Plasma permeation enhanced DBD wound treatment patch device

Abstract

The invention relates to the field of medical equipment, in particular to a plasma permeation enhanced DBD wound treatment patch device which comprises a power supply host and a high-voltage electrode patch, the power supply host comprises a dual-mode modulation module and a power supply high-voltage output end, and the power supply host outputs low-frequency high-voltage pulses and high-frequency low-voltage pulses at intervals under modulation of the dual-mode modulation module; the high-voltage electrode patch is connected with a power supply high-voltage output end and receives low-frequency high-voltage pulses and high-frequency low-voltage pulses output by the power supply high-voltage output end at intervals, the high-voltage electrode patch receives the low-frequency high-voltage pulses to excite and generate discharge plasma, and the high-voltage electrode patch receives the high-frequency low-voltage pulses to form reversible electroporation field intensity. Pulse power output of two functional modes is achieved through the dual-mode modulation module, more stable and safer plasma generation is achieved, the reversible electroporation effect on the wound skin surface is enhanced through high-frequency low-voltage pulses, the permeability of plasma active ingredients is enhanced, and therefore the more efficient wound treatment effect is achieved.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to a plasma-enhanced DBD wound treatment patch device. Background Technology

[0002] Dielectric barrier discharge (DBD) technology is an effective way to generate low-temperature plasma under atmospheric pressure. Because low-temperature plasma discharge produces a large number of reactive oxygen species and reactive nitrogen species, these reactive substances can interact with biological tissues, promote wound healing, inhibit bacterial growth, and can also be combined with drugs and microneedles to promote the absorption of topical drugs by the skin. Therefore, low-temperature plasma discharge has a wide range of applications in the biomedical field, especially showing significant advantages in wound treatment.

[0003] Traditional plasma wound treatment techniques have many limitations, especially in terms of plasma penetration. Existing equipment usually relies on a single high-voltage pulse discharge mode to excite plasma, lacking an effective mechanism to promote the penetration of active ingredients (such as reactive oxygen species and reactive nitrogen species) into deep tissues. In particular, the treatment effect is limited for areas with thick stratum corneum (such as foot skin or burn scabs), which seriously affects the treatment effect and the scope of clinical application. Summary of the Invention

[0004] This invention provides a plasma-penetration-enhanced DBD wound treatment patch device to address the shortcomings of existing plasma wound treatment devices that rely on a single high-voltage pulse discharge mode to excite plasma, resulting in limited therapeutic effects on deep tissues. This invention enhances the permeability of the active components of the plasma, thereby achieving a more efficient wound treatment effect.

[0005] This invention provides a plasma-enhanced DBD wound treatment patch device, comprising a power supply unit and a high-voltage electrode patch. The power supply unit includes a dual-mode modulation module and a high-voltage output terminal. The power supply unit is adapted to output low-frequency high-voltage pulses and high-frequency low-voltage pulses at intervals from the high-voltage output terminal under the modulation of the dual-mode modulation module. The high-voltage electrode patch is connected to the high-voltage output terminal of the power supply unit and is adapted to receive the low-frequency high-voltage pulses and high-frequency low-voltage pulses output at intervals from the high-voltage output terminal. The high-voltage electrode patch receives the low-frequency high-voltage pulses to generate discharge plasma and receives the high-frequency low-voltage pulses to form a reversible electroporation field.

[0006] According to the present invention, a plasma-enhanced DBD wound treatment patch device includes a dual-mode modulation module comprising a transformer, a power supply unit circuit, a control circuit, and a digital controller. The secondary winding of the transformer forms the high-voltage output terminal of the power supply unit, which is used to connect the high-voltage electrode patch. The power supply unit circuit is connected to the primary winding of the transformer to provide drive power. The control circuit is connected between the output terminal of the power supply unit circuit and the primary winding of the transformer, and is used to switch the conduction state of the power supply unit circuit and the transformer. The digital controller is connected to the control circuit and is used to control the control circuit to regulate the conduction frequency of the power supply unit circuit and the transformer.

[0007] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the power supply unit circuit includes a DC power supply V1, an inductor L1, a diode D1 and a capacitor C1 connected in series to form a circuit, and the capacitor C1 is coupled to the primary winding of the transformer through the control circuit.

[0008] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the control circuit includes a drive power supply V2 and a switching transistor Q1, and the capacitor C1, the drive power supply V2, the switching transistor Q1 and the primary winding of the transformer are connected in series to form a circuit.

[0009] According to the plasma penetration enhanced DBD wound treatment patch device provided by the present invention, when the switch Q1 is switched to the non-conducting state, the DC power supply V1 charges and stores energy for the capacitor C1; when the switch Q1 is switched to the conducting state, the primary winding of the transformer resonates with the capacitor C1, providing energy storage current.

[0010] The digital controller is adapted to modulate the dual-mode modulation module to form a first functional mode and a second functional mode. In the first functional mode, the conduction frequency of the power supply unit circuit and the transformer is a first frequency, and the charging and energy storage time of the capacitor C1 is a first energy storage time. In the second functional mode, the conduction frequency of the power supply unit circuit and the transformer is a second frequency, and the charging and energy storage time of the capacitor C1 is a second energy storage time. The first frequency is less than the second frequency, and the first energy storage time is greater than the second energy storage time, so that in the first functional mode, the high-voltage output terminal of the power supply outputs a low-frequency high-voltage pulse, and in the second functional mode, the high-voltage output terminal of the power supply outputs a high-frequency low-voltage pulse.

[0011] According to the plasma penetration enhanced DBD wound treatment patch device provided by the present invention, the power supply host further includes an adaptive adjustment module, which is connected to the digital controller and is adapted to modulate the conduction frequency and energy storage time duty cycle of the dual-mode modulation module in a first functional mode or a second functional mode through the digital controller.

[0012] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the high-voltage electrode patch includes a high-voltage metal electrode sheet, a flexible insulating protrusion layer, and a flexible insulating dielectric layer. The high-voltage metal electrode sheet is connected to the high-voltage output terminal of the power supply host via a wire. The flexible insulating protrusion layer is disposed on the surface of the high-voltage metal electrode sheet for adhering to the treatment site, and the flexible insulating protrusion layer consists of a plurality of flexible insulating protrusions arranged in a dot matrix. The flexible insulating dielectric layer is disposed on the surface of the high-voltage metal electrode sheet opposite to the flexible insulating protrusion layer.

[0013] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the flexible insulating protrusion layer is a matrix of silicone particles disposed on the high-voltage metal electrode sheet, which is suitable for forming an air gap between the high-voltage metal electrode sheet and the treatment site when the high-voltage metal electrode sheet is attached to the treatment site, so that the high-voltage electrode patch forms a suspended DBD discharge structure at the treatment site.

[0014] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the plasma-penetration enhanced DBD wound treatment patch device further includes a grounding electrode patch, the grounding electrode patch being connected to the grounding port of the power supply unit via a wire, and the grounding electrode patch being used to adhere to the periphery of the treatment site to adjust the grounding circuit of the discharge current.

[0015] According to the present invention, a plasma-penetration enhanced DBD wound treatment patch device is provided, wherein the grounding electrode patch includes a grounding metal electrode sheet and an insulating silicone layer, the grounding metal electrode sheet being connected to the grounding port of the power supply unit via a wire; the insulating silicone layer is disposed on the surface of the grounding metal electrode sheet facing away from the treatment site.

[0016] The plasma-penetration-enhanced DBD wound treatment patch device provided by this invention utilizes dual-mode modulation technology of a dual-mode modulation module to achieve pulse power output in two functional modes. The low-frequency, high-voltage pulses output by the power supply unit are used to excite the high-voltage electrode patch to generate discharge plasma for plasma wound treatment at the treatment site. The high-frequency, low-voltage pulses output by the power supply unit are used to create a reversible electroporation field at the contact point between the high-voltage electrode patch and the treatment site. This high-frequency, low-voltage pulses enhance the reversible electroporation effect on the skin surface of the wound, increasing the permeability of the plasma's active ingredients and achieving a more efficient wound treatment effect. The high-voltage electrode patch maintains a reversible electroporation field after each discharge pulse until the next high-voltage discharge pulse, directly enhancing the penetration depth of the plasma into the skin in the next discharge cycle. This invention utilizes dual-mode modulation technology to enable the high-voltage electrode patch to continuously switch between generating discharge plasma and forming a reversible electroporation field, achieving more stable and safer plasma generation. At the same time, it uses high-frequency low-voltage pulses to enhance the reversible electroporation effect on the skin surface of the wound, thereby enhancing the permeability of the plasma active ingredients and achieving a more efficient wound treatment effect. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the structure of the plasma-penetration enhanced DBD wound treatment patch device provided by the present invention.

[0019] Figure 2 This is a circuit topology diagram of the dual-mode modulation module provided by the present invention.

[0020] Figure 3 This is a pulse control waveform and power output diagram of the plasma penetration enhanced DBD wound treatment patch device provided by the present invention.

[0021] Figure 4 This is a schematic diagram of the penetration depth control pulse output of the plasma penetration enhanced DBD wound treatment patch device provided by the present invention.

[0022] Figure 5 This is a schematic diagram of the structure of the high-voltage electrode patch provided by the present invention.

[0023] Figure 6 This is a schematic diagram of the structure of the grounding electrode patch provided by the present invention.

[0024] Figure 7 This is a schematic diagram of the current circuit of the plasma-penetration enhanced DBD wound treatment patch device provided by the present invention.

[0025] Reference numerals: 1. Power supply unit; 2. High-voltage electrode patch; 21. High-voltage metal electrode sheet; 22. Flexible insulating raised layer; 23. Flexible insulating dielectric layer; 3. Grounding electrode patch; 31. Grounding metal electrode sheet; 32. Insulating silicone layer; 4. Second frequency f H 5. Short energy storage time t on2 . Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0027] In the description of the embodiments of the present invention, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention. In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0028] In the description of the embodiments of the present invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of the present invention based on the specific circumstances.

[0029] In embodiments of the present invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0030] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0031] The following is combined Figures 1 to 7 The specific structure and working principle of the plasma penetration enhanced DBD wound treatment patch device of the present invention are described.

[0032] One embodiment of the present invention provides a plasma-penetration enhanced DBD wound treatment patch device, see [link to relevant documentation]. Figure 1 As shown, the plasma-penetration enhanced DBD wound treatment patch device includes a power supply unit 1 and a high-voltage electrode patch 2. The power supply unit 1 includes a dual-mode modulation module and a high-voltage output terminal. The power supply unit 1 is adapted to output low-frequency high-voltage pulses and high-frequency low-voltage pulses at intervals from the high-voltage output terminal under the modulation of the dual-mode modulation module. The high-voltage electrode patch 2 is connected to the high-voltage output terminal of the power supply unit 1 and is adapted to receive the low-frequency high-voltage pulses and high-frequency low-voltage pulses output at intervals from the high-voltage output terminal. The high-voltage electrode patch 2 receives the low-frequency high-voltage pulses to generate discharge plasma and receives the high-frequency low-voltage pulses to form a reversible electroporation field.

[0033] It is understood that this plasma-penetration-enhanced DBD wound treatment patch device in this embodiment achieves pulse power output in two functional modes through the dual-mode modulation technology of the dual-mode modulation module. The low-frequency, high-voltage pulse output from the power supply unit 1 is used to excite the high-voltage electrode patch 2 to generate discharge plasma for plasma wound treatment at the treatment site. The high-frequency, low-voltage pulse output from the power supply unit 1 is used to create a reversible electroporation field at the contact point between the high-voltage electrode patch 2 and the treatment site. This high-frequency, low-voltage pulse enhances the reversible electroporation effect on the skin surface of the wound, increasing the permeability of the plasma active ingredients and thus achieving a more efficient wound treatment effect. The high-voltage electrode patch 2 creates a reversible electroporation field after each discharge pulse, continuing until the next high-voltage discharge pulse, directly enhancing the penetration depth of the plasma into the skin in the next discharge cycle.

[0034] It should be understood that the "high" and "low" in the low-frequency high-voltage pulse and high-frequency low-voltage pulse involved in this embodiment are not particularly limited. The values ​​are selected based on achieving the corresponding functions. For example, the function of the low-frequency high-voltage pulse is to excite the high-voltage electrode patch 2 to generate discharge plasma. Therefore, the pulse value that can excite the high-voltage electrode patch 2 to generate discharge plasma is the required value. Similarly, the high-frequency low-voltage pulse is used to form a reversible electroporation field strength. The required pulse value is selected based on achieving the generation of a reversible electroporation field strength. This embodiment utilizes dual-mode modulation technology to continuously switch between generating discharge plasma and forming a reversible electroporation field on the high-voltage electrode patch 2. The low-frequency high-voltage pulses output by the power supply unit 1 cause the high-voltage electrode patch 2 to generate plasma, and the active ingredients (such as reactive oxygen and nitrogen) directly act on the wound. The high-frequency low-voltage pulses output by the power supply unit 1 apply a low-voltage high-frequency electric field between the high-voltage electrode patch 2 and the treatment site. Through the electroporation effect, the permeability of the skin cell membrane is temporarily increased, enhancing the penetration depth of the active ingredients. This achieves more stable and safer plasma generation. At the same time, the high-frequency low-voltage pulses enhance the reversible electroporation effect on the skin surface of the wound, enhancing the permeability of the plasma active ingredients, thereby achieving a more efficient wound treatment effect.

[0035] In some embodiments of the plasma-penetration enhanced DBD wound treatment patch device of the present invention, see [link to relevant documentation]. Figure 2 As shown, the dual-mode modulation module includes a transformer, a power supply unit circuit, a control circuit, and a digital controller. The secondary winding of the transformer forms the high-voltage output terminal of the power supply host 1, which is used to connect to the high-voltage electrode patch 2. The power supply unit circuit is connected to the primary winding of the transformer to provide drive power. The control circuit is connected between the output terminal of the power supply unit circuit and the primary winding of the transformer, and is used to switch the conduction state of the power supply unit circuit and the transformer. The digital controller is connected to the control circuit and is used to control the control circuit to regulate the conduction frequency of the power supply unit circuit and the transformer.

[0036] It is understood that this embodiment defines the specific structure of the dual-mode modulation module. The transformer is the core component for voltage conversion. The secondary winding of the transformer is directly connected to the high-voltage electrode patch 2. The power supply unit circuit is an energy supply system that provides driving power to the primary side of the transformer. The control circuit is a switching control system connected between the power supply unit and the transformer. The digital controller is the intelligent control center of the entire modulation module. Based on the collaborative working relationship of the four components of the dual-mode modulation module, in particular, the digital controller precisely regulates the conduction state of the power supply unit and the transformer through the control circuit.

[0037] Specifically, in some examples, see again Figure 2 As shown, the power supply unit circuit includes a DC power supply V1, an inductor L1, a diode D1, and a capacitor C1 connected in series to form a loop. Capacitor C1 is coupled to the primary winding of the transformer through a control circuit. When the switch Q1 in the control circuit is not conducting, the DC power supply V1 charges and stores energy in capacitor C1. The control circuit includes a drive power supply V2 and a switch Q1. Capacitor C1, drive power supply V2, switch Q1, and the primary winding of the transformer are connected in series to form a loop. When switch Q1 in the control circuit is conducting, drive power supply V2 triggers resonance, and capacitor C1 and the primary inductance of the transformer form an LC oscillation, generating a high-frequency energy storage current. This current is boosted by the transformer turns ratio (e.g., 1:10), and a high-voltage pulse is output from the secondary side of the transformer.

[0038] When switch Q1 is switched to the non-conducting state, DC power supply V1 charges capacitor C1 to store energy. When switch Q1 is switched to the conducting state, the primary winding of the transformer resonates with capacitor C1, providing energy storage current. It can be understood that this embodiment uses the switching state of switch Q1 to achieve different functional stages of the power supply unit circuit, mainly including an energy storage stage and an energy release stage. In the energy storage stage, switch Q1 is off, and DC power supply V1 charges capacitor C1 through inductor L1 and diode D1. Inductor L1 suppresses current surges to ensure smooth charging, diode D1 prevents reverse current, and capacitor C1 stores energy, its voltage increasing linearly with charging time (the energy storage time is set by the digital controller). In the energy release stage, switch Q1 is on, and capacitor C1 forms a resonant circuit with the primary winding of the transformer through the control circuit. The energy stored in capacitor C1 is coupled to the secondary winding through the transformer, generating a high-voltage pulse.

[0039] The digital controller is adapted to modulate a dual-mode modulation module to form a first functional mode and a second functional mode. In the first functional mode, the conduction frequency of the power supply unit circuit and the transformer is the first frequency, and the charging and energy storage time of capacitor C1 is the first energy storage time. In the second functional mode, the conduction frequency of the power supply unit circuit and the transformer is the second frequency, and the charging and energy storage time of capacitor C1 is the second energy storage time. The first frequency is less than the second frequency, and the first energy storage time is greater than the second energy storage time. In the first functional mode, the high-voltage output terminal of the power supply outputs a low-frequency high-voltage pulse, and in the second functional mode, the high-voltage output terminal of the power supply outputs a high-frequency low-voltage pulse.

[0040] See Figure 3 As shown, it can be understood that the digital controller achieves pulse power output in two functional modes by adjusting the conduction frequency and duty cycle of the switching transistor Q1. The first functional mode corresponds to a low-frequency high-voltage pulse, and the conduction frequency of the power supply unit circuit and transformer is the first frequency (low frequency f). L =1~10KHz), the charging and energy storage time of capacitor C1 is the first energy storage time (long energy storage time t). on1 =100~200us), the low frequency and high energy storage time are given by the digital controller to control the pulse power supply to output a high pulse amplitude voltage. The low discharge frequency is used to excite the high voltage electrode patch 2 to generate a discharge plasma pulse; the second functional mode corresponds to a high frequency low voltage pulse, and the conduction frequency of the power supply unit circuit and the transformer is the second frequency (high frequency f). H =50~100KHz), the charging and energy storage time of capacitor C1 is the second energy storage time (short energy storage time t). on2 =10~20us), the high frequency and low energy storage time of the digital controller are used to control the output of the pulse power supply with a low pulse amplitude voltage. The high frequency pulse power is used to form a reversible electroporation field strength E1 at the position where the high voltage electrode patch 2 is in contact with the human body. The high frequency electric field causes the skin cell membrane to form reversible micropores, thereby improving the permeability of active ingredients.

[0041] The first functional mode generates high-voltage discharge pulses to generate plasma, while the second functional mode enhances electroporation. After each high-voltage discharge pulse, the digital controller switches to create a reversible electroporation field strength until the next high-voltage discharge pulse, directly enhancing the plasma's penetration depth into the skin in the next discharge cycle. The digital controller can also monitor the load impedance in real time based on a dynamic switching algorithm, automatically optimizing the conduction frequency and energy storage time in both the first and second functional modes. The power ratio of the two operating modes is adjustable (e.g., 7:3), balancing therapeutic efficacy and energy consumption. Experiments have verified that in the second functional mode, using a second frequency of 80kHz for enhanced electroporation, compared to the absence of electroporation, skin impedance is reduced by approximately 60%, and drug penetration depth is increased by 3 times. When the two operating modes alternate (power ratio 7:3), compared to single plasma treatment, wound healing speed can be increased by 40%.

[0042] Due to differences in skin properties and stratum corneum thickness across different wound sites, genders, and ages, achieving a significant plasma penetration effect requires varying electrical parameters for the electroporation effect provided by the power supply. To broaden the applicability of the plasma-penetration enhanced DBD wound treatment patch device of this invention, in some specific examples, the power supply unit 1 further includes an adaptive adjustment module. This module is connected to a digital controller and is adapted to modulate the conduction frequency and energy storage duty cycle of the dual-mode modulation module in either the first or second functional mode. That is, the user can adjust the frequency parameters (second frequency f) of the control signal output by the digital controller through the adaptive adjustment module according to the skin conditions of the target wound. H ) and duty cycle time parameter (short energy storage time t) on2 See also Figure 4 As shown, Figure 4 The second frequency f on the left H 4 and short energy storage time t on2 5. Adjust to the second frequency f on the right. H 4 and short energy storage time t on2 5. The electroporation pulse parameters, with adjustable output frequency and amplitude, are controlled by the pulse power supply to achieve electroporation effects and depths tailored to different skin characteristics, ensuring scenario compatibility for treatment effectiveness.

[0043] Regarding the discharge method, existing electrode patches mostly employ rigid electrodes or non-adhesive designs, resulting in poor flexibility and adhesion. This makes them difficult to closely adapt to irregular wound surfaces, leading to poor contact between the electrode and the skin. This can easily create high-voltage hotspots, increasing the risk of tissue damage. While some studies have attempted to improve biocompatibility using silicone electrodes, their surfaces are mostly smooth, making it impossible to enhance discharge uniformity or promote wound contact through physical morphology optimization. This results in uneven plasma distribution, with some wound areas not being effectively covered, significantly reducing treatment efficacy. In some embodiments of the plasma-penetration enhanced DBD wound treatment patch device of this invention, see [reference needed]. Figure 5 As shown, the high-voltage electrode patch 2 includes a high-voltage metal electrode 21, a flexible insulating protrusion layer 22, and a flexible insulating dielectric layer 23. The high-voltage metal electrode 21 is connected to the high-voltage output terminal of the power supply host 1 via a wire. The flexible insulating protrusion layer 22 is disposed on the surface of the high-voltage metal electrode 21 for adhering to the treatment site, and the flexible insulating protrusion layer 22 consists of multiple flexible insulating protrusions arranged in a dot matrix. The flexible insulating dielectric layer 23 is disposed on the surface of the high-voltage metal electrode 21 facing away from the flexible insulating protrusion layer 22.

[0044] It is understood that the high-voltage electrode patch 2 in this embodiment is composed of a three-layer structure. The upper layer of the high-voltage metal electrode 21 is a flexible insulating dielectric layer 23 (such as a silicone dielectric layer), and the lower layer of the high-voltage metal electrode 21 is a flexible insulating protrusion layer 22. The flexible insulating protrusion layer 22 is a layer of multiple flexible insulating protrusions arranged in a dot matrix. Its protrusion surface is in direct contact with the target wound surface, and the contact degree is a tight pressing state (the flexible insulating protrusion layer 22 deforms under pressure and can fit tightly with the irregular wound surface). Therefore, the flexible insulating protrusion layer 22 makes the high-voltage metal electrode 21 and the skin surface form a relatively sealed air gap. The discharge plasma is generated in the air gap. Moreover, the high-voltage metal electrode 21 and the human skin can form a certain electric field. This electric field can be generated during the interval of the discharge pulse to form a reversible electroporation effect, improve the permeability of the skin surface, and enhance the penetration depth of the plasma on the skin surface.

[0045] In some specific examples, the flexible insulating protrusion layer 22 is a matrix of silicone particles disposed on the high-voltage metal electrode patch 21. This allows an air gap to form between the high-voltage metal electrode patch 21 and the treatment site when the high-voltage metal electrode patch 21 is attached to the treatment site, enabling the high-voltage electrode patch 2 to form a suspended DBD discharge structure at the treatment site. It can be understood that the matrix silicone particle surface is in direct contact with the target wound surface, with a tight, pressed contact. Therefore, a relatively sealed air gap is formed between the protruding silicone particles and the wound surface, and the discharge plasma is generated within this air gap. Simultaneously, the silicone particles are in close contact with the human skin, and the high-voltage electrode patch 2 forms a reversible electroporation field strength E1 with the human skin. High-frequency, low-voltage pulses enhance the reversible electroporation effect on the wound surface, increasing the permeability of the plasma active ingredients, thereby achieving a more efficient wound treatment effect.

[0046] Regarding safety and compatibility, traditional wound treatment patch devices lack a reliable levitation discharge design, which can lead to current flowing through the body's circuitry in the event of poor grounding, posing a potential risk of electric shock. In some embodiments of the plasma-penetration enhanced DBD wound treatment patch device of this invention, the device further includes a grounding electrode patch 3. The grounding electrode patch 3 is connected to the grounding port of the power supply unit 1 via a wire. The grounding electrode patch 3 is used to adhere to the periphery of the treatment site to adjust the grounding circuit of the discharge current. See also [link to specific examples]. Figure 6 As shown, the grounding electrode patch 3 includes a grounding metal electrode 31 and an insulating silicone layer 32. The grounding metal electrode 31 is connected to the grounding port of the power supply host 1 through a wire; the insulating silicone layer 32 is disposed on the surface of the grounding metal electrode 31 facing away from the treatment site.

[0047] It is understood that this embodiment, based on the discharge structure of the suspended DBD, additionally designs a grounding electrode patch 3. The grounding electrode patch 3 has a two-layer structure, with an insulating silicone layer 32 on top of the grounding metal electrode 31. The grounding metal electrode 31 is in direct contact with human skin. See [link to documentation]. Figure 7 As shown, Figure 7 The diagram illustrates the current loop of the plasma-penetration enhanced DBD wound treatment patch device. Users can arbitrarily select a location near the wound as the connection point for the grounding electrode patch 3, based on the wound's location. Compared to traditional wound treatment patches that directly use the entire human body as the ground loop for the discharge current, the electrode structure design proposed in this embodiment allows for the artificial setting of the electrical loop for the discharge current. That is, both the discharge current and the electroporation displacement current can form current loops at specific selected locations, preventing the entire current from flowing through sensitive nerves and other areas of the body, thus avoiding electrical safety issues.

[0048] Based on the plasma-penetration enhanced DBD wound treatment patch device described in the above embodiments and examples, the plasma-penetration enhanced DBD wound treatment patch device of the present invention achieves more stable and safer plasma generation through a suspended DBD discharge structure, silicone patch electrode design, and dual-frequency modulation technology, effectively avoiding the safety hazards of current flowing through sensitive areas by traditional electrodes; it utilizes a high-frequency, low-voltage pulsed electric field to enhance the reversible electroporation effect of the skin, significantly improving the permeability of active ingredients (such as reactive oxygen species and reactive nitrogen species) to deep tissues, thereby accelerating wound healing and drug absorption; the patch electrode uses a dot matrix silicone layer to closely adhere to the skin, and combined with adaptively adjustable pulse parameters (frequency and amplitude), it can flexibly adapt to different stratum corneum thicknesses, wound conditions, and individual differences, ensuring treatment accuracy and broad compatibility.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A plasma-penetration enhanced DBD wound treatment patch device, characterized in that, include: The power supply host (1) includes a dual-mode modulation module and a high-voltage output terminal. The power supply host (1) is adapted to output low-frequency high-voltage pulses and high-frequency low-voltage pulses at intervals from the high-voltage output terminal under the modulation of the dual-mode modulation module. The high-voltage electrode patch (2) is connected to the high-voltage output terminal of the power supply host (1) and is adapted to receive the low-frequency high-voltage pulse and high-frequency low-voltage pulse output from the high-voltage output terminal of the power supply. The high-voltage electrode patch (2) receives the low-frequency high-voltage pulse to generate discharge plasma and receives the high-frequency low-voltage pulse to form a reversible electroporation field strength.

2. The plasma-penetration enhanced DBD wound treatment patch device according to claim 1, characterized in that, The dual-mode modulation module includes: The transformer, the secondary winding of which forms the high voltage output terminal of the power supply host (1), is used to connect the high voltage electrode patch (2). The power supply unit circuit is connected to the primary winding of the transformer to provide drive power; A control circuit is connected between the output terminal of the power supply unit circuit and the primary winding of the transformer, and is used to switch the conduction state of the power supply unit circuit and the transformer. A digital controller, connected to the control circuit, is used to control the control circuit to regulate the conduction frequency of the power supply unit circuit and the transformer.

3. The plasma-penetration enhanced DBD wound treatment patch device according to claim 2, characterized in that, The power supply unit circuit includes a DC power supply V1, an inductor L1, a diode D1 and a capacitor C1 connected in series to form a loop. The capacitor C1 is coupled to the primary winding of the transformer through the control circuit.

4. The plasma-penetration enhanced DBD wound treatment patch device according to claim 3, characterized in that, The control circuit includes a drive power supply V2 and a switching transistor Q1. The capacitor C1, the drive power supply V2, the switching transistor Q1, and the primary winding of the transformer are connected in series to form a circuit.

5. The plasma-penetration enhanced DBD wound treatment patch device according to claim 4, characterized in that, When the switch Q1 is switched to the non-conducting state, the DC power supply V1 charges and stores energy for the capacitor C1; when the switch Q1 is switched to the conducting state, the primary winding of the transformer resonates with the capacitor C1, providing energy storage current. The digital controller is adapted to modulate the dual-mode modulation module to form a first functional mode and a second functional mode. In the first functional mode, the conduction frequency of the power supply unit circuit and the transformer is a first frequency, and the charging and energy storage time of the capacitor C1 is a first energy storage time. In the second functional mode, the conduction frequency of the power supply unit circuit and the transformer is a second frequency, and the charging and energy storage time of the capacitor C1 is a second energy storage time. The first frequency is less than the second frequency, and the first energy storage time is greater than the second energy storage time, so that in the first functional mode, the high-voltage output terminal of the power supply outputs a low-frequency high-voltage pulse, and in the second functional mode, the high-voltage output terminal of the power supply outputs a high-frequency low-voltage pulse.

6. The plasma-penetration enhanced DBD wound treatment patch device according to claim 5, characterized in that, The power supply unit (1) also includes an adaptive adjustment module, which is connected to the digital controller and is adapted to modulate the conduction frequency and energy storage time duty cycle of the dual-mode modulation module in the first or second functional mode through the digital controller.

7. The plasma-penetration enhanced DBD wound treatment patch device according to any one of claims 1 to 6, characterized in that, The high-voltage electrode patch (2) includes: The high-voltage metal electrode sheet (21) is connected to the high-voltage output terminal of the power supply host (1) via a wire; A flexible insulating protrusion layer (22) is disposed on the surface of the high-voltage metal electrode sheet (21) for adhering to the treatment site. The flexible insulating protrusion layer (22) consists of multiple flexible insulating protrusions arranged in a dot matrix. A flexible insulating dielectric layer (23) is disposed on the surface of the high-voltage metal electrode sheet (21) away from the flexible insulating protrusion layer (22).

8. The plasma-penetration enhanced DBD wound treatment patch device according to claim 7, characterized in that, The flexible insulating protrusion layer (22) is a matrix of silicone particles disposed on the high-voltage metal electrode sheet (21). It is suitable for forming an air gap between the high-voltage metal electrode sheet (21) and the treatment site when the high-voltage metal electrode sheet (21) is attached to the treatment site, so that the high-voltage electrode patch (2) forms a suspended DBD discharge structure at the treatment site.

9. The plasma-penetration enhanced DBD wound treatment patch device according to any one of claims 1 to 6, characterized in that, The plasma-penetration enhanced DBD wound treatment patch device also includes a grounding electrode patch (3), which is connected to the grounding port of the power supply unit (1) via a wire. The grounding electrode patch (3) is used to adhere to the periphery of the treatment site to adjust the grounding circuit of the discharge current.

10. The plasma-penetration enhanced DBD wound treatment patch device according to claim 9, characterized in that, The grounding electrode patch (3) includes: The grounding metal electrode plate (31) is connected to the grounding port of the power supply unit (1) via a wire; An insulating silicone layer (32) is disposed on the surface of the grounded metal electrode sheet (31) facing away from the treatment site.

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