Preparation system for improving homogeneity of paeoniflorin dropping pills

Abstract

The invention relates to the field of dropping pill preparation, and discloses a preparation system for improving the homogeneity of paeoniflorin dropping pills, which comprises a liquid medicine tank, a dripping nozzle and a cooling tank, an air bag assembly is arranged in the cooling tank, the top of the air bag assembly penetrates through the top of the cooling tank to be connected with an air outlet pipe, the bottom of the air bag assembly penetrates through the cooling tank to be connected with an input motor, and the input motor quantitatively introduces a cooling medium into the air bag assembly to enable space above cooling liquid to form a pre-cooling area; the bottom of the air bag assembly can be arranged on the cooling liquid in a floating mode, and along with dropping of liquid drops, the air bag assembly is arranged on the cooling liquid in a pressing mode to reduce liquid level fluctuation. The cooling area is arranged in the dropping process of the dropping pill, the height of the cooling area is variable, the outer layer of the liquid drop is firstly cooled in air to form a thin-layer hard shell, the scattering and bouncing situation possibly existing when the liquid drop is in contact with cooling liquid is reduced, the homogeneity degree of the dropping pill is improved, and the dropping speed is increased. And meanwhile, the influence of ripples generated after the liquid drops enter the liquid level of the cooling liquid on the next liquid drops is reduced.

Description

Technical Field

[0001] The present invention relates to the field of drop pill preparation, and in particular to a preparation system for improving the homogeneity of paeoniflorin drop pills. Background Art

[0002] Compared to the compression-based manufacturing method, the advantages of drop pills are low automation, high production efficiency, and rapid product formation. They are typically made by mixing the drug with a matrix, heating it to a liquid, and then dripping it into a coolant to form the pills. Existing drop pill machines are capable of automatically dripping and discharging the drug solution. However, conventional drop pill machines also have significant drawbacks: large variations in weight and shape of the individual pills, poor roundness, and difficulty in control.

[0003] The main reasons for the large differences in the form and quality of the above-mentioned pills are: 1. When the liquid medicine is dripped into the coolant, it is in a liquid state with a higher temperature. During the dripping process, the surface tension of the coolant causes the droplets to decompose, resulting in a decrease in the quality of the pills. 2. When the liquid medicine is dripped into the coolant, the liquid surface fluctuates due to the dripping of the droplets. When the dripping speed is too fast, the dripping angle of the pills will be different. The resistance of the pills will increase when they are dripped, causing the pills to tail and have poor roundness.

[0004] Differences in quality and roundness will not only affect the assembly of the drug, but also, for the fast-acting paeoniflorin drops, the difference in the quality of the pill monomers will also affect the effect of subsequent treatment.

[0005] Therefore, a preparation system for improving the homogeneity of paeoniflorin dropping pills is currently needed, so that the homogeneity and roundness of the paeoniflorin dropping pills after cooling are greatly improved. Summary of the Invention

[0006] The object of the present invention is to provide a preparation system for improving the homogeneity of paeoniflorin dropping pills, so as to solve the technical problems in the prior art that droplets are easily decomposed when dripping and the coolant level is unstable.

[0007] In order to solve the above technical problems, the present invention specifically provides the following technical solutions: The present invention provides a preparation system for improving the homogeneity of paeoniflorin dropping pills, comprising a mounting bracket, a medicine liquid tank being provided on the top of the mounting bracket, a cooling tank being provided on the bottom of the mounting bracket, the medicine liquid tank being connected to the cooling tank via a drip nozzle, a cooling liquid being provided in the cooling tank, the medicine liquid melted in the medicine liquid tank being able to drip into the cooling tank via the drip nozzle, the medicine liquid forming spherical droplets falling into the cooling liquid and solidifying into shape, and a discharger being provided at the bottom of the cooling tank; The cooling tank is provided with an airbag assembly, the top of the airbag assembly is connected to an air outlet pipe through the top of the cooling tank, and the bottom of the airbag assembly is connected to an input motor through the cooling tank. The input motor quantitatively introduces cooling medium into the airbag assembly so that the space above the coolant forms a pre-cooling zone; The bottom of the airbag assembly can be floated on the coolant, and as the liquid drops drip in, the airbag assembly is pressed on the coolant to reduce the fluctuation of the liquid level.

[0008] As a preferred embodiment of the present invention, the airbag assembly includes a shrinkable airbag, the top end of which is connected to the outlet pipe via a quantitative outlet valve, and the quantitative outlet valve is used to release the cooling medium in the shrinkable airbag to the outlet pipe at a constant speed.

[0009] As a preferred solution of the present invention, the shrinkage airbag is made of elastic rubber.

[0010] As a preferred solution of the present invention, the shrinkable airbag is a spring-shaped annular structure, and a shrinkage component is provided on the shrinkable airbag, and the shrinkage component can compress the height of the shrinkable airbag in the cooling tank.

[0011] As a preferred solution of the present invention, the shrinking assembly includes a first pressure ring arranged on the top of the shrinking airbag and a second pressure ring arranged on the bottom of the shrinking airbag, and the first pressure ring and the second pressure ring are fixed to the shrinking airbag by a fixing belt; The first pressure ring and the second pressure ring are connected together by an elastic pull rope. As the cooling medium flows into the shrinking airbag, the distance between the first pressure ring and the second pressure ring increases, and the elastic pull rope accumulates elastic potential energy.

[0012] As a preferred solution of the present invention, a plurality of elastic pull ropes are provided, and the plurality of elastic pull ropes are arranged on the circumference of the first pressure ring and the second pressure ring, and the shrink airbag is surrounded by the elastic pull ropes.

[0013] As a preferred solution of the present invention, a flow pipe is provided on the side of the cooling tank protruding outward, the flow pipe is connected to a surplus tank, and the flow pipe is arranged at the standard height position of the coolant. When the coolant in the cooling tank exceeds the standard height, the coolant flows into the surplus tank through the flow pipe.

[0014] As a preferred solution of the present invention, the residual tank and the cooling tank are both made of transparent materials.

[0015] As a preferred solution of the present invention, a sealing cover body is provided between the cooling tank and the drip nozzle, the sealing cover body is fixedly installed on the drip nozzle, the peripheral side of the sealing cover body is slidably installed in the cooling tank, a sealing ring is provided between the sealing cover body and the inner wall of the cooling tank, and the air outlet pipe is provided through the sealing cover body.

[0016] As a preferred solution of the present invention, the air outlet pipe is made of soft material.

[0017] Compared with the prior art, the present invention has the following beneficial effects: The present invention provides a spring-shaped cooling airbag above the liquid surface of the coolant. The cooling airbag surrounds the inner wall of the cooling tank to form a cooling zone. The liquid medicine can pass through the cooling zone for pre-cooling during the droplet addition process, so that the outer layer of the droplets is first cooled in the air to form a thin hard shell, thereby reducing the dispersion and bouncing that may occur when the droplets come into contact with the coolant, and improving the homogeneity of the droplets. The cooling airbag of the present invention floats in an annular shape on the surface of the coolant, which facilitates maintaining a constant air pressure in the dripping space and ensuring that the air pressure in the annular cooling zone is a constant value. As the droplets drip into the coolant, the airbag assembly is pressed against the coolant to reduce liquid surface fluctuations, thereby reducing the impact of ripples generated by the droplets entering the coolant surface on the next droplet, ensuring that the dripping angle of each droplet is constant, thereby improving the homogeneity of the pills. The height of the cooling airbag of the present invention can be changed with the flow rate of the medium, so that the height of the cooling zone can be adjusted to adapt to various drop distances, thereby optimizing the preparation process of the drop pills by combining single-factor investigation and orthogonal experimental design, providing an experimental basis for further quality standard research and clinical application of paeoniflorin drop pills. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the embodiments or the description of the prior art. Obviously, the drawings described below are merely exemplary, and those skilled in the art can derive other implementation drawings based on the provided drawings without inventive effort.

[0019] Figure 1 The present invention provides a schematic structural diagram of a preparation system for improving the homogeneity of paeoniflorin dropping pills; Figure 2 The present invention provides Figure 1 A schematic structural diagram of the airbag assembly of the illustrated embodiment; Figure 3 The present invention provides Figure 1 A schematic diagram of the front structure of the airbag assembly of the illustrated embodiment.

[0020] The numbers in the figure represent the following: 1-Mounting bracket; 2-Medicine tank; 3-Cooling tank; 4-Drip nozzle; 5-Airbag assembly; 6-Exhaust pipe; 7-Input motor; 8-Discharge machine; 9-Circulation pipe; 10-Residual tank; 11-Sealing cover; 12-Sealing ring; 501- shrinking airbag; 502- quantitative air outlet valve; 503- shrinking component; 5031-first pressure ring; 5032-second pressure ring; 5033-fixing belt; 5034-elastic drawstring. DETAILED DESCRIPTION

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0022] The present invention is based on a preparation process for improving the homogeneity of paeoniflorin dropping pills, comprising the following steps: According to the mass ratio, PEG4000 and PEG6000 were mixed at a mass ratio of 1:1 to obtain a composite matrix; The paeoniflorin powder and the composite matrix were mixed at a mass ratio of 1:4, heated to 90°C, and mixed evenly to obtain a drug solution; The drug solution is dripped into dimethyl silicone oil at a temperature of 10-15° C. at a dripping rate of 10-30 d / min, and the drug solution is cooled in the dimethyl silicone oil and formed into a spherical shape to prepare paeoniflorin dripping pills; During the pill dropping process, air (cold air) containing a small amount of liquid nitrogen is passed into the dimethyl silicone oil in a circular manner, so that the space above the dimethyl silicone oil forms an annular cooling zone. The annular cooling zone is set on the upper surface of the dimethyl silicone oil to keep the dimethyl silicone oil liquid level stable.

[0023] The air temperature between the drug solution and the dimethyl silicone oil drops, and the annular cooling zone can cool the temperature of the dimethyl silicone oil to prevent the temperature of the dimethyl silicone oil from rising. At the same time, the annular cooling can reduce the air temperature on the surface of the dimethyl silicone oil and pre-cool the drug droplets, so that the drug solution can be initially shaped before entering the dimethyl silicone oil.

[0024] Compared with the general cooling method (external cooling), annular cooling can be a floating pipe set on the side of the coolant (built-in cooling). When inputting cooling gas, annular cooling mainly targets the side of the cooling zone, which is convenient for maintaining the constant air pressure in the dripping space. It can reduce the impact of gas on the dripping speed and dripping angle of the liquid during the input process, ensure that the air pressure in the annular cooling zone is a constant value, and at the same time can quickly calm the liquid surface of the coolant, keep the coolant surface stable, and reduce the impact of ripples generated by the droplet after entering the coolant surface on the next droplet.

[0025] In the method disclosed in the present invention, multiple conditions such as the matrix type, matrix ratio, melting temperature, dripping rate, dripping distance, coolant type, and coolant temperature that need to be selected during the preparation process of paeoniflorin droplets are provided, thereby reducing the deformation of the drug droplets at the moment of entering the coolant, enabling rapid cooling and forming in the coolant, and the droplets have a moderate sedimentation rate. The final droplets have no adhesion, good roundness, little tailing, and good gloss.

[0026] After testing, the temperature of the annular cooling zone is optimally 0-5°C, while the temperature of the dimethyl silicone oil can be maintained between 10-15°C. The air pressure in the annular cooling zone is 2-3 times the standard atmospheric pressure.

[0027] The preparation conditions of the dropping pills are described below through a number of examples: Example 1 Take PEG4000 matrix and PEG6000 matrix, place them in a beaker at a mass ratio of 1:1, heat and stir in a water bath at a certain temperature until they melt, and obtain 1 composite matrix; Add one-quarter of the paeoniflorin powder to the water bath, stir until evenly mixed, keep warm and let stand for 15 minutes, then pour into a pellet machine preheated to 90°C; Cool the dimethyl silicone oil in the pill machine to 10°C, introduce air containing liquid nitrogen into the pill machine, and control the deflation speed to keep it at 0-10°C and 2-3 times the standard atmospheric pressure (approximately). Keep the drop distance at 8 cm, control the drop pill machine drop speed at 30d / min, drop the medicine solution into the coolant, collect the drop pills, absorb the residual liquid of the drop pills with filter paper, dry, and collect the pills.

[0028] Example 2: The operation was the same as in Example 1, except that the dripping rate was 10 d / min.

[0029] Example 3: The operation was the same as in Example 1, except that the temperature of the dimethyl silicone oil (i.e., the cooling temperature) was 15°C.

[0030] Example 4: The operation was the same as in Example 1, except that the drop distance was 10 cm.

[0031] Comparative Example 1: The operation was the same as in Example 1, except that the mass ratio of PEG4000 matrix to PEG6000 matrix was 3:1.

[0032] Comparative Example 2: The operation was the same as in Example 1, except that the mass ratio of the PEG4000 matrix to the PEG6000 matrix was 2:1.

[0033] Comparative Example 3: The operation was the same as that in Example 1, except that the mass ratio of paeoniflorin powder to the composite matrix was 1:1.

[0034] Comparative Example 4: The operation was the same as in Example 1, except that the mass ratio of paeoniflorin powder to the composite matrix was 1:2.

[0035] Comparative Example 5: The operation was the same as in Example 1, except that the temperature of the dimethyl silicone oil (i.e., the cooling temperature) was 5°C.

[0036] Comparative Example 6: The operation was the same as in Example 1, except that the temperature of the dimethyl silicone oil (i.e., the cooling temperature) was 20°C.

[0037] Comparative Example 7: The operation was the same as in Example 1, except that the drop distance was 15 cm.

[0038] Comparative Example 8: The operation was the same as in Example 1, except that the dripping rate was 50 d / min.

[0039] Comparative Example 9: The operation was the same as in Example 1, except that the dripping rate was 70 d / min.

[0040] Characterization: A single-factor experiment was used to screen suitable conditions from the aspects of coolant, cooling temperature, drop distance, and drop rate. The judgment criteria were the appearance indicators of the pills: hardness, roundness, tailing, adhesion, and gloss. The appearance indicator evaluation score table is shown in Table 1. The comprehensive score is the sum of the scores of each item.

[0041] The following is a comparison of the results of the examples and the comparative examples. See Table 2 for details. Table 2 shows the effects of different cooling temperatures, drop distances, and drop speeds on the formation of the drop pills. On the basis of single factor comparison, considering the influencing factors of the preparation process of the pellets, the three factors A-PEG4000:PEG6000 ratio, factor B-drug:matrix ratio, and factor C-liquid temperature were determined to design an orthogonal experiment. Referring to the results of the preliminary experiment, three levels were designed for each factor. The coefficient of difference of pill weight and dissolution time were used as the two parameters for investigation. The L9(34) orthogonal experiment was designed. The factor level table is shown in Table 3. The orthogonal design analysis was performed using the Orthogonal Experiment Assistant IIV3.1. The orthogonal experiment results are shown in Table 4. The variance analysis is shown in Tables 5 and 6.

[0042] Visual analysis of the orthogonal table reveals that, using the coefficient of variation of pellet weight as the evaluation metric, the influence of the three factors is B > A > C, A1 > A2 ≈ A3, B1 > B2 > B3, and C1 > C2 > C3. Using the dissolution time as the evaluation metric, the influence of the three factors is similar. The results of the variance analysis indicate that factor B has a significant impact on the coefficient of variation of pellet weight, while factors A, B, and C have no significant effect on the dissolution time. Since a smaller coefficient of variation of pellet weight is preferred, the optimal process is A3B3C3.

[0043] That is, the composite matrix is made of PEG4000 and PEG6000 in a ratio of 1:1, the drug-to-matrix ratio is 1:4, the drug solution temperature is 90°C, the coolant is dimethyl silicone oil, the coolant temperature is 10°C, the annular cooling zone height is 8 cm, and the drip rate is 30 d / min.

[0044] The above method discloses a method for pre-cooling liquid droplets. In the process of preparing droplets, a droplet machine of the prior art is used, and pre-cooling can be controlled by airflow. However, the gas flow easily leads to uneven air above the coolant, and uneven air easily leads to changes in the direction of droplet inflow. In order to solve this technical problem, Figures 1 to 3 As shown, the present invention provides a preparation system for improving the homogeneity of paeoniflorin pills, comprising a mounting bracket 1, a medicine liquid tank 2 is provided on the top of the mounting bracket 1, a cooling tank 3 is provided on the bottom of the mounting bracket 1, the medicine liquid tank 2 is connected to the cooling tank 3 through a drip nozzle 4, a coolant is provided in the cooling tank 3, the melted medicine liquid in the medicine liquid tank 2 can be dripped into the cooling tank 3 through the drip nozzle 4, the medicine liquid forms spherical droplets and falls into the coolant to solidify and form, and a discharger 8 is provided at the bottom of the cooling tank 3.

[0045] The liquid medicine tank 2 heats the liquid medicine to a suitable temperature, and the drip nozzle 4 controls the dripping speed of the liquid medicine. A cooling pipe is provided on the outside of the cooling tank 3 to cool the coolant in the cooling tank 3 and keep it at a fixed temperature. Furthermore, the discharger 8 drives the pills at the bottom of the cooling tank 3 out of the cooling tank 3. This structure is common in pill making machines and can achieve automatic discharge of pills in existing pill making machines.

[0046] Among them, an airbag assembly 5 is provided in the cooling tank 3, the top of the airbag assembly 5 is connected to the air outlet pipe 6 through the top of the cooling tank 3, and the bottom of the airbag assembly 5 is connected to the input motor 7 through the cooling tank 3. The input motor 7 quantitatively introduces cooling medium into the airbag assembly 5 so that the space above the coolant forms a pre-cooling zone, and the medicine drops can pass through the cooling zone into the coolant.

[0047] The bottom of the airbag assembly 5 can be floated on the coolant. As the liquid drops drip in, the airbag assembly 5 is pressed on the coolant to reduce the fluctuation of the liquid level.

[0048] A cooling medium, such as gas, can be passed into the airbag assembly 5 to perform internal cooling on the space between the drip nozzle 4 and the coolant to form a pre-cooling space. Compared with external cooling, internal cooling can not only increase the cooling speed and improve the efficiency of temperature control, but also, by floating the airbag assembly 5 on the surface of the coolant, the surface of the coolant can be cooled at the same time, thereby reducing the upper and lower temperature differences of the coolant caused by the instantaneous heat exchange when the pills are dripped.

[0049] Secondly, the airbag assembly 5 is used to maintain the constant air pressure in the dripping space, ensuring that the air pressure in the annular cooling zone is a constant value. At the same time, it is pressed on the edge of the liquid, which can quickly calm the liquid surface of the coolant, keep the coolant surface stable, and reduce the impact of ripples generated after the droplet enters the coolant surface on the next droplet.

[0050] The specific structure of this airbag assembly 5 has certain similarities with the existing condenser. The difference is that the airbag assembly 5 can expand in the pre-cooling zone. Specifically, the airbag assembly 5 includes a shrinkable airbag 501. The top of the shrinkable airbag 501 is connected to the outlet pipe 6 through a quantitative outlet valve 502. The quantitative outlet valve 502 is used to release the cooling medium in the shrinkable airbag 501 at a constant speed to the outlet pipe 6 for discharge.

[0051] Input motor 7 controls the speed at which the cooling medium enters the shrinking airbag 501. Exit pipe 6 releases the cooling medium at a constant rate. Specifically, as the flow rate from input motor 7 increases, the cooling medium accumulates in the shrinking airbag 501, increasing its height. This controls the height of the pre-cooling zone and allows for adaptability to various dripping distances. The shrinking airbag 501 is made of elastic rubber, and the pre-cooling medium can be a cooled gas.

[0052] Furthermore, the shrink airbag 501 is a spring-shaped annular structure, and a shrink component 503 is provided on the shrink airbag 501 . The shrink component 503 can compress the height of the shrink airbag 501 in the cooling tank 3 .

[0053] The shrinking assembly 503 includes a first pressure ring 5031 arranged on the top of the shrinking airbag 501 and a second pressure ring 5032 arranged on the bottom of the shrinking airbag 501 . The first pressure ring 5031 and the second pressure ring 5032 are fixed on the shrinking airbag 501 via a fixing belt 5033 .

[0054] The first pressure ring 5031 and the second pressure ring 5032 are connected together by an elastic pull rope 5034. As the cooling medium flows into the shrinkage airbag 501, the distance between the first pressure ring 5031 and the second pressure ring 5032 increases, the height of the cooling zone increases, and the elastic pull rope 5034 accumulates elastic potential energy; when the input flow of the input motor 7 decreases, the shrinkage airbag 501 is flattened by the elastic pull rope 5034, and the height of the cooling zone decreases, thereby being able to change the height of the cooling zone.

[0055] A plurality of elastic pull ropes 5034 are provided, and the plurality of elastic pull ropes 5034 are arranged around the first pressure ring 5031 and the second pressure ring 5032 , and the shrink airbag 501 is surrounded by the elastic pull ropes 5034 .

[0056] Since the bottom of the cooling tank 3 can automatically discharge the pellets, during the discharge process, the pellets will carry out some of the coolant, causing the coolant level to drop. The solution in the prior art is to re-introduce the coolant to maintain the coolant level at an appropriate height. From the above process, it can be seen that a difference of 2 cm in the drop distance will result in a large difference in the homogeneity of the pellets.

[0057] The present invention provides a novel liquid-level maintenance structure, namely a collapsible airbag 501, which can control the liquid level by varying the flow rate of the cooling medium. This is because the collapsible airbag 501 is floating within the cooling tank 3. As the height of the collapsible airbag 501 increases, its upper end rests on the top of the cooling tank 3, and the volume of its lower portion extends into the coolant, thereby raising the coolant level. This structure can achieve a certain degree of control over the coolant level, but it cannot completely replace the existing liquid-level maintenance method. It only serves as an auxiliary liquid-level maintenance device to quickly maintain a constant drip distance.

[0058] When the coolant level reaches a preset standard height, it is necessary to quickly lower the coolant level. Based on the above description of the shrinking airbag 501, the volume of the shrinking airbag 501 can be reduced by reducing the flow of the cooling medium, thereby lowering the coolant level. However, the liquid level adjustment speed of this method is relatively low. In order to quickly maintain a stable liquid level, a flow tube 9 is provided on the side of the cooling tank 3 protruding outward. The flow tube 9 is connected to a residual tank 10. The flow tube 9 is set at the coolant standard height position. When the coolant in the cooling tank 3 exceeds the standard height, the coolant flows into the residual tank 10 through the flow tube 9, thereby maintaining a stable liquid level.

[0059] The residual tank 10 and the cooling tank 3 are both made of transparent materials, and scale values are set on the residual tank 10 and the cooling tank 3. A liquid level detector, such as an infrared detector, can also be set at the height of the circulation tube 9. This infrared detector can be communicated with the input motor 7. The infrared detector and the input motor 7 are also connected to a control system. When the coolant level is lower than the circulation tube 9, the flow rate of the input motor 7 increases, so that the coolant level is increased, thereby keeping the coolant level at a constant value.

[0060] In order to facilitate the adjustment of the drip distance, a sealing cover 11 is provided between the cooling tank 3 and the drip nozzle 4. The sealing cover 11 is fixedly installed on the drip nozzle 4, and the peripheral side of the sealing cover 11 is slidably installed in the cooling tank 3. A sealing ring 12 is provided between the sealing cover 11 and the inner wall of the cooling tank 3. The air outlet pipe 6 is provided through the sealing cover 11, and the air outlet pipe 6 is made of soft material.

[0061] By adjusting the height of the sealing cover 11 , the distance between the drip nozzle 4 and the coolant surface can be adjusted, thereby adjusting the drip distance.

[0062] The above embodiments are merely exemplary embodiments of the present application and are not intended to limit the scope of the present application. The scope of protection of the present application is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present application within the essence and scope of protection of the present application, and such modifications or equivalent substitutions shall also be deemed to fall within the scope of protection of the present application.

Claims

1. A preparation system for improving the homogeneity of paeoniflorin dripping pills, characterized in that: The invention comprises a mounting bracket (1), a medicine liquid tank (2) is provided on the top of the mounting bracket (1), a cooling tank (3) is provided on the bottom of the mounting bracket (1), the medicine liquid tank (2) is connected to the cooling tank (3) through a drip nozzle (4), a cooling liquid is provided in the cooling tank (3), the melted medicine liquid in the medicine liquid tank (2) can be dripped into the cooling tank (3) through the drip nozzle (4), the medicine liquid forms spherical droplets and falls into the cooling liquid to solidify and form, and a discharge machine (8) is provided at the bottom of the cooling tank (3); The cooling tank (3) is provided with an airbag assembly (5), the top of the airbag assembly (5) passes through the top of the cooling tank (3) and is connected to an air outlet pipe (6), the bottom of the airbag assembly (5) passes through the cooling tank (3) and is connected to an input motor (7), and the input motor (7) quantitatively introduces cooling medium into the airbag assembly (5) so that the space above the coolant forms a pre-cooling zone; The bottom of the airbag assembly (5) can be floated on the cooling liquid, and as the liquid drops drip in, the airbag assembly (5) is pressed on the cooling liquid to reduce the fluctuation of the liquid level.

2. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 1, characterized in that: The airbag assembly (5) comprises a shrinkable airbag (501), the top end of which is connected to the air outlet pipe (6) via a quantitative air outlet valve (502), and the quantitative air outlet valve (502) is used to release the cooling medium in the shrinkable airbag (501) to the air outlet pipe (6) at a constant speed for discharge.

3. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 2, characterized in that: The shrinkable airbag (501) is made of elastic rubber.

4. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 3, characterized in that: The shrinkable airbag (501) is a spring-shaped annular structure. A shrinkable component (503) is provided on the shrinkable airbag (501). The shrinkable component (503) can compress the height of the shrinkable airbag (501) in the cooling tank (3).

5. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 4, characterized in that: The shrinkage component (503) comprises a first pressure ring (5031) arranged at the top of the shrinkage airbag (501) and a second pressure ring (5032) arranged at the bottom of the shrinkage airbag (501), wherein the first pressure ring (5031) and the second pressure ring (5032) are fixed to the shrinkage airbag (501) via a fixing belt (5033); The first pressure ring (5031) and the second pressure ring (5032) are connected together by an elastic pull rope (5034). As the cooling medium flows into the shrinking airbag (501), the distance between the first pressure ring (5031) and the second pressure ring (5032) increases, and the elastic pull rope (5034) accumulates elastic potential energy.

6. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 5, characterized in that: A plurality of elastic pull ropes (5034) are provided, and the plurality of elastic pull ropes (5034) are arranged on the peripheral sides of the first pressure ring (5031) and the second pressure ring (5032), and the shrinkage airbag (501) is surrounded by the elastic pull ropes (5034).

7. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 6, characterized in that: A flow pipe (9) is provided on the side of the cooling tank (3) protruding outward, and the flow pipe (9) is connected to a residual tank (10). The flow pipe (9) is set at the standard height position of the coolant. When the coolant in the cooling tank (3) exceeds the standard height, the coolant flows into the residual tank (10) through the flow pipe (9).

8. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 7, characterized in that: The residual tank (10) and the cooling tank (3) are both made of transparent materials.

9. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 6, characterized in that: A sealing cover (11) is provided between the cooling tank (3) and the drip nozzle (4), the sealing cover (11) is fixedly mounted on the drip nozzle (4), the peripheral side of the sealing cover (11) is slidably mounted in the cooling tank (3), a sealing ring (12) is provided between the sealing cover (11) and the inner wall of the cooling tank (3), and the air outlet pipe (6) is provided through the sealing cover (11).

10. A preparation system for improving the homogeneity of paeoniflorin dripping pills according to claim 9, characterized in that: The air outlet pipe (6) is made of soft material.

Images