Composition for weight management and preparation method thereof

Abstract

The invention provides a composition comprising the following components: a hydrogel material, monovalent or divalent cation salt, a filler, a disintegrating agent and a lubricant. The composition is scientific and reasonable in formula combination, free of toxic and side effects on human bodies and easy to prepare. The product prepared from the composition disclosed by the invention can simultaneously have good preparation performance, disintegration performance and gelling performance through specific components, proportion and preparation process, is relatively high in stability of product quality, is suitable for large-scale application and development, and can occupy the space in the stomach, promote satiety and reduce appetite after being eaten; therefore, the purposes of weight management, obesity treatment, blood sugar control, diabetes prevention and treatment, blood cholesterol reduction and the like are achieved.

Description

Composition for weight management and preparation method thereof

[0001] This application claims priority to the following prior application: Patent application number 202310263448.1, filed with the State Intellectual Property Office of China on March 17, 2023, entitled “Composition for weight management and preparation method thereof.” The entire text of that prior application is incorporated herein by reference. Technical Field

[0002] The present invention generally relates to compositions for weight management and methods for their preparation. Background Art

[0003] The rapid growth of the obese population and the health problems it causes have gradually become a focus of social attention. Conventional weight loss methods include surgical liposuction, weight loss medications, meal replacements, and weight loss devices. However, most meal replacements only serve to replace staple foods, lack a strong sense of satiety, and fail to effectively reduce caloric intake, resulting in poor weight loss results. Surgical liposuction is painful and leads to poor patient tolerance. Weight loss medications can easily cause endocrine imbalances and side effects. Weight loss devices, such as balloons, are difficult to operate, lack user comfort, and are difficult to adhere to.

[0004] In recent years, a weight loss composition that promotes or induces satiety as a means of suppressing appetite has gradually emerged. It can swell in the stomach, occupying the stomach space, and provide a longer period of fullness, thereby achieving the purpose of suppressing appetite and controlling weight. As a simple weight management method, users take it before the three main meals to create a sense of fullness and thus reduce the intake of staple food. Compared with weight loss drugs and devices, it has natural convenience and tolerability advantages. At the same time, it can also ensure sufficient energy supply to the human body compared to meal replacement foods. This type of weight loss composition generally has various forms such as granules and tablets. Granules need to be brewed with water and drunk. When consumed, a large amount of water is required at the same time, which is not a good user experience. Tablets are simple to take, have high tolerance, and are easy for users to adhere to. They have natural advantages over granular dosage forms. The preparation of this type of tablet is generally made by mixing multiple raw materials and then pressing them into tablets. It is expected that the tablets will disintegrate into granules in the gastric environment, and then absorb water to expand into a hydrogel that occupies the stomach space and creates a sense of fullness. However, in actual application, the tableting process after mixing multiple excipients is prone to cause powder agglomeration and poor fluidity, and it is difficult for it to completely disintegrate in the body. Therefore, if the requirements for tableting performance are high, the hardness of the tablets produced will also be high, and their disintegration and gelation properties in the body will usually be unsatisfactory. If the requirements for tableting hardness performance are lowered, the product quality and stability will be difficult to guarantee, and it is difficult to meet both requirements at the same time.

[0005] Currently, there is an urgent need to develop a composition that can be used for weight management and has both good tableting properties and good disintegration and swelling gelling properties, a simple preparation method, is suitable for large-scale development, has good effects, and is well tolerated by users.

[0006] Summary of the Invention

[0007] In order to solve the above technical problems, the present invention provides a solid composition and a preparation method and application thereof.

[0008] A solid composition comprises the following components in parts by weight: 35-45 parts of a hydrogel material, 15-25 parts of a disintegrant, 5-15 parts of a monovalent or divalent cation salt and 5-35 parts of a filler.

[0009] According to an embodiment of the present invention, the solid composition comprises the following components in parts by weight: 35-45 parts of hydrogel material, 15-25 parts of disintegrant, 5-15 parts of monovalent or divalent cation salt, 0.5-5 parts of lubricant and 5-35 parts of filler.

[0010] According to an embodiment of the present invention, the hydrogel material can be selected from one or a combination of two or more of konjac flour, carrageenan, xanthan gum, gelatin, hyaluronic acid and / or chitosan; preferably, a combination of konjac flour and carrageenan; and preferably, a combination ratio of 15-25 parts konjac flour to 10-20 parts carrageenan.

[0011] According to an embodiment of the present invention, the hydrogel material is first granulated and then mixed with other ingredients to prepare the solid composition. For example, the hydrogel material dry powder is first granulated and then mixed with other ingredients to prepare the solid composition. For example, konjac flour and carrageenan are first mixed and dry granulated.

[0012] According to an embodiment of the present invention, konjac flour is also known as konjac gum, and can be konjac flour that meets QB494-2012 or NY / T494-2010 standard, for example common konjac flour, common konjac powder, common konjac micropowder, purified konjac flour, purified konjac powder, purified konjac micropowder. As an example, the glucomannan content of the konjac flour can be 50%, 60%, 70% and above. Pure glucomannan can also be used.

[0013] According to an embodiment of the present invention, the monovalent or divalent cation salt may be a water-soluble potassium salt and / or a water-soluble sodium salt; the water-soluble potassium salt is selected from at least one of potassium bicarbonate, potassium chloride and potassium citrate; the water-soluble sodium salt is selected from at least one of sodium bicarbonate, sodium chloride and sodium citrate, and is preferably potassium bicarbonate.

[0014] According to an embodiment of the present invention, the filler can be selected from one or a combination of two or more of oligofructose, sugar alcohol, starch, sucrose, lactose, dextrin, etc.; preferably sugar alcohol or oligofructose, and optionally starch; the sugar alcohol can be one or a combination of two or more of sorbitol, mannitol, erythritol, maltitol, lactitol, xylitol, etc., preferably sorbitol.

[0015] According to an embodiment of the present invention, the disintegrant may be one or a combination of two or more of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone, cross-linked sodium carboxymethyl cellulose, etc., preferably microcrystalline cellulose.

[0016] According to an embodiment of the present invention, the solid composition may further include 0.5-5 parts of a lubricant according to the specific dosage form. The lubricant may be one or a combination of two or more of magnesium stearate, micropowdered silica gel, talc, magnesium lauryl sulfate, polyethylene glycol (PEG) 4000 or 6000, etc., preferably magnesium stearate or polyethylene glycol 4000 or 6000.

[0017] According to an embodiment of the present invention, the composition comprises the following components in parts by weight: 20-30 parts of sugar alcohol or oligofructose, 15-25 parts of konjac flour, 10-20 parts of carrageenan, 15-25 parts of microcrystalline cellulose, 5-15 parts of water-soluble potassium salt, 0.5-5 parts of magnesium stearate, polyethylene glycol 6000 or polyethylene glycol 4000, a combination of two or three of the above, and 0-5 parts of starch.

[0018] According to an embodiment of the present invention, the composition comprises the following components in parts by weight:

[0019] 20-26 parts of sugar alcohol or oligofructose, 20-25 parts of konjac flour, 10-20 parts of carrageenan, 20-25 parts of microcrystalline cellulose, 8-12 parts of water-soluble potassium salt, 1-3 parts of one of magnesium stearate, polyethylene glycol 6000 or polyethylene glycol 4000, or a combination of two or three thereof, and 0-5 parts of starch; preferably, the total weight of the composition is 100 parts.

[0020] According to an embodiment of the present invention, the composition comprises the following components in parts by weight:

[0021] 20-26 parts sorbitol or oligofructose, 20-25 parts konjac flour, 10-20 parts carrageenan, 20-25 parts microcrystalline cellulose, 8-12 parts potassium bicarbonate, 1-3 parts magnesium stearate and 0-5 parts starch; or

[0022] 20-26 parts of sorbitol or oligofructose, 20-25 parts of konjac flour, 10-20 parts of carrageenan, 20-25 parts of microcrystalline cellulose, 8-12 parts of potassium bicarbonate, 1-3 parts of magnesium stearate, and 1-3 parts of one or both of polyethylene glycol 6000 and polyethylene glycol 4000.

[0023] In a preferred embodiment, the solid composition comprises the following components in parts by weight:

[0024] 25 parts of konjac flour, 15 parts of carrageenan, 10 parts of potassium bicarbonate, 24 parts of microcrystalline cellulose, 21.5 parts of sorbitol, 1 part of magnesium stearate and 3.5 parts of starch; or,

[0025] 25 parts konjac flour, 15 parts carrageenan, 10 parts potassium bicarbonate, 24 parts microcrystalline cellulose, 25 parts sorbitol and 1 part magnesium stearate; or,

[0026] 25 parts of konjac flour, 15 parts of carrageenan, 10 parts of potassium bicarbonate, 24 parts of microcrystalline cellulose, 21.5 parts of oligofructose, 1 part of magnesium stearate and 3.5 parts of starch; or

[0027] 23.9 parts of konjac flour, 16 parts of carrageenan, 10 parts of potassium bicarbonate, 23.6 parts of microcrystalline cellulose, 24.5 parts of sorbitol, 2 parts of polyethylene glycol 6000; or,

[0028] 24.4 parts of konjac flour, 16 parts of carrageenan, 10 parts of potassium bicarbonate, 23.6 parts of microcrystalline cellulose, 25 parts of sorbitol, 1 part of polyethylene glycol 6000; or,

[0029] 25 parts of konjac flour, 15 parts of carrageenan, 10 parts of potassium bicarbonate, 24 parts of microcrystalline cellulose, 25 parts of sorbitol, 1 part of polyethylene glycol 6000.

[0030] In a preferred embodiment, the konjac flour in the solid composition is further preferably purified konjac flour.

[0031] According to an embodiment of the present invention, the solid composition is in the form of tablets, capsules, powders, granules, lozenges, etc., preferably tablets; tablets can be optionally coated, and the coating can be a gastric-soluble and / or enteric coating, preferably a gastric-soluble coating; capsules can optionally use a gastric-soluble and / or enteric capsule shell, preferably a gastric-soluble capsule shell.

[0032] According to an embodiment of the present invention, the solid composition is a medicine, food, health product, health food, or candy (such as compressed candy), dietary supplement, meal replacement or food additive.

[0033] The present invention also provides a method for preparing the solid composition, comprising: first granulating the hydrogel material, and then mixing it with other ingredients to prepare the solid composition.

[0034] According to an embodiment of the present invention, the granulation is dry granulation.

[0035] According to an embodiment of the present invention, after granulation is completed, the particle size of the obtained granules is 30-80 meshes.

[0036] According to an embodiment of the present invention, the solid composition is prepared by the following method: the hydrogel material (such as konjac flour and carrageenan) is uniformly mixed using a mixer, and 0-4 parts of a disintegrant (such as 1-4 parts, 1.5-3 parts, etc.) is added during mixing; a dry granulation process is used to prepare 30-80 mesh granules for standby use; the above granules are taken and uniformly mixed with other ingredients using a mixer; a tablet press is used to obtain tablets by adjusting the tablet press pressure; the obtained tablets can be optionally coated, and gastric soluble and / or enteric coatings can be selected, preferably gastric soluble coatings, such as commercially available gastric soluble coating components.

[0037] The present invention also provides the use of the solid composition described above in the preparation of medicines or foods related to human weight or health, wherein the medicines or foods related to human weight or health are used to achieve the following purposes: weight loss, obesity prevention and treatment, weight management, reduced calorie intake, reduced appetite, promoted satiety, auxiliary prevention and treatment of diabetes, blood sugar control, lowering blood cholesterol, relief or treatment of constipation, etc.

[0038] The present invention also provides the following uses of the solid composition as described above: weight loss, obesity prevention and treatment, weight management, reducing calorie intake, reducing appetite, promoting satiety, auxiliary prevention and treatment of diabetes, controlling blood sugar, lowering blood cholesterol, relieving or treating constipation, etc.

[0039] According to an embodiment of the present invention, the solid composition can be taken 10-60 minutes before a meal (e.g., 10, 20, 30, 40, 50, 60 minutes before a meal), preferably a certain amount is taken between 30-60 minutes before a meal (e.g., 30, 40, 50, 60 minutes before a meal).

[0040] According to an embodiment of the present invention, the solid composition can be taken once a day, twice a day, three times a day or more times a day. Preferably, it can be taken three times a day, and optimally, 30 minutes to 60 minutes before three meals a day.

[0041] According to an embodiment of the present invention, a suitable dosage can include a calculated predetermined amount of the solid composition of the present invention to produce a desired therapeutic effect in combination with a desired carrier. Medical technicians in the art can determine the effective amount based on patient characteristics well known in the art, such as age, weight, sex, symptoms, complications, other diseases, etc.

[0042] In solid composition of the present invention, each component plays a synergistic effect. For example, the effect of sugar alcohol is to play a bearing body, especially the bearing body of solid composition. The effect of konjac flour and carrageenan is to produce swellable viscosity and indigestible hydrogel in the stomach, thereby increasing satiety. Simultaneously, the content of sugar alcohol, konjac flour and carrageenan also can have a comprehensive impact on performances such as subsequent preparations, disintegration, gelling. The effect of monovalent or divalent cation salt is to strengthen the intensity of the hydrogel formed after konjac flour and carrageenan absorb water, and then improve the time that hydrogel keeps in the stomach, neutralizes gastric acid acidity simultaneously, improves appetite suppression effect. Microcrystalline cellulose acts as the disintegrant of solid composition, can promote the disintegration of solid composition in the stomach after entering the stomach, makes to form dispersed hydrogel particles, improves swelling effect.

[0043] In the solid composition of the present invention, konjac flour, carrageenan, monovalent or divalent cation salt, microcrystalline cellulose, etc. are mixed in a specific ratio to achieve a more excellent synergistic effect. In addition, under the above ratio, the application's unique process of first using konjac flour and carrageenan to mix and granulate, and then mixing with other components to prepare the solid composition can obtain a hardness that meets the requirements of use and transportation, a fast disintegration rate, and the viscosity and strength of the disintegrated gel block can produce a feeling of fullness in the stomach, thereby achieving the purpose of daily weight management.

[0044] In summary, the composition of the present invention has a scientific and reasonable formula combination, has no toxic side effects on the human body, and is easy to prepare. The product prepared by the composition of the present invention can simultaneously have good formulation performance, disintegration performance and gelation performance through specific ingredients, proportions and preparation processes. The product quality is highly stable and suitable for large-scale application development. After consumption, it can occupy space in the stomach, promote satiety, reduce appetite, thereby achieving the purposes of weight management, treating obesity, controlling blood sugar, preventing and treating diabetes, and lowering blood cholesterol. DETAILED DESCRIPTION

[0045] The technical solutions of the present invention will be described in further detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanations of the present invention and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are encompassed within the scope of protection that the present invention is intended to protect.

[0046] Unless otherwise specified, all “parts” in the following examples refer to parts by weight.

[0047] The types and specifications of some raw materials used in the examples and comparative examples are shown in Table 1 below:

[0048] Table 1

[0049] The preparation process of the solid composition of the embodiment of the present invention and the comparative example is as follows:

[0050] 1. Screening and determining the basic formula and process

[0051] Preparation process of the solid composition of Examples 1-3 and Comparative Examples 1-6:

[0052] Konjac flour and carrageenan were evenly mixed using a mixer for 30 min;

[0053] Use dry granulation process to prepare 30-80 mesh granules for later use;

[0054] Take the above granules and other ingredients and mix them evenly in a mixer for 30 minutes (see Table 2 for specific composition ratios);

[0055] Tablets are obtained by using a tablet press and adjusting the tablet press pressure.

[0056] Preparation process of the solid composition of Comparative Examples 7-9:

[0057] The effect of the granulation process on the tablet performance of the composition was investigated. Either konjac flour or carrageenan was dry-granulated to produce 30-80 mesh granules (Comparative Examples 8 and 9), or both were used directly as dry powders without granulation (Comparative Example 7). The granules were then mixed with other ingredients and tableted. The specific granulation and tableting processes were the same as in Examples 1-3 and Comparative Examples 1-6.

[0058] The formulas (unit: g) of the solid compositions for weight management of Examples 1-3 and Comparative Examples 1-9 are shown in Table 2, and the performance test results of each formula are shown in Table 3 below:

[0059] Table 2

[0060] Table 3 Note: In Table 3, the hardness of the tablets was tested using a hardness tester, Sinopharm Longli Z10. The hardness grades of the tablets under the same pressure are divided into the following categories: 1: hardness <1KPa; 2: 1≤hardness <4KPa; 3: 4≤hardness <8KPa; 4: 8≤hardness <11KPa; 5: hardness ≥11KPa.

[0061] The above-mentioned tablets are fast-disintegrating products and are expected to achieve complete disintegration in 30 seconds. The test method is to place the tablets in 100 ml of mixed liquid (80 ml of water + 20 ml of simulated gastric fluid), test them 3 times (test at 37°C, take the average of 3 times), remove the undisintegrated blocks after 30 seconds, scrape off the surface gel, and weigh M1. Disintegration degree = M1 / total mass of a single tablet * 100%.

[0062] The scoring results are as follows: 1: no disintegration at all; 2: slight disintegration, 10% ≤ disintegration < 50%, and obvious tablet lumps; 3: disintegration ≥ 50%, with obvious lumps; 4: complete disintegration, disintegration time ≥ 30s; 5: complete disintegration, disintegration time < 30s.

[0063] The tablet gelation test method and scoring results are as follows: the tablets are placed in 100ml of mixed solution (80ml water + 20ml simulated gastric fluid, 37°C): 1: No visible gel lumps, water absorption rate ≤ 2 times; 2: A small amount of gel lumps are present in the solution, 2 times < water absorption rate ≤ 10 times, (water absorption rate = gel mass / tablet weight); 3: There are large gel lumps in the solution, 10 times < water absorption rate ≤ 20 times, and free water is obvious; 4: Large gel lumps can be formed in the solution, there is no free water, but there are visible opaque lumps (caused by partial disintegration or insufficient water absorption and gelation), 20 times < water absorption rate ≤ 30 times; 5: A uniform large gel lumps are formed, no visible opaque lumps, and water absorption rate > 30 times.

[0064] 2. Adaptability of formula and process

[0065] By expanding the production scale, the effects of the formulations of Examples 1-3 and lubricants on tablet performance during the scale-up process were further investigated. It was found that the choice of lubricant did not affect the disintegration performance and gelation state of the tablets. Depending on the adjustment of the tableting equipment mold and tableting parameters during the scale-up process, the lubricant can be replaced with other conventional lubricants, such as talc, polyethylene glycol (PEG) 4000 or 6000, etc.; it was also found that in the granulation step, a small amount (e.g., 0-4 parts, 1-4 parts, 1.5-3 parts, etc.) of the disintegrant can be selected as needed and mixed with the hydrogel material for granulation.

[0066] Taking Example 2 as an example, based on the selection of lubricant, the proportions of other ingredients and processes were adaptively adjusted (as shown in Examples 4-6, where 1 portion corresponds to an actual sampling amount of 500 g). The results did not adversely affect the performance of the tablets, but better adapted to the production conditions of the scale-up process.

[0067] Example 4

[0068] Formula: 23.9 parts of konjac flour, 16 parts of carrageenan, 10 parts of potassium bicarbonate, 23.6 parts of microcrystalline cellulose, 24.5 parts of sorbitol, and 2 parts of polyethylene glycol 6000.

[0069] Preparation process: Konjac flour, carrageenan, and 2.1 parts of microcrystalline cellulose are uniformly mixed in a mixer for 30 minutes; 30-60 mesh granules are prepared using a dry granulation process for later use; the above granules are uniformly mixed with other ingredients in a mixer for 30 minutes; and tablets are obtained by adjusting the tablet pressing pressure using a tablet press.

[0070] Example 5

[0071] Formula: 24.4 parts konjac flour, 16 parts carrageenan, 10 parts potassium bicarbonate, 23.6 parts microcrystalline cellulose, 25 parts sorbitol, 1 part polyethylene glycol 6000.

[0072] Preparation process: Konjac flour, carrageenan, and 1.6 parts of microcrystalline cellulose are uniformly mixed in a mixer for 30 minutes; 30-60 mesh granules are prepared using a dry granulation process for later use; the above granules are uniformly mixed with other ingredients in a mixer for 30 minutes; and tablets are obtained by adjusting the tablet pressing pressure using a tablet press.

[0073] Example 6

[0074] Formula: 25 parts konjac flour, 15 parts carrageenan, 10 parts potassium bicarbonate, 24 parts microcrystalline cellulose, 25 parts sorbitol, 1 part polyethylene glycol 6000.

[0075] Preparation process: Konjac flour, carrageenan, and 2.8 parts of microcrystalline cellulose are uniformly mixed in a mixer for 30 minutes; 30-60 mesh granules are prepared using a dry granulation process for later use; the above granules are uniformly mixed with other ingredients in a mixer for 30 minutes; and tablets are obtained by adjusting the tablet pressing pressure using a tablet press.

[0076] Tablets prepared using the formulation and process of the solid composition of the above embodiment of the present invention have the following final properties: a hardness of 3 kPa or greater, preferably 4 kPa or greater, and more preferably 8-13 kPa, a friability of 0.3% or less, rapid and complete disintegration (no tablet lumps remaining) in a 100 ml solution (80 ml water + 20 ml simulated gastric fluid) at 37°C, and a viscous, thick gel structure formed within 30-60 minutes. The preparation method is simple, making it suitable for large-scale development.

[0077] In addition, the tablets of the present invention may be optionally coated. The coating may be gastric-soluble and / or enteric-soluble, preferably gastric-soluble. For example, the product of the above embodiment may be further coated with a commercially available gastric-soluble coating component.

[0078] The above describes the embodiments of the present invention. However, the present invention is not limited to the above embodiments. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. A solid composition, characterized in that The invention comprises the following components in parts by weight: 35-45 parts of hydrogel material, 15-25 parts of disintegrant, 5-15 parts of monovalent or divalent cation salt and 5-35 parts of filler.

2. The solid composition according to claim 1, characterized in that The invention comprises the following components in parts by weight: 35-45 parts of hydrogel material, 15-25 parts of disintegrant, 5-15 parts of monovalent or divalent cation salt, 0.5-5 parts of lubricant and 5-35 parts of filler.

3. The solid composition according to claim 1 or 2, characterized in that The hydrogel material is one or a combination of two or more of konjac flour, carrageenan, xanthan gum, gelatin, hyaluronic acid and chitosan; Preferably, the hydrogel material is a combination of konjac flour and carrageenan.

4. The solid composition according to claim 3, characterized in that The konjac flour is common konjac flour, common konjac refined flour, common konjac micro-powder, purified konjac flour, purified konjac refined flour, purified konjac micro-powder or glucomannan.

5. The solid composition according to claim 1 or 2, characterized in that The monovalent or divalent cation salt is a water-soluble potassium salt and / or a water-soluble sodium salt; Preferably, the filler is one or a combination of two or more of oligofructose, sugar alcohol, starch, sucrose, lactose or dextrin; and optionally starch; Preferably, the sugar alcohol is one or a combination of two or more of sorbitol, mannitol, erythritol, maltitol, lactitol and xylitol; Preferably, the disintegrant is one or a combination of two or more of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone, and cross-linked sodium carboxymethyl cellulose; Preferably, the lubricant is one or a combination of two or more of magnesium stearate, micro powder silica gel, talc, magnesium lauryl sulfate, polyethylene glycol 4000 or 6000.

6. The solid composition according to any one of claims 1 to 5, characterized in that The composition comprises the following components in parts by weight: 20-30 parts of sugar alcohol or oligofructose, 15-25 parts of konjac flour, 10-20 parts of carrageenan, 15-25 parts of microcrystalline cellulose, 5-15 parts of water-soluble potassium salt, 0.5-5 parts of magnesium stearate, one of polyethylene glycol 6000 and polyethylene glycol 4000, a combination of two or three thereof, and 0-5 parts of starch.

7. The solid composition according to claim 6, characterized in that The composition comprises the following components in parts by weight: (1) 21.5 parts of sorbitol, 25 parts of konjac flour, 15 parts of carrageenan, 24 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate, 1 part of magnesium stearate and 3.5 parts of starch; or, (2) 25 parts of sorbitol, 25 parts of konjac flour, 15 parts of carrageenan, 24 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate, and 1 part of magnesium stearate; or, (3) 21.5 parts of oligofructose, 25 parts of konjac flour, 15 parts of carrageenan, 24 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate, 1 part of magnesium stearate and 3.5 parts of starch; or, (4) 24.5 parts of sorbitol, 23.9 parts of konjac flour, 16 parts of carrageenan, 23.6 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate and 2 parts of polyethylene glycol 6000; or, (5) 25 parts of sorbitol, 24.4 parts of konjac flour, 16 parts of carrageenan, 23.6 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate and 1 part of polyethylene glycol 6000; or, (6) 25 parts of sorbitol, 25 parts of konjac flour, 15 parts of carrageenan, 24 parts of microcrystalline cellulose, 10 parts of potassium bicarbonate and 1 part of polyethylene glycol 6000.

8. The solid composition according to any one of claims 1 to 7, characterized in that The solid composition is a tablet, capsule, powder, granule or lozenge, or the solid composition is a medicine, food, health product, health food, candy, dietary supplement, meal replacement or food additive.

9. The method for preparing the solid composition according to any one of claims 1 to 8, characterized in that: The hydrogel material is first granulated and then the solid composition is prepared.

10. Use of the solid composition according to any one of claims 1 to 9 in the preparation of medicines or foods related to human weight or health, wherein the medicines or foods related to human weight or health are used to achieve the following purposes: weight loss, obesity prevention and treatment, weight management, reduction of calorie intake, reduction of appetite, promotion of satiety, auxiliary prevention and treatment of diabetes, control of blood sugar, reduction of blood cholesterol, relief or treatment of constipation.