Traditional Chinese medicine dropping pill for treating pharyngolaryngitis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine dropping pill for treating pharyngolaryngitis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. Comprising the following raw materials in parts by weight: 13-18 parts of glabrous sarcandra herb, 10-20 parts of radix tinosporae, 2-4 parts of scaphium scaphigerum, 3-5 parts of burdock, 3-5 parts of scutellaria baicalensis, 5-7 parts of liquorice, 4-6 parts of puffball, 4-6 parts of herba violae, 2-4 parts of oldenlandia diffusa, 3-5 parts of dandelion, 2-4 parts of houttuynia cordata, 1-3 parts of sculellaria barbata, 2-4 parts of saffron crocus, 1-3 parts of oenanthe rivularis, 0.3-0.5 part of borneol, 0.1-0.3 part of menthol and 0.1-0.2 part of sucralose. The traditional Chinese medicine dropping pill has the advantages of obvious effect on treating pharyngolaryngitis, good taste, quick effect, small side effect and convenience in taking.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and particularly to a traditional Chinese medicine dropping pill for treating pharyngeal inflammation and a preparation method thereof. Background Art

[0002] With the changes of autumn and winter seasons, the acceleration of the modern life rhythm, and the increase of pressures from work, life, etc., various colds, bacteria, viruses, and some physical and chemical factors (such as smoking, drinking, etc.) stimulation can cause inflammation in the pharynx and larynx of the human body, forming pharyngeal inflammation. As a common upper respiratory disease, pharyngeal inflammation is mainly manifested as sore throat, dryness, foreign body sensation, and is often accompanied by various symptoms such as cough and headache, seriously affecting people's normal life, work, and social interaction. If not treated in time, it will also induce other lesions.

[0003] At present, there are a wide variety of drugs for treating pharyngeal inflammation, mainly including antibiotics, anti-inflammatory drugs, and traditional Chinese medicine preparations. The abuse of antibiotics easily causes the problem of increasing drug resistance. The use of traditional anti-inflammatory drugs may bring side effects to the gastrointestinal tract. Traditional Chinese medicine preparations have unique advantages in treating pharyngeal inflammation, but there is still room for improvement in the efficacy and dosage form of existing traditional Chinese medicine preparations. For example, traditional Chinese medicine decoctions have disadvantages such as inconvenient taking, poor taste, and difficult preservation. It is in this situation that traditional Chinese medicine dropping pills came into being. Traditional Chinese medicine dropping pills are a new type of traditional Chinese medicine preparation, which have the advantages of rapid onset, high bioavailability, convenient taking, and good taste.

[0004] Due to the unreasonable composition formula of existing traditional Chinese medicine dropping pills for treating pharyngeal inflammation, the drug efficacy is not ideal, the onset is slow, the drug taste is poor, the patient's taking experience is poor, and it is difficult to adhere to taking. As a result, the treatment effect of patients is reduced, they cannot be completely cured, and the recurrence rate is greatly increased. For example, the Chinese invention patent with the authorization announcement number of CN102204971B discloses a traditional Chinese medicine preparation for treating oral and pharyngeal diseases and a preparation method thereof. It is prepared from licorice, bitter apricot kernels, radish seeds, platycodon grandiflorum, and excipients, and is mainly used for various clinically common pharyngeal discomfort such as acute and chronic pharyngitis, laryngitis, tonsillitis, sore throat, oral inflammation, oral ulcer, dry mouth and bitter taste. Compared with the prior art, this invention has the effects of clearing heat and detoxifying, clearing the voice and relieving sore throat, and detumescence and pain relief, and has a significant effect on treating oral and pharyngeal diseases without side effects and is safe to take. However, its onset is slow, and there is still room for further improvement in the efficacy and taste.

[0005] It can be seen that there is still a need in this field for a traditional Chinese medicine dropping pill for treating pharyngeal inflammation and a preparation method thereof, which have a significant treatment effect on pharyngeal inflammation, good taste, rapid onset, small side effects, and convenient taking. Summary of the Invention

[0006] The object of the present invention is to provide a traditional Chinese medicine dropping pill for treating pharyngeal inflammation, which has remarkable curative effect, good taste, quick effect, small side effects and convenient administration, and a preparation method thereof, so as to overcome the deficiencies of the prior art.

[0007] To achieve the above object, the technical solution adopted by the present invention is: a traditional Chinese medicine dropping pill for treating pharyngeal inflammation, which is made from the following raw materials in parts by weight: 13-18 parts of Sarcandra glabra, 10-20 parts of Tinospora capillipes, 2-4 parts of Sterculia lychnophora, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Glycyrrhiza uralensis, 4-6 parts of Lasiosphaera fenzlii, 4-6 parts of Viola philippica, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum mongolicum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Crocus sativus, 1-3 parts of Oenanthe rivularis, 0.3-0.5 part of Borneol, 0.1-0.3 part of Menthol, 0.1-0.2 part of Sucralose.

[0008] Preferably, the preparation raw materials of the traditional Chinese medicine dropping pill for treating pharyngeal inflammation further include: 5-7 parts of Isatis indigotica, 2-4 parts of Dracocephalum tanguticum, 2-4 parts of plant polysaccharide, 1-3 parts of honey, 2-4 parts of Platycodon grandiflorum, 0.5-0.8 part of Trollius chinensis, 3-6 parts of Forsythia suspensa.

[0009] Preferably, the plant polysaccharide is a mixture of Tremella polysaccharide, Ginkgo biloba polysaccharide and Schisandra chinensis polysaccharide in a mass ratio of 1:(0.8-1.2):(1-2).

[0010] Another object of the present invention is to provide a preparation method of the traditional Chinese medicine dropping pill for treating pharyngeal inflammation, which includes the following steps:

[0011] Step S1: Mix Sarcandra glabra, Tinospora capillipes, Sterculia lychnophora, Arctium lappa, Scutellaria baicalensis, Glycyrrhiza uralensis, Lasiosphaera fenzlii, Viola philippica, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Oenanthe rivularis, Isatis indigotica, Dracocephalum tanguticum, Platycodon grandiflorum, Trollius chinensis and Forsythia suspensa in parts by weight to obtain a mixed material, add water for decoction, filter, and extract the filter residue with ethanol; combine the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, concentrate under reduced pressure to recover ethanol and water, and obtain an extract with a relative density of 1.10-1.20; the extract is dried by vacuum drying technology and pulverized to obtain an extract powder;

[0012] Step S2: First, heat and melt the matrix, then add the extract powder, Borneol, Menthol, Sucralose, plant polysaccharide and honey, and stir evenly to obtain a medicinal liquid;

[0013] Step S3: Use modern traditional Chinese medicine dropping pill technology to obtain the specified dropping pills.

[0014] Preferably, in step S1, the mass ratio of the mixed material, water and ethanol is 1:(5-8):(6-10).

[0015] Preferably, the matrix described in step S2 is polyethylene glycol 6000.

[0016] Preferably, the mass ratio of the matrix to the extract powder in step S2 is (1.5 - 3):1.

[0017] Preferably, the decocting temperature in step S1 is 95 - 98°C.

[0018] Preferably, the extraction in step S1 is heating reflux extraction, extracting 2 times, 1 - 2 h each time, and combining the two extraction liquids.

[0019] Due to the application of the above technical solution, the present invention has the following beneficial effects:

[0020] (1) The preparation method of the traditional Chinese medicine dropping pills for treating pharyngeal inflammation disclosed by the present invention has simple process, convenient operation, high preparation efficiency and finished product qualification rate, low dependence on equipment, and little environmental impact, which is conducive to industrial continuous production, and the prepared dropping pills have high clinical popularization and application value.

[0021] (2) The traditional Chinese medicine dropping pills for treating pharyngeal inflammation disclosed by the present invention are made from the following raw materials in parts by weight: Sarcandra glabra 13 - 18 parts, Tinospora capillipes 10 - 20 parts, Sterculia lychnophora 2 - 4 parts, Arctium lappa 3 - 5 parts, Scutellaria baicalensis 3 - 5 parts, Glycyrrhiza uralensis 5 - 7 parts, Lasiosphaera fenzlii 4 - 6 parts, Viola philippica 4 - 6 parts, Hedyotis diffusa 2 - 4 parts, Taraxacum mongolicum 3 - 5 parts, Houttuynia cordata 2 - 4 parts, Scutellaria barbata 1 - 3 parts, Crocus sativus 2 - 4 parts, Oenanthe rivularis 1 - 3 parts, Borneol 0.3 - 0.5 parts, Menthol 0.1 - 0.3 parts, Sucralose 0.1 - 0.2 parts, Isatis indigotica 5 - 7 parts, Dracocephalum tanguticum 2 - 4 parts, Plant polysaccharide 2 - 4 parts, Honey 1 - 3 parts, Platycodon grandiflorum 2 - 4 parts, Trollius chinensis 0.5 - 0.8 parts, Forsythia suspensa 3 - 6 parts; through the reasonable compatibility of each raw material, the prepared product has a significant effect on treating pharyngeal inflammation, good taste, quick effect, small side effects, and convenient taking; the traditional treatment principles for pharyngeal inflammation mostly focus on clearing heat and detoxifying, while on the basis of clearing heat and detoxifying, the present invention pays attention to dispersing wind and relieving sore throat, regulating qi and blood, forming a treatment principle of "clearing, dispersing, and regulating" in one. The present invention follows the compatibility principle of "sovereign, ministerial, adjuvant, and guiding" in traditional Chinese medicine in the formulation, selects Sarcandra glabra, Tinospora capillipes, etc. as the sovereign drugs to clear heat and detoxify, Arctium lappa, Sterculia lychnophora, Menthol, etc. as the ministerial drugs to disperse wind and relieve sore throat, Glycyrrhiza uralensis, etc. as the adjuvant and guiding drugs to harmonize various drugs and enhance the drug effect. Such a compatibility not only conforms to traditional Chinese medicine theory but also has a synergistic effect.

[0022] (3) The traditional Chinese medicine dropping pills for treating pharyngeal inflammation disclosed by the present invention introduce medicinal materials with good curative effects but certain "toxicities" (such as burdock fruit, common globeflower, and fortune's drynaria rhizome) into the formula. Through compatibility with other medicinal materials, the toxicity is reduced while the curative effect is enhanced. Through the reasonable design of the formula, the traditional Chinese medicine dropping pills not only target the surface symptoms of pharyngeal inflammation (such as redness, swelling, and pain), but also fundamentally treat pharyngeal inflammation through multi-target effects such as regulating immunity, inhibiting inflammatory factors, and antibacterial effects.

[0023] (4) The traditional Chinese medicine dropping pills for treating pharyngeal inflammation disclosed by the present invention adopt the dropping pill dosage form, which has the advantages of rapid onset, high bioavailability, convenient administration, good taste, etc., significantly improving the compliance and treatment effect of patients. The added plant polysaccharides, sucralose, and honey can not only play a role in compatibility and detoxification, but also regulate immune function and improve the taste of the dropping pills, completely covering the bitter taste of medicinal materials such as fortune's drynaria rhizome; when polyethylene glycol 6000 is used as the matrix, other medicinal materials can be better mixed with polyethylene glycol, the dropping process is smoother, the produced dropping pills are round, smooth on the surface, and the pill weight is stable and controllable, and the dropping speed is also ideal, meeting the requirements of industrial production.

[0024] (5) The traditional Chinese medicine dropping pills for treating pharyngeal inflammation disclosed by the present invention provide a new solution for the treatment of pharyngeal inflammation through the scientific nature of the raw material formula, the uniqueness of the treatment principle, the advancement of the drug dosage form, and the synergistic effect of the technical effect, having important clinical significance and market value. Detailed implementation mode

[0025] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments in the following description are only examples, and those skilled in the art can think of other obvious variants.

[0026] Example 1

[0027] A traditional Chinese medicine dropping pill for treating pharyngeal inflammation is prepared from the following raw materials in parts by weight: 13 parts of fortune's drynaria rhizome, 10 parts of cape jasmine fruit, 2 parts of boat-fruited sterculia seed, 3 parts of burdock fruit, 3 parts of scutellaria baicalensis, 5 parts of liquorice, 4 parts of lasiosphaera fenzlii, 4 parts of viola philippica, 2 parts of oldenlandia diffusa, 3 parts of dandelion, 2 parts of houttuynia cordata, 1 part of barbata, 2 parts of saffron, 1 part of montpellier waterdropwort, 0.3 part of borneol, 0.1 part of menthol, 0.1 part of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0028] The preparation raw materials of the traditional Chinese medicine dropping pill for treating pharyngeal inflammation further include: 5 parts of isatis root, 2 parts of tibetan medicinal herb, 2 parts of plant polysaccharide, 1 part of honey, 2 parts of platycodon grandiflorum, 0.5 part of common globeflower, 3 parts of forsythia suspense; the plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:0.8:1.

[0029] A preparation method of the traditional Chinese medicine dropping pills for treating pharyngeal inflammation, comprising the following steps:

[0030] Step S1: Mix sarcandra glabra, tinospora capillipes, sterculia lychnophora, arctium lappa, scutellaria baicalensis, licorice, lasiosphaera fenzlii, viola philippica, oldenlandia diffusa, taraxacum mongolicum, houttuynia cordata, scutellaria barbata, crocus sativus, oenanthe rivularis, isatis root, dracocephalum tanguticum, platycodon grandiflorum, trollius chinensis, forsythia suspense according to parts by weight to obtain a mixed material, add water and decoct, filter, and add ethanol to the filter residue for extraction; combine the medicinal liquid obtained by filtering after decocting with the medicinal liquid obtained by filtering after ethanol extraction, and concentrate under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.10; the extract is dried by vacuum drying technology and pulverized to obtain an extract powder;

[0031] Step S2: First, heat and melt the matrix, then add the extract powder, borneol, menthol, sucralose, plant polysaccharide and honey, and stir evenly to obtain a medicinal liquid;

[0032] Step S3: Obtain the specified dropping pills by using modern traditional Chinese medicine dropping pill technology.

[0033] In step S1, the mass ratio of the mixed material, water and ethanol is 1:5:6; the decocting temperature in step S1 is 95 °C; the extraction in step S1 is heating reflux extraction, extracting 2 times, 1 h each time, and combining the two extraction liquids; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0034] Example 2

[0035] A traditional Chinese medicine dropping pill for treating pharyngeal inflammation, prepared from the following raw materials by parts by weight: 14 parts of sarcandra glabra, 12 parts of tinospora capillipes, 2.5 parts of sterculia lychnophora, 3.5 parts of arctium lappa, 3.5 parts of scutellaria baicalensis, 5.5 parts of licorice, 4.5 parts of lasiosphaera fenzlii, 4.5 parts of viola philippica, 2.5 parts of oldenlandia diffusa, 3.5 parts of taraxacum mongolicum, 2.5 parts of houttuynia cordata, 1.5 parts of scutellaria barbata, 2.5 parts of crocus sativus, 1.5 parts of oenanthe rivularis, 0.35 part of borneol, 0.15 part of menthol, 0.12 part of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0036] The preparation raw materials of the traditional Chinese medicine dropping pill for treating pharyngeal inflammation further include: 5.5 parts of isatis root, 2.5 parts of dracocephalum tanguticum, 2.5 parts of plant polysaccharide, 1.5 parts of honey, 2.5 parts of platycodon grandiflorum, 0.6 part of trollius chinensis, 4 parts of forsythia suspense; the plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide and schisandra chinensis polysaccharide in a mass ratio of 1:0.9:1.2.

[0037] A preparation method of the traditional Chinese medicine dropping pills for treating pharyngeal inflammation, comprising the following steps:

[0038] Step S1: Mix Sarcandra glabra, Tinospora capillipes, Sterculia lychnophora, Arctium lappa, Scutellaria baicalensis, Glycyrrhiza uralensis, Lasiosphaera fenzlii, Viola philippica, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Oenanthe rivularis, Isatis tinctoria, Dracocephalum tanguticum, Platycodon grandiflorus, Trollius chinensis, Forsythia suspense by weight to obtain a mixed material, add it to water for decoction, filter, and add ethanol to the filter residue for extraction; Combine the decoction liquid obtained by filtering after decoction and the decoction liquid obtained by filtering after ethanol extraction, and concentrate under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.13; The extract is dried using vacuum drying technology and pulverized to obtain an extract powder;

[0039] Step S2: First, heat the matrix until it melts, then add the extract powder, borneol, menthol, sucralose, plant polysaccharide, and honey, and stir evenly to obtain a liquid medicine;

[0040] Step S3: Use modern traditional Chinese medicine dropping pill technology to obtain the specified dropping pills.

[0041] In Step S1, the mass ratio of the mixed material, water, and ethanol is 1:6:7; The decoction temperature in Step S1 is 96°C; The extraction in Step S1 is heating reflux extraction, extracted 2 times, 1.2 hours each time, and the two extraction liquids are combined; The matrix in Step S2 is polyethylene glycol 6000; The mass ratio of the matrix to the extract powder in Step S2 is 2:1.

[0042] Example 3

[0043] A traditional Chinese medicine dropping pill for treating throat inflammation, which is made from the following raw materials by weight: 16 parts of Sarcandra glabra, 15 parts of Tinospora capillipes, 3 parts of Sterculia lychnophora, 4 parts of Arctium lappa, 4 parts of Scutellaria baicalensis, 6 parts of Glycyrrhiza uralensis, 5 parts of Lasiosphaera fenzlii, 5 parts of Viola philippica, 3 parts of Hedyotis diffusa, 4 parts of Taraxacum mongolicum, 3 parts of Houttuynia cordata, 2 parts of Scutellaria barbata, 3 parts of Crocus sativus, 2 parts of Oenanthe rivularis, 0.4 part of borneol, 0.2 part of menthol, 0.15 part of sucralose; The polyethylene glycol is polyethylene glycol 6000.

[0044] The preparation raw materials of the traditional Chinese medicine dropping pill for treating throat inflammation also include: 6 parts of Isatis tinctoria, 3 parts of Dracocephalum tanguticum, 3 parts of plant polysaccharide, 2 parts of honey, 3 parts of Platycodon grandiflorus, 0.65 part of Trollius chinensis, 4.5 parts of Forsythia suspense; The plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:1:1.5.

[0045] A preparation method of the traditional Chinese medicine dropping pill for treating throat inflammation, which includes the following steps:

[0046] Step S1: Mix Sarcandra glabra, Tinospora capillipes, Sterculia lychnophora, Arctium lappa, Scutellaria baicalensis, Glycyrrhiza uralensis, Lasiosphaera fenzlii, Viola philippica, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Oenanthe rivularis, Isatis tinctoria, Dracocephalum tanguticum, Platycodon grandiflorum, Trollius chinensis, Forsythia suspense according to parts by weight to obtain a mixed material, add water and decoct, filter, and extract the filter residue with ethanol; Combine the decoction liquid obtained by filtering after decoction and the decoction liquid obtained by filtering after ethanol extraction, and concentrate under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.15; The extract is dried using a vacuum drying technique and pulverized to obtain an extract powder;

[0047] Step S2: First, heat and melt the matrix, then add the extract powder, borneol, menthol, sucralose, plant polysaccharide, and honey, and stir evenly to obtain a liquid medicine;

[0048] Step S3: Use modern traditional Chinese medicine dropping pill technology to obtain the specified dropping pills.

[0049] In Step S1, the mass ratio of the mixed material, water, and ethanol is 1:6.5:8; The decocting temperature in Step S1 is 97°C; The extraction in Step S1 is heating reflux extraction, extracting 2 times, 1.5 hours each time, and combining the two extraction liquids; The matrix in Step S2 is polyethylene glycol 6000; The mass ratio of the matrix to the extract powder in Step S2 is 2:1.

[0050] Example 4

[0051] A traditional Chinese medicine dropping pill for treating throat inflammation is prepared from the following raw materials by weight: 17 parts of Sarcandra glabra, 18 parts of Tinospora capillipes, 3.5 parts of Sterculia lychnophora, 4.5 parts of Arctium lappa, 4.5 parts of Scutellaria baicalensis, 6.5 parts of Glycyrrhiza uralensis, 5.5 parts of Lasiosphaera fenzlii, 5.5 parts of Viola philippica, 3.5 parts of Hedyotis diffusa, 4.5 parts of Taraxacum mongolicum, 3.5 parts of Houttuynia cordata, 2.5 parts of Scutellaria barbata, 3.5 parts of Crocus sativus, 2.5 parts of Oenanthe rivularis, 0.45 parts of borneol, 0.25 parts of menthol, 0.18 parts of sucralose; The polyethylene glycol is polyethylene glycol 6000.

[0052] The preparation raw materials of the traditional Chinese medicine dropping pill for treating throat inflammation further include: 6.5 parts of Isatis tinctoria, 3.5 parts of Dracocephalum tanguticum, 3.5 parts of plant polysaccharide, 2.5 parts of honey, 3.5 parts of Platycodon grandiflorum, 0.75 parts of Trollius chinensis, 5.5 parts of Forsythia suspense; The plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:1.1:1.8.

[0053] A preparation method of the traditional Chinese medicine dropping pill for treating throat inflammation includes the following steps:

[0054] Step S1: Mix Sarcandra glabra, Tinospora capillipes, Sterculia lychnophora, Arctium lappa, Scutellaria baicalensis, Glycyrrhiza uralensis, Lasiosphaera fenzlii, Viola philippica, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Oenanthe rivularis, Isatis tinctoria, Dracocephalum tanguticum, Platycodon grandiflorum, Trollius chinensis, Forsythia suspensa by weight to obtain a mixed material. Add water and decoct, then filter. Add ethanol to the filter residue for extraction. Combine the decoction liquid obtained after filtration of the decoction with the extraction liquid obtained after filtration of the ethanol extraction, and concentrate under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.18. The extract is dried using vacuum drying technology and pulverized to obtain an extract powder.

[0055] Step S2: First, heat the matrix to melt it, then add the extract powder, borneol, menthol, sucralose, plant polysaccharide, and honey, and stir evenly to obtain a liquid medicine.

[0056] Step S3: Use modern traditional Chinese medicine dropping pill technology to obtain the specified dropping pills.

[0057] In step S1, the mass ratio of the mixed material, water, and ethanol is 1:7.5:9.5; the decocting temperature in step S1 is 97.5°C; the extraction in step S1 is heating reflux extraction, for 2 times, 1.8 hours each time, and the two extraction liquids are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0058] Example 5

[0059] A traditional Chinese medicine dropping pill for treating throat inflammation, which is made from the following raw materials by weight: 18 parts of Sarcandra glabra, 20 parts of Tinospora capillipes, 4 parts of Sterculia lychnophora, 5 parts of Arctium lappa, 5 parts of Scutellaria baicalensis, 7 parts of Glycyrrhiza uralensis, 6 parts of Lasiosphaera fenzlii, 6 parts of Viola philippica, 4 parts of Hedyotis diffusa, 5 parts of Taraxacum mongolicum, 4 parts of Houttuynia cordata, 3 parts of Scutellaria barbata, 4 parts of Crocus sativus, 3 parts of Oenanthe rivularis, 0.5 part of borneol, 0.3 part of menthol, 0.2 part of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0060] The preparation raw materials of the traditional Chinese medicine dropping pill for treating throat inflammation further include: 7 parts of Isatis tinctoria, 4 parts of Dracocephalum tanguticum, 4 parts of plant polysaccharide, 3 parts of honey, 4 parts of Platycodon grandiflorum, 0.8 part of Trollius chinensis, 6 parts of Forsythia suspensa; the plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:1.2:2.

[0061] A preparation method of the traditional Chinese medicine dropping pill for treating throat inflammation, which includes the following steps:

[0062] Step S1: Mix Sarcandra glabra, Tinospora capillipes, Sterculia lychnophora, Arctium lappa, Scutellaria baicalensis, Glycyrrhiza uralensis, Lasiosphaera fenzlii, Viola philippica, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Oenanthe rivularis, Isatis tinctoria, Dracocephalum tanguticum, Platycodon grandiflorum, Trollius chinensis, Forsythia suspense by weight to obtain a mixed material, add water and decoct, filter, and extract the filter residue with ethanol; combine the decoction liquid obtained by filtering after decoction and the decoction liquid obtained by filtering after ethanol extraction, concentrate under reduced pressure to recover ethanol and water, and obtain an extract with a relative density of 1.20; dry the extract using vacuum drying technology and pulverize to obtain extract powder;

[0063] Step S2: First, heat the matrix to melt it, then add the extract powder, borneol, menthol, sucralose, plant polysaccharide, and honey, and stir evenly to obtain a liquid medicine;

[0064] Step S3: Use modern traditional Chinese medicine dropping pill technology to obtain the specified dropping pills.

[0065] In Step S1, the mass ratio of the mixed material, water, and ethanol is 1:8:10; the decocting temperature in Step S1 is 98°C; the extraction in Step S1 is heating reflux extraction, extracting 2 times, 2 hours each time, and combining the two extraction liquids; the matrix in Step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in Step S2 is 2:1.

[0066] Comparative Example 1

[0067] A traditional Chinese medicine dropping pill for treating throat inflammation and its preparation method are basically the same as those in Example 1, except that plant polysaccharide, Oenanthe rivularis, and Crocus sativus are not added.

[0068] Comparative Example 2

[0069] A traditional Chinese medicine dropping pill for treating throat inflammation and its preparation method are basically the same as those in Example 1, except that Scutellaria barbata, Arctium lappa, and Lasiosphaera fenzlii are not added.

[0070] Comparative Example 3

[0071] A traditional Chinese medicine dropping pill for treating throat inflammation and its preparation method are basically the same as those in Example 1, except that an equal amount of Sarcandra glabra is used to replace Tinospora capillipes.

[0072] Comparative Example 4

[0073] A traditional Chinese medicine dropping pill for treating throat inflammation and its preparation method are basically the same as those in Example 1, except that an equal amount of Tinospora capillipes is used to replace Sarcandra glabra.

[0074] To further illustrate the beneficial technical effects of the traditional Chinese medicine dropping pills for treating throat inflammation involved in each embodiment of the present invention, relevant performance tests are carried out on the traditional Chinese medicine dropping pills for treating throat inflammation involved in Examples 1-5 and Comparative Examples 1-4. The test methods are as follows:

[0075] (1) Clinical data:

[0076] Taking acute and chronic pharyngitis as an example, 270 cases were solicited from the society for clinical observation. They were evenly divided into 9 groups, corresponding to Examples 1-5 and Comparative Examples 1-4 respectively. The standard for traditional Chinese medicine diagnosis of acute and chronic pharyngitis was selected.

[0077] Symptoms of acute pharyngitis: At the initial stage of acute pharyngitis, there will be a feeling of dryness and burning in the pharynx, and gradually pain symptoms will occur. Sometimes even swallowing saliva will cause discomfort in the throat pain, and some patients will be accompanied by symptoms such as fever and headache. Due to physical discomfort, they will also have a loss of appetite and can't eat. There will also be soreness in the limbs of the body.

[0078] Symptoms of chronic pharyngitis: The main symptoms are discomfort in the pharynx, as well as symptoms such as dryness, itching, and swelling. Chronic pharyngitis will have obvious symptoms of increased secretions, with symptoms of burning and pain, and it is very easy to cause retching and burning pain. Even brushing teeth or walking in a hurry can cause retching. Sometimes when drinking less water, there will be an obvious foreign body sensation in the throat, wanting to cough but unable to cough out, yet also unable to swallow; when talking too much, the symptoms of dry itching and foreign body sensation in the throat are more severe.

[0079] Finally, there were 6 cases of acute pharyngitis patients in each group (5 males and 1 female), and 24 cases of chronic pharyngitis patients (18 males and 6 females), all without other serious diseases, with an average age of 43 years.

[0080] Efficacy determination:

[0081] 1) There is a significant effect: The burning and pain in the throat are significantly reduced, the symptoms of fever, headache, and limb soreness are significantly improved, and the symptoms of dry itching and swelling in the throat are greatly improved.

[0082] 2) There is an effect: The swelling and pain in the throat are relieved to some extent, and the dry itching and swelling in the throat are improved.

[0083] 3) Ineffective: The symptoms of acute and chronic pharyngitis are not reduced, and even worsened.

[0084] 4) There are adverse reactions: There are adverse reactions such as diarrhea and vomiting after taking.

[0085] During the clinical experiment, other medications and health care nutritional products were stopped for comparison. Taking this specification of dripping pills and observing for 14 days was regarded as one course of treatment. Administration method: 3 times a day, 4 pills each time, and each pill is 0.5 g. The clinical experiment results are shown in Tables 1-2. Table 1 is the clinical experiment result of Example 1 of the present invention, and Table 2 is the effective rate calculated based on the statistical calculation of each case's clinical experiment results.

[0086] Table 1 Clinical experiment results of the product of Example 1

[0087]

[0088] As can be seen from Table 1, among the 30 patients in the clinical trial of Example 1 group, 21 had significant effects, 9 had effects, 0 had no effects, no adverse reaction cases occurred, and no psychological resistance to drug taking was generated. The total effective rate was 100%.

[0089] Table 2 Effective Rate of Clinical Trial

[0090]

[0091] As can be seen from Table 2, the traditional Chinese medicine dropping pills for treating throat inflammation involved in the embodiments of the present invention have better curative effects than the products of the comparative examples; the combined use of plant polysaccharides, Oenanthe rivularis, saffron, Scutellaria barbata, Arctium lappa, Lasiosphaera fenzlii, Tinospora sagittata and Sarcandra glabra is beneficial to improving the above performance.

[0092] The above embodiments are only used to illustrate the technical concept and characteristics of the present invention, and the purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it accordingly. It cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit and essence of the present invention should be covered within the protection scope of the present invention.

Claims

1. A Chinese medicine pill for treating pharyngitis, characterized in that: The invention comprises the following raw materials in parts by weight: 13-18 parts of Sarcandra scabra, 10-20 parts of Olea europaea, 2-4 parts of Sterculia lychnophora, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Licorice, 4-6 parts of Puffball, 4-6 parts of Viola yedoensis, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Saffron, 1-3 parts of Water celery, 0.3-0.5 parts of Artemisia annua tablets, 0.1-0.3 parts of menthol and 0.1-0.2 parts of sucralose.

2. The Chinese medicine dripping pill for treating pharyngitis according to claim 1, characterized in that: The raw materials for preparing the Chinese medicine pills for treating pharyngitis also include: 5-7 parts of Radix Isatidis, 2-4 parts of Radix Glycyrrhizae, 2-4 parts of plant polysaccharides, 1-3 parts of honey, 2-4 parts of Platycodon grandiflorum, 0.5-0.8 parts of Nasturtium, and 3-6 parts of Forsythia suspensa.

3. The Chinese medicine dripping pill for treating pharyngitis according to claim 2, characterized in that: The plant polysaccharide is prepared by mixing Tremella polysaccharide, Ginkgo biloba polysaccharide and Schisandra chinensis polysaccharide in a mass ratio of 1:(0.8-1.2):(1-2).

4. A method for preparing the Chinese medicine pills for treating pharyngitis according to any one of claims 2-3, characterized in that: The steps include: Step S1, mixing Sargassum sutchuenensis, Oleander, Sterculia lychnophora, Fructus Arctii, Radix Scutellariae, Radix Glycyrrhizae, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum officinale, Houttuynia cordata, Scutellaria barbata, Saffron, Water celery, Radix Isatidis, Radix Glycyrrhizae, Platycodon grandiflorum, Trollius, and Fructus Forsythiae according to weight portions to obtain a mixed material, adding the mixed material into water for decoction, filtering, taking the filter residue for extraction with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, concentrating under reduced pressure to recover ethanol and water, and obtaining an extract with a relative density of 1.10-1.20; drying the extract by vacuum drying technology, and crushing to obtain an extract powder; Step S2, first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution; Step S3, using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

5. The method for preparing the Chinese medicine dripping pill for treating pharyngitis according to claim 4, characterized in that: The mass ratio of the mixed material, water and ethanol in step S1 is 1:(5-8):(6-10).

6. The method for preparing the Chinese medicine dripping pill for treating pharyngitis according to claim 4, characterized in that: The matrix is ​​polyethylene glycol 6000.

7. The method for preparing the Chinese medicine dripping pills for treating pharyngitis according to claim 4, characterized in that: The mass ratio of the matrix to the extract powder is (1.5-3):

1.

8. The method for preparing the Chinese medicine dripping pills for treating pharyngitis according to claim 4, characterized in that: The decoction temperature in step S1 is 95-98°C.

9. The method for preparing the Chinese medicine dripping pills for treating pharyngitis according to claim 4, characterized in that: The extraction in step S1 is a heating reflux extraction, which is performed twice, each time for 1-2 hours, and the two extracts are combined.

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