Antenna type sensor, system and method for monitoring biochemical indexes

Abstract

The invention relates to an antenna type sensor, system and method for monitoring biochemical indexes. The sensor comprises a flexible substrate; the radio frequency tag chip works in a first frequency band and is matched with the planar antenna of the first frequency band, and the antenna has a first performance parameter; the sensing area is modified with a sensitive group, after the sensitive group combines / adsorbs biochemical substances, the physical characteristics of the sensing area are changed, and then the first performance parameter of the antenna is changed into a second performance parameter; the first frequency band is matched with a set frequency band of radio frequency communication of the mobile terminal or matched with a frequency band corresponding to a close-range radio frequency communication function of the mobile terminal, so that the sensor senses electromagnetic waves of the first frequency band emitted by the mobile terminal through the antenna, the electromagnetic waves cause electromagnetic induction in the antenna, and electric energy is obtained; and transmitting a radio frequency signal containing the identifier in the radio frequency tag chip through the antenna based on the current second performance parameter. Highly integrated design, a self-powered mechanism and wireless communication with an intelligent terminal are realized, and a more practical and efficient solution is provided for biochemical index detection.

Description

Technical Field

[0001] The present application relates to the technical field of biochemical indicator detection, and in particular to an antenna sensor, system and method for monitoring biochemical indicators. Background Art

[0002] With the rapid development of science and technology, the detection of biochemical indicators has shown increasingly important application value in many fields such as medical treatment, environmental monitoring, food safety, etc. Although sensing technology has made certain progress in recent years, the existing biochemical indicator sensors still have some shortcomings, mainly including the following aspects:

[0003] First, sensors usually require external analog-to-digital / digital-to-analog converters and microcontrollers to process the transmitted data, which not only increases the complexity and cost of the system, but also these additional components increase the overall size, limiting its application in miniaturized devices, especially in application scenarios of wearable monitoring that needs to fit the human body.

[0004] Second, the sensor relies on external power sources such as batteries, which not only increases the size and weight of the device, but also reduces its endurance, especially in application scenarios that require long-term continuous monitoring.

[0005] Third, although some sensors can achieve wireless transmission, they are often limited by the communication frequency band and distance. Due to the limitations of frequency band and distance, sensors may not be able to communicate directly with smart terminal devices such as smartphones, thus limiting their application in remote monitoring and real-time feedback.

[0006] In view of the above-mentioned deficiencies of the prior art, the present invention proposes a new sensor, which aims to solve the problems of integration, portability, complex data processing and limited power supply in the detection of biochemical indicators. Summary of the invention

[0007] In view of the above problems in the prior art, the present application provides an antenna sensor, system and method for monitoring biochemical indicators, which realizes a highly integrated design, a self-powered mechanism and wireless communication with smart terminals, effectively solves the problems existing in the prior art, and provides a more practical and efficient solution for biochemical indicator detection.

[0008] To achieve the above-mentioned purpose, the first aspect of the present application provides an antenna sensor for monitoring biochemical indicators, comprising:

[0009] Flexible substrate;

[0010] A radio frequency tag chip operating in a first frequency band is disposed on the substrate, wherein the radio frequency tag chip includes an RF interface and a GND interface;

[0011] A planar antenna matching the first frequency band is disposed on the substrate, two ends of the antenna are respectively connected to the RF interface and the GND interface, and the antenna has a first performance parameter;

[0012] A sensing region modified with a sensitive group is disposed on the substrate, wherein the sensing region comprises two signal ends, which are respectively connected to the RF interface and the GND interface, wherein the sensitive group changes the physical properties of the sensing region after binding / adsorbing biochemical substances, thereby affecting the change of the first performance parameter of the antenna into the second performance parameter;

[0013] Among them, the first frequency band matches the established frequency band of the mobile terminal's radio frequency communication, or matches the frequency band corresponding to the mobile terminal's short-range radio frequency communication function, so that the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through the antenna, and the electromagnetic waves cause electromagnetic induction in the antenna, thereby obtaining electrical energy, and emitting a radio frequency signal containing the identification in the radio frequency tag chip through the antenna based on the current second performance parameter.

[0014] In this way, the present application directly uses the antenna as a sensor, integrating the antenna and the sensing function, so no additional analog-to-digital / digital-to-analog converter, microcontroller or Bluetooth module is needed to process and transmit data, thereby reducing the number of internal components of the sensor, reducing costs, and significantly reducing the overall size, making it more suitable for application on miniaturized devices, and the flexible substrate makes it more suitable for application scenarios of wearable monitoring that needs to fit the human body. In addition, the sensor is self-powered by absorbing the energy emitted by the mobile terminal, and no longer relies on battery power, making the sensor smaller and lighter, and improving the portability of the sensor; furthermore, the sensor operates in a radio frequency band compatible with mobile terminals (such as smart phones), such as the NFC band or the UHF band, ensuring good compatibility with smart terminal devices, which enables the sensor to communicate efficiently with devices such as smart phones, and users can also edit the measured biochemical index values ​​displayed on the smart phone, supporting remote monitoring and real-time feedback.

[0015] As a possible implementation of the first aspect, the substrate is made of a transparent material and is generally circular;

[0016] The antenna is spiral-shaped and distributed on the peripheral side of the circular base;

[0017] The radio frequency tag chip and the sensing area are arranged adjacent to each other and are located inside the antenna and at the center of the non-circular substrate.

[0018] In this way, the transparent material substrate not only improves the aesthetics and concealment of the sensor, but also allows the sensor to be applied to areas where transparency is required, such as the surface of the eyes; the spiral antenna is distributed on the peripheral side of the substrate, which can maximize the coverage area of ​​the antenna and enhance the effect of signal reception and transmission; the RFID tag chip and the sensing area are adjacent to each other and located in a non-central position, making the overall layout compact and reasonable, reducing the space occupied by the sensor, and improving integration and portability.

[0019] As a possible implementation of the first aspect, the sensing area includes: a one-dimensional linear array and signal ends located on both sides of the linear array, the line width and spacing of the linear array are in the nanometer to micrometer level, and the linear array is modified with sensitive groups.

[0020] In this way, the fineness of the line array allows the sensitive groups to be arranged more closely on the line array, increasing the number of sensitive groups per unit area, thereby improving the detection sensitivity of the target biochemical substances. In addition, the line width and spacing from nanometers to micrometers ensure the high precision of the sensing area, allowing the sensor to accurately reflect the changes in biochemical substances. Therefore, this fine design enables the sensor to achieve high-precision monitoring in a limited space.

[0021] As a possible implementation manner of the first aspect, the sensor is in a circular shape with a diameter of 15 mm and a thickness of 0.11 mm.

[0022] In this way, due to the small size and light weight of the sensor, users can easily carry and use it, and it is suitable for various portable monitoring devices. In addition, the sensor can also be easily attached to the skin surface or wearable devices without complicated installation process.

[0023] As a possible implementation of the first aspect, the radio frequency tag chip includes an identification chip for assigning a unique number to each sensor, thereby performing parallel detection on sensors of different detection objects; the first frequency band matches an NFC frequency band, a UHF frequency band or a specific frequency band.

[0024] In this way, the present application can select the required identification chip according to actual needs, and at the same time make the first frequency band match the corresponding frequency band, thereby improving the flexibility of the design to meet the needs of different scenarios.

[0025] As a possible implementation of the first aspect, the physical property of the sensing area includes at least one of the following: dielectric constant, equivalent resistance, equivalent capacitance, and equivalent inductance;

[0026] The first performance parameter and the second performance parameter include at least one of the following: a reflection coefficient S11 of the antenna, a resonant frequency of the antenna, and a phase of the antenna.

[0027] In this way, when the biochemical substances combine with the sensing area, the dielectric constant, equivalent resistance, equivalent capacitance or equivalent inductance of the sensing area will change. The changes in these physical properties will further affect the performance parameters such as the reflection coefficient S11, resonant frequency or phase of the antenna, thereby accurately reflecting the presence of biochemical substances and realizing the detection of biochemical substances.

[0028] To achieve the above-mentioned purpose, the second aspect of the present application provides a system for monitoring biochemical indicators, comprising:

[0029] The antenna-type sensor for monitoring biochemical indicators described in the first aspect, after the sensitive group modified by the sensing area of ​​the sensor binds / adsorbs the biochemical substance, the antenna of the sensor is compatible with a first frequency band, and the first frequency band matches the established frequency band of the radio frequency communication of the mobile terminal, or matches the frequency band corresponding to the short-range radio frequency communication function of the mobile terminal;

[0030] A mobile terminal, whose established frequency band for radio frequency communication includes a first frequency band, or whose short-range radio frequency communication function uses the first frequency band; when the mobile terminal is used to communicate with the sensor based on the first frequency band, it receives the radio frequency signal sent by the sensor, identifies the identifier in the radio frequency tag chip of the sensor and the current second performance parameter of the antenna, and determines the monitored biochemical indicator based on this.

[0031] In this way, through the efficient communication between the sensor and the mobile terminal based on the first frequency band, real-time monitoring and data transmission of biochemical indicators are realized; the mobile terminal can receive the radio frequency signal sent by the sensor, and identify the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, so as to accurately determine the monitored biochemical indicators, ensure the reliability and real-time nature of the monitoring data, and improve the user experience and the practicality of the system.

[0032] To achieve the above-mentioned purpose, the third aspect of the present application provides a method for monitoring biochemical indicators, comprising: using the system for monitoring biochemical indicators according to the second aspect, the method comprising:

[0033] After the sensor binds / adsorbs biochemical substances through the sensitive groups modified in the sensing region, the antenna of the sensor is compatible with a first frequency band, and the first frequency band matches a predetermined frequency band of radio frequency communication of the mobile terminal, or matches a frequency band corresponding to a short-range radio frequency communication function of the mobile terminal, so that the physical properties of the sensing region change, thereby affecting the current performance parameter of the antenna to change to a second performance parameter;

[0034] When the distance between the mobile terminal and the sensor enters the range in which communication based on the first frequency band is possible, the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through its antenna, and the electromagnetic waves induce electromagnetic induction in the antenna, thereby obtaining electric energy, and emitting a radio frequency signal containing the identification in the radio frequency tag chip through the antenna based on the current second performance parameter;

[0035] The mobile terminal receives the radio frequency signal sent by the sensor, identifies the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, and determines the monitored biochemical index accordingly.

[0036] In this way, through the efficient communication between the sensor and the mobile terminal based on the first frequency band, real-time monitoring and data transmission of biochemical indicators are realized; the mobile terminal can receive the radio frequency signal sent by the sensor, and identify the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, so as to accurately determine the monitored biochemical indicators, ensure the reliability and real-time nature of the monitoring data, and improve the user experience and the practicality of the system.

[0037] As a possible implementation of the third aspect, the following also is included:

[0038] The mobile terminal determines the sensor used, the object monitored, or the location monitored based on the identification in the identified radio frequency tag chip.

[0039] In this way, the mobile terminal determines the sensor to be used, the object to be monitored or the location to be monitored based on the identification in the identified radio frequency tag chip, which not only improves the flexibility and reliability of monitoring, but also makes data management more accurate.

[0040] As a possible implementation manner of the third aspect, the sensor is a flexible wearable sensor;

[0041] The sensor is specifically arranged at one of the following positions: skin surface, eye surface, and subcutaneous.

[0042] In this way, by setting sensors at these locations, non-invasive or minimally invasive monitoring of biochemical indicators can be achieved, which improves user comfort and acceptance; at the same time, this design enables the sensors to monitor biochemical indicators in real time and continuously. Whether it is a patch sensor on the skin surface, a contact lens sensor on the surface of the eye, or an implanted sensor under the skin, it can provide accurate data to ensure the reliability and timeliness of the monitoring results. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is a structural diagram of an antenna sensor for monitoring biochemical indicators provided by the present application;

[0044] Figure 2 It is a structural schematic diagram of a system for monitoring biochemical indicators provided by the present application;

[0045] Figure 3 It is a flow chart of a method for monitoring biochemical indicators provided by the present application;

[0046] Figure 4 It is a schematic diagram of a mathematical relationship model provided by this application;

[0047] Figure 5 This application is 10 5 Schematic diagram of the relationship between CFU / mL Staphylococcus aureus solution and frequency;

[0048] It should be understood that the size and shape of each block diagram in the above structural diagram are for reference only and should not constitute an exclusive interpretation of the embodiment of the present invention. The relative position and inclusion relationship between the blocks presented in the structural diagram are only schematic representations of the structural association between the blocks, and do not limit the physical connection method of the embodiment of the present invention. DETAILED DESCRIPTION

[0049] The technical solution provided by the present application is further described below with reference to the accompanying drawings and examples. It should be understood that the system structure and business scenarios provided in the examples of the present application are mainly to illustrate the possible implementation methods of the technical solution of the present application and should not be interpreted as the only limitation on the technical solution of the present application. It is known to those of ordinary skill in the art that with the evolution of the system structure and the emergence of new business scenarios, the technical solution provided by the present application is also applicable to similar technical problems.

[0050] It should be understood that the separation scheme of submicron and nanometer-scale particles in solution provided in the embodiments of the present application includes a separation device, system and method for submicron and nanometer-scale particles in solution. Since the principles of solving the problems in these technical solutions are the same or similar, some repetitions may not be repeated in the introduction of the following specific embodiments, but it should be regarded as that these specific embodiments have been referenced to each other and can be combined with each other.

[0051] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present application. In case of any inconsistency, the meaning described in this specification or the meaning derived from the contents recorded in this specification shall prevail. In addition, the terms used herein are only for the purpose of describing the embodiments of the present application and are not intended to limit the present application.

[0052] NFC (Near Field Communication) is a short-range wireless communication technology with a frequency band of 13.56MHz, which allows two devices to exchange data contactlessly at a very close distance (usually a few centimeters). Currently, some mobile phones have NFC communication function.

[0053] UHF (Ultra High Frequency), the frequency band is usually between 860MHz and 960MHz, which can be used for long-distance identification and multi-tag simultaneous identification. Currently, some mobile phones have UHF communication function.

[0054] One thing to note is that the working distance of NFC is very short, generally within a few centimeters. Compared with NFC, UHF can achieve longer-distance communication, generally between a few meters to tens of meters, and the signal penetration of the UHF frequency band is strong, and it can maintain good communication performance in crowded cities, dense jungles and severe weather conditions.

[0055] Biochemical indicators may include, but are not limited to, blood sugar, blood oxygen, pH value, concentration of specific biomolecules (such as DNA, protein, hormone, etc.). The sensing area senses changes in these biochemical indicators through specific chemical reactions, physical effects, or biorecognition mechanisms. These changes are then converted into electrical signals or other measurable physical quantities.

[0056] Before introducing the present invention, the existing technical solutions and their existing problems are summarized.

[0057] Solution 1: When monitoring biochemical indicators, existing equipment usually includes three main parts: sensor, microcontroller unit (MCU) controller and Bluetooth module.

[0058] Its working principle is as follows: the sensor collects data on biochemical indicators, and after the collected data is processed by analog-to-digital converter (ADC) and digital signal processor (DSP) such as discrete Fourier transform (DFT), it is sent to the MCU controller. The MCU controller processes the data, and the processed data is sent to the terminal device (such as a smart phone) via the Bluetooth module.

[0059] However, Solution 1 has the following shortcomings: Since sensors, MCU controllers and Bluetooth modules are required, the overall device size is large, which limits its application in miniaturized devices, especially in application scenarios where wearable monitoring needs to fit the human body.

[0060] Solution 2: Based on Solution 1, in order to reduce the size of the device, the Bluetooth module was removed and an MCU controller combined with an RFID antenna was used.

[0061] Its working principle is as follows: the sensor collects data of biochemical indicators and sends the collected data to the MCU controller, which processes the data. The processed data is sent to the terminal device (such as a smart phone) through the RFID antenna on the MCU controller according to the communication frequency band in which it works.

[0062] This solution is an improvement over Solution 1, but still has the following shortcomings: Although the Bluetooth module is removed, the combination of the MCU controller and the antenna still takes up a large space, limiting its application in miniaturized devices, especially in wearable monitoring applications that need to fit the human body. In addition, the combination of the MCU controller and the antenna still requires an external power supply or battery, which increases the size and weight of the device and reduces its battery life.

[0063] Based on the above-mentioned deficiencies in the prior art, the inventors proposed the following technical solutions.

[0064] The present application embodiment provides an antenna sensor for monitoring biochemical indicators, such as Figure 1 As shown, including:

[0065] A flexible substrate 1; wherein the substrate 1 is made of a transparent material and is generally circular;

[0066] A radio frequency tag chip 2 operating in the first frequency band is disposed on the substrate 1, and the radio frequency tag chip 2 includes an RF interface and a GND interface; wherein the radio frequency tag chip 2 and the sensing area 4 are disposed adjacent to each other and are located inside the antenna 3 and at the center of the non-circular substrate 1;

[0067] A planar antenna 3 matching the first frequency band is disposed on the substrate 1, two ends of the antenna 3 are respectively connected to the RF interface and the GND interface, and the antenna 3 has a first performance parameter; wherein the antenna 3 is spiral-shaped and distributed near the peripheral side of the circular substrate 1;

[0068] A sensing region 4 modified with a sensitive group is disposed on the substrate 1, wherein the sensing region 4 comprises two signal terminals, which are respectively connected to the RF interface and the GND interface, wherein the sensitive group changes the physical properties of the sensing region 4 after binding / adsorbing biochemical substances, thereby affecting the first performance parameter of the antenna 3 to change into a second performance parameter;

[0069] Among them, the first frequency band matches the established frequency band of the mobile terminal's radio frequency communication, or matches the frequency band corresponding to the mobile terminal's short-range radio frequency communication function, so that the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through the antenna 3, and the electromagnetic waves cause electromagnetic induction in the antenna 3, thereby obtaining electrical energy, and emitting a radio frequency signal containing the identification in the radio frequency tag chip 2 through the antenna 3 based on the current second performance parameter.

[0070] In this way, the present application directly uses the antenna as a sensor, integrating the antenna and the sensing function, so no additional analog-to-digital / digital-to-analog converter, microcontroller or Bluetooth module is needed to process and transmit data, thereby reducing the number of internal components of the sensor, reducing costs, and significantly reducing the overall size, making it more suitable for application on miniaturized devices, and the flexible substrate makes it more suitable for application scenarios of wearable monitoring that needs to fit the human body. In addition, the sensor is self-powered by absorbing the energy emitted by the mobile terminal, and no longer relies on battery power, making the sensor smaller and lighter, and improving the portability of the sensor; furthermore, the sensor operates in a radio frequency band compatible with mobile terminals (such as smart phones), such as the NFC band or the UHF band, ensuring good compatibility with smart terminal devices, which enables the sensor to communicate efficiently with devices such as smart phones, and users can also edit the measured biochemical index values ​​displayed on the smart phone, supporting remote monitoring and real-time feedback.

[0071] In some embodiments, the sensor is a self-powered sensor or a flexible wearable sensor. The self-powered sensor is first introduced here, and the introduction of the flexible wearable sensor can be found below.

[0072] Specifically, the self-powered sensor obtains electrical energy by sensing the electromagnetic waves emitted by the mobile terminal through the antenna, without the need for external power or battery power, which significantly reduces the size and weight of the sensor, making it lighter and more portable. Since there is no need to replace batteries or external charging, the endurance of the self-powered sensor is greatly improved, which is particularly suitable for application scenarios that require long-term continuous monitoring.

[0073] In some embodiments, the flexible substrate 1 can be set to a polyimide (PI) material because it has excellent mechanical strength, thermal stability, chemical stability and electrical insulation properties. However, in addition to polyimide, there are several other materials that can be used as the flexible substrate 1, such as polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polycarbonate (PC). In practical applications, the selection of which material to use as the flexible substrate 1 needs to be determined according to the specific application scenario, and is not specifically limited here to meet the needs of different scenarios.

[0074] In some embodiments, the sensing area 4 includes: a one-dimensional line array, and signal terminals located on both sides of the line array. The line width and spacing of the line array are in the nanometer to micrometer level, and the line array is modified with sensitive groups.

[0075] For example, the width of each line in a line array can range from a few hundred nanometers to tens of micrometers;

[0076] The distance between two adjacent lines in the line array can be from hundreds of nanometers to tens of micrometers.

[0077] In addition, the sensitive groups can be specific antibodies, enzymes, receptors, etc. for specific biochemical substances. The sensitive groups can be fixed on the line array by chemical bonds, physical adsorption, etc. At the same time, the modification density of the sensitive groups can be adjusted according to the different detection targets to optimize the detection sensitivity.

[0078] It is worth noting that after the sensor is modified, that is, after the sensitive groups are modified on the linear array, the antenna can still match the NFC frequency band, UHF frequency band or specific frequency band.

[0079] Thus, the fineness of the line array allows the sensitive groups to be arranged more closely on the line array, increasing the number of sensitive groups per unit area, thereby improving the detection sensitivity of the target biochemical substances. In addition, the line width and spacing from nanometers to micrometers ensure the high precision of the sensing area 4, allowing the sensor to accurately reflect the changes in biochemical substances. Therefore, this fine design enables the sensor to achieve high-precision monitoring in a limited space.

[0080] In some embodiments, the sensor is generally circular with a diameter of 15 mm and a thickness of 0.11 mm.

[0081] In this way, due to the small size and light weight of the sensor, users can easily carry and use it, and it is suitable for various portable monitoring devices. In addition, the sensor can also be easily attached to the skin surface or wearable devices without complicated installation process.

[0082] In some embodiments, the RFID chip 2 includes an identification chip for assigning a unique number to each sensor, thereby performing parallel detection on sensors of different detection objects; the first frequency band matches the NFC frequency band, the UHF frequency band or a specific frequency band.

[0083] Specifically, the identification chip can give each sensor a unique EPC code, which means that each sensor is assigned a unique identity, so even when multiple sensors are working at the same time, the system can accurately distinguish each sensor. Secondly, through the EPC code, different sensors can be easily classified and managed. For example, sensors for monitoring blood sugar levels and sensors for monitoring heart rate.

[0084] It is worth noting that in actual applications, the sensor can not only work in NFC and UHF bands, but also in other frequency bands. For example, the specific frequency band is the ISM band (2.4GHz). In this case, the RFID tag chip is a chip corresponding to its frequency band.

[0085] In summary, the present application can select the required identification chip according to actual needs, and at the same time make the first frequency band match the corresponding frequency band, thereby improving the flexibility of the design to meet the needs of different scenarios.

[0086] In some embodiments, the physical properties of the sensing area 4 include at least one of the following: dielectric constant, equivalent resistance, equivalent capacitance, equivalent inductance;

[0087] The first performance parameter and the second performance parameter include at least one of the following: a reflection coefficient S11 of the antenna 3 , a resonant frequency of the antenna 3 , and a phase of the antenna 3 .

[0088] The reflection coefficient S11 of the antenna, the resonant frequency of the antenna, and the phase of the antenna are specifically introduced as follows.

[0089] Reflection coefficient S11: a parameter that measures the ratio of the reflected signal to the incident signal at the antenna input port. Specifically, when the physical characteristics of the sensing area change, the reflection coefficient S11 changes accordingly, which is reflected in the antenna as a change in the matching degree between the antenna and the feeder.

[0090] Resonant frequency: The frequency at which an antenna exhibits maximum gain or minimum loss at a specific frequency. Specifically, when the physical properties of the sensing area change, the resonant frequency of the antenna will change accordingly.

[0091] Phase: The phase angle of a signal propagating from an antenna at a specific frequency. Specifically, the phase of the antenna changes when the physical properties of the sensing area change.

[0092] For example, when the sensing area 4 absorbs specific biochemical substances, its dielectric constant increases or decreases, resulting in changes in the reflection coefficient S11, resonant frequency or phase of the antenna 3.

[0093] For another example, when the sensing area 4 adsorbs specific biochemical substances, the equivalent resistance of the sensing area 4 increases or decreases, affecting the reflection coefficient S11 of the antenna 3 .

[0094] For another example, when the sensing area 4 adsorbs specific biochemical substances, the equivalent capacitance of the sensing area 4 increases or decreases, affecting the resonant frequency and phase of the antenna 3 .

[0095] For another example, when the sensing area 4 adsorbs specific biochemical substances, the equivalent inductance of the sensing area 4 increases or decreases, affecting the resonant frequency and phase of the antenna 3 .

[0096] In this way, when the biochemical substances combine with the sensing area 4, the dielectric constant, equivalent resistance, equivalent capacitance or equivalent inductance of the sensing area 4 will change. The changes in these physical properties will further affect the performance parameters such as the reflection coefficient S11, resonant frequency or phase of the antenna 3, thereby accurately reflecting the presence of biochemical substances and realizing the detection of biochemical substances.

[0097] The present application also provides a system for monitoring biochemical indicators, such as Figure 2 As shown, it is characterized by comprising:

[0098] The antenna sensor 201 for monitoring biochemical indicators, after the sensitive group modified by the sensing area of ​​the sensor binds / adsorbs the biochemical substance, the antenna of the sensor is compatible with a first frequency band, and the first frequency band matches the established frequency band of the mobile terminal radio frequency communication, or matches the frequency band corresponding to the short-range radio frequency communication function of the mobile terminal;

[0099] The mobile terminal 202 has a predetermined frequency band for radio frequency communication including a first frequency band, or a short-range radio frequency communication function thereof uses the first frequency band; the mobile terminal is used to receive the radio frequency signal sent by the sensor when communicating with the sensor based on the first frequency band, identify the identifier in the radio frequency tag chip of the sensor and the current second performance parameter of the antenna, and determine the monitored biochemical index accordingly.

[0100] In this way, through the efficient communication between the sensor and the mobile terminal based on the first frequency band, real-time monitoring and data transmission of biochemical indicators are realized; the mobile terminal can receive the radio frequency signal sent by the sensor, and identify the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, so as to accurately determine the monitored biochemical indicators, ensure the reliability and real-time nature of the monitoring data, and improve the user experience and the practicality of the system.

[0101] The present application also provides a method for monitoring biochemical indicators, such as Figure 3 As shown, using the system for monitoring biochemical indicators, the method includes:

[0102] S301, after the sensor binds / adsorbs the biochemical substance through the sensitive group modified by the sensing region, the antenna of the sensor is compatible with the first frequency band, the first frequency band matches the established frequency band of the radio frequency communication of the mobile terminal, or matches the frequency band corresponding to the short-range radio frequency communication function of the mobile terminal, so that the physical characteristics of the sensing region are changed, thereby affecting the change of the current performance parameter of the antenna to the second performance parameter;

[0103] S302, when the distance between the mobile terminal and the sensor enters the range in which communication based on the first frequency band is possible, the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through its antenna, and the electromagnetic waves induce electromagnetic induction in the antenna, thereby obtaining electric energy, and emitting a radio frequency signal containing the identifier in the radio frequency tag chip through the antenna based on the current second performance parameter;

[0104] S303: The mobile terminal receives the radio frequency signal sent by the sensor, identifies the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, and determines the monitored biochemical index accordingly.

[0105] In this way, through the efficient communication between the sensor and the mobile terminal based on the first frequency band, real-time monitoring and data transmission of biochemical indicators are realized; the mobile terminal can receive the radio frequency signal sent by the sensor, and identify the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, so as to accurately determine the monitored biochemical indicators, ensure the reliability and real-time nature of the monitoring data, and improve the user experience and the practicality of the system.

[0106] In some embodiments, it also includes:

[0107] The mobile terminal determines the sensor used, the object monitored, or the location monitored based on the identification in the identified radio frequency tag chip.

[0108] Specifically, the identifier in the RFID tag chip has the following three functions.

[0109] Sensor identification: Through the identification in the RFID tag chip, the mobile terminal can identify the model and number of the specific sensor. Each sensor's identification is unique, ensuring the clarity of data ownership and facilitating the subsequent management of multiple sensors, such as classifying sensors.

[0110] Object identification: It can help determine the specific object that the sensor is monitoring, such as a patient's health indicators. The presence of the identifier makes it difficult for the data to be forged or tampered with, enhancing the security and authenticity of the data.

[0111] Location identification: It can be associated with a specific geographic location, allowing users to know the source location of the monitoring data, facilitating remote monitoring and positioning.

[0112] In this way, the mobile terminal determines the sensor to be used, the object to be monitored or the location to be monitored based on the identification in the identified radio frequency tag chip, which not only improves the flexibility and reliability of monitoring, but also makes data management more accurate.

[0113] In some embodiments, the sensor is a flexible wearable sensor;

[0114] The sensor is specifically arranged at one of the following positions: skin surface, eye surface, and subcutaneous.

[0115] Among them, the types of flexible wearable sensors can be divided into: patch sensors, contact lens sensors, and implantable sensors.

[0116] Patch sensors: sensors designed to be attached to the surface of the skin, suitable for monitoring blood sugar, body temperature, etc.

[0117] Contact lens sensors: Sensors integrated into contact lenses, suitable for monitoring intraocular pressure, tear composition, etc.

[0118] Implantable sensors: Sensors implanted into the body through minimally invasive surgery, suitable for monitoring blood sugar, drug concentrations, etc.

[0119] In this way, by setting sensors at these locations, non-invasive or minimally invasive monitoring of biochemical indicators can be achieved, which improves user comfort and acceptance; at the same time, this design enables the sensors to monitor biochemical indicators in real time and continuously. Whether it is a patch sensor on the skin surface, a contact lens sensor on the surface of the eye, or an implanted sensor under the skin, it can provide accurate data to ensure the reliability and timeliness of the monitoring results.

[0120] In order to more clearly illustrate the above method, the present application provides a specific embodiment.

[0121] This embodiment takes monitoring the concentration of Staphylococcus aureus solution as an example.

[0122] Step 1: adding a Staphylococcus aureus solution to the sensing area of ​​the sensor, wherein the sensing area is modified with a sensitive group that can specifically adsorb to Staphylococcus aureus;

[0123] Specifically, Staphylococcus aureus in the solution rapidly and specifically binds to the modified sensitive group on the sensing region, causing the physical properties of the sensing region to change, thereby affecting the first performance parameter of the antenna to change to the second performance parameter.

[0124] Step 2: When the sensor is close to the mobile terminal, the sensor matches the frequency band corresponding to the short-range radio frequency communication function of the mobile terminal, so that the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through the antenna. The electromagnetic waves cause electromagnetic induction in the antenna to obtain electrical energy, and transmit the radio frequency signal containing the identification in the radio frequency tag chip through the antenna based on the current second performance parameter.

[0125] Step 3: The mobile terminal receives the radio frequency signal sent by the sensor, and identifies the identifier in the radio frequency tag chip and the current second performance parameter of the antenna.

[0126] Among them, the identification in the radio frequency tag chip can determine the sensor used, the monitored object, or the monitored location.

[0127] Step 4: The mobile terminal determines the monitored biochemical index according to the pre-stored data analysis model;

[0128] Among them, the strength of the radio frequency signal received by the mobile terminal can reflect the state change of the sensor, that is, by analyzing the strength of the received radio frequency signal, the mobile terminal can infer the concentration or existence of biochemical substances. The dedicated application (APP) installed on the mobile terminal can display the schematic diagram of the biochemical indicators and radio frequency signals monitored by the sensor in real time. In this way, users can understand the monitoring results more intuitively.

[0129] Specifically, how to build a data analysis model is described below.

[0130] Prepare five groups of Staphylococcus aureus samples with different concentrations, 10 3 CFU / mL, 10 4 CFU / mL, 10 5 CFU / mL, 10 6 CFU / mL and 10 7 CFU / mL; the five groups of samples were added to the sensor area of ​​the sensor respectively, and a period of time was allowed for the samples to fully react with the sensor area. After the sensitive groups combined with / adsorbed the biochemical substances, the physical properties of the sensor area changed, which in turn affected the first performance parameter of the antenna to change to the second performance parameter, which was the S11 parameter. After the reaction was completed, the S11 parameters corresponding to the samples of different concentrations were analyzed to establish a mathematical relationship model between the S11 parameter and the concentration of Staphylococcus aureus, see Figure 4 The relationship curve between the S11 parameter value and the concentration of Staphylococcus aureus is shown.

[0131] exist Figure 4 Medium, concentration 10 3 The modulus parameter value of S11 corresponding to CFU / mL is 8.01245;

[0132] Concentration 10 4 The modulus parameter value of S11 corresponding to CFU / mL is 8.33257;

[0133] Concentration 10 5 The modulus parameter value of S11 corresponding to CFU / mL is 8.63964;

[0134] Concentration 10 6 The modulus parameter value of S11 corresponding to CFU / mL is 9.01062;

[0135] Concentration 10 7 The modulus parameter value of S11 corresponding to CFU / mL is 9.32993.

[0136] And, if Figure 5 shown in 10 5 Relationship between CFU / mL of Staphylococcus aureus solution and frequency.

[0137] Specifically, the S11 parameter is an indicator used to measure the size of the reflected wave. The smaller its value (the closer it is to 0), the higher the impedance matching between the antenna and the feeder, and the less reflected energy. When the impedance of the antenna and the feeder are completely matched, the reflection coefficient S11 reaches its minimum value, that is, Figure 5 Therefore, the S11 parameter value measured by the sensor is the absolute value of the S11 parameter value corresponding to the lowest point of the curve.

[0138] The reason for taking the absolute value of the S11 parameter is:

[0139] First, taking the absolute value can ensure that the result is a non-negative number, because the reflection coefficient represents the amplitude ratio of the reflected wave to the incident wave, which is a proportional value and should be a non-negative number.

[0140] Second, in practical applications, what we care about is the magnitude of the reflection coefficient, not its phase information. After taking the absolute value, it is easier to compare the magnitude of the reflection coefficient at different frequencies.

[0141] Third, in RF engineering, the standard representation of the S11 parameter is usually its amplitude value, not the complex value. After taking the absolute value, it can be directly used for subsequent data processing and analysis.

[0142] In summary, in step 4, the parameter value of the second performance parameter S11 can be substituted into the pre-established data analysis model to determine the concentration of Staphylococcus aureus.

[0143] In addition, the words "first, second, third, etc." or module A, module B, module C and other similar terms in the specification and claims are only used to distinguish similar objects and do not represent a specific ordering of the objects. It can be understood that the specific order or sequence can be interchanged where permitted so that the embodiments of the present application described herein can be implemented in an order other than that illustrated or described herein.

[0144] In the above description, the numbers representing the steps, such as S110, S120, etc., do not necessarily mean that the steps will be executed in this manner. If permitted, the order of the steps can be interchanged or they can be executed simultaneously.

[0145] The term "comprising" as used in the description and claims should not be interpreted as being limited to what is listed thereafter; it does not exclude other elements or steps. Therefore, it should be interpreted as specifying the presence of the features, integers, steps or components mentioned, but does not exclude the presence or addition of one or more other features, integers, steps or components and groups thereof. Therefore, the expression "a device comprising means A and B" should not be limited to a device consisting of components A and B only.

[0146] References to "one embodiment" or "an embodiment" in this specification mean that a particular feature, structure, or characteristic described in conjunction with the embodiment is included in at least one embodiment of the present application. Therefore, the phrases "in one embodiment" or "in an embodiment" appearing in various places in this specification do not necessarily refer to the same embodiment, but may refer to the same embodiment. In addition, in one or more embodiments, the particular features, structures, or characteristics can be combined in any appropriate manner, as would be apparent to one of ordinary skill in the art from this disclosure.

[0147] Note that the above are only preferred embodiments of the present application and the technical principles used. Those skilled in the art will understand that the present application is not limited to the specific embodiments described herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present application. Therefore, although the present application is described in more detail through the above embodiments, the present application is not limited to the above embodiments, and may also include more other equivalent embodiments without departing from the concept of the present application, all of which belong to the scope of protection of the present application.

Claims

1. An antenna sensor for monitoring biochemical indicators, characterized in that: include: A flexible substrate (1); A radio frequency tag chip (2) operating in a first frequency band is arranged on the substrate (1), and the radio frequency tag chip (2) comprises an RF interface and a GND interface; A planar antenna (3) matching the first frequency band is arranged on the substrate (1), two ends of the antenna (3) are respectively connected to the RF interface and the GND interface, and the antenna (3) has a first performance parameter; A sensing region (4) modified with a sensitive group is disposed on the substrate (1), wherein the sensing region (4) comprises two signal terminals, which are respectively connected to the RF interface and the GND interface, wherein the sensitive group changes the physical properties of the sensing region (4) after binding / adsorbing biochemical substances, thereby affecting the change of the first performance parameter of the antenna (3) into a second performance parameter; The first frequency band matches a predetermined frequency band of radio frequency communication of the mobile terminal, or matches a frequency band corresponding to a short-range radio frequency communication function of the mobile terminal, so that the sensor senses electromagnetic waves of the first frequency band emitted by the mobile terminal through the antenna (3), and the electromagnetic waves induce electromagnetic induction in the antenna (3), thereby obtaining electric energy, and emitting a radio frequency signal containing an identification in the radio frequency tag chip (2) through the antenna (3) based on the current second performance parameter.

2. The sensor according to claim 1, characterized in that The base (1) is made of a transparent material and is generally circular; The antenna (3) is spiral-shaped and is distributed on the peripheral side of the circular base (1); The radio frequency tag chip (2) and the sensing area (4) are arranged adjacent to each other and are located inside the antenna (3) and at the center of the non-circular base (1).

3. The sensor according to claim 1, characterized in that The sensing area (4) comprises: a one-dimensional line array and signal ends located on both sides of the line array. The line width and spacing of the line array are in the nanometer to micrometer level. The line array is modified with sensitive groups.

4. The sensor according to claim 2 or 3, characterized in that The sensor is circular in shape with a diameter of 15 mm and a thickness of 0.11 mm.

5. The sensor according to claim 1, characterized in that The radio frequency tag chip (2) comprises an identification chip, which is used to assign a unique number to each sensor, so as to perform parallel detection on sensors of different detection objects; the first frequency band matches the NFC frequency band, the UHF frequency band or a specific frequency band.

6. The sensor according to claim 1, characterized in that The physical properties of the sensing area (4) include at least one of the following: dielectric constant, equivalent resistance, equivalent capacitance, equivalent inductance; The first performance parameter and the second performance parameter include at least one of the following: a reflection coefficient S11 of the antenna (3), a resonant frequency of the antenna (3), and a phase of the antenna (3).

7. A system for monitoring biochemical indicators, characterized in that: include: The antenna-type sensor for monitoring biochemical indicators according to any one of claims 1 to 6, wherein after the sensitive group modified by the sensing region of the sensor binds / adsorbs the biochemical substance, the antenna of the sensor is compatible with a first frequency band, and the first frequency band matches a predetermined frequency band of radio frequency communication of the mobile terminal, or matches a frequency band corresponding to a short-range radio frequency communication function of the mobile terminal; A mobile terminal, whose established frequency band for radio frequency communication includes a first frequency band, or whose short-range radio frequency communication function uses the first frequency band; when the mobile terminal is used to communicate with the sensor based on the first frequency band, it receives the radio frequency signal sent by the sensor, identifies the identifier in the radio frequency tag chip of the sensor and the current second performance parameter of the antenna, and determines the monitored biochemical indicator based on this.

8. A method for monitoring biochemical indicators, characterized in that: Using the system for monitoring biochemical indicators according to claim 7, the method comprises: After the sensor binds / adsorbs the biochemical substance through the sensitive group modified by the sensing area, the antenna of the sensor is compatible with the first frequency band, and the first frequency band matches the established frequency band of the mobile terminal radio frequency communication, or matches the frequency band corresponding to the short-range radio frequency communication function of the mobile terminal, so that the physical characteristics of the sensing area are changed, thereby affecting the change of the current performance parameter of the antenna to the second performance parameter; When the distance between the mobile terminal and the sensor enters the range in which communication based on the first frequency band is possible, the sensor senses the electromagnetic waves of the first frequency band emitted by the mobile terminal through its antenna, and the electromagnetic waves induce electromagnetic induction in the antenna, thereby obtaining electric energy, and emitting a radio frequency signal containing the identification in the radio frequency tag chip through the antenna based on the current second performance parameter; The mobile terminal receives the radio frequency signal sent by the sensor, identifies the identifier in the radio frequency tag chip and the current second performance parameter of the antenna, and determines the monitored biochemical index accordingly.

9. The method according to claim 8, characterized in that Also includes: The mobile terminal determines the sensor used, the object monitored, or the location monitored based on the identification in the identified radio frequency tag chip.

10. The method according to claim 8, characterized in that The sensor is a flexible wearable sensor; The sensor is specifically arranged at one of the following positions: skin surface, eye surface, and subcutaneous.

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