Bird's nest acid nourishing paste and preparation method thereof

Abstract

The invention relates to sialic acid nourishing paste with the effects of warming and tonifying qi and blood, delaying senescence, maintaining beauty and keeping young and a preparation method thereof. The preparation method of the sialic acid nourishing paste comprises the following steps: S101, firstly freeze-drying four medicinal materials, namely codonopsis pilosula, prepared rehmannia root (roasted), poria cocos (roasted) and roasted rhizoma atractylodis macrocephalae (roasted), and then crushing the four medicinal materials through an ultrafine grinder to obtain ultrafine powder mixed by the four medicinal materials; s102, forging honey-fried licorice root, Chinese angelica, Ligusticum wallichii, wine-processed white peony root, honey-fried Radix Astragali and cinnamon into fragments, decocting with water, filtering, and removing slag to obtain a liquid medicine; and S103, adding the superfine powder obtained in the S101, donkey-hide gelatin and red date powder into the liquid medicine obtained in the S102, decocting, concentrating, decocting into oral thick paste, finally adding sialic acid and honey, stirring, and filling to obtain the oral thick paste. According to the invention, on the basis of a'Taiping Hui for people and an agent bureau ', the bioavailability of the medicine is increased by improving the formula and the process, the effects of warming and tonifying qi and blood are remarkably improved, the effects of resisting aging, maintaining beauty and keeping young are also enhanced, the oral compliance of a user is increased, and the curative effect of the medicine is improved. The traditional Chinese medicine composition has very positive significance for fully exerting preventive treatment of diseases in traditional Chinese medicine to prevent and treat sub-health.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine tonic ointment, in particular to a bird's nest acid tonic ointment and a preparation method thereof. Background Art

[0002] Sub-health has become a global hot topic since 2007. The "Sub-health Chinese Medicine Clinical Guidelines" issued by the Chinese Association of Traditional Chinese Medicine in 2007 describes sub-health as follows: Sub-health refers to a state in which the human body is between health and disease. People in a sub-healthy state cannot meet the standard of health, and are manifested as symptoms of reduced vitality, decreased function and adaptability over a period of time, but do not meet the clinical or sub-clinical diagnostic standards of modern medicine for related diseases. With the continuous growth of people's demand for health, my country's medical service model is also undergoing corresponding adjustments. Nowadays, the focus of health care has gradually shifted from the traditional "treatment of diseases" to "improving the health level of the general public". The focus of the medical and health service system should shift from focusing only on diseased people to covering healthy people, sub-healthy people and diseased people. Sub-health is a transitional state between health and disease, with the characteristics of two-way transformation. After early identification of sub-healthy status and appropriate intervention, it can effectively promote the transformation of sub-healthy people to a healthy state; otherwise, this state may further deteriorate and develop into a disease. Various methods and techniques of Chinese medicine in preventing diseases play an important role in artificial intervention in sub-health. It is also an important treasure of my country. The combined treatment of multiple medicinal effects is a theory originally created by Chinese medicine, and improved new-type tonic pastes are the only choice.

[0003] As an important part of traditional Chinese medicine, Chinese medicine has a long history and rich clinical experience. In Chinese medicine theory, paste prescription is a kind of medicine with advanced nutritional nourishment and comprehensive treatment and prevention effects, which can replenish deficiency and support weakness, prevent and treat diseases, and enhance resistance. Therefore, it is applicable to a wide range of people. Different from other Chinese medicine preparations, paste prescriptions often have unique advantages in preventing and treating chronic diseases, difficult and complicated diseases, and regulating sub-health status. Chinese medicine paste prescriptions are not simply "tonifying", but combining treatment and prevention, conditioning and nourishment. Chinese medicine advocates the concept of "treating before illness" and "nurturing before old age". Paste prescriptions are the most representative and commonly used dosage forms of Chinese medicine and are an excellent choice for winter tonic and health preservation. After continuous development in clinical practice, paste prescriptions play a unique role in human health and longevity.

[0004] The preparation method of paste prescriptions gradually matured during the Qin and Han dynasties, and the selection of drugs and ingredients became increasingly rich. In the Han Dynasty, the famous medical scientist Zhang Zhongjing elaborated on the preparation method and efficacy of paste prescriptions in "Treatise on Febrile and Miscellaneous Diseases". In the Tang Dynasty, paste prescriptions gradually became popular among the royal family and were hailed as "secret medicines of the palace", providing a strong guarantee for the health of royal family members.

[0005] With the development of history, paste prescriptions not only circulated in the palace, but also gradually spread to the people, becoming a common health care method for the people. In the Song Dynasty, the famous medical scientist Li Shizhong summarized and improved the preparation methods and efficacy of paste prescriptions in his book "Shengji Zonglu". During the Ming and Qing Dynasties, the preparation technology of paste prescriptions became more exquisite and the efficacy became more significant, gradually becoming an important part of traditional Chinese medicine. In 2018, Xuan Zhicheng's "Chinese Medicine Paste Prescriptions" introduced the use of paste prescriptions for different body constitutions and special paste prescriptions for prolonging life, beautifying the skin, and strengthening the body. It also introduced the correct use of paste prescriptions and scientific preservation methods, laying a good foundation for subsequent research.

[0006] The invention is based on the innovative Shiquan Dabu Gao, the earliest "Shiquan Soup". In the Taiping Huimin Hejijufang, it is used to treat "all kinds of deficiency in men and women, five kinds of fatigue and seven kinds of injuries, no food intake; long-term illness and weakness, occasional hot flashes, qi attacking the bones and spine, tightness and pain, nocturnal dream and nocturnal emission, sallow complexion, weak feet and knees, all kinds of qi not as good as before after illness, worry and anxiety hurting blood and qi, wheezing and coughing, spleen and kidney qi weakness, and five hearts upset". The main effect is to greatly replenish qi and blood. The warming and replenishing power of this prescription is relatively strong, and it is not suitable for yin deficiency and hyperactivity of fire. This makes this prescription continue to be upgraded and used.

[0007] The "Shiquan Dabu Pills" in the "Chinese Pharmacopoeia" record that its effect is "warming and nourishing qi and blood". Modern pharmacological research shows that "Shiquan Dabu Pills (ointment, soup)" has a wide range of pharmacological activities.

[0008] Bird's nest acid is the main active ingredient of the precious medicinal material bird's nest. It was originally separated from the submandibular gland mucin, hence the name "sialic acid". Bird's nest acid generally refers to sialic acid (SA), and its scientific name is "N-acetylneuraminic acid", which is a naturally occurring carbohydrate.

[0009] Sialic acid is widely present in the human body, with the highest content in the central nervous system. It participates in many physiological and pathological processes through the interaction between carbohydrates and proteins, including cell recognition and communication, cell aggregation and development, controlling the life span of glycoconjugates in organisms, mediating bacterial and viral infections, etc., and plays an important role in the nervous and immune systems. It has various physiological activities such as promoting brain development in infants and young children, fighting various degenerative diseases in the elderly, resisting viral and bacterial infections, improving the growth of probiotics in the intestines and the absorption of nutrients, whitening and anti-aging. Summary of the invention

[0010] In view of this, the present invention provides a bird's nest acid nourishing paste and a preparation method thereof. The present invention not only improves the bioavailability of the drug, strengthens the effect of warming and nourishing qi and blood, enhances the anti-aging and beauty-enhancing effects of the product, but also improves the oral compliance of users.

[0011] The present invention provides a bird's nest acid nourishing paste and a preparation method thereof, which comprises the following steps: S101, freeze-drying four kinds of medicinal materials, namely, Codonopsis pilosula, Radix Rehmanniae Preparata (roasted), Poria cocos (roasted), and Rhizoma Atractylodis Macrocephalae (roasted), and then grinding them by an ultrafine grinder to obtain ultrafine powder of a mixture of the four medicines (for example, the mesh number of the ultrafine powder is 300, 600, 900, 1200, 1500, 1800, 2100, 2400, 2700, and 3000 mesh); S102, forging licorice root, angelica root, chuanxiong, wine white peony root, roasted astragalus root, and cinnamon into pieces, adding purified water, heating to a high temperature (e.g., 95° C., 100° C., 105° C.), decocting (e.g., 6 h, 8 h, 10 h, 12 h), filtering, removing residues to obtain a medicinal solution; S103, adding the ultrafine powder, donkey-hide gelatin and red date powder obtained in S101 to the medicinal solution obtained in S102, decocting and concentrating the mixture into a paste, and finally adding bird's nest acid and honey, stirring and filling.

[0012] In terms of weight, the ingredients include 70-90 parts of Codonopsis pilosula, 110-135 parts of Rehmannia root, 70-90 parts of Poria cocos, 70-90 parts of Atractylodes macrocephala, 15-25 parts of cinnamon bark, 35-45 parts of Ligusticum chuanxiong, 70-90 parts of Astragalus membranaceus, 110-135 parts of Angelica sinensis, 70-90 parts of White Peony Root, 30-50 parts of Licorice, 20-30 parts of Red Dates, 5-15 parts of Donkey-hide Gelatin, 5-15 parts of Honey, and 1-5 parts of Bird's Nest Acid.

[0013] In some optional embodiments of the present disclosure, in parts by weight, there are 80 parts of Codonopsis pilosula, 120 parts of Rehmannia root, 80 parts of Poria cocos, 80 parts of Atractylodes macrocephala, 20 parts of cinnamon bark, 40 parts of Ligusticum chuanxiong, 80 parts of Astragalus membranaceus, 120 parts of Angelica sinensis, 80 parts of White Peony Root, 40 parts of Licorice, 20 parts of red dates, 10 parts of donkey-hide gelatin, 5 parts of honey, and 2 parts of bird's nest acid.

[0014] In some optional embodiments of the present disclosure, the amount of pure water used in step S102 is 10-16 times (e.g., 11 times, 12 times, 13 times, 14 times, 15 times, etc.) the total weight of the Codonopsis pilosula, the Rehmannia root, the Poria cocos, the Atractylodes macrocephala, the Cinnamon bark, the Ligusticum chuanxiong, the Astragalus membranaceus, the Angelica sinensis, the White Peony Root and the Licorice.

[0015] In summary, the present disclosure has the following innovative effects: The present invention greatly improves the bioavailability of the drug by beating the meat-based drug into ultrafine powder and directly using it as medicine, and greatly improves the extraction rate of the drug's active ingredients by forging the fiber-based drug into fine pieces. It is supplemented with bird's nest acid and donkey-hide gelatin to enhance anti-aging and beauty, and red dates and honey to enhance palatability, greatly improving the product's edible compliance. Compared with other product dosage forms, the innovation and novelty are as follows: pill Decoction The present invention Is the whole plant used as medicine? most back part Bioavailability generally good excellent Taste generally bitter excellent Absorbability generally good excellent effect generally good excellent DETAILED DESCRIPTION

[0016] Prescription (mass ratio) 80 parts of Codonopsis pilosula, 120 parts of Rehmannia root, 80 parts of Poria, 80 parts of Atractylodes macrocephala, 20 parts of Cinnamon bark, 40 parts of Ligusticum chuanxiong, 80 parts of Astragalus, 120 parts of Angelica sinensis, 80 parts of White Peony Root, 40 parts of Licorice, 20 parts of Red Dates, 10 parts of Donkey-hide Gelatin, 5 parts of Honey, and 2 parts of Bird's Nest Acid.

[0017] Preparation process Step 1. 80 parts of Codonopsis pilosula, 120 parts of Rehmannia glutinosa, 80 parts of Poria cocos, and 80 parts of Atractylodes macrocephala are placed in a freezing low-temperature grinder and crushed, passed through a 600-mesh sieve, and then the four superfine powders are mixed to obtain drug material A; Step 2. Put 3 parts of Chinese date seeds, 3 parts of cinnamon, 6 parts of Chuanxiong, 12 parts of Astragalus, 18 parts of Angelica, 12 parts of white peony, and 6 parts of licorice into a decoction pot and wash them with pure water first, then add 12 times the total amount of the above medicinal materials and heat to 100 ° C and boil for 8 hours, filter and remove the residue to obtain liquid B; Step 3. First add liquid B into the refining copper pot, add material A, 4 parts of red dates (powder), 3 parts of donkey-hide gelatin in turn while heating, start the mixer, increase the temperature and keep it below 75°C, when the liquid medicine becomes a paste, add 5 parts of honey and 2 parts of swiftlet's nest acid, stop heating, stir for another 15 minutes, take samples for quality inspection, if qualified, fill them and get the finished product.

Claims

1. A method for preparing a bird's nest acid nourishing paste, characterized in that: It includes the following steps: S101, freeze-drying four kinds of medicinal materials, namely, Codonopsis pilosula, Radix Rehmanniae Preparata (roasted), Poria cocos (roasted), and Roasted Atractylodes macrocephala (roasted), and then grinding them by an ultrafine grinder to obtain ultrafine powder of a mixture of the four medicines; S102, forging roasted licorice root, Chinese angelica root, Chuanxiong root, white peony root with wine, roasted astragalus root, and cinnamon bark into pieces, adding water to boil and filtering, removing the residue to obtain a medicinal liquid; S103, adding the ultrafine powder, donkey-hide gelatin and red date powder obtained in S101 to the medicinal solution obtained in S102, decocting and concentrating the mixture into a paste, and finally adding bird's nest acid and honey, stirring and filling.

2. In terms of weight, the ingredients include 70-90 parts of Codonopsis pilosula, 110-135 parts of Rehmannia root, 70-90 parts of Poria cocos, 70-90 parts of Atractylodes macrocephala, 15-25 parts of cinnamon bark, 35-45 parts of Ligusticum chuanxiong, 70-90 parts of Astragalus membranaceus, 110-135 parts of Angelica sinensis, 70-90 parts of White Peony Root, 30-50 parts of Licorice, 20-30 parts of Red Dates, 5-15 parts of Donkey-hide Gelatin, 5-15 parts of Honey, and 1-5 parts of Bird's Nest Acid.

3. The preparation method according to claim 1, characterized in that: In step S101, the ultrafine particles are between 300-3000 meshes.

4. The preparation method according to claim 1, characterized in that: In step S102, the conditions for decocting with water include: the amount of water added is 10-16 times the total amount of the medicinal materials, the temperature is 95-105°C, and the time is 6-12 hours.