Modularized intelligent breast cancer organ chip system and use method thereof

Through the integration of standardized microfluidic channel units and sensors, the shortcomings of existing breast cancer organ-on-a-chip systems in simulating the multi-stage metastasis process of breast cancer cells have been resolved, efficient multi-stage simulation and intelligent regulation have been achieved, and the needs of high-throughput research have been met.

CN120607964APending Publication Date: 2025-09-09DALIAN UNIV OF TECH
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Patent Information

Application Number
CN202510819572.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-19
Publication Date
2025-09-09

AI Technical Summary

Technical Problem

Existing breast cancer organ-on-a-chip systems lack standardization, modularity, and intelligent design, making it difficult to truly simulate the multi-stage metastasis process of breast cancer cells. They also have limited capabilities in real-time monitoring and intelligent feedback regulation, making it difficult to meet the needs of high throughput, quantification, and mechanism analysis.

Method used

By adopting standardized microfluidic channel units, detachable interface components and functional partitioning modules, combined with sensor integration mechanisms, the organ chip system can be rapidly assembled, flexibly reconfigured and intelligently controlled, supporting simulation modeling and drug testing of multi-stage transfer processes.

Benefits of technology

It has achieved multi-stage simulation of the breast cancer metastasis process, improved the adaptability and scalability of the experiment, and has the ability of dynamic monitoring and feedback regulation, supporting microenvironment research under multi-factor coupling conditions.

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Abstract

The invention discloses a modular intelligent breast cancer organ chip system and a use method thereof, and aims to simulate the processes of breast cancer primary lesion invasion, lymphatic / hematogenous metastasis and far-end colonization and realize tumor metastasis mechanism research, microenvironment dynamic monitoring and related drug evaluation. All the modules (such as a tumor primary focus module, a bionic blood vessel module, a lymphatic network module and a far-end organ module) have independent cell culture, fluid perfusion control and integrated sensor arrays so as to realize micro-environment dynamic monitoring. The modules are connected and subjected to material exchange through standardized reconfigurable interfaces (including direct fluid butt joint and selective permeable membrane interfaces). The modular architecture endows the system with high flexibility and expandability, can quickly customize and combine specific transfer mechanism research, microenvironment parameter monitoring or drug efficiency evaluation, and ensures the quality control and function specificity of each unit. And a foundation is laid for developing an intelligent sensing and feedback regulation organ chip system for cancer research.
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