Formula camel milk powder with function of reducing blood sugar

Abstract

The invention relates to the technical field of modified milk powder preparation, and discloses a formula camel milk powder with a blood sugar reducing function, which comprises the following raw materials: camel milk powder and an auxiliary blood sugar reducing composition, the composition for assisting in reducing blood sugar comprises naringenin, kaempferol and a ginsenoside extract. A brand-new formula is found, the auxiliary blood sugar reducing composition and camel milk powder can generate a synergistic effect, the blood sugar reducing function of the camel milk powder is remarkably improved, the time for taking the blood sugar reducing function of the camel milk powder is shortened, and the blood sugar reducing taking dosage of the camel milk powder is reduced; according to the camel milk powder disclosed by the invention, lignin is added on the basis of an auxiliary blood sugar reducing composition containing naringenin, kaempferol and a ginsenoside extract, so that the blood sugar reducing function of the camel milk powder can be further improved, particularly the postprandial blood sugar reducing rate is accelerated, and the experience of people taking the camel milk powder is improved.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of modulated milk powder, in particular to a formula camel milk powder with blood sugar lowering function. Background Art

[0002] As people age, their risk of obesity and diabetes increases. Since obesity and diabetes may also cause other complications such as cardiovascular and cerebrovascular diseases and organ failure, this not only brings both mental and physical harm to patients, but also has an adverse impact on society and even national development.

[0003] For overweight and obese people and diabetic patients, they currently use diet pills, controlled diet, insulin injections and other methods to control their weight or lower their blood sugar. Therefore, it is particularly important to provide a food that can not only provide nutritional energy, but also significantly reduce carbohydrate intake and inhibit a sharp increase in blood sugar.

[0004] According to the "Experimental Study on the Preventive and Therapeutic Effects of Camel Milk on Type 2 Diabetes", regular consumption of camel milk has a certain diabetic treatment effect on mice, but there are the following problems in actual operation: 1. For the human body, the dose of camel milk must reach a higher level and be taken for a long time to achieve the effect of lowering blood sugar. 2. When taking large doses of camel milk, in addition to hypoglycemic substances, there are more indigestible substances such as lactose in camel milk, which leads to excessive digestive burden on the human body. Long-term use is not conducive to the health of the digestive system. 3. The transportation cost of camel milk is high, which is not conducive to promotion.

[0005] Patent CN201810498455.9 discloses a camel milk tablet with auxiliary blood sugar lowering function and its preparation, including camel milk powder and selenium-enriched yeast, which has the advantages of accelerated blood sugar lowering effect and improved effect, but selenium-enriched yeast has the following disadvantages: 1. Selenium-enriched yeast has the effects of moisturizing the intestines and promoting bowel movements, promoting gastrointestinal motility, and promoting intestinal excretion. If taken in excess, secondary digestion and malabsorption of food will occur, resulting in the adverse reactions and side effects of nutrients not being absorbed by the body in time and being excreted and metabolized with feces; 2. If the selenium-enriched yeast is taken in excessive amounts, it will also cause side effects and adverse reactions of the liver and kidneys, because selenium yeast tablets are usually detoxified by the liver and excreted and metabolized by the kidneys. Therefore, if the selenium yeast tablets are taken in excessive amounts, chronic damage to liver and kidney function will occur, and side effects such as chronic failure of liver and kidney function will occur, which is even higher for diabetic patients.

[0006] Therefore, there is an urgent need to launch a camel milk powder formula with the function of lowering blood sugar. On the one hand, by constructing the formula to achieve the effect of lowering blood sugar by taking a low dose, on the other hand, the formula composition is optimized to shorten the time to produce the blood sugar lowering effect, while avoiding the use of formulas that are risky for people with obesity and diabetes to improve safety. Summary of the invention

[0007] In order to solve the above-mentioned existing problems, the present invention discloses a camel milk powder formula with blood sugar lowering function, and finds a brand-new formula. The auxiliary blood sugar lowering composition and camel milk powder can produce a synergistic effect, significantly enhance the blood sugar lowering effect, shorten the onset time, and ensure the safety of the formula at the same time, and the application prospect is broad.

[0008] The hypoglycemic function of the formula camel milk powder of the present invention has the following meanings: 1. When the individual blood sugar is at a higher value, the formula camel milk brewed by oral formula camel milk powder can significantly reduce blood sugar compared with the oral equivalent placebo; 2. When the individual blood sugar is at a higher value, the formula camel milk brewed by oral formula camel milk powder can significantly reduce blood sugar compared with the oral equivalent camel milk; 3. When the individual blood sugar is in a higher range for a long time, the formula camel milk brewed by oral formula camel milk powder can shorten the time for the overall range of blood sugar to drop significantly compared with the oral equivalent camel milk; 4. When the individual blood sugar is in a higher range for a long time, if the time for shortening the overall range of blood sugar to drop significantly is equal, the total amount of formula camel milk brewed by oral formula camel milk powder is significantly lower than the total amount of oral camel milk. The above-mentioned higher value refers to a blood sugar value higher than the clinically recognized fasting blood sugar range of healthy people, and the above-mentioned higher range refers to a blood sugar range higher than the clinically recognized fasting blood sugar range of healthy people.

[0009] On the one hand, the present invention provides a formula camel milk powder with blood sugar lowering function, comprising the following raw materials: camel milk powder and an auxiliary blood sugar lowering composition; the auxiliary blood sugar lowering composition comprises naringenin, kaempferol and ginsenoside extract.

[0010] Naringenin (CAS: 480-41-1) Naringenin is the aglycone of naringin, a dihydroflavonoid compound. It has antibacterial, anti-inflammatory, free radical scavenging, antioxidant, cough and expectorant, lipid-lowering, anti-cancer and anti-tumor, spasmolytic and choleretic effects, prevention and treatment of liver disease, inhibition of platelet aggregation, and anti-atherosclerosis. It can be widely used in medicine, food and other fields.

[0011] Kaempferol (CAS: 520-18-3) is one of the most common dietary flavonoids. Studies have shown that kaempferol plays a neuroprotective role in various neurological diseases by reducing anti-inflammatory and oxidative stress mediated by microglial activation. It can remove excess superoxide free radicals in the human body and prevent oxidative damage to DNA and cells. It has anti-tumor, anti-inflammatory, anti-aging and other pharmacological effects. In addition, kaempferol also has the function of treating diabetes and osteoporosis.

[0012] The preparation method of the ginsenoside extract comprises: taking fresh ginseng, washing with clean water, chopping, adding 60-75% ethanol aqueous solution with a volume of 5-15 times the weight of the medicinal material to soak for 4-12 hours, heating and refluxing for extraction for 2-5 hours, filtering, combining the filtrate, and concentrating under reduced pressure to obtain a concentrated solution, adding ether with a volume of 1-2 times the volume of the concentrated solution to extract 2-5 times, retaining the lower layer solution, adding n-butanol with a volume of 2-5 times the volume of the lower layer solution to extract, concentrating under reduced pressure, and vacuum drying to obtain the ginsenoside extract.

[0013] Ginsenosides are important active ingredients of ginseng and belong to triterpenoid glycoside compounds. They can be divided into protopanaxadiol saponins (PPD-type saponins), protopanaxatriol saponins (PPT-type saponins) and oleanane-type. More than 40 types of ginsenosides have been isolated from ginseng, which have multiple therapeutic effects such as antioxidant, anti-inflammatory, vasodilation, anti-allergic, and anti-diabetic.

[0014] The present invention obtains an auxiliary hypoglycemic composition including naringenin, kaempferol and ginsenoside extracts through a large number of formula screening tests. The auxiliary hypoglycemic composition and camel milk powder can produce a synergistic effect, significantly enhance the hypoglycemic effect and shorten the onset time. According to research, its mechanism of action may be: 1. Protecting the hypoglycemic active ingredients. For example, the linolenic acid in camel milk belongs to γ-3 rare unsaturated fatty acids, which are long-chain unsaturated fatty acids and are easily oxidized into other substances in the digestive tract environment. It interacts with naringenin, kaempferol and ginsenosides at the molecular level. Different regions of the long chain may be combined with the above-mentioned different flavonoids or saponin compounds. The combination is in the form of π electron donor coordination or other possible forms. The active structure is protected during the digestion process until 1. It is absorbed and utilized by intestinal cells together with the auxiliary hypoglycemic composition; 2. It improves the bioavailability of hypoglycemic active ingredients. In practice, there are complex synergistic or antagonistic effects between flavonoids and saponin compounds, but naringenin, kaempferol and ginsenosides have a synergistic promoting effect on the pathway of intestinal cells absorbing hypoglycemic active ingredients in camel milk, thereby improving bioavailability; 3. It improves the action pathway of hypoglycemic active ingredients. For example, the linolenic acid γ-3 unsaturated fatty acid in camel milk promotes insulin secretion by a mechanism similar to that of insulin activators. Naringenin, kaempferol and ginsenosides may have a catalytic promoting effect on the binding of receptor proteins to active ingredients; other possible mechanisms of action are not excluded here, and the specific mechanism of action needs further research and verification.

[0015] It is worth noting that the generation of synergistic effect is unrelated to the efficacy of the ingredients themselves. The present invention has no significant improvement in the hypoglycemic effect of kaempferol and ginsenosides, which have certain anti-diabetic effects, mixed separately into camel milk powder, compared with camel milk powder without addition. This is because the hypoglycemic effect of kaempferol and ginsenosides alone is achieved through another pathway of action, and their effects are covered by the hypoglycemic effect of camel milk itself; therefore, the key to the synergistic effect is to find multiple substances that are effective on the same pathway of action, exist simultaneously, and are indispensable. This is not a matter of piling up substances with the same efficacy. Substances with the same efficacy may even have antagonistic effects on each other, especially for flavonoids and saponins.

[0016] In some embodiments, the following raw materials are included, calculated by weight: 100-500 parts of camel milk powder and 5-10 parts of auxiliary blood sugar lowering composition.

[0017] In some embodiments, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol and 1-3 parts of ginsenoside extract, calculated by weight.

[0018] In some embodiments, the auxiliary blood sugar lowering composition further comprises lignin.

[0019] Lignin is a biopolymer with a three-dimensional network structure formed by three phenylpropane units interconnected by ether bonds and carbon-carbon bonds, and contains rich aromatic ring structures, aliphatic and aromatic hydroxyl groups, and quinone groups and other active groups. In the field of food, lignin is a high-quality dietary fiber and belongs to water-insoluble dietary fiber. The present invention unexpectedly found that the addition of lignin to the auxiliary hypoglycemic composition including naringenin, kaempferol and ginsenoside extracts can further improve the hypoglycemic effect, especially the rate of post-fasting blood sugar reduction. Its mechanism of action may be to encapsulate the active ingredients through the three-dimensional network structure and active groups, slow down the metabolic rate of the active ingredients, prolong the action time of the active ingredients, and improve their bioavailability. Other possible mechanisms of action are not excluded here, and the specific mechanism of action needs further research and verification; such an effect is conducive to improving the experience of the people taking it.

[0020] In some embodiments, the auxiliary hypoglycemic composition includes, calculated by weight, 1-2 parts of naringenin, 3-5 parts of kaempferol, 1-3 parts of ginsenoside extract and 2-5 parts of lignin.

[0021] On the other hand, the present invention provides a method for preparing a camel milk powder formula having a blood sugar lowering function, comprising the following steps:

[0022] S1, taking fresh camel milk, filtering it with a double filter, purifying it with a milk purifier, and spray drying it to obtain camel milk powder;

[0023] S2, placing the camel milk powder obtained in step S1 in a fluidized bed, uniformly mixing the camel milk powder and the auxiliary blood sugar lowering composition on the fluidized bed, and sieving to obtain a formula camel milk powder with blood sugar lowering function;

[0024] Wherein, the auxiliary hypoglycemic composition comprises naringenin, kaempferol and ginsenoside extract.

[0025] In some embodiments, in step S2, 100-500 parts of camel milk powder and 5-10 parts of the auxiliary blood sugar lowering composition are mixed evenly on a fluidized bed according to weight parts.

[0026] In some embodiments, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol and 1-3 parts of ginsenoside extract, calculated by weight.

[0027] In some embodiments, the auxiliary blood sugar lowering composition further comprises lignin.

[0028] In another aspect, the present invention provides a use of a composition for preparing an agent for improving the blood sugar-lowering function of camel milk powder, wherein the composition comprises naringenin, kaempferol and ginsenoside extract.

[0029] In another aspect, the present invention provides a use of a composition for preparing an agent for shortening the blood sugar lowering effect of camel milk powder, wherein the composition comprises naringenin, kaempferol and ginsenoside extract.

[0030] In another aspect, the present invention provides a use of a composition for preparing an agent for reducing the blood sugar lowering dosage of camel milk powder, wherein the composition comprises naringenin, kaempferol and ginsenoside extract.

[0031] Furthermore, the composition also includes lignin.

[0032] In another aspect, the present invention provides a use of lignin for preparing an agent for improving the blood sugar lowering function of formula camel milk powder, wherein the formula camel milk powder comprises camel milk powder and an auxiliary blood sugar lowering composition, wherein the auxiliary blood sugar lowering composition comprises naringenin, kaempferol and ginsenoside extract.

[0033] In another aspect, the present invention provides a use of lignin for preparing an agent for improving the postprandial blood sugar lowering function of formula camel milk powder, wherein the formula camel milk powder comprises camel milk powder and an auxiliary blood sugar lowering composition, wherein the auxiliary blood sugar lowering composition comprises naringenin, kaempferol and ginsenoside extract.

[0034] In summary, the present invention includes at least one of the following beneficial technical effects:

[0035] 1. The present invention discloses a camel milk powder formula with blood sugar lowering function, and finds a new formula. The auxiliary blood sugar lowering composition and camel milk powder can produce a synergistic effect, significantly improve the blood sugar lowering function of the camel milk powder, shorten the time for the blood sugar lowering function of the camel milk powder to take effect, and reduce the blood sugar lowering dosage of the camel milk powder;

[0036] 2. The present invention finds that adding lignin to the auxiliary hypoglycemic composition including naringenin, kaempferol and ginsenoside extract can further improve the hypoglycemic function of camel milk powder, especially the rate of blood sugar reduction after fasting, which is beneficial to improving the experience of people taking it. DETAILED DESCRIPTION

[0037] The present invention is further described in detail below in conjunction with specific examples, which are only used to explain the present invention and are not used to limit the scope of the present invention. The materials, reagents, etc. used in the following examples are reagents and materials available from commercial sources unless otherwise specified.

[0038] Example 1

[0039] First, fresh camel milk transported from the pasture is taken and filtered using a double filter to remove most of the impurities and microorganisms in the fresh camel milk through filtration and adsorption; then it is purified using a milk purifier to further remove mammary gland cells and certain microorganisms in the fresh camel milk; then it is sent to a spray drying equipment for spray drying to obtain camel milk powder.

[0040] Take fresh ginseng, wash it with clean water, chop it, soak it in a 75% ethanol aqueous solution with a volume 10 times the weight of the medicinal material for 6 hours, heat and reflux for extraction for 3 hours, filter, combine the filtrate, and concentrate it under reduced pressure to obtain a concentrated solution. Add ether with a volume twice that of the concentrated solution to extract it 3 times, retain the lower layer solution, add n-butanol with a volume 3 times that of the lower layer solution to extract it, concentrate it under reduced pressure, and vacuum dry it to obtain a ginsenoside extract.

[0041] Calculated by weight, 1 part of commercially available naringenin, 3 parts of commercially available kaempferol and 1 part of the homemade ginsenoside extract were uniformly mixed to prepare an auxiliary hypoglycemic composition, and its weight was recorded as 5 parts.

[0042] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 5 parts of the auxiliary hypoglycemic composition are evenly mixed on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0043] Example 2

[0044] The preparation was carried out according to the method of Example 1, except that:

[0045] Calculated by weight, 2 parts of commercially available naringenin, 5 parts of commercially available kaempferol and 3 parts of the homemade ginsenoside extract were uniformly mixed to prepare an auxiliary hypoglycemic composition, and the weight of the mixture was recorded as 10 parts.

[0046] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 10 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0047] Example 3

[0048] The preparation was carried out according to the method of Example 1, except that:

[0049] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 500 parts of camel milk powder and 5 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0050] Example 4

[0051] The preparation was carried out according to the method of Example 1, except that:

[0052] Calculated by weight, 1 part of commercially available naringenin, 3 parts of commercially available kaempferol, 1 part of the homemade ginsenoside extract and 2 parts of commercially available lignin were uniformly mixed to form an auxiliary hypoglycemic composition, and its weight was recorded as 8 parts.

[0053] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 7 parts of the auxiliary hypoglycemic composition are evenly mixed on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0054] Example 5

[0055] The preparation was carried out according to the method of Example 1, except that:

[0056] Calculated by weight, 1 part of commercially available naringenin, 3 parts of commercially available kaempferol, 1 part of the homemade ginsenoside extract and 5 parts of commercially available lignin were uniformly mixed to form an auxiliary hypoglycemic composition, and its weight was recorded as 8 parts.

[0057] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 10 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0058] Comparative Example 1

[0059] The fresh camel milk transported from the pasture is filtered using a double filter to remove most of the impurities and microorganisms in the fresh camel milk through filtration and adsorption; it is then purified using a milk purifier to further remove mammary gland cells and certain microorganisms in the fresh camel milk, and then sent to a spray drying device for spray drying to obtain filtered and purified camel milk powder.

[0060] Comparative Example 2

[0061] The preparation was carried out according to the method of Example 1, except that:

[0062] Calculated by weight, 1 part of commercially available naringenin and 3 parts of commercially available kaempferol were uniformly mixed to prepare an auxiliary hypoglycemic composition, and the weight of the mixture was recorded as 4 parts.

[0063] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 4 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0064] Comparative Example 3

[0065] The preparation was carried out according to the method of Example 1, except that:

[0066] Calculated by weight, 1 part of commercially available naringenin and 1 part of the homemade ginsenoside extract were uniformly mixed to form an auxiliary hypoglycemic composition, and the weight of the mixture was recorded as 2 parts.

[0067] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 2 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0068] Comparative Example 4

[0069] The preparation was carried out according to the method of Example 1, except that:

[0070] Calculated by weight, 3 parts of commercially available kaempferol and 1 part of the homemade ginsenoside extract were uniformly mixed to form an auxiliary hypoglycemic composition, and its weight was recorded as 4 parts.

[0071] The camel milk powder obtained in the above steps is placed in a fluidized bed, and 100 parts of camel milk powder and 4 parts of the auxiliary hypoglycemic composition are mixed evenly on the fluidized bed according to the proportion, and sieved to obtain a formula camel milk powder with hypoglycemic function.

[0072] Example 6: Efficacy test in rats

[0073] 90 clean-grade male SD rats were taken and divided into 10 groups, with 9 rats in each group corresponding to Examples 1-5, Comparative Examples 1-4 and a blank control group. A small dose of streptozotocin (STZ, 50 mg / kg (bw)) was intraperitoneally injected once to induce a type II diabetic rat model, and fasting blood glucose>300 mg / dL was included in the experiment. The dose of camel milk powder corresponding to daily oral gavage of rats was 10 g / kg (bw), and the blank control group was gavaged with an equal volume of distilled water for 8 weeks. The tail was cut and blood was taken every 2 weeks to measure the blood sugar value (fasting but not water for 6 hours), and the rat blood sugar ELISA detection kit of Shenzhen Zike Biology was used for detection. The detection method refers to the kit manual, and the average blood sugar of 9 rats in the group was taken. The fasting blood sugar test results of rats are shown in Table 1.

[0074] Table 1: Fasting blood glucose values ​​of type Ⅱ diabetic rats after intragastric administration (n=9)

[0075]

[0076]

[0077] According to the test results, compared with the blank control group, the blood sugar of comparative examples 1-4 decreased to a certain extent only at the 8th week, indicating that the camel milk powder used alone has a slow onset of effect and the blood sugar lowering effect is not significant. However, adding two of the auxiliary blood sugar lowering compositions of the present invention has no additional blood sugar lowering effect compared with the camel milk powder used alone, indicating that its blood sugar lowering effect is covered by the effect of the camel milk powder. In fact, during the research process, the research and development team of the present invention first tested the schemes of comparative examples 2-4, and unexpectedly found in the combined test that the scheme of Example 1 has a significant blood sugar lowering effect.

[0078] Compared with comparative examples 1-4 and the blank control group, the blood glucose of the rats in Examples 1-5 decreased significantly in the second week and reached the lowest blood glucose platform in the sixth week. At this time, the fasting blood glucose of the rats was ≤7mmol / L, indicating that the type 2 diabetes of the rats was alleviated and the blood glucose was controlled; indicating that naringenin, kaempferol and ginsenoside extracts and camel milk powder have a synergistic effect, shortening the onset time of camel milk powder and improving the blood glucose-lowering effect of camel milk powder.

[0079] Among them, Example 5 has a better hypoglycemic effect than Examples 1-4, indicating that the addition of lignin can further improve the synergistic effect between the above-mentioned naringenin, kaempferol and ginsenoside extracts and camel milk powder.

[0080] Further experiments show that 100-500 parts of camel milk powder and 5-10 parts of auxiliary hypoglycemic composition, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol and 1-3 parts of ginsenoside extract, the above ratio can play a good hypoglycemic effect, and the most preferred is the formula ratio of Example 1. When lignin is added, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol, 1-3 parts of ginsenoside extract and 2-5 parts of lignin, the above ratio can play a better hypoglycemic effect, and the most preferred is the formula ratio of Example 5.

[0081] The 10 groups of mice that had undergone 8 weeks of gavage were further tested for full blood glucose. The time when each mouse finished eating was recorded. The tails of the mice were cut and blood was collected 1 hour and 2 hours later to measure blood glucose levels. The method was the same as above. The average blood glucose level of the 9 rats in the group was taken. The results are shown in Table 2.

[0082] Table 2: Satiated blood glucose values ​​of type Ⅱ diabetic rats after intragastric administration (n=9)

[0083]

[0084]

[0085] According to the above test results, compared with the blank control group, the satiety blood sugar of the rats in Examples 1-4 was reduced to a certain extent, which was the effect of 8 weeks of camel milk powder gavage, but the blood sugar was still higher than 10mmol / L 2 hours after the meal, and the blood sugar lowering effect was not good; compared with the blank control group and Comparative Examples 1-4, the blood sugar of the rats in Examples 1-5 was lower than 10mmol / L 1 hour after the meal, and the blood sugar was lower than 8mmol / L 2 hours after the meal, indicating that long-term use of naringenin, kaempferol and ginsenoside extracts and camel milk powder can promote the synergistic effect of postprandial hypoglycemia in diabetic rats; among them, the blood sugar lowering rate of Example 5 was significantly higher, and the blood sugar returned to normal 2 hours after the meal, which was lower than 6mmol / L, indicating that adding lignin to the auxiliary hypoglycemic composition can further accelerate the effect of postprandial hypoglycemia.

[0086] The naringenin, kaempferol and ginsenoside extracts, as well as lignin in the auxiliary hypoglycemic composition of the present invention are all substances that have been verified for safety and have been used in the food field for a long time. After the experiment, blood was taken for biochemical detection, and all indicators were within the normal range. All the test rats were killed by ether anesthesia and dissected. No pathological changes were found in the organs of the rats after examination, which proved that the camel milk powder containing the auxiliary hypoglycemic composition is safe.

[0087] Example 7: Rat dosage test

[0088] Type II diabetic rats were induced according to the method of Example 6 and divided into 5 groups (9 rats in each group). The control group was gavaged with 10 g / kg (bw) of camel milk powder daily, and the 4 experimental groups were gavaged with 10 g / kg (bw), 5 g / kg (bw), 2.5 g / kg (bw), and 1.25 g / kg (bw) of camel milk powder in Example 1 daily, respectively; gavage lasted for 8 weeks, and blood was collected by cutting the tail every 2 weeks to measure blood glucose level according to the method of Example 6 (fasting but not water deprivation for 6 hours).

[0089] The results of the fasting blood glucose test of rats are shown in Table 3.

[0090] Table 3: Fasting blood glucose values ​​of type Ⅱ diabetic rats after intragastric administration (n=9)

[0091]

[0092] According to the test results, even if the oral dose of rats is reduced to 1.25g / kg (bw), it can still have a significant blood sugar lowering effect, indicating that the synergistic effect of the auxiliary blood sugar lowering composition increases the bioavailability of the active ingredients in camel milk by more than 4 times; in practical applications, the addition of the auxiliary blood sugar lowering composition can reduce the dose of camel milk powder taken by the human body and reduce the gastrointestinal digestive burden of the human body, without significantly weakening the blood sugar lowering effect.

[0093] Example 8: Formula comparison test

[0094] In the preliminary tests, in addition to the formula tests of Examples 2-4, the present invention also tested a variety of camel milk powder formulas containing flavonoid compounds and saponin compounds, such as the following groups:

[0095] Formula 1, 1 part of naringenin, 3 parts of kaempferol and 1 part of notoginseng saponin extract; the preparation method of notoginseng saponin extract is to replace the raw material of ginsenoside extract in the present invention with notoginseng;

[0096] Formula 2, 1 part of naringenin, 3 parts of luteolin (CAS: 491-70-3) and 1 part of ginsenoside extract;

[0097] Formula 3, 1 part of quercetin (CAS: 117-39-5), 3 parts of kaempferol and 1 part of ginsenoside extract;

[0098] Formula 4, 1 part of naringenin, 3 parts of kaempferol, 1 part of ginsenoside extract and 2 parts of chitosan (CAS: 1398-61-4).

[0099] The camel milk powder was prepared according to the method of Example 1, and the rat efficacy test was carried out according to the method of Example 6. It was found that compared with the blank control group, the camel milk powders of the above formulas 1-3 had no obvious hypoglycemic effect. The reason is that there are complex antagonisms and synergies between flavonoid compounds and saponin compounds. It is very likely that there is an antagonism between the above ingredients, and the hypoglycemic effect is ineffective.

[0100] Formula 4, in which chitosan is additionally added, has an actual efficacy close to that of the camel milk powder in Example 1, but is inferior to that of Example 5 in which lignin is added. This is because chitosan and other auxiliary hypoglycemic compositions do not have a synergistic effect.

[0101] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto, and any equivalent modifications or substitutions that can be easily thought of by any technician familiar with the technical field within the technical scope disclosed by the present invention should be included in the protection scope of the present invention.

Claims

1. A camel milk powder formula with blood sugar lowering function, characterized in that: The invention comprises the following raw materials: camel milk powder and an auxiliary blood sugar lowering composition; the auxiliary blood sugar lowering composition comprises naringenin, kaempferol and ginsenoside extract.

2. The camel milk powder formula with hypoglycemic function according to claim 1, characterized in that: Calculated by weight, the raw materials include: 100-500 parts of camel milk powder and 5-10 parts of auxiliary blood sugar lowering composition.

3. The camel milk powder formula with hypoglycemic function as claimed in claim 1 or 2, characterized in that: Calculated by weight, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol and 1-3 parts of ginsenoside extract.

4. The camel milk powder formula with hypoglycemic function according to claim 1, characterized in that: The auxiliary blood sugar lowering composition also includes lignin.

5. A method for preparing a camel milk powder formula having a blood sugar lowering function, characterized in that: The following steps are involved: S1, taking fresh camel milk, filtering it with a double filter, purifying it with a milk purifier, and spray drying it to obtain camel milk powder; S2, placing the camel milk powder obtained in step S1 in a fluidized bed, uniformly mixing the camel milk powder and the auxiliary blood sugar lowering composition on the fluidized bed, and sieving to obtain a formula camel milk powder with blood sugar lowering function; Wherein, the auxiliary hypoglycemic composition comprises naringenin, kaempferol and ginsenoside extract.

6. The method for preparing the camel milk powder with hypoglycemic function according to claim 5, characterized in that: The preparation method of the ginsenoside extract comprises: taking fresh ginseng, washing with clean water, chopping, adding 60-75% ethanol aqueous solution with a volume of 5-15 times the weight of the medicinal material to soak for 4-12 hours, heating and refluxing for extraction for 2-5 hours, filtering, combining the filtrate, and concentrating under reduced pressure to obtain a concentrated solution, adding ether with a volume of 1-2 times the volume of the concentrated solution to extract 2-5 times, retaining the lower layer solution, adding n-butanol with a volume of 2-5 times the volume of the lower layer solution to extract, concentrating under reduced pressure, and vacuum drying to obtain the ginsenoside extract.

7. The method for preparing the camel milk powder with hypoglycemic function according to claim 5, characterized in that: In the step S2, 100-500 parts of camel milk powder and 5-10 parts of the auxiliary blood sugar lowering composition are mixed evenly on a fluidized bed according to weight parts.

8. The method for preparing the camel milk powder with hypoglycemic function according to claim 5 or 7, characterized in that: Calculated by weight, the auxiliary hypoglycemic composition includes 1-2 parts of naringenin, 3-5 parts of kaempferol and 1-3 parts of ginsenoside extract.

9. The method for preparing the camel milk powder with hypoglycemic function according to claim 5, characterized in that: The auxiliary blood sugar lowering composition also includes lignin.

10. A composition for preparing a reagent for improving the hypoglycemic function of camel milk powder, characterized in that: The composition includes naringenin, kaempferol and ginsenoside extract.

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