Tibetan medicine ear drops for treating ear diseases as well as preparation method and application of Tibetan medicine ear drops

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a Tibetan medicine ear drop for treating ear diseases and a preparation method and application thereof, and the Tibetan medicine ear drop is prepared from the following raw materials in parts by weight: 150-300 parts of flos carthami, 150-250 parts of radish, 150-250 parts of garlic, 100-200 parts of common vladimiria root, 5-15 parts of ferula asafetida and 1-3 parts of musk. The Tibetan medicine ear drops can effectively relieve tinnitus, ear pain, auditory meatus suppuration and other symptoms caused by ear inflammation. In clinical tests, the total effective rate of an experimental group is remarkably higher than that of a control group, and the effect of the composition in treating ear diseases is shown. According to the Tibetan medicine ear drops, through the unique herbal medicine formula, symptoms can be relieved, hearing recovery can be promoted, the ear health condition of a patient can be fundamentally improved, and inflammation relapse is reduced.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a Tibetan medicine ear drop for treating ear diseases, its preparation method, and its application. Background Technology

[0002] Ear diseases can be classified anatomically into external ear diseases, middle ear diseases, inner ear diseases, and sensorineural ear diseases. External ear diseases, such as otitis externa and cerumen impaction, primarily lead to conductive hearing loss and local infection. Middle ear diseases, such as otitis media and cholesteatoma, can cause hearing loss and potentially lead to serious intracranial complications like meningitis. Inner ear diseases, such as Meniere's disease and noise-induced hearing loss, often cause irreversible sensorineural hearing loss and vertigo, severely impacting patients' quality of life. Sensorineural ear diseases, such as acoustic neuroma, can cause hearing impairment and potentially compress the brainstem, endangering life. The harm caused by ear diseases is not limited to the auditory system; it can also affect balance, language development, and even lead to psychological disorders.

[0003] Currently, treatment for ear diseases mainly relies on medication, surgery, and hearing aids. Drug treatments, such as antibiotics and corticosteroids, are effective for infectious and immune-mediated ear diseases, but they suffer from problems such as drug resistance and significant side effects, and their effectiveness is limited for sensorineural hearing loss. Surgical treatments, such as tympanoplasty and cochlear implantation, can repair structure or replace function, but they are subject to problems such as postoperative recurrence, high costs, and high technical barriers. Hearing aids can improve hearing, but they cannot cure the disease and have drawbacks such as poor adaptability and noise interference.

[0004] Therefore, there is an urgent need to provide a new strategy for the treatment of ear diseases. Summary of the Invention

[0005] This invention provides a Tibetan medicine ear drop that is highly effective in treating ear inflammation, and it significantly relieves symptoms such as tinnitus, dizziness, ear canal itching, ear canal discharge, ear pain, and hearing loss caused by ear inflammation.

[0006] This invention provides a Tibetan medicine ear drop solution for treating ear diseases, which is made from the following raw materials in parts by weight: 150-300 parts of pineapple flowers, 150-250 parts of radish, 150-250 parts of garlic, 100-200 parts of costus root, 5-15 parts of asafoetida, and 1-3 parts of musk.

[0007] Preferably, the Tibetan medicine ear drops are made from the following raw materials in parts by weight: 230 parts of bougainvillea, 200 parts of radish, 200 parts of garlic, 150 parts of costus root, 10 parts of asafoetida, and 2 parts of musk.

[0008] A second aspect of the present invention provides a method for preparing the Tibetan medicine ear drops, comprising the following steps: Prepare pollen from *Dendrobium nobile* flowers, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder; weigh out the pollen from *Dendrobium nobile* flowers, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder according to the stated weight proportions, and set aside for later use; Add radish powder to sesame oil, heat to 110℃~150℃ and maintain for 8min~12min to prepare radish powder-sesame oil; Once the radish powder-sesame oil has cooled to 90℃~100℃, add the pollen of *Platycladus orientalis*, garlic powder, costus root powder, and asafoetida powder. Maintain the temperature at 90℃~100℃ and continue heating for 30min~50min until the pollen of *Platycladus orientalis* turns yellowish-brown. Cool to room temperature, filter, and collect the filtrate. Add musk powder to the filtrate, stir well, and filter again to obtain the Tibetan medicine ear drops.

[0009] Preferably, the mass-to-volume ratio of the radish powder to the sesame oil is 1g:14mL~18mL.

[0010] Preferably, the heating conditions for preparing radish powder-sesame oil are: 130℃ for 10 minutes.

[0011] Preferably, the stirring conditions after adding musk powder are: 120 rpm for 20 min.

[0012] Preferably, the pollen of *Platycladus orientalis* is obtained by crushing *Platycladus orientalis* flowers and passing them through a 40-mesh sieve; The radish powder is obtained by crushing radish and passing it through a 40-mesh sieve. The garlic powder is obtained by crushing garlic and passing it through a 40-mesh sieve. The Sichuan costus powder is obtained by pulverizing Sichuan costus and passing it through a 40-mesh sieve. The asafoetida powder is obtained by pulverizing asafoetida and passing it through a 40-mesh sieve. The musk powder is obtained by crushing musk and passing it through a 200-mesh sieve.

[0013] A third aspect of the present invention provides an application of the Tibetan medicine ear drops, wherein the Tibetan medicine ear drops are used to prepare a drug for treating ear inflammation.

[0014] Preferably, the ear inflammation is otitis media.

[0015] The Tibetan medicine ear drops of this invention, in which the principal ingredient is *Prunus serrulata* flower, the assistant ingredients are radish and garlic, the adjuvant ingredient is *Saussurea costus*, and the guiding ingredients are *Ferula assa-foetida* and musk. The Tibetan medicine ear drops provided by this invention have the effect of treating ear canal diseases. Radish and garlic have the effect of promoting blood circulation and removing dampness; in combination with *Prunus serrulata* flower, they have the function of treating ear diseases, especially tinnitus; *Saussurea costus* has the effect of clearing pus and blood, and promoting blood circulation; combined with *Prunus serrulata* flower, radish, and garlic, it has the effect of improving hearing; *Ferula assa-foetida* and musk have the effects of clearing heat and detoxifying, and reducing inflammation; combined with *Prunus serrulata* flower, radish, garlic, and *Saussurea costus*, they have the effects of treating ear diseases, clearing heat and reducing inflammation, improving hearing, and eliminating tinnitus.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a Tibetan medicine ear drop solution for treating ear diseases. The ear drop solution is made from the following ingredients in parts by weight: 150-300 parts of *Platycladus orientalis* flower, 150-250 parts of radish, 150-250 parts of garlic, 100-200 parts of *Saussurea costus*, 5-15 parts of *Ferula assa-foetida*, and 1-3 parts of musk. This Tibetan medicine ear drop solution effectively relieves symptoms such as tinnitus, ear pain, and ear discharge caused by ear inflammation. In clinical trials, the total effective rate in the experimental group reached 92.0%, significantly higher than the 84.0% in the control group, demonstrating its high efficacy in treating ear diseases. Through its unique herbal formula, this Tibetan medicine ear drop solution not only relieves symptoms but also promotes hearing recovery, helping patients fundamentally improve their ear health and reduce the recurrence of inflammation.

[0017] In addition, the Tibetan medicine ear drops described in this invention have the following advantages: 1. Improve patient comfort.

[0018] Reduced drug irritation: Compared with traditional ear medications, the Tibetan medicine ear drops formula of this invention is carefully designed to reduce drug irritation, decrease discomfort during use, and improve the patient's medication experience.

[0019] Safe and non-invasive: The ear drops of this invention are a non-invasive treatment method that avoids the trauma and complications that may result from surgical treatment, and are especially suitable for special groups such as children and the elderly.

[0020] 2. The drug has high stability and safety.

[0021] Natural herbal ingredients: The raw materials used in this invention are all natural herbs, which have a long history of use in traditional medicine and whose safety has been widely recognized.

[0022] Scientific preparation process: A scientific preparation process ensures the stability and consistency of the drug. Strict procedures for pulverization, heating, filtration, and stirring ensure uniform distribution of drug components, guaranteeing efficacy with each use.

[0023] 3. High cost-effectiveness.

[0024] Low raw material cost: The raw materials of this invention are relatively easy to obtain and have low cost, which makes the ear drops have a high cost-performance ratio when produced and used on a large scale.

[0025] Low treatment cost: Compared with some high-cost biological agents or surgical procedures, the Tibetan medicine ear drops of this invention have a lower treatment cost, which can save patients a lot of medical expenses and make effective treatment affordable for more patients.

[0026] 4. Wide range of applications.

[0027] Various ear diseases: The Tibetan medicine ear drops of this invention are suitable for various types of ear diseases, including otitis media, otitis externa, etc., and have wide applicability.

[0028] Patients of different ages: This ear drop is suitable for patients of different ages, especially children and the elderly, providing a safe and effective treatment option for these special groups.

[0029] 5. High clinical application value Filling a market gap: Current treatments for ear diseases have certain limitations. The Tibetan medicine ear drops of this invention provide a new treatment strategy, filling a market gap.

[0030] Improving treatment adherence: Due to its ease of use, significant effects, and low cost, it can improve patient adherence to treatment and help improve long-term patient outcomes.

[0031] 6. Multi-target therapy.

[0032] Comprehensive Efficacy: The Tibetan medicine ear drops of this invention achieve multi-target treatment through the synergistic effect of multiple herbs. Ingredients such as *Prunus armeniaca* flower, radish, and garlic have the effects of clearing heat and detoxifying, antibacterial and anti-inflammatory properties; *Saussurea costus* has the effects of promoting pus drainage and blood circulation, and clearing the meridians and regulating qi; *Ferula assa-foetida* and musk have the effects of clearing heat and detoxifying, and reducing inflammation. The combined use of these ingredients can comprehensively improve ear inflammation and enhance the treatment effect.

[0033] Enhance hearing: The ingredients in the formula not only relieve inflammation, but also promote blood circulation in the ear and enhance hearing through the effects of promoting blood circulation, removing blood stasis, and relieving pain. It has a significant effect on improving tinnitus and hearing loss.

[0034] In summary, the Tibetan medicine ear drops of the present invention have significant benefits in the treatment of ear diseases. It can not only effectively relieve symptoms, promote hearing recovery, but also improve patient comfort. It has high stability and safety, and at the same time, it has high cost-effectiveness and a wide range of applications, having important clinical application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a finished product diagram of the Tibetan medicine ear drops. A: Appearance picture of the Tibetan medicine ear drops; B: Single display diagram of A.

[0036] Figure 2 It is the experimental process of the researchers in this research group for preparing the Tibetan medicine ear drops. SPECIFIC EMBODIMENTS

[0037] The present invention will be further described below through specific embodiments, but it does not limit the scope of the present invention. Without departing from the spirit and scope of the present invention, modifications or substitutions can be made to the details and forms of the technical solutions of the present invention, but these modifications or substitutions all fall within the protection scope of the present invention.

[0038] The inventive concept of the present invention is as follows: In Tibetan medicine theory, otitis media belongs to the category of "ear diseases", which is mostly caused by the imbalance of the three factors of lung qi, bile qi, and phlegm qi. External invasion of wind-cold or wind-heat pathogens into the ear causes the upward reversal of lung qi and the exuberance of bile qi heat, or improper diet leads to the accumulation of phlegm qi, resulting in poor qi and blood circulation in the ear canal and the retention of pathogenic toxins, presenting symptoms such as earache, tinnitus, and ear discharge. The treatment should take the core principles of regulating the three factors, clearing heat and detoxifying, dredging the channels and reducing swelling, and removing necrosis and promoting granulation.

[0039] Tibetan medical classics record that the densely growing Indian pennywort is astringent, bitter, and cool in nature, and is good at clearing away the heat pathogen of bile qi. The flavonoids, alkaloids and other components it contains can inhibit the inflammatory reaction in the ear, reduce swelling, heat and pain, and eliminate the symptoms of ear canal congestion and swelling caused by excessive bile qi. The astringency of the densely growing Indian pennywort can astringe the damaged mucosa in the ear and promote the repair of local tissues; at the same time, it can reduce inflammatory exudation and accelerate the discharge of pus in the ear canal, which conforms to the Tibetan medical treatment concept of "removing necrosis and promoting granulation".

[0040] Radish is pungent, sweet, and cool in nature, and can promote digestion and resolve the accumulation of phlegm qi caused by improper diet. The imbalance of phlegm qi is often accompanied by the endogenous generation of damp turbidity, leading to an increase in ear canal secretions and blockage. Radish can indirectly improve the state of damp turbidity stagnation in the ear by regulating gastrointestinal function. Its cold nature can clear and descend the upward-reversing fire, make the lung qi flow smoothly, qi and blood unobstructed, relieve symptoms such as ear fullness and tinnitus, and restore the patency of the ear orifices.

[0041] Garlic is pungent and warm in nature, possessing a warming and unblocking effect. It can dispel symptoms of cold stagnation in the ear caused by external cold pathogens or stagnation of qi. Its components, such as allicin, have antibacterial and anti-inflammatory properties, inhibiting pathogenic bacteria such as Staphylococcus aureus and Escherichia coli in the ear canal and eliminating sources of infection. Its pungent flavor can stimulate blood circulation in the ear, clearing the meridians of the ear canal and relieving pain and stuffiness caused by poor blood flow, aligning with the Tibetan medicine principle of "treating by unblocking."

[0042] Sichuan oak has a pungent and bitter aroma, and is warm in nature. It excels at promoting qi circulation and relieving pain, and can regulate disordered qi. Otitis media is often accompanied by ear distension and pain, and tinnitus. Sichuan oak can relieve pain and blood stasis caused by the upward flow of qi in the ear by unblocking the qi flow in the ear. It can also enhance the spleen and stomach's digestive function, reduce the internal generation of dampness, and fundamentally improve problems such as increased ear secretions and dampness stagnation caused by excessive spleen and stomach qi.

[0043] Asafoetida has a pungent and warm flavor with a strong irritating odor. It can break up stagnation, detoxify, and kill parasites. In the treatment of otitis media, it can dispel toxins accumulated in the ear canal, promote the drainage of pus, eliminate necrotic tissue, and improve the putrefactive environment in the ear canal. Its aromatic and penetrating properties can penetrate ear canal blockages, quickly improve symptoms of ear obstruction, and relieve tinnitus and hearing loss.

[0044] Musk, with its pungent and penetrating aroma and warm properties, is considered the "primary medicine for clearing the orifices" in Tibetan medicine. It can quickly penetrate the ear's meridians, unblock blood and qi, and eliminate the feeling of blockage in the ear, showing significant efficacy for symptoms of ear obstruction such as tinnitus and deafness. Musk can promote blood circulation in the ear, dissipate blood stasis, and reduce swelling and pain caused by inflammation; at the same time, its anti-inflammatory active ingredients can inhibit inflammatory responses and accelerate the repair of damaged tissues.

[0045] The above-mentioned medicinal materials are used in combination: *Platycladus orientalis* flower and radish clear away heat and dampness; garlic and costus root warm and invigorate qi, relieve pain; asafoetida removes putrefaction and detoxifies; and musk opens the orifices and promotes blood circulation. The entire formula works synergistically to harmonize the three factors (cause, effect, and symptom), clear heat and detoxify, and open the orifices to drain pus. It not only eliminates the local symptoms of otitis media but also regulates the body's overall balance, achieving both symptomatic and root-cause treatment, reflecting the unique advantages of Tibetan medicine's "holistic conditioning and syndrome differentiation-based treatment."

[0046] To enable those skilled in the art to better understand and implement the technical solutions of this invention, the invention will be further described below with reference to specific embodiments. Unless otherwise specified, all reagents used in this invention are commercially available, and all methods used are conventional techniques in the art.

[0047] In the following examples, 1g represents one part by weight.

[0048] Example 1 A method for preparing Tibetan medicine ear drops for treating ear diseases is as follows: S1: Prepare pollen from *Rhododendron simsii*, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder.

[0049] The flowers of *Platycladus orientalis*, radish, garlic, costus root, and asafoetida were each pulverized using a grinder and passed through a 40-mesh sieve to obtain *Platycladus orientalis* flower powder, radish powder, garlic powder, costus root powder, and asafoetida powder. Musk was pulverized using a small grinder and passed through a 200-mesh sieve to obtain musk powder.

[0050] S2: Add radish powder to sesame oil and heat to prepare radish powder-sesame oil.

[0051] Take 200g of radish powder, add 3000mL of sesame oil, and slowly heat it to 130℃ in a reaction vessel. Maintain this temperature for 10 minutes, then cool it to 100℃. To enhance the mixing of radish powder and sesame oil and improve the heat-clearing and fire-reducing effects of radish powder, it is recommended to heat the radish powder and sesame oil together before processing.

[0052] S3: After the radish powder and sesame oil have cooled, add the pollen of *Platycladus orientalis*, garlic powder, costus root powder and asafoetida powder, and continue heating until the pollen of *Platycladus orientalis* turns yellowish-brown. Cool to room temperature, filter, and collect the filtrate.

[0053] Add 230g of pineapple pollen, 200g of garlic powder, 150g of costus root powder and 10g of asafoetida powder, and continue heating to 90℃ for 40 minutes until the pineapple flowers turn yellowish-brown. Let it cool to room temperature, filter it four times with filter paper until the filtrate is completely clear, and collect the filtrate.

[0054] S4: Add musk powder to the filtrate, stir well, and filter again to obtain the Tibetan medicine ear drops.

[0055] Add 2g of musk powder to the filtrate, stir at 120rpm for 20min, pass through a 200-mesh sieve, and dispense the pure solution into individual containers to obtain the Tibetan medicine ear drops. Store in sterile containers in sealed containers. See finished product image. Figure 1 . Figure 2 The experimental process for preparing Tibetan medicine ear drops for our research group.

[0056] In Tibetan medicine theory, because musk is a volatile drug, prolonged heating will cause the medicinal properties to evaporate and the efficacy to decrease. Therefore, it is added at the end of the preparation process.

[0057] Example 2 A method for preparing Tibetan medicine ear drops for treating ear diseases is as follows: S1: Prepare pollen from *Rhododendron simsii*, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder.

[0058] The flowers of *Platycladus orientalis*, radish, garlic, costus root, and asafoetida were each ground separately using a grinder and passed through a 40-mesh sieve to obtain powders of *Platycladus orientalis*, radish, garlic, costus root, and asafoetida, which were then set aside. Musk was ground using a small grinder and passed through a 200-mesh sieve to obtain musk powder.

[0059] S2: Add radish powder to sesame oil and heat to prepare radish powder-sesame oil.

[0060] Take 150g of radish powder, add 2500mL of sesame oil, and slowly heat it to 110℃ in a reaction vessel. After maintaining this temperature for 8 minutes, cool it to 90℃.

[0061] S3: After the radish powder and sesame oil have cooled, add the pollen of *Platycladus orientalis*, garlic powder, costus root powder and asafoetida powder, and continue heating until the pollen of *Platycladus orientalis* turns yellowish-brown. Cool to room temperature, filter, and collect the filtrate.

[0062] Add 150g of bougainvillea flowers, 150g of garlic powder, 100g of costus root powder, and 5g of asafoetida powder. Continue heating to 90℃ for 30 minutes until the bougainvillea flowers turn yellowish-brown. Let it cool to room temperature and filter it four times with filter paper until the filtrate is completely clear. Collect the filtrate.

[0063] S4: Add musk powder to the filtrate, stir well, and filter again to obtain the Tibetan medicine ear drops.

[0064] Add 1g of musk powder to the filtrate, stir at 110rpm for 15min, pass through a 200-mesh sieve, and dispense the pure liquid into aliquots to obtain the Tibetan medicine ear drops. Store in a sterile container in a sealed container.

[0065] Example 3 A method for preparing Tibetan medicine ear drops for treating ear diseases is as follows: S1: Prepare pollen from *Rhododendron simsii*, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder.

[0066] The flowers of *Platycladus orientalis*, radish, garlic, costus root, and asafoetida were each pulverized using a grinder and passed through a 40-mesh sieve to obtain *Platycladus orientalis* flower powder, radish powder, garlic powder, costus root powder, and asafoetida powder. Musk was pulverized using a small grinder and passed through a 200-mesh sieve to obtain musk powder.

[0067] S2: Add radish powder to sesame oil and heat to prepare radish powder-sesame oil.

[0068] Take 250g of radish powder, add 3500mL of sesame oil, and slowly heat it to 150℃ in a reaction vessel. Maintain this temperature for 12 minutes and then cool it to 100℃.

[0069] S3: After the radish powder and sesame oil have cooled, add the pollen of *Platycladus orientalis*, garlic powder, costus root powder and asafoetida powder, and continue heating until the pollen of *Platycladus orientalis* turns yellowish-brown. Cool to room temperature, filter, and collect the filtrate.

[0070] Add 300g of *Prunus mume* flowers, 250g of garlic powder, 200g of *Saussurea costus* powder, and 15g of *Ferula assa-foetida* powder. Continue heating to 100℃ for 50 minutes until the *Prunus mume* flowers turn yellowish-brown. Let it cool to room temperature and filter it four times with filter paper until the filtrate is completely clear. Collect the filtrate.

[0071] S4: Add musk powder to the filtrate, stir well, and filter again to obtain the Tibetan medicine ear drops.

[0072] Add 3g of musk powder to the filtrate, stir at 130rpm for 20min, pass through a 200-mesh sieve, and dispense the pure liquid into individual containers to obtain the Tibetan medicine ear drops. Store the solutions in sterile containers.

[0073] Example 4 The application of a Tibetan medicine ear drop for treating ear diseases is as follows: This embodiment studies the efficacy of the Tibetan medicine ear drops prepared in Examples 1 to 3, and their efficacy is similar. For the convenience of subsequent discussion and reference, the results of Example 1 are used here.

[0074] The standards for ear disease testing in this invention are as follows: Diagnostic criteria for ear diseases: The diagnostic criteria for chronic otitis media are established by Cao Kao in "Diagnosis and Treatment of Chronic Otitis Media in China". Patients with symptoms such as tinnitus, ear pain, ear fullness, and ear itching are diagnosed with chronic otitis media by otoscopy.

[0075] Diagnostic criteria for ear diseases: Referring to the diagnostic criteria for nasal diseases in the "Four Medical Classics", the main symptoms are tinnitus, ear pain, and ear discharge, while the secondary symptoms are fever, nausea, ear fullness, headache, etc.

[0076] Inclusion criteria for ear diseases: gender not limited, age 18-60 years; meeting the diagnostic and diagnostic criteria, with stable physical signs under blindness, and signing an informed consent form.

[0077] Exclusion criteria for ear diseases: patients who have received or are currently receiving treatment for chronic sinusitis, have a history of drug allergies, or have undergone nasal surgery.

[0078] General Information: Patients with otitis media admitted to the Qinghai Provincial Tibetan Medicine Hospital from January 2023 to December 2024 were selected and randomly divided into a control group and an experimental group, with 50 patients in each group. The average age was 24-28 years and the duration of illness was 2-8 months.

[0079] Implementation method: The experimental group was given the Tibetan medicine ear drops prepared in Example 1 of this invention, 3 drops 3 times a day, for 2 courses of treatment, one course of treatment being 7 days.

[0080] The control group received conventional treatment, including Eleven-Ingredient Golden Pills, taken 3 pills three times daily for two courses of treatment, each course lasting 7 days. The Eleven-Ingredient Golden Pills were purchased from the Qinghai Provincial Tibetan Medicine Hospital, with batch number 202405118.

[0081] The results are shown in Table 1. Compared with the control group, the experimental group showed significant relief from tinnitus, dizziness, ear canal itching, ear canal discharge, ear pain, and hearing loss, with a total effective rate of 92.0%.

[0082] Table 1. Clinical efficacy of Tibetan medicine ear drops in treating otitis media. Although preferred embodiments of the invention have been described, those skilled in the art, once they have learned the basic inventive concept, can make other changes and modifications to these embodiments.

[0083] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A Tibetan medicine ear drop solution for treating ear diseases, characterized in that, The Tibetan medicine ear drops are made from the following raw materials in parts by weight: 150-300 parts of pineapple flowers, 150-250 parts of radish, 150-250 parts of garlic, 100-200 parts of costus root, 5-15 parts of asafoetida, and 1-3 parts of musk.

2. The Tibetan medicine ear drops as described in claim 1, characterized in that, The Tibetan medicine ear drops are made from the following raw materials in parts by weight: 230 parts of bougainvillea, 200 parts of radish, 200 parts of garlic, 150 parts of costus root, 10 parts of asafoetida, and 2 parts of musk.

3. The method for preparing Tibetan medicine ear drops as described in claim 1, characterized in that, Includes the following steps: Prepare pollen from *Dendrobium nobile* flowers, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder; weigh out the pollen from *Dendrobium nobile* flowers, radish powder, garlic powder, *Saussurea costus* powder, *Ferula assa-foetida* powder, and musk powder according to the stated weight proportions, and set aside for later use; Add radish powder to sesame oil, heat to 110℃~150℃ and maintain for 8min~12min to prepare radish powder-sesame oil; Once the radish powder-sesame oil has cooled to 90℃~100℃, add the pollen of *Platycladus orientalis*, garlic powder, costus root powder, and asafoetida powder. Maintain the temperature at 90℃~100℃ and continue heating for 30min~50min until the pollen of *Platycladus orientalis* turns yellowish-brown. Cool to room temperature, filter, and collect the filtrate. Add musk powder to the filtrate, stir well, and filter again to obtain the Tibetan medicine ear drops.

4. The preparation method according to claim 3, characterized in that, The mass-to-volume ratio of the radish powder to the sesame oil is 1g:14mL~18mL.

5. The preparation method according to claim 3, characterized in that, The heating conditions for preparing radish powder-sesame oil are: 130℃ for 10 minutes.

6. The preparation method according to claim 3, characterized in that, The stirring conditions after adding musk powder were: 120 rpm for 20 min.

7. The preparation method according to claim 3, characterized in that, The pollen from the flowers of the *Prunus cerasifera* species is obtained by crushing the flowers and passing them through a 40-mesh sieve. The radish powder is obtained by crushing radish and passing it through a 40-mesh sieve. The garlic powder is obtained by crushing garlic and passing it through a 40-mesh sieve. The Sichuan costus powder is obtained by pulverizing Sichuan costus and passing it through a 40-mesh sieve. The asafoetida powder is obtained by pulverizing asafoetida and passing it through a 40-mesh sieve. The musk powder is obtained by crushing musk and passing it through a 200-mesh sieve.

8. The application of the Tibetan medicine ear drops as described in claim 1, characterized in that, The Tibetan medicine ear drops are used to prepare medicine for treating otitis media.

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