Egg yolk globulin for relieving rhinitis and application thereof

By using the extracellular region sequences of IL-4, IL-5, IL-4Rα and IL-5Rα combined as immune antigens, the problem of difficulty in effectively alleviating rhinitis in the prior art is solved, the inhibition of allergic rhinitis-related indicators and the reduction of rhinitis symptoms is achieved, and new treatment methods are provided for rhinitis patients.

CN119638834AInactive Publication Date: 2025-03-18YOULIKANG (JIANGSU) BIOPHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202411947549.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-27
Publication Date
2025-03-18
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art is difficult to effectively alleviate rhinitis, especially in inhibiting the IL-4, IL-5 and IgE content and Th2 cell differentiation associated with allergic rhinitis.

Method used

Oral egg yolk globulin was prepared through the laying hen immune program to inhibit allergic rhinitis by combining the extracellular region sequences of IL-4, IL-5, IL-4Rα and IL-5Rα as immune antigens.

Benefits of technology

The egg yolk globulin can effectively inhibit the content of IL-4, IL-5 and IgE in mice, inhibit the differentiation of Th2 cells, reduce the symptoms of rhinitis, and provide a new treatment method for rhinitis patients.

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Abstract

The invention provides egg yolk globulin for relieving rhinitis as well as a preparation method and application of the egg yolk globulin. The egg yolk globulin can effectively inhibit the content of IL4, IL5 and IgE on the periphery of a mouse with allergic rhinitis, inhibit differentiation of Th2 cells and relieve rhinitis symptoms of the mouse. The preparation prepared by taking the egg yolk globulin as the raw material can effectively relieve rhinitis symptoms of people, such as nasal obstruction, running nose and rhinocnesmus. The preparation method of the specific egg yolk globulin is simple, safe and effective, and provides a new treatment means for rhinitis patients. Meanwhile, the egg yolk globulin can also be effectively used for adjuvant therapy of EBV positive nasopharynx cancer and gastric cancer, and has a relatively great application prospect.
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