Coaxial electrostatic spinning fiber scaffold preparation method
By using the coaxial electrospinning fiber support preparation method, the polylactic acid and polytrimethylene carbonate solution are stably coated through a coated charged nozzle, which solves the problem of unstable flow of the electrospinning solution and realizes the stability of the quality of the electrospinning fiber support.
Patent Information
- Application Number
- CN202411895027.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-21
- Publication Date
- 2025-03-25
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
During the spray forming process of existing electrospinning, the flow of the solution cannot be fully stable, resulting in the quality of the electrospinning bracket being affected.
The preparation method of coaxial electrospinning fiber support is adopted. By inputting the polylactic acid solution and the polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, the polytrimethylene carbonate solution is sprayed out in a straight line using the coated nozzle, and the polylactic acid solution is injected into the coated charged nozzle, so that the polylactic acid solution is stably coated on the surface of the polytrimethylene carbonate solution.
The discharged polytrimethylene carbonate solution drives the flow of the polylactic acid solution, keeping the quality of the electrospinned fiber stent stable, solving the problem of unstable solution flow.
Smart Images
Figure CN119686029A_ABST
Abstract
Description
Technical Field
[0001] The invention discloses a method for preparing a coaxial electrostatic spinning fiber bracket, and belongs to the technical field of electrostatic spinning brackets. Background Art
[0002] Electrospinning is a process that uses a high-voltage electrostatic field to charge a polymer solution or melt and further refine it into fibers. The diameter of these fibers can range from a few nanometers to a few microns. They are collected to form a fiber membrane or scaffold structure. This technology is particularly suitable for applications in tissue engineering and biomedicine because the morphology and properties of the fibers can be precisely controlled by adjusting various parameters.
[0003] The existing electrospinning scaffolds need to be prepared by spraying solutions through a charged syringe. However, when the nozzle of the syringe sprays two solutions, the flow of the fluid cannot remain completely stable. This results in the two fluids being unable to stably encapsulate the shell solution in the core solution during the flow process. This leads to defects in the prepared electrospinning and affects the quality of the formed electrospinning scaffold. Summary of the invention
[0004] The technical problem to be solved by the present invention is that the flow of the solution in the conventional electrostatic spinning of fluid cannot be kept completely stable during the ejection forming process.
[0005] To achieve the above object, the present invention provides the following technical solutions: A method for preparing a coaxial electrospinning fiber scaffold comprises the following steps: S1, firstly, a powdered polylactic acid resin is selected as a shell layer raw material, and then the shell layer raw material is put into a dichloromethane solution, heated and stirred, so that the polylactic acid resin is dissolved in the dichloromethane solution to prepare a polylactic acid solution, and the prepared polylactic acid solution is used as a shell layer solution for spinning fibers; S2, selecting a powdered polytrimethylene carbonate resin as a core layer raw material, then placing the core layer raw material into a dichloromethane solution, heating and stirring, so that the polytrimethylene carbonate resin is dissolved in the dichloromethane solution to prepare a polytrimethylene carbonate solution, and the prepared polytrimethylene carbonate solution is used as a core layer solution; S3, inputting the polylactic acid solution and the polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, and spraying the polytrimethylene carbonate solution in a straight line through the coated nozzle; S4. Simultaneously, the polylactic acid solution is injected into the coated charged nozzle to coat the surface of the polytrimethylene carbonate solution, and then the sprayed mixed solution is emitted onto a receiving plate to form fiber filaments.
[0006] The sheathed charged spray nozzle comprises a material box, the lower end of which is fixedly connected to the spray nozzle, the inner wall of which is fixedly connected to a fixing plate, a spray needle is embedded in the center of the fixing plate, the surface of the spray needle is fixedly connected to an electric connecting rod, the electric connecting rod extends to the outside of the spray nozzle, the outer wall of the spray nozzle is fixedly connected to a first material delivery pipe, and the upper end outer wall of the material box is fixedly connected to a second material delivery pipe.
[0007] As a preferred technical solution of the present invention, the concentration of the polylactic acid solution in step S1 is 13%, and the reaction temperature during the preparation of the polylactic acid solution is 110°C.
[0008] As a preferred technical solution of the present invention, the concentration of the polytrimethylene carbonate solution in step S2 is 10%, and the reaction temperature during the preparation of the polytrimethylene carbonate solution needs to be controlled between 20° C. and 25° C.
[0009] As a preferred technical solution of the present invention, the injection flow rate of the polylactic acid solution in step S1 is 0.1 ml / h.
[0010] As a preferred technical solution of the present invention, the injection flow rate of the polytrimethylene carbonate solution in step S2 is 0.2 ml / h.
[0011] As a preferred technical solution of the present invention, the voltage of the coated charged nozzle in step S3 is between 10.5-10.8Kv.
[0012] The beneficial effects achieved by the present invention are as follows: the present invention provides a method for preparing a coaxial electrospinning fiber scaffold, wherein the method comprises the following steps: inputting a polylactic acid solution and a polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, spraying the polytrimethylene carbonate solution in a straight line through the coated nozzle, injecting the polylactic acid solution into the coated charged nozzle at the same time, and then emitting the sprayed mixed solution onto a receiving plate to form fiber filaments, and driving the polylactic acid solution to flow through the sprayed polytrimethylene carbonate solution, so that the polylactic acid solution is stably coated on the surface of the polytrimethylene carbonate solution, thereby maintaining the quality of the electrospinning fiber scaffold stable. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 is a flow chart of the present invention; Figure 2 It is a schematic diagram of the structure of the encapsulated charged nozzle of the present invention.
[0014] In the figure: 1. material box; 2. nozzle; 3. fixing plate; 4. spray needle; 5. connecting pole; 6. first material delivery pipe; 7. second material delivery pipe. DETAILED DESCRIPTION
[0015] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0016] See also Figure 1-2 The present invention provides a technical solution: a method for preparing a coaxial electrospinning fiber scaffold, comprising the following steps: S1, firstly, a powdered polylactic acid resin is selected as a shell layer raw material, and then the shell layer raw material is put into a dichloromethane solution, heated and stirred, so that the polylactic acid resin is dissolved in the dichloromethane solution to prepare a polylactic acid solution, and the prepared polylactic acid solution is used as a shell layer solution for spinning fibers; Polylactic acid is a biocompatible material, which means it can coexist harmoniously with biological tissues without causing immune responses or toxicity. In addition, polylactic acid has good biodegradability and can gradually decompose into carbon dioxide and water in the natural environment, which is a very important property for medical and environmental applications. Polylactic acid has high strength and modulus, which enables it to maintain good mechanical properties when preparing nanofibers; S2, selecting a powdered polytrimethylene carbonate resin as a core layer raw material, then placing the core layer raw material into a dichloromethane solution, heating and stirring, so that the polytrimethylene carbonate resin is dissolved in the dichloromethane solution to prepare a polytrimethylene carbonate solution, and the prepared polytrimethylene carbonate solution is used as a core layer solution; Polytrimethylene carbonate has good biocompatibility and biodegradability, which makes it have broad application prospects in the biomedical field. At body temperature, polytrimethylene carbonate is in a rubbery state and has a certain elasticity, which is very important for some application scenarios that require elasticity. S3, inputting the polylactic acid solution and the polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, and spraying the polytrimethylene carbonate solution in a straight line through the coated nozzle; S4. Simultaneously, the polylactic acid solution is injected into the coated charged nozzle to coat the surface of the polytrimethylene carbonate solution, and then the sprayed mixed solution is emitted onto a receiving plate to form fiber filaments.
[0017] The sheathed charged spray nozzle comprises a material box 1, a spray nozzle 2 is fixedly connected to the lower end of the material box 1, a fixing plate 3 is fixedly connected to the inner wall of the material box 1, a spray needle 4 is embedded in the center of the fixing plate 3, a power connection rod 5 is fixedly connected to the surface of the spray needle 4, the power connection rod 5 extends to the outside of the spray nozzle 2, a first material delivery pipe 6 is fixedly connected to the outer wall of the spray nozzle 2, and a second material delivery pipe 7 is fixedly connected to the outer wall of the upper end of the material box 1.
[0018] As a preferred technical solution of the present invention, the concentration of the polylactic acid solution in step S1 is 13%, and the reaction temperature during the preparation of the polylactic acid solution is 110°C.
[0019] As a preferred technical solution of the present invention, the concentration of the polytrimethylene carbonate solution in step S2 is 10%, and the reaction temperature during the preparation of the polytrimethylene carbonate solution needs to be controlled between 20°C and 25°C.
[0020] As a preferred technical solution of the present invention, the injection flow rate of the polylactic acid solution in step S1 is 0.1 ml / h.
[0021] As a preferred technical solution of the present invention, the injection flow rate of the polytrimethylene carbonate solution in step S2 is 0.2 ml / h.
[0022] As a preferred technical solution of the present invention, the voltage of the coated charged nozzle in step S3 is between 10.5-10.8Kv.
[0023] Specifically, the method first selects powdered polylactic acid resin as a shell layer raw material, then puts the shell layer raw material into a dichloromethane solution, heats and stirs, so that the polylactic acid resin is dissolved in the dichloromethane solution to prepare a polylactic acid solution, and the prepared polylactic acid solution is used as a shell layer solution for spinning fibers, and selects powdered polytrimethylene carbonate resin as a core layer raw material, then puts the core layer raw material into a dichloromethane solution, heats and stirs, so that the polytrimethylene carbonate resin is dissolved in the dichloromethane solution to prepare a polytrimethylene carbonate solution, and the prepared polytrimethylene carbonate solution is used as a core layer solution. liquid, inputting the polylactic acid solution and the polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, spraying the polytrimethylene carbonate solution in a straight line through the coated nozzle, and injecting the polylactic acid solution into the coated charged nozzle at the same time, so that the polylactic acid solution is coated on the surface of the polytrimethylene carbonate solution, and then launching the sprayed mixed solution onto a receiving plate to form fiber filaments, and the polylactic acid solution is driven to flow by the sprayed polytrimethylene carbonate solution, so that the polylactic acid solution is stably coated on the surface of the polytrimethylene carbonate solution, so that the quality of the electrospun fiber scaffold remains stable.
[0024] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A method for preparing a coaxial electrospinning fiber scaffold, characterized in that: The following steps are involved: S1, firstly, a powdered polylactic acid resin is selected as a shell layer raw material, and then the shell layer raw material is put into a dichloromethane solution, heated and stirred, so that the polylactic acid resin is dissolved in the dichloromethane solution to prepare a polylactic acid solution, and the prepared polylactic acid solution is used as a shell layer solution for spinning fibers; S2, selecting a powdered polytrimethylene carbonate resin as a core layer raw material, then placing the core layer raw material into a dichloromethane solution, heating and stirring, so that the polytrimethylene carbonate resin is dissolved in the dichloromethane solution to prepare a polytrimethylene carbonate solution, and the prepared polytrimethylene carbonate solution is used as a core layer solution; S3, inputting the polylactic acid solution and the polytrimethylene carbonate solution into the same coated charged nozzle through two injectors, and spraying the polytrimethylene carbonate solution in a straight line through the coated nozzle; S4, simultaneously injecting the polylactic acid solution into the coated charged nozzle, so that the polylactic acid solution is coated on the surface of the polytrimethylene carbonate solution, and then the sprayed mixed solution is emitted onto a receiving plate to form fiber filaments; The enclosed charged spray head comprises a material box (1), the lower end of the material box (1) is fixedly connected to a spray head (2), the inner wall of the material box (1) is fixedly connected to a fixing plate (3), a spray needle (4) is embedded at the center of the fixing plate (3), a power connection rod (5) is fixedly connected to the surface of the spray needle (4), the power connection rod (5) extends to the outside of the spray head (2), a first material delivery pipe (6) is fixedly connected to the outer wall of the spray head (2), and a second material delivery pipe (7) is fixedly connected to the outer wall of the upper end of the material box (1).
2. The method for preparing a coaxial electrospinning fiber scaffold according to claim 1, characterized in that: The concentration of the polylactic acid solution in step S1 is 13%, and the reaction temperature during the preparation of the polylactic acid solution is 110°C.
3. The method for preparing a coaxial electrospinning fiber scaffold according to claim 1, characterized in that: The concentration of the polytrimethylene carbonate solution in step S2 is 10%, and the reaction temperature during the preparation of the polytrimethylene carbonate solution needs to be controlled between 20° C. and 25° C.
4. The method for preparing a coaxial electrospinning fiber scaffold according to claim 1, characterized in that: The injection flow rate of the polylactic acid solution in step S1 is 0.1 ml / h.
5. The method for preparing a coaxial electrospinning fiber scaffold according to claim 1, characterized in that: The injection flow rate of the polytrimethylene carbonate solution in step S2 is 0.2 ml / h.
6. The method for preparing a coaxial electrospinning fiber scaffold according to claim 1, characterized in that: In step S3, the voltage of the coated charged nozzle is between 10.5-10.8Kv.