Children intestine and stomach health-care probiotic powder and production method thereof

Abstract

The invention relates to the field of biological medicine, in particular to child intestine and stomach health-care probiotic powder and a production method thereof. Every 2 g of the child intestine and stomach health-care probiotic powder comprises the following components: a probiotic group comprising 50-70 billion CFU of lactobacillus rhamnosus, 50-70 billion CFU of bifidobacterium animalis subsp. Lactis and 40-60 billion CFU of streptococcus thermophilus; the prebiotic composition comprises 80 mg of galactooligosaccharide and 50 mg of fructo-oligosaccharide; the traditional Chinese medicine extract comprises 50 mg of fried malt flour, 30 mg of hawthorn fruit powder, 40 mg of Chinese yam peptide powder and 20 mg of pericarpium citri reticulatae volatile oil micro-capsules; the nutrient enrichment combination comprises 3mg of yeast zinc and 0.5 mg of vitamin B1; the carrier and the protective agent comprise 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; 80 mg of a seasoning composition; and 20mg of process auxiliary materials. According to the whole design, the efficacy, safety and palatability are balanced, and the health-care effect on intestines and stomach is obvious while the food standard and the use requirement of children are completely met.

Description

Technical Field

[0001] The present invention relates to the field of biomedicine, and in particular to a probiotic powder for children's gastrointestinal health care and a production method thereof. Background Art

[0002] Currently, children's probiotic formulas on the market primarily utilize strain combinations primarily based on Bifidobacterium and Lactobacillus, such as BB-12 and LGG, clinically validated strains. These products often incorporate prebiotics (such as FOS and GOS) to promote probiotic proliferation, and some also include nutrients such as vitamins and minerals. Powders and chewable tablets are the primary dosage forms, with a focus on palatability and the addition of fruit flavors to enhance child acceptance. Most products improve digestion by regulating the balance of intestinal flora, and some high-end products incorporate strain encapsulation to enhance survival rates. These formulas generally meet the general intestinal health needs of children and most meet food safety standards.

[0003] Existing formulas still have several shortcomings: First, the bacterial strain combination is relatively simple, lacking personalized designs for children's special needs (such as allergies and lactose intolerance); second, the ratio of prebiotics to probiotics lacks scientific basis, resulting in limited synergistic effects; third, the integration of traditional Chinese medicine ingredients is neglected, resulting in weak functions in promoting digestive enzyme secretion and intestinal mucosal repair; fourth, trace element additions are often calculated based on experience rather than strictly according to recommended intakes, posing the risk of overdose; fifth, the flavoring system relies on artificial sweeteners or excessive sugar, which is inconsistent with healthy dietary principles; and finally, product stability research is insufficient, with strain survival rates significantly decreasing with storage time. These shortcomings limit the product's efficacy and scope of application. Summary of the Invention

[0004] In response to the problems existing in the background technology, a probiotic powder for children's gastrointestinal health care and a production method thereof are proposed. The overall design balances efficacy, safety and palatability. While fully meeting children's food standards and usage requirements, it has obvious effects on gastrointestinal health care.

[0005] The present invention provides a probiotic powder for children's gastrointestinal health care, comprising: per 2g of the probiotic powder for children's gastrointestinal health care, the probiotic group includes 5 billion to 7 billion CFU of Lactobacillus rhamnosus, 5 billion to 7 billion CFU of Bifidobacterium animalis lactis subsp. lactis, and 4 billion to 6 billion CFU of Streptococcus thermophilus; wherein the biological preservation number of Streptococcus thermophilus is CGMCC No. 20980, and the reference biological material is JL-03; the biological preservation number of Bifidobacterium animalis lactis subsp. lactis is CGMCC No. 20981, and the reference biological material is JL-04; the biological preservation number of Lactobacillus rhamnosus .... No.20979, the reference biological material is JL-02; the prebiotic combination includes 80mg galacto-oligosaccharide and 50mg fructo-oligosaccharide; the Chinese medicine extract includes 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel essential oil microcapsule; the nutritional fortification combination includes 3mg yeast zinc and 0.5mg vitamin B1; the carrier and protective agent includes 600mg microcrystalline cellulose, 100mg trehalose and 60mg hydroxypropyl methylcellulose; the flavoring combination 80mg; and the process excipient 20mg.

[0006] Preferably, every 2g of children's gastrointestinal health probiotic powder includes: probiotic groups including 5 billion CFU of Lactobacillus rhamnosus, 5 billion CFU of Bifidobacterium animalis subsp. lactis and 4 billion CFU of Streptococcus thermophilus; prebiotic combination including 80mg of galacto-oligosaccharides and 50mg of oligofructose; Chinese medicine extracts including 50mg of roasted malt powder, 30mg of hawthorn powder, 40mg of yam peptide powder and 20mg of tangerine peel volatile oil microcapsules; nutritional fortification combination including 3mg of yeast zinc and 0.5mg of vitamin B1; carrier and protective agent including 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; flavoring combination 80mg; and process excipients 20mg.

[0007] Preferably, every 2g of children's gastrointestinal health probiotic powder includes: probiotic groups including 6 billion CFU Lactobacillus rhamnosus, 6 billion CFU Bifidobacterium animalis subsp. lactis and 5 billion CFU Streptococcus thermophilus; prebiotic combination including 80mg galacto-oligosaccharides and 50mg fructo-oligosaccharides; Chinese medicine extracts including 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel volatile oil microcapsules; nutritional fortification combination including 3mg yeast zinc and 0.5mg vitamin B1; carrier and protective agent including 600mg microcrystalline cellulose, 100mg trehalose and 60mg hydroxypropyl methylcellulose; flavoring combination 80mg; and process excipients 20mg.

[0008] Preferably, every 2g of children's gastrointestinal health probiotic powder includes: a probiotic group including 57 billion CFU of Lactobacillus rhamnosus, 7 billion CFU of Bifidobacterium animalis subsp. lactis and 6 billion CFU of Streptococcus thermophilus; a prebiotic combination including 80mg of galacto-oligosaccharides and 50mg of oligofructose; a Chinese medicine extract including 50mg of roasted malt powder, 30mg of hawthorn powder, 40mg of yam peptide powder and 20mg of tangerine peel volatile oil microcapsules; a nutritional fortification combination including 3mg of yeast zinc and 0.5mg of vitamin B1; a carrier and protective agent including 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; a flavoring combination of 80mg; and 20mg of process excipients.

[0009] Preferably, the 80 mg flavoring combination includes 50 mg freeze-dried mango powder and 30 mg coconut powder.

[0010] Preferably, the process auxiliary material is resistant dextrin.

[0011] Preferably, the hawthorn powder is extracted using a 10:1 concentrated extraction.

[0012] The present invention provides a method for producing the above-mentioned children's gastrointestinal health probiotic powder, which comprises the following steps: S1, Chinese medicine pretreatment: preparation of roasted malt, extraction of hawthorn, and preparation of yam peptide; S2. Preparation of probiotic carrier: Mix galacto-oligosaccharide and fructo-oligosaccharide in appropriate proportions, add microcrystalline cellulose as an adsorption matrix, and mix in a three-dimensional mixer for 10 minutes until uniform. Add trehalose to the mixed matrix, dissolve it in a small amount of purified water to form a spray solution, and perform fluidized bed granulation to prepare a porous probiotic protective carrier. The moisture content is controlled to be below 3%. S3, staged mixing process: First, pre-mix the Chinese medicine layer. In a clean room with humidity less than 30% and temperature of 20-25°C, mix the freeze-dried bacterial powder and the prebiotic carrier at low speed for 20 minutes using a three-dimensional motion mixer. Then, mix the Chinese medicine pre-mix powder and the probiotic mixed powder in a double-layer conical mixer according to the proportion for 10 minutes. Then, add the nutritional enhancer and flavoring agent in sequence. The total mixing time is strictly controlled within 30 minutes, and the mixing uniformity RSD is ≤5%. S4, stability treatment: fluidized bed coating and addition of tangerine peel oil microcapsules; S5. Packaging and activation verification.

[0013] Preferably, the ambient humidity during the entire production process is ≤40%, and temperature-sensitive steps must be completed in a constant temperature and humidity room.

[0014] Compared with existing technologies, this invention offers the following beneficial technical benefits: This formula utilizes a scientifically formulated probiotic combination, with 130mg of prebiotics and 140mg of traditional Chinese medicine extracts (such as roasted malt and hawthorn) forming a synergistic ratio of 1:1.07, promoting both probiotic proliferation and enhancing digestion. Regarding safety, zinc content is strictly controlled at 3mg / day (30% of the recommended daily recommended intake), minimizing the risk of overdose. Furthermore, 80mg of natural flavoring (mango and coconut) is used, resulting in a sweetness equivalent to only 2% sucrose, ensuring both palatability and health benefits. The overall design balances efficacy, safety, and palatability, fully complying with children's food standards and usage requirements while providing significant gastrointestinal health benefits. DETAILED DESCRIPTION

[0015] The three strains described in the present invention were all deposited in the General Microbiology Center of China Culture Collection Administration of Microorganisms (CGMCC) in Chaoyang District, Beijing on October 29, 2020, among which Lactobacillus rhamnosus Lactobacillus buckthorn The biological deposit number is CGMCC No.20979, and the reference biological material is JL-02; Streptococcus thermophilus Streptococcus thermophilus The biological deposit number is CGMCC No.20980, and the reference biological material is JL-03; Bifidobacterium animalis subsp. lactis Bifidobacterium animalis subsp. lactis The biological deposit number is CGMCC No. 20981, and the reference biological material is JL-04.

[0016] Example 1. The present invention proposes a probiotic powder for children's gastrointestinal health care. Every 2g of the probiotic powder for children's gastrointestinal health care includes: a probiotic group including 5 billion CFU of Lactobacillus rhamnosus, 5 billion CFU of Bifidobacterium animalis subspecies lactis and 4 billion CFU of Streptococcus thermophilus; a prebiotic combination including 80mg of galacto-oligosaccharides and 50mg of oligofructose; a traditional Chinese medicine extract including 50mg of roasted malt powder, 30mg of hawthorn powder, 40mg of yam peptide powder and 20mg of tangerine peel volatile oil microcapsules; a nutritional fortification combination including 3mg of yeast zinc and 0.5mg of vitamin B1; a carrier and protective agent including 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; a seasoning combination of 80mg; and 20mg of process excipients.

[0017] It should be further clarified that the 80mg flavoring combination includes 50mg of freeze-dried mango powder and 30mg of coconut powder. The process excipient is resistant dextrin. The hawthorn powder is extracted using a 10:1 concentrated extract.

[0018] In embodiment 2, the present invention proposes a probiotic powder for children's gastrointestinal health care. Every 2g of the probiotic powder for children's gastrointestinal health care includes: a probiotic group including 6 billion CFU of Lactobacillus rhamnosus, 6 billion CFU of Bifidobacterium animalis subspecies lactis and 5 billion CFU of Streptococcus thermophilus; a prebiotic combination including 80mg of galacto-oligosaccharides and 50mg of oligofructose; a traditional Chinese medicine extract including 50mg of roasted malt powder, 30mg of hawthorn powder, 40mg of yam peptide powder and 20mg of tangerine peel volatile oil microcapsules; a nutritional fortification combination including 3mg of yeast zinc and 0.5mg of vitamin B1; a carrier and protective agent including 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; a seasoning combination of 80mg; and 20mg of process excipients.

[0019] It should be further clarified that the 80mg flavoring combination includes 50mg of freeze-dried mango powder and 30mg of coconut powder. The process excipient is resistant dextrin. The hawthorn powder is extracted using a 10:1 concentrated extract.

[0020] Example 3. The present invention proposes a probiotic powder for children's gastrointestinal health care. Every 2g of the probiotic powder for children's gastrointestinal health care includes: a probiotic group including 57 billion CFU of Lactobacillus rhamnosus, 7 billion CFU of Bifidobacterium animalis subspecies lactis and 6 billion CFU of Streptococcus thermophilus; a prebiotic combination including 80mg of galacto-oligosaccharides and 50mg of oligofructose; a Chinese medicine extract including 50mg of roasted malt powder, 30mg of hawthorn powder, 40mg of yam peptide powder and 20mg of tangerine peel volatile oil microcapsules; a nutritional fortification combination including 3mg of yeast zinc and 0.5mg of vitamin B1; a carrier and protective agent including 600mg of microcrystalline cellulose, 100mg of trehalose and 60mg of hydroxypropyl methylcellulose; a seasoning combination of 80mg; and 20mg of process excipients.

[0021] It should be further clarified that the 80mg flavoring combination includes 50mg of freeze-dried mango powder and 30mg of coconut powder. The process excipient is resistant dextrin. The hawthorn powder is extracted using a 10:1 concentrated extract.

[0022] Example 4: Based on the above examples, this example proposes a method for producing the probiotic powder for children's gastrointestinal health care, and the steps are as follows: S1, Chinese medicine pretreatment; Preparation of roasted malt: Selected barley is soaked until it germinates. When the buds grow to 0.5 cm, they are slowly roasted over low heat (60-80°C) until the surface is fragrant and the interior is light yellow. Then, they are ground with an ultra-fine grinder and passed through a 200-mesh sieve to ensure that the powder is fine and uniform and retains the amylase activity. Hawthorn Extraction: Fresh hawthorns are pitted and crushed, and pectinase (0.1%) is added for enzymatic hydrolysis at 45°C for 2 hours. The mixture is then vacuum concentrated at 60°C to a solid content of ≥30%, and then spray dried (inlet air temperature 85°C, outlet air temperature 55°C) to form a powder with a moisture content of ≤5%. Preparation of yam peptides: Fresh yam was peeled and pulped, the pH was adjusted to 6.0, and Aspergillus oryzae (inoculation amount 3%) was inoculated and solid-state fermented at 30°C for 48 hours. After enzyme inactivation, the supernatant was centrifuged and the small molecule peptides were separated by ultrafiltration (5kDa membrane), and freeze-dried to obtain yam peptide powder; S2, probiotic carrier preparation; Galacto-oligosaccharides (GOS) and fructo-oligosaccharides (FOS) were mixed in proportion, and then an equal amount of microcrystalline cellulose was added as an adsorption matrix, and mixed in a three-dimensional mixer for 10 minutes until uniform.

[0023] 5% trehalose (w / w) was added to the mixed matrix, dissolved in a small amount of purified water to form a spray liquid, and granulated in a fluidized bed (inlet air temperature 40°C) to prepare a porous probiotic protection carrier with moisture content controlled below 3%.

[0024] S3, staged mixing process; Premixing of the Chinese medicine layer: Add roasted malt powder, hawthorn powder, and yam peptide powder according to the formula ratio into a V-type mixer and mix at 15 rpm for 15 minutes to ensure consistent powder fluidity; Probiotic loading: In a clean room with humidity <30% and temperature 20-25°C, freeze-dried bacterial powder (LGG, BB-12, etc.) and prebiotic carrier were mixed with a three-dimensional motion mixer at low speed (10 rpm) for 20 minutes to avoid mechanical thermal damage to the bacteria.

[0025] Step-by-step mixing: First, mix the traditional Chinese medicine premix powder and the probiotic mixed powder in proportion in a double-layer conical mixer for 10 minutes; then add nutritional enhancers such as yeast zinc and vitamin B1, as well as freeze-dried mango powder and coconut powder flavorings in sequence. The total mixing time is strictly controlled within 30 minutes, and the mixing uniformity RSD is ≤5%.

[0026] S4, stability processing; Fluidized bed coating: The mixed powder is placed in a bottom-spray fluidized bed and a 3% hydroxypropyl methylcellulose (HPMC) aqueous solution is used as the coating agent (atomization pressure 0.8 bar, inlet air temperature 35°C) to form an isolation layer with a thickness of about 20 μm. The coating weight gain is controlled at 5%.

[0027] Tangerine peel oil microcapsule addition: Resistant dextrin and tangerine peel volatile oil are included in a molar ratio of 1:4, spray-dried to form microcapsules, and manually blended after the mixed powder is cooled to room temperature to prevent the volatile oil from escaping due to high temperature.

[0028] S5, packaging and activation verification; Nitrogen-filled packaging: Use four-side sealed aluminum foil bags (oxygen transmission rate <0.1cc / m² / day), automatically packaged under nitrogen replacement (residual oxygen <0.5%) environment, 2g per bag, heat seal strength ≥3N / 15mm.

[0029] Stability test: Randomly sample finished products and conduct accelerated testing at 38°C and RH75% for 3 months. Every 30 days, test the viable cell count (GB 4789.35) and moisture content (GB 5009.3). The CFU loss rate must be less than 15% and the moisture content must be less than 1%.

[0030] It should be noted that the ambient humidity throughout the production process should be ≤40%, and temperature-sensitive steps (probiotic mixing and coating) must be completed in a constant temperature and humidity room (20±2℃, RH30±5%).

[0031] Gastrointestinal health effect verification experiment This study employed a randomized, double-blind, placebo-controlled clinical trial to systematically evaluate the effects of a probiotic formula on improving gastrointestinal function in children aged 3-12 years. A total of 100 eligible children were recruited and randomly divided into an experimental group (n=50) and a control group (n=50) for an 8-week intervention study. The experimental group received 2g of a probiotic formula (containing 20 billion CFU of a complex bacterial strain and a traditional Chinese medicine extract) daily, while the control group received an equivalent placebo (maltodextrin and flavoring). The study consisted of three phases: a baseline period (Day 0), an intervention period (Weeks 1-8), and a follow-up period (4 weeks after discontinuation of the treatment). The efficacy of the probiotic formula was evaluated using multiple indicators.

[0032] The study utilized a combined subjective and objective evaluation system for evaluation indicators. Subjective indicators included daily parent-recorded bowel movement frequency (Bristol Stool Scale) and abdominal distension / pain scores (0-10 scale); objective indicators included fecal microbiome 16S rRNA sequencing, short-chain fatty acid HPLC analysis, intestinal permeability L / M testing, and serum inflammatory cytokine ELISA. The experimental protocol adhered to strict standardized procedures: initial sample collection (feces, blood, and urine) and symptom assessment were completed at baseline; a mid-term follow-up was conducted at week 4 of the intervention period; baseline testing was repeated at week 8; and the persistence of efficacy was observed during the follow-up period. Data were analyzed using repeated-measures analysis of variance (for primary symptom indicators), LEfSe analysis (for microbiome differences), and Spearman correlation tests. The primary efficacy endpoint was a bowel movement improvement rate ≥60% in the experimental group (≤30% in the control group), with statistical significance of at least two microbiological / biochemical indicators (p<0.05). Stratified randomization was used to control for individual variability, and a double-blind design and objective evaluation were employed to minimize the impact of placebo effects.

[0033] Children's Probiotic Formula Clinical Trial Results Record Form Combined with the results in the above table, the effectiveness of the present invention in gastrointestinal health can be confirmed. In terms of strain ratio design, this formula adopts a combination strategy with dominant bacteria (LGG + BB-12) accounting for 60% and auxiliary bacteria (M-16V + Streptococcus thermophilus) accounting for 40%. This strategy not only ensures the dominant role of the core strains (LGG and BB-12) in intestinal colonization and immune regulation, but also achieves more comprehensive microecological regulation through the auxiliary functions of M-16V (for allergic constitutions) and Streptococcus thermophilus (promoting lactose digestion). This ratio strictly complies with the strain compatibility requirements of China's "Regulations on the Evaluation of Probiotic Health Foods," ensuring a balance between safety and efficacy. The synergistic design of traditional Chinese medicine (TCM) and prebiotics in the formula includes a total of 130mg of prebiotics (GOS + FOS), with a controlled ratio of 1:1.07 to the TCM extracts (roasted malt, hawthorn, Chinese yam, and dried tangerine peel, totaling 140mg). This allows the prebiotics to precisely promote the proliferation of probiotics (particularly bifidobacteria and lactobacilli). Simultaneously, the TCM ingredients synergistically improve digestion by promoting the secretion of digestive enzymes (such as malt amylase and hawthorn organic acids) and intestinal mucosal repair (Chinese yam polysaccharides), achieving a dual mechanism of "microbiome regulation and digestive support." Regarding safe dosage control, the zinc (in the form of yeast zinc) is strictly set at 30% of the RNI (Recommended Daily Intake) for children aged 1-3 years in China, or 3mg / day. This ensures the safety of long-term use by meeting the needs of intestinal repair and immune support while avoiding the potential gastrointestinal irritation or interference with copper metabolism caused by excessive intake. To optimize taste, the formula utilizes a natural flavor system, with freeze-dried mango powder and coconut powder as the primary flavorings. The total added amount is controlled at 80mg (4%), resulting in a sweetness equivalent to 2% sucrose. This effectively masks the off-flavors of the probiotics and traditional Chinese medicine while avoiding the addition of refined sugar, aligning with healthy dietary principles for children and enhancing product palatability and compliance. Overall, this formulation achieves a balance between scientific rationality, safety, and palatability, meeting functional requirements while complying with children's food regulations and consumer preferences. The aforementioned Streptococcus thermophilus has a biodeposit number of CGMCC No. 20980, and its reference biological material is JL-03; Bifidobacterium animalis subsp. lactis has a biodeposit number of CGMCC No. 20981, and its reference biological material is JL-04; and Lactobacillus rhamnosus has a biodeposit number of CGMCC No. 20979, and its reference biological material is JL-02.

[0034] The embodiments of the present invention are described in detail above, but the present invention is not limited thereto. Various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention.

Claims

1. A probiotic powder for children's gastrointestinal health care, characterized in that: Each 2g of children's gastrointestinal health probiotic powder contains: The probiotic flora includes 5-7 billion CFU of Lactobacillus rhamnosus, 5-7 billion CFU of Bifidobacterium animalis subsp. lactis, and 4-6 billion CFU of Streptococcus thermophilus. The biological deposit number of Streptococcus thermophilus is CGMCC No.20980, and the reference biological material is JL-03; The biological deposit number of Bifidobacterium animalis subsp. lactis is CGMCC No. 20981, and the reference biological material is JL-04; The biological deposit number of Lactobacillus rhamnosus is CGMCC No.20979, and the reference biological material is JL-02; The prebiotic combination includes 80mg of galacto-oligosaccharides and 50mg of fructo-oligosaccharides; The Chinese herbal extracts include 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel essential oil microcapsules; Nutritional fortification combination includes 3mg yeast zinc and 0.5mg vitamin B1; The carrier and protective agent include 600 mg microcrystalline cellulose, 100 mg trehalose and 60 mg hypromellose; Flavoring combination 80mg; and 20 mg of process excipients.

2. The children's gastrointestinal health probiotic powder according to claim 1, characterized in that Each 2g of children's gastrointestinal health probiotic powder contains: The probiotic flora includes 5 billion CFU of Lactobacillus rhamnosus, 5 billion CFU of Bifidobacterium animalis subsp. lactis, and 4 billion CFU of Streptococcus thermophilus. The prebiotic combination includes 80mg of galacto-oligosaccharides and 50mg of fructo-oligosaccharides; The Chinese herbal extracts include 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel essential oil microcapsules; Nutritional fortification combination includes 3mg yeast zinc and 0.5mg vitamin B1; The carrier and protective agent include 600 mg microcrystalline cellulose, 100 mg trehalose and 60 mg hypromellose; Flavoring combination 80mg; and 20 mg of process excipients.

3. The probiotic powder for children's gastrointestinal health care according to claim 1, characterized in that Each 2g of children's gastrointestinal health probiotic powder contains: The probiotic flora includes 6 billion CFU of Lactobacillus rhamnosus, 6 billion CFU of Bifidobacterium animalis subsp. lactis, and 5 billion CFU of Streptococcus thermophilus; The prebiotic combination includes 80mg of galacto-oligosaccharides and 50mg of fructo-oligosaccharides; The Chinese herbal extracts include 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel essential oil microcapsules; Nutritional fortification combination includes 3mg yeast zinc and 0.5mg vitamin B1; The carrier and protective agent include 600 mg microcrystalline cellulose, 100 mg trehalose and 60 mg hypromellose; Flavoring combination 80mg; and 20 mg of process excipients.

4. The probiotic powder for children's gastrointestinal health care according to claim 1, characterized in that Each 2g of children's gastrointestinal health probiotic powder contains: The probiotic flora includes 57 billion CFU of Lactobacillus rhamnosus, 7 billion CFU of Bifidobacterium animalis subsp. lactis, and 6 billion CFU of Streptococcus thermophilus; The prebiotic combination includes 80mg of galacto-oligosaccharides and 50mg of fructo-oligosaccharides; The Chinese herbal extracts include 50mg roasted malt powder, 30mg hawthorn powder, 40mg yam peptide powder and 20mg tangerine peel essential oil microcapsules; Nutritional fortification combination includes 3mg yeast zinc and 0.5mg vitamin B1; The carrier and protective agent include 600 mg microcrystalline cellulose, 100 mg trehalose and 60 mg hypromellose; Flavoring combination 80mg; and 20 mg of process excipients.

5. The probiotic powder for children's gastrointestinal health care according to claim 1, characterized in that: The 80mg flavored combination includes 50mg freeze-dried mango powder and 30mg coconut powder.

6. The probiotic powder for children's gastrointestinal health care according to claim 5, characterized in that: The process auxiliary material is resistant dextrin.

7. The probiotic powder for children's gastrointestinal health care according to claim 6, characterized in that: Hawthorn powder is extracted from a 10:1 concentrated solution.

8. The method for producing the probiotic powder for children's gastrointestinal health care according to claim 7, characterized in that: Here are the steps: S1, Chinese medicine pretreatment: preparation of roasted malt, extraction of hawthorn, and preparation of yam peptide; S2. Preparation of probiotic carrier: Mix galacto-oligosaccharide and fructo-oligosaccharide in appropriate proportions, add microcrystalline cellulose as an adsorption matrix, and mix in a three-dimensional mixer for 10 minutes until uniform. Add trehalose to the mixed matrix, dissolve it in a small amount of purified water to form a spray solution, and perform fluidized bed granulation to prepare a porous probiotic protective carrier. The moisture content is controlled to be below 3%. S3, staged mixing process: first pre-mix the Chinese medicine layer, and in a clean room with humidity <30% and temperature 20-25°C, mix the freeze-dried bacterial powder and the prebiotic carrier at low speed for 20 minutes using a three-dimensional motion mixer; Then, the Chinese medicine premix powder and the probiotic mixed powder were mixed in proportion in a double-layer conical mixer for 10 minutes; the nutritional enhancer and flavoring agent were added in sequence, and the total mixing time was strictly controlled within 30 minutes, and the mixing uniformity RSD was ≤5%; S4, stability treatment: fluidized bed coating and addition of tangerine peel oil microcapsules; S5. Packaging and activation verification.

9. The method for producing the probiotic powder for children's gastrointestinal health care according to claim 8, characterized in that: The ambient humidity during the entire production process is ≤40%, and temperature-sensitive steps must be completed in a constant temperature and humidity room.

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