Glucosamine chondroitin capsule and preparation method thereof

Abstract

The invention discloses a glucosamine chondroitin capsule and a preparation method thereof, relates to the technical field of health-care food, and aims to improve the calcium absorption efficiency and protect articular cartilage through the synergistic effect of multiple components so as to realize preventive intervention and symptom improvement on osteoporosis. The capsule comprises the following components in parts by weight: 160-190 parts of calcium carbonate, 230-270 parts of glucosamine sulfate, 30-70 parts of chondroitin sulfate, 15-25 parts of casein phosphopeptides and 1-3 parts of magnesium stearate, preferably 175 parts of the components, 250 parts of the components, 50 parts of the components, 23 parts of the components and 2 parts of the components, and the dosage form is a hard capsule of which the total weight of each capsule is 0.5 g. The preparation method comprises the following steps: sieving the raw materials through a 60-mesh sieve, crushing the glucosamine sulfate, sieving, mixing twice, respectively controlling the rotating speeds of a mixer at 20-25r / min and 15-20r / min, filling into a No. 0 capsule shell, polishing, internally packaging, externally packaging and the like. According to the invention, multiple components synergistically supplement calcium and protect joints, step-by-step mixing and particle size control ensure quality, the raw materials are safe and compliant, and both effectiveness and safety are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of health-care foods, in particular to a glucosamine chondroitin capsule and a preparation method thereof. Background Art

[0002] With the increasing global aging population, osteoporosis (OP) has become a major health threat to the elderly, with its incidence continuing to climb, placing a heavy burden on families and social healthcare. As a systemic metabolic bone disease, OP is characterized by a decrease in bone mass per unit volume and deterioration of bone microstructure, leading to increased bone brittleness and decreased strength. Even minor external forces can cause fractures in the spine, hip, and other areas. OP is also accompanied by symptoms such as musculoskeletal pain, stature shortening, and spinal deformities, severely impairing patients' quality of life.

[0003] Medical science has established that calcium deficiency is the primary cause of OP. Vitamin D deficiency, decreased estrogen levels, and unhealthy lifestyle habits can also trigger or exacerbate the condition. Currently, oral calcium supplements are commonly used as a primary intervention in clinical practice, but they have significant limitations: First, they are slow to show results, as calcium absorption relies on intestinal function and vitamin D. Bone repair and reconstruction cycles are long, requiring months to years to see improvement in bone density. Second, treatment is long, and long-term medication can easily lead to gastrointestinal reactions such as constipation, reducing patient compliance. Third, their limited effectiveness fails to address core issues such as bone microstructural degeneration and cartilage damage, making it difficult to fundamentally prevent and treat OP.

[0004] Therefore, in response to the current needs for the prevention and treatment of OP, the development of a safe, efficient, and compliant glucosamine chondroitin capsule, as well as the corresponding optimized preparation method, which can simultaneously supplement calcium, regulate bone metabolism, and protect cartilage tissue, has become a key direction that urgently needs breakthroughs in the medical field. Summary of the Invention

[0005] The purpose of the present invention is to provide a glucosamine chondroitin capsule and a preparation method thereof, so as to overcome the above-mentioned technical problems, improve calcium absorption efficiency and protect articular cartilage through the synergistic effect of multiple components, and achieve preventive intervention and symptom improvement of osteoporosis.

[0006] The present invention solves the above technical problems through the following technical solutions: A glucosamine chondroitin capsule, comprising the following components by weight: 160-190 parts of calcium carbonate, 230-270 parts of glucosamine sulfate, 30-70 parts of chondroitin sulfate, 15-25 parts of casein phosphopeptide, and 1-3 parts of magnesium stearate.

[0007] Furthermore, the preferred ratio of the capsule is 175 parts of calcium carbonate, 250 parts of glucosamine sulfate, 50 parts of chondroitin sulfate, 23 parts of casein phosphopeptide, and 2 parts of magnesium stearate.

[0008] Furthermore, the dosage form of the capsule is a hard capsule, with a total weight of 0.5g per capsule.

[0009] A method for preparing glucosamine chondroitin capsules comprises the following steps: (1) Raw material sieving: Calcium carbonate, magnesium stearate, chondroitin sulfate, and casein phosphopeptide were sieved through a 60-mesh sieve respectively; (2) Grinding: Grind the glucosamine sulfate and pass it through a 60-mesh sieve; (3) primary mixing: placing the calcium carbonate, chondroitin sulfate, and casein phosphopeptide sieved in step (1) and the glucosamine sulfate crushed in step (2) in a mixer and mixing for 30 minutes to obtain a mixed powder; (4) Secondary mixing: adding sifted magnesium stearate to the mixed powder and mixing for 5 minutes to obtain a total mixed powder; (5) Capsule filling: Fill the total mixed powder into size 0 capsule shells to prepare 0.5 g / capsule capsules; (6) Polishing and inner packaging: Polish the filled capsules and remove capsules with unqualified appearance in time. Then, pack them into high-density polyethylene bottles at a rate of 60 capsules / bottle and transfer them to outer packaging through a buffer device; (7) Outer packaging and warehousing: Pack the products according to the packaging operating procedures, obtain the product certificate after passing the inspection, and then put them into storage and go through the warehousing procedures.

[0010] Furthermore, the sieving in step (1) and step (2) is through a 60-mesh oscillating sieve with a sieve aperture of 0.25 mm.

[0011] Furthermore, the rotating speed of the mixer in step (3) is 20 to 25 r / min, and the rotating speed of the mixer in step (4) is 15 to 20 r / min.

[0012] Furthermore, in the inner packaging process in step (6), unqualified products such as those with poor sealing need to be eliminated.

[0013] Furthermore, steps (1) to (6) are carried out in a Class 300,000 clean work area. Beneficial effects

[0014] Calcium carbonate + casein phosphopeptide for efficient calcium supplementation: Calcium carbonate, as a calcium supplement raw material, has high calcium content and good safety. Calcium carbonate chelates with casein phosphopeptide to form a soluble complex to promote gastrointestinal absorption of calcium, significantly improving the body's calcium absorption rate and solving the absorption bottleneck of traditional calcium supplements.

[0015] 2. Glucosamine sulfate + chondroitin sulfate protect joints: The two work synergistically in a 5:1 ratio to promote the synthesis of synovial fluid and cartilage matrix, inhibit degenerative factors such as MMP-3 and IL-1β, help the development of cartilage in the joint cavity and increase the lubricating fluid in the joint cavity, providing good cushioning and protection functions.

[0016] 3. Step-by-step mixing + particle size control: The main ingredients are mixed for 30 minutes before adding magnesium stearate and mixing for 5 minutes to prevent the excipients from wrapping and affecting absorption; all materials are sieved through a 60-mesh sieve to ensure particle size uniformity, mixing uniformity RSD ≤ 2%, and capsule filling volume difference within ± 3%; and this product is produced in a 300,000-level clean area, in compliance with health food standards, to avoid microbial contamination and ensure product hygiene and safety.

[0017] 4. All raw materials are food grade or pharmacopoeia ingredients, which comply with the health food declaration regulations. The daily intake of the formula (420mg of calcium and 1.5g of glucosamine) is within the safe range, and it has both effectiveness and safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the process flow of the present invention. DETAILED DESCRIPTION

[0019] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0020] Source of raw materials Calcium carbonate was produced by Yichang Huanyu Calcium Carbonate Development Co., Ltd., casein phosphopeptide was produced by Jiangxi Kesheng Biological Co., Ltd.; glucosamine sulfate and chondroitin sulfate were produced by Shandong Yibao Biological Products Co., Ltd.; and magnesium stearate was produced by Beijing Donghe Jiarui Technology Development Co., Ltd.

[0021] Preparation process (1) Raw material sieving: Calcium carbonate, magnesium stearate, chondroitin sulfate, and casein phosphopeptide were sieved through a 60-mesh sieve respectively; (2) Grinding: Grind the glucosamine sulfate and pass it through a 60-mesh sieve; (3) primary mixing: placing the calcium carbonate, chondroitin sulfate, and casein phosphopeptide sieved in step (1) and the glucosamine sulfate crushed in step (2) in a mixer and mixing for 30 minutes to obtain a mixed powder; (4) Secondary mixing: Add sifted magnesium stearate to the mixed powder and mix for 5 minutes to obtain the total mixed powder; (5) Capsule filling: Fill the total mixed powder into size 0 capsule shells to prepare 0.5 g / capsule capsules; (6) Polishing and inner packaging: polish the filled capsules, and timely remove the capsules with unqualified appearance, then pack 60 capsules in a high-density polyethylene bottle, and convey to outer packaging through a buffering device.

[0022] (7) Outer packaging and warehousing: package according to the packaging operation regulation, obtain a product qualification certificate after inspection, and then enter the warehouse and handle the warehousing formalities.

[0023] The sieving in step (1) and step (2) is 60-mesh oscillating sieving, and the mesh size is 0.25 mm.

[0024] The rotating speed of the mixer in step (3) is 20 r / min, and the rotating speed of the mixer in step (4) is 15 r / min.

[0025] Product formula

[0026] Prepare 1000 capsules according to the formula in Table I, and the specification is 0.5 g / capsule.

[0027] Table of the amount and safe amount of each raw material

[0028] The raw materials in the product are safe and reliable. The glucosamine sulfate widely exists in humans and animals, and can be synthesized from glucose in the body. It is one of the components of cartilage tissue. It can also be used in food, cosmetics and feed additives, and has quite wide application. Chondroitin sulfate is mainly extracted from the cartilage of pigs, cattle, chickens and sharks. The main application way is to be used as a drug for treating joint diseases, which is often used with glucosamine, has the effects of analgesia and promoting cartilage regeneration, and can fundamentally improve joint problems. The two raw materials have wide application and long use history, and the safety and efficacy are worthy of affirmation. Casein phosphopeptide is a biologically active polypeptide prepared from cow milk casein by biotechnology, which can be used in various nutritional and health foods, and can effectively promote the absorption and utilization of calcium, iron, zinc and other divalent mineral nutrients in the human body, and is a commonly used additive.

[0029] The amount of each raw material in the product formula and the highest safe amount are shown in Table II.

[0030] The calcium carbonate, glucosamine sulfate and casein phosphopeptide in the raw materials of the product are common nutritional additives, and chondroitin sulfate is usually used with glucosamine sulfate to improve joint problems.

[0031] Although the specific embodiments of the present application are described above, those skilled in the art should understand that this is only an example, and the protection scope of the present application is defined by the appended claims.

[0032] Those skilled in the art may make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but these changes and modifications shall fall within the scope of protection of the present invention.

Claims

1. A glucosamine chondroitin capsule, characterized in that: The components in parts by weight include: 160-190 parts of calcium carbonate, 230-270 parts of glucosamine sulfate, 30-70 parts of chondroitin sulfate, 15-25 parts of casein phosphopeptide, and 1-3 parts of magnesium stearate.

2. The capsule according to claim 1, wherein The preferred proportion of the capsule is 175 parts of calcium carbonate, 250 parts of glucosamine sulfate, 50 parts of chondroitin sulfate, 23 parts of casein phosphopeptide, and 2 parts of magnesium stearate.

3. The capsule according to claim 1, wherein The dosage form of the capsule is a hard capsule, and each capsule has a total weight of 0.5 g.

4. A method for preparing glucosamine chondroitin capsules, characterized in that: The following steps are involved: (1) Raw material sieving: Calcium carbonate, magnesium stearate, chondroitin sulfate, and casein phosphopeptide were sieved through a 60-mesh sieve respectively; (2) Grinding: Grind the glucosamine sulfate and pass it through a 60-mesh sieve; (3) Primary mixing: the calcium carbonate, chondroitin sulfate, and casein phosphopeptide sieved in step (1) and the glucosamine sulfate crushed in step (2) are placed in a mixer and mixed for 30 minutes to obtain a mixed powder; (4) Secondary mixing: adding sifted magnesium stearate to the mixed powder and mixing for 5 minutes to obtain a total mixed powder; (5) Capsule filling: Fill the total mixed powder into size 0 capsule shells to prepare 0.5 g / capsule capsules; (6) Polishing and inner packaging: Polish the filled capsules and remove capsules with unqualified appearance in time. Then, pack them into high-density polyethylene bottles at a rate of 60 capsules per bottle and transfer them to outer packaging through a buffer device; (7) Outer packaging and warehousing: Pack the products according to the packaging operating procedures, obtain the product certificate after passing the inspection, and then put them into storage and go through the warehousing procedures.

5. The preparation method according to claim 4, characterized in that The sieving in step (1) and step (2) is performed by sieving through a 60-mesh oscillating sieve with a sieve aperture of 0.25 mm.

6. The preparation method according to claim 4, characterized in that The rotating speed of the mixer in step (3) is 20 to 25 r / min, and the rotating speed of the mixer in step (4) is 15 to 20 r / min.

7. The preparation method according to claim 4, characterized in that In the inner packaging process of step (6), unqualified products such as those with poor sealing need to be eliminated.

8. The preparation method according to any one of claims 4 to 6, characterized in that Steps (1) to (6) are carried out in a Class 300,000 clean work area.

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