Bletilla striata hemorrhoid cream and preparation method thereof

Abstract

The invention discloses bletilla striata hemorrhoid cream and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the bletilla striata hemorrhoid cream comprises the following raw materials by weight: 10-30 parts of bletilla striata, 10-30 parts of pseudo-ginseng, 10-30 parts of sophora fruit, 10-30 parts of rheum officinale, 10-30 parts of phellodendron and 10-30 parts of borneol. The haemorrhoids ointment prepared by the invention highlights the effects of promoting tissue regeneration and stopping bleeding, treats both symptoms and root causes, is pure herbal and easy to absorb, can perform targeted detoxification and stasis dissipation, detumescence and tissue regeneration promotion, blood circulation activation and cooling on an affected part, has a good treatment effect and is not easy to relapse, meanwhile, the preparation process is simple, the raw materials only need to be mixed, wall-broken and crushed and then prepared into the ointment, and the method is simple, easy to control and suitable for popularization and application. The large-scale production can be realized.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a Bletilla striata hemorrhoid ointment and a preparation method thereof. BACKGROUND

[0002] The human anus part has rich venous plexus, when the human body is invaded by external wind, cold and damp, a kind of skin called hemorrhoids, that is, hemorrhoids occurs in the lower vena cava plexus expansion. According to the different growth positions, hemorrhoids are divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, the growth above the dentate line is called internal hemorrhoids, the growth below the dentate line is called external hemorrhoids, and the growth in the rectal wall is called polyp hemorrhoids. At the same time, hemorrhoids can grow anywhere on the edge of the anus, and according to the position of the clock direction, it is divided into 1-12 point hemorrhoids. Combined with the course and clinical manifestations, hemorrhoids have early symptoms, medium-term symptoms and late symptoms, among which the early hemorrhoids have no feeling, no pain, no swelling and no itching, only slightly skin; the medium-term skin gradually grows up, the long-term constipation, eats the spicy food or excessive drinking, smoking after the pain is intensified. Individual internal hemorrhoids will produce bleeding points, mostly with blood in the stool, often with internal hemorrhoids prolapse outside the anus, but it can be recovered after defecation. When the patient in the early and medium-term is not treated correctly, the course develops to the late period, the hemorrhoids can prolapse at any time, often with bleeding, and cannot be recovered after prolapse, and is accompanied by severe pain. There are many patients with hemorrhoids in China, and the incidence rate is 30%-40%, once the hemorrhoids attack the patient, it affects the normal work and life, at present, the surgical method is mostly used for treatment, but the surgical cost is high, the risk is big, the postoperative recovery time is long, and it brings great psychological pressure to the patient. The drug treatment can save the medical cost, reduce the risk, and eliminate the psychological pressure and long recovery period brought by the operation to the patient, but the existing hemorrhoid treatment drugs have the problems of many drug components, complex proportioning, high cost and long treatment course.

[0003] For example, Chinese Patent No. CN107213402B discloses an ice and yellow hemorrhoid ointment, which comprises, by weight, Huanglian 30-120 parts, Huangbai 30-120 parts, Dahuang 30-120 parts, Longxuejie 10-50 parts, Zicao 10-50 parts, Baibu 30-120 parts, Kushen 30-120 parts, Baiji 30-120 parts, Zhenzhu 10-50 parts, Huanggu 100-300 parts, natural ice 30-90 parts, Bohe 20-80 parts, vaseline 1900-2100 parts, tea oil 25-35 parts. Each raw material is ground and sieved through a 200-mesh sieve for use; the vaseline and tea oil are weighed and mixed, heated, and cooled to 60-70 DEG C, and then Huanglian, Huangbai, Dahuang, Longxuejie, Zicao, Baibu, Kushen, Baiji and Huanggu are added and stirred, and then Zhenzhu, Bohe and natural ice are added and stirred, and then cooled to room temperature to obtain the product. The present application contains antibacterial drugs, anti-inflammatory, detumescence, analgesic and antipruritic drugs, has significant curative effect, and is suitable for treating internal hemorrhoids, external hemorrhoids, mixed hemorrhoids and anal fissures.

[0004] For example, Chinese Patent No. CN116159105B discloses a pharmaceutical composition for treating hemorrhoids, which includes a first-stage composition comprising, by mass fraction, 8-12 parts of Coptis chinensis, 13-17 parts of Scutellaria baicalensis, 13-17 parts of Phellodendron amurense, 25-35 parts of Gypsum fibrosum, 13-17 parts of Anemarrhena asphodeloides, 13-17 parts of Gardenia jasminoides, 13-17 parts of Paeonia lactiflora, 13-17 parts of Platycodon grandiflorum, 13-17 parts of Citrus aurantium, 13-17 parts of Radix Paeoniae Alba, and 10-14 parts of Rheum officinale, and 8-12 parts of Glycyrrhiza uralensis. The present application can effectively improve the condition of hemorrhoids in patients, and promote the body's detoxification and pus discharge while addressing the root cause, thereby eliminating skin lesions and curing hemorrhoids.

[0005] For example, Chinese Patent No. CN114533859B discloses a traditional Chinese medicine ointment for treating hemorrhoids and a preparation method thereof. The traditional Chinese medicine ointment comprises, by weight fraction, 10-20 parts of a five-yellow traditional Chinese medicine component, 10-20 parts of a five-white traditional Chinese medicine component, 8-12 parts of a high-efficiency hemostatic component, 6-9 parts of a skin-healing component, 20-40 parts of Mentha haplocalyx, 4-8 parts of borneol, and 30-60 parts of vaseline. The preparation method comprises the following steps: Step 1: processing of traditional Chinese medicine raw materials; Step 2: preparation of ointment base; Step 3: pretreatment of other components; Step 4: ointment preparation; and Step 5: production of finished product. The ointment can clear dampness and heat, regulate Qi movement, dissipate blood stasis, and absorb moisture to promote edema regression, pain relief, and accelerate wound healing. Moreover, the materials used in the present application are natural, green, and safe, have no side effects, and do not produce drug resistance and dependence. The preparation method is simple, and the production cost is low.

[0006] The above-disclosed traditional Chinese medicine composition for treating hemorrhoids has the problems of multiple drug components, complex proportioning, high cost, and long treatment course. SUMMARY

[0007] In view of the deficiencies of the prior art, the present application provides a Bletilla striata hemorrhoid ointment and a preparation method thereof. Bletilla striata is the monarch drug, Sophora japonica is the ministerial drug, Phellodendron amurense and Rheum officinale are the auxiliary drugs, and Panax notoginseng and borneol are the ministerial drugs. The components are fewer, the proportioning is simple, and the cost is lower. The specific technical solutions are as follows: A Bletilla striata hemorrhoid ointment, which comprises, by weight fraction, 10-30 parts of Bletilla striata, 10-30 parts of Panax notoginseng, 10-30 parts of Sophora japonica, 10-30 parts of Rheum officinale, 10-30 parts of Phellodendron amurense, and 10-30 parts of borneol.

[0008] Preferably, the ointment comprises, by weight fraction, 12-27 parts of Bletilla striata, 10-25 parts of Panax notoginseng, 13-27 parts of Sophora japonica, 15-30 parts of Rheum officinale, 11-30 parts of Phellodendron amurense, and 12-28 parts of borneol.

[0009] Preferably, the following components are used by weight parts: 25 parts of bletilla striata, 26 parts of panax notoginseng, 22 parts of sophora fruit, 16 parts of rhubarb, 21 parts of phellodendron, and 28 parts of borneol.

[0010] Another object of the present application is to provide a preparation method of the bletilla striata hemorrhoid ointment, which comprises the following steps: using selected pure natural traditional Chinese medicine bletilla striata, panax notoginseng, sophora fruit, and rhubarb, cleaning the selected traditional Chinese medicine, airing and drying the traditional Chinese medicine after the cleaning, breaking the cell walls of the traditional Chinese medicine by using the ultrasonic airflow crushing technology in the modern traditional Chinese medicine breaking technology under the sterile and dust-free conditions, breaking the cell walls of the traditional Chinese medicine again by adding borneol, and adjusting the crushed traditional Chinese medicine into a medicinal ointment state.

[0011] The functions and effects of the various medicinal materials in the present application are as follows: Bletilla striata tastes bitter and is neutral in nature, and is used for stopping bleeding and promoting tissue regeneration, and is used for treating abscess, sore, gangrene, yin injury, and dead muscle; Sophora fruit tastes bitter, sour, and salty, is cold in nature, and is non-toxic, and is used for treating five internal pathogenic heat, stopping saliva, treating five hemorrhoids, and treating five hemorrhoids.

[0012] Phellodendron tastes bitter and is cold in nature, and is used for treating five internal pathogenic heat, jaundice, and intestinal hemorrhoids. Rhubarb tastes bitter and is cold in nature, and is used for treating blood stasis, blood stasis, cold and heat, and accumulation of cancer.

[0013] Panax notoginseng tastes sweet and bitter, and enters liver meridian of Foot-Jueyin, and is used for stopping bleeding, promoting blood circulation, and removing blood stasis. Borneol tastes bitter and is warm in nature, and is non-toxic, and enters lung and liver meridians, and is used for treating accumulation of heart and abdominal pathogenic factors, throat obstruction, tonsillitis, tongue swelling, hemorrhoids, and other diseases.

[0014] Compared with the prior art, the present application has the following beneficial effects: In the present application, bletilla striata is the monarch drug, which can stop bleeding, promote tissue regeneration, and promote wound healing. Sophora fruit is the ministerial drug, which is cold in nature and bitter in taste, and is used for treating five internal pathogenic heat, jaundice, and intestinal hemorrhoids. Phellodendron and rhubarb are the auxiliary drugs, which can clear heat and dryness, detoxify and purge fire, and break accumulation and blood stasis. Panax notoginseng and borneol are the ministerial drugs, which have the effects of clearing heat and removing blood stasis, promoting blood circulation, stopping bleeding, and preventing tissue regeneration. The present application highlights the effects of tissue regeneration and bleeding, and treats the symptoms and the root cause. The prepared hemorrhoid ointment is pure herbal and easy to absorb, and can effectively treat the symptoms and the root cause of hemorrhoids, and has good treatment effect and is not easy to relapse. At the same time, the preparation process is simple, which only needs to mix the raw materials, break the cell walls, and then crush them into an ointment. The method is simple, easy to control, and can be mass-produced. DETAILED DESCRIPTION

[0015] The technical solutions of the present application will be described clearly and completely below in connection with specific embodiments. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application. Embodiment

[0016] A white yam hemorrhoids ointment is prepared from raw medicinal materials: white yam 25 parts, sanqi 26 parts, sophora fruit 22 parts, rhubarb 16 parts, golden cypress 21 parts, and borneol 28 parts. The raw medicinal materials are washed, dried, and broken in a wall under sterile and dust-free conditions by using the supersonic airflow crushing technology in the modern Chinese medicine wall breaking technology to break the plant cell wall of the Chinese medicine. The broken powder is then broken again with borneol and adjusted into a medicinal ointment state. Embodiment

[0017] A white yam hemorrhoids ointment is prepared from raw medicinal materials: white yam 26 parts, sanqi 20 parts, sophora fruit 18 parts, rhubarb 20 parts, golden cypress 19 parts, and borneol 22 parts. The raw medicinal materials are washed, dried, and broken in a wall under sterile and dust-free conditions by using the supersonic airflow crushing technology in the modern Chinese medicine wall breaking technology to break the plant cell wall of the Chinese medicine. The broken powder is then broken again with borneol and adjusted into a medicinal ointment state. Embodiment

[0018] A white yam hemorrhoids ointment is prepared from raw medicinal materials: white yam 27 parts, sanqi 20 parts, sophora fruit 20 parts, rhubarb 25 parts, golden cypress 20 parts, and borneol 20 parts. The raw medicinal materials are washed, dried, and broken in a wall under sterile and dust-free conditions by using the supersonic airflow crushing technology in the modern Chinese medicine wall breaking technology to break the plant cell wall of the Chinese medicine. The broken powder is then broken again with borneol and adjusted into a medicinal ointment state.

[0019] Experimental Example 1 Acute toxicity test: The hemorrhoids ointments provided in embodiments 1-3 are tested, and the half lethal dose (LD50) of the mice is tested and determined, but no LD50 is measured, so the maximum tolerance test is performed. Result: According to 500 times of the clinical daily dose per unit weight of adult, no mouse died within ten days, and no toxic reaction was found in the dissection of the organs of the mice, and there was no difference between the mice in the administration group and the control group.

[0020] Long-term toxicity test: Wistar rats were used to set the experimental drug as high, medium and low three doses, respectively, according to the human unit weight of 80 times, 40 times and 20 times of the drug dosage for the experimental group, and another normal feeding control group, continuous anal administration for 90 days, 180 days, part of the animals stopped 10 days after drug administration, the influence on the physiological and biochemical indexes of rats was observed. The experimental results show that: the food intake and growth and development (body weight gain) of rats have no effect, no obvious toxic effect on liver function and kidney function, no obvious influence on blood routine, blood biochemistry, urine biochemistry and bone marrow smear, etc. There is no significant difference between each group and the control group.

[0021] Experimental example 2 The clinical diseases are as follows: Huang, male, 45 years old, hemorrhoids are external hemorrhoids, have been suffering for three years, each time defecation has pain, occasionally a small amount of blood, after using the hemorrhoid ointment provided by example 2 of the present application for the first time, defecation has no pain, also no blood, defecation is smooth, insist on continuous use for 4 days, wipe once before going to bed every night, wipe once after defecation every day, defecation has no pain, also no blood, no discomfort, after continuous use for 10 days, after examination, hemorrhoids have recovered, no recurrence has been found so far.

[0022] Liu, female, 52 years old, hemorrhoids are internal hemorrhoids, have been suffering for four years, surgery in the hospital, due to penicillin shock allergy, can not use anti-inflammatory drugs, postoperative edema is very serious, using Ma Yinglong and other drugs is not very effective, after using the hemorrhoid ointment provided by example 1 of the present application for 7 days, no recurrence was found, after 2 weeks of reexamination, the patient has recovered, no recurrence has been found so far.

[0023] Zeng, female, 53 years old, patient diagnosed as mixed hemorrhoids, one suffering for 5 years, using the hemorrhoid ointment provided by example 3 of the present application, 3 times a day, 18 days later, the patient recovered, no recurrence has been found so far.

[0024] The above-mentioned is only an embodiment of the present application, it should be pointed out that for ordinary skilled in the art, without departing from the technical principles of the present application, a variety of changes, modifications, replacements and modifications can be made to these embodiments, these changes, modifications, replacements and modifications should also be considered as the protection scope of the present application.

Claims

1. A Bletilla striata hemorrhoid ointment, characterized in that, The product is composed of the following components by weight: 10-30 parts of Bletilla striata, 10-30 parts of Panax notoginseng, 10-30 parts of Sophora japonica fruit, 10-30 parts of rhubarb, 10-30 parts of Phellodendron chinense, and 10-30 parts of borneol.

2. The Bletilla striata hemorrhoid ointment according to claim 1, characterized in that, The product is composed of the following components by weight: Bletilla striata 12-27 parts, Panax notoginseng 10-25 parts, Sophora japonica fruit 13-27 parts, Rheum palmatum 15-30 parts, Phellodendron chinense 11-30 parts, and Borneol 12-28 parts.

3. The Bletilla striata hemorrhoid ointment according to claim 1, characterized in that, The product is composed of the following components by weight: 25 parts Bletilla striata, 26 parts Panax notoginseng, 22 parts Sophora japonica fruit, 16 parts Rheum palmatum, 21 parts Phellodendron chinense, and 28 parts Borneol.

4. The method for preparing a Bletilla striata hemorrhoid ointment according to claim 1, characterized in that, Includes the following steps: Selected pure natural Chinese herbs, including Bletilla striata, Panax notoginseng, Sophora japonica, Rheum palmatum, and Phellodendron chinense, are used. The selected herbs are cleaned and then dried. Under sterile and dust-free conditions, the dried herbs are broken down using supersonic airflow pulverization technology, a modern technique for breaking down the cell walls of Chinese herbs. Finally, borneol is added for another cell wall breaking process. The powdered herbs are then formulated into a paste.