surface, and the cleaning roller 1 717 contains disinfectant inside, so that the cleaning roller 1 717 can disinfect and sterilize the detection plate 4 when wiping it to ensure the detection results. Not being affected by these interfering factors can improve the accuracy and reliability of the test. By wiping it clean, these residues can be prevented from cross-contaminating subsequent test samples or reagents, thereby ensuring the authenticity of the test results. Wiping the test board 4 clean can ensure the smoothness and flatness of the board surface, so that the test sample can evenly contact the board surface, which can improve the sensitivity and accuracy of the test and ensure the reliability of the test results. Regularly wiping and cleaning the test board 4 can extend the service life of the equipment. Removing dirt and residues on the board surface can prevent corrosion, blockage or damage to the equipment and keep the equipment in normal working condition. Wiping the test board 4 clean can comply with relevant hygiene and safety standards, reduce the risk of contamination and cross infection, and a clean test board 4 can reduce errors and repeated operations during the test process.

[0075] At the same time, as the impurity removing cylinder 604 continues to rotate, the conical end of the conical cleaning plug 806 is inserted into the filter hole 605. When the impurity removing cylinder 604 rotates, the rotational force can push the conical cleaning plug 806 to slide in the direction of the mounting cylinder 801, so that the conical cleaning plug 806 compresses the compression spring 1 802 inside the mounting cylinder 801. After the conical cleaning plug 806 is separated from the filter hole 605, the push rod 804 continues to rotate to align the hole position of the connecting plate 2 805 with the conical cleaning plug 806. Without the restriction of force, the conical cleaning plug 806 can push the slide plate 803 to slide through the restoring resilience of the compression spring 1 802. The sliding of 803 pushes the push rod 804 to slide, the sliding of the push rod 804 pushes the connecting plate 805 to slide, and the sliding of the connecting plate 805 pushes the conical clearing plug 806 to slide, so that the conical clearing plug 806 is repeatedly inserted into the filter hole 605, so that the drug raw material blocked in the filter hole 605 can be dredged, and the filter hole 605 can be kept in the best impurity removal and filtration state by dredging, which can effectively improve the impurity removal effect of the drug raw material and the impurity removal efficiency of the drug raw material. At the same time, when the fixed tube 1 612 rotates, it drives the fixed purification net 614 to rotate synchronously, and the rotation of the purification net 614 drives the fixed fixing ring 623 to rotate, and the fixed The rotation of the ring 623 drives the internal conical protrusion 903 to rotate synchronously, and when the conical protrusion 903 rotates to the arc-shaped protrusion 901, the conical protrusion 903 can slide on the bottom of the arc-shaped protrusion 901 through the arc-shaped surfaces at both ends of the arc-shaped protrusion 901 and the inclined surface of the conical protrusion 903. At this time, the conical protrusion 903 slides into the fixed ring 623 under the pressure of the arc-shaped protrusion 901, and the downward movement of the conical protrusion 903 pushes the push plate 902 to slide down, and the push plate 902 pushes the fixed moving rod 904 and the compression spring 905 to slide down, so that the compression spring 905 is compressed, and the conical protrusion 903 continues to rotate with the fixed ring 623 until it is separated from the arc-shaped protrusion 901. 01, the return resilience of the compression spring 2 905 can push the moving rod 904 and the fixed push plate 902 to slide up, and the upward sliding of the push plate 902 pushes the conical protrusion 903 to slide up, and the upward sliding of the moving rod 904 drives the fixed connecting plate 3 906 and the vibration head 907 to slide up, so that the round end of the vibration head 907 is in contact with the bottom of the purification net 614, and the vibration head 907 reciprocates to knock on the bottom of the purification net 614, so that a vibration force can be generated on the purification net 614, and the pharmaceutical raw materials on the purification net 614 can be quickly discharged by the vibration force, and at the same time, the vibration force can prevent the drug from being blocked, thereby effectively improving the screening efficiency of the pharmaceutical raw materials.

[0076] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0077] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug raw material detection device for improving the purity of raw materials, comprising a base (1) and a support box (2), wherein the bottom of the support box (2) is fixedly connected to the outside of the base (1), the top of the base (1) is fixedly connected with a detection mechanism (3), and the top of the detection mechanism (3) is fixedly connected with a detection plate (4), characterized in that: The top of the support box (2) is fixedly connected to a driving box (5); the driving box (5) and the support box (2) are provided with impurity removal components for removing impurities from the pharmaceutical raw materials and improving the purity of the pharmaceutical raw materials; the support box (2) is provided with a leveling component for leveling the pharmaceutical raw materials and removing the leveled pharmaceutical raw materials on the detection plate (4); the impurity removal component is provided with an anti-blocking component for preventing the pharmaceutical raw materials from being blocked and a vibration component for improving the screening efficiency of the pharmaceutical raw materials; The impurity removal component comprises a driving motor (601) fixedly connected to the top of a driving box (5); the output shaft of the driving motor (601) is fixedly connected to a reciprocating screw rod (602); the outer sides of the supporting box (2) are respectively fixedly connected to a fixed box (603) and a placement box (622); the interior of the fixed box (603) is rotatably connected to an impurity removal cylinder (604); the impurity removal cylinder (604) is provided with filter holes (605) arranged in a circular array; the outer wall of the impurity removal cylinder (604) is fixedly connected to a gear ring (606); the reciprocating screw rod (602) is fixedly connected to an adjusting gear (607); the gear ring (606) and the adjusting gear (607) are meshed with each other; the reciprocating screw rod (602) is slidably connected to a moving block (608); the moving block (608) The outer side of the movable block (608) is fixedly connected to an extension rod (609), one end of the extension rod (609) away from the moving block (608) is fixedly connected to a fixing rod (610), the bottom end of the fixing rod (610) is fixedly connected to a screening frame (611), the bottom of the impurity removal cylinder (604) is fixedly connected to a fixing pipe 1 (612), the bottom of the fixing box (603) is fixedly connected to a fixing pipe 2 (613), the interior of the placement box (622) is fixedly connected to a mixing cylinder (619), the bottom end of the fixing pipe 2 (613) is fixedly connected to the mixing cylinder (619), the interior of the fixing pipe 2 (613) is fixedly connected to a purification net (614), the purification net (614) is rotatably connected to the fixing pipe 1 (612), and the outer side of the purification net (614) is fixedly connected to a fixing ring (623).

2. The pharmaceutical raw material detection device for improving raw material purity according to claim 1, characterized in that: The leveling assembly comprises a rotating rod (701) rotatably connected to the interior of the support box (2); the bottom end of the reciprocating screw (602) is fixedly connected to a bevel gear (702); the rotating rod (701) is fixedly connected to a bevel gear (703); the bevel gear (703) and the bevel gear (702) are meshed with each other; the interior of the support box (2) is fixedly connected to a micro electric cylinder (704); the top end of the micro electric cylinder (704) is fixedly connected to a fixed frame (705); the interior of the fixed frame (705) is rotatably connected to a reciprocating screw (707); the interior of the fixed frame (705) is fixedly connected to a limiting rod (706); the limiting rod (706) and the reciprocating screw (707) are slidably connected to a slider (710); the slider (710) ) is fixedly connected to the outer wall of a mounting frame (711), both sides of the mounting frame (711) are fixedly connected to a connecting plate 1 (712), the bottom of the connecting plate 1 (712) is fixedly connected to a micro electric cylinder 2 (713), the telescopic end of the micro electric cylinder 2 (713) is fixedly connected to a connecting frame (714), the interior of the connecting frame (714) is rotatably connected to a leveling roller (715), the bottom of the mounting frame (711) is fixedly connected to a cleaning scraper (716) and a cleaning roller 1 (717), the rotating rod 1 (701) and the reciprocating screw rod 2 (707) are respectively fixedly connected to a mounting gear (708) and a moving gear (709), the mounting gear (708) and the moving gear (709) are meshed with each other, and the interior of the cleaning roller 1 (717) contains disinfectant.

3. The drug raw material detection equipment for improving raw material purity according to claim 1, characterized in that: The anti-blocking component includes two groups of mounting tubes (801) symmetrically fixedly connected to the inner wall of the fixed box (603), the two groups of mounting tubes (801) having four in total, the interior of each mounting tube (801) is fixedly connected with a compression spring 1 (802), one end of each compression spring 1 (802) close to the filter hole (605) is fixedly connected with a slide plate (803), a side of each slide plate (803) away from the compression spring 1 (802) is fixedly connected with a push rod (804), an end of each push rod (804) away from the slide plate (803) is fixedly connected with a connecting plate 2 (805), a side of each connecting plate (805) away from the push rod (804) is fixedly connected with conical clearing plugs (806) arranged in an equidistant linear array, and the conical end of each conical clearing plug (806) is inserted into the filter hole (605).

4. The drug raw material detection equipment for improving raw material purity according to claim 1, characterized in that: The vibration assembly includes four arc-shaped protrusions (901) symmetrically fixedly connected to the inner wall of the second fixed tube (613); the interior of the fixed ring (623) is symmetrically slidably connected with four push plates (902); the tops of the push plates (902) are fixedly connected with conical protrusions (903); the bottoms of the push plates (902) are fixedly connected with moving rods (904); the bottom ends of the moving rods (904) are fixedly connected with connecting plates three (906); the moving rods (904) are provided with compression springs two (905) fixedly connected to the push plates (902); the connecting plates three (906) are fixedly connected with vibration heads (907) arranged in an equidistant linear array; the tops of the vibration heads (907) are in contact with the bottom of the purification net (614).

5. The drug raw material detection equipment for improving raw material purity according to claim 1, characterized in that: The impurity removal component also includes a connecting rod 1 (615) symmetrically fixedly connected to the bottom of the fixed tube 1 (612); the ends of the two connecting rods 1 (615) that are close to each other are fixedly connected to a conical discharge tube 1 (616); the bottom of the conical discharge tube 1 (616) is symmetrically fixedly connected to a connecting rod 2 (617); the ends of the two connecting rods 2 (617) that are far away from each other are fixedly connected to a conical discharge tube 2 (618); the bottom end of the conical discharge tube 2 (618) passes through the interior of the mixing barrel (619); the conical discharge tube 2 (618) is fixedly connected to stirring blades (621) in an equidistant circular array; the bottom of the mixing barrel (619) is fixedly connected to a solution tube (620); and the fixed tube 1 (612) is located inside the fixed tube 2 (613).

6. The drug raw material detection equipment for improving raw material purity according to claim 2, characterized in that: A sliding opening (10) is provided on one side of the support box (2) close to the detection plate (4), the mounting frame (711) is slidably connected inside the sliding opening (10), a fixing opening (11) is provided on the drive box (5), and the extension rod (609) is slidably connected inside the fixing opening (11).

7. The drug raw material detection device for improving raw material purity according to claim 5, characterized in that: The apertures of the screening frame (611), the filter holes (605) and the purification net (614) decrease from top to bottom. The fixed tube 1 (612), the fixed tube 2 (613), the conical feed tube 1 (616), the conical feed tube 2 (618) and the solution tube (620) are all provided with solenoid valves. The support box (2) is provided with an external power supply. The drive motor (601), the micro electric cylinder 1 (704) and the solenoid valve are all electrically connected to the controller.

8. A method for detecting a pharmaceutical raw material for improving the purity of a raw material, applied to a pharmaceutical raw material detection device for improving the purity of a raw material according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1: Obtain the drug raw material sample to be tested and perform appropriate sample preparation as needed, such as grinding, dissolving or extraction; Step 2: Pre-treat the drug raw material sample by screening and filtering the drug raw material sample multiple times to remove impurities or interfering substances contained in the drug raw material sample, and simultaneously screen out the agglomerated drug raw material sample; Step 3: The drug raw material samples after the removal of impurities or interfering substances can be discharged in two states; Step 4: First, drop the powdered drug raw material sample from which impurities or interfering substances have been removed onto the detection plate (4); Step 5: Leveling the powdered pharmaceutical raw material sample that has fallen onto the testing plate (4), and testing the purity of the powdered pharmaceutical raw material sample using the testing mechanism (3); Step 6: Scrape away the powdered drug raw material sample after purity testing and wipe it clean; Step 7: Then, the drug raw material sample from which impurities or interfering substances have been removed is mixed evenly with the standard solution and then flowed onto the detection plate (4); Step 8: The liquid drug raw material sample is dropped onto the detection plate (4) by the detection mechanism (3), and the purity of the liquid drug raw material sample is re-detected by the detection mechanism (3); Step 9: Finally, scrape the liquid drug raw material sample off the test plate (4) and wipe it clean.

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