Shampoo containing pistacia weinmannifolia extract and preparation method thereof

Abstract

The invention provides shampoo containing a pistacia weinmannifolia extract and a preparation method of the shampoo, and relates to the technical field of shampoo, the shampoo is composed of a pistacia weinmannifolia composite active matter, a mild surfactant system, a biocompatible thickening adhesion system, an auxiliary care component and other auxiliary materials. The shampoo is endowed with a condensed texture, so that the shampoo can safely stay on scalp for 2-5 minutes, and the technical problems that the contact time of active ingredients of a traditional shampoo is too short and the efficacy is difficult to play are solved; the formula is mild, the pH value is appropriate, and irritation to scalp is low; by combining the antibacterial, anti-inflammatory and antioxidant activities of the Pistacia weinmannifolia extract and the barrier repairing and microcirculation improving effects of the auxiliary nursing components, the problems of scalp dryness, itching and susceptibility to infection of sensitive people such as diabetic patients can be effectively solved, and comprehensive cleaning and nursing effects are provided.

Description

Technical Field

[0001] This invention belongs to the field of shampoo technology, specifically relating to a shampoo containing a fragrant wood extract and its preparation method. Background Technology

[0002] Chronic metabolic diseases such as diabetes are often accompanied by various skin complications, such as dry skin, itching, impaired barrier function, and slow wound healing. The scalp is also affected. Long-term high blood sugar can damage the microvessels in the scalp, leading to poor blood circulation and reduced nutrition and oxygen to the hair follicles. At the same time, the high-sugar environment and damaged skin barrier weaken the scalp's immune defenses, making it more susceptible to bacterial and fungal infections, such as folliculitis, further exacerbating inflammatory responses such as scalp itching and redness.

[0003] Most commercially available shampoos currently focus on strong cleaning and often contain highly irritating surfactants such as sodium lauryl sulfate (SLS), which may exacerbate dryness and discomfort on sensitive scalps. Although some herbal or mild shampoos are available on the market, there is still a lack of comprehensive scalp care solutions specifically designed for special populations such as diabetics, which can provide both extreme gentleness and effective antibacterial and anti-inflammatory benefits.

[0004] Pistacia weinmannifolia, a plant belonging to the genus Pistacia in the Anacardiaceae family, has a long history of medicinal use in China, often used for its anti-inflammatory, detoxifying, astringent, and antidiarrheal properties. Modern research shows that the leaves and branches of Pistacia weinmannifolia are rich in volatile oils, polyphenols, flavonoids, and other bioactive components. Its volatile oils have a significant inhibitory effect on common pathogenic microorganisms such as Staphylococcus aureus, Escherichia coli, and Rhodotorula rubrum. Its extracts also possess excellent antioxidant and anti-inflammatory activities, effectively scavenging free radicals and inhibiting the production of inflammatory factors. These properties make Pistacia weinmannifolia an ideal natural raw material for developing gentle yet effective scalp care products.

[0005] However, how to apply these beneficial properties of fragrant wood to shampoo products and overcome the limitations of traditional shampoos, such as short action time and insufficient gentleness on sensitive scalps, is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0006] To overcome the problems in the prior art, the present invention provides a scalp care shampoo containing fragrant wood extract specifically designed for sensitive and damaged scalps such as those of diabetic patients, and a method for preparing the same.

[0007] To achieve the above objectives, the present invention is implemented through the following technical solution: A shampoo containing a fragrant wood extract, wherein the shampoo components comprise, by weight percentage: The active ingredients in the Pistacia chinensis complex range from 0.5% to 5.0%, including Pistacia chinensis extract and Pistacia chinensis leaf essential oil. The surfactant system comprises 12%-25% and is selected from at least one of amino acid surfactants, alkyl glucoside surfactants, and betaine surfactants. A biocompatible thickening and adhesion system of 1.0%-5.0% is composed of xanthan gum, carbomer and sodium hyaluronate; The auxiliary care component is 0.5%-3.0%, selected from at least one of panthenol, ceramide, and nicotinamide; Phenoxyethanol 0.8%; Citric acid in appropriate amount; The remaining deionized water; The shampoo has a pH value of 4.5-6.5.

[0008] Furthermore, the surfactant system is composed of sodium cocoyl glutamate, decyl glucoside, and cocamidopropyl betaine.

[0009] Furthermore, in the biocompatible thickening and adhesion system, the weight percentage of xanthan gum is 0.5%-1.5%, the weight percentage of carbomer is 0.3%-1.0%, and the weight percentage of sodium hyaluronate is 0.2%-0.5%.

[0010] Furthermore, the scalp synergistic care component comprises 1.0% panthenol, 0.2% ceramide, and 1.0% nicotinamide.

[0011] A method for preparing a shampoo containing a fragrant wood extract includes the following steps: S1. Preparation of active ingredients: Fragrant wood extract was prepared by solvent extraction and fragrant wood leaf essential oil was prepared by ultrasound-assisted hydrolysis to obtain the fragrant wood composite active ingredients; S2. Preparation of aqueous gel matrix: Deionized water is heated to 70-80°C, and xanthan gum, carbomer and sodium hyaluronate are added in sequence. The mixture is stirred at high speed to fully hydrate and dissolve the xanthan gum to form a uniform gel matrix. S3. Emulsification and cooling: While stirring, slowly add the mild surfactant system to the gel matrix obtained in step S2, mix evenly, and then begin cooling. S4. Addition of active ingredients: When the system temperature drops below 40°C, add the fragrant wood extract, fragrant wood leaf essential oil and the scalp synergistic care components prepared in step S1 in sequence, and stir gently until completely dispersed and uniform; S5. pH Adjustment and Finished Product: Use a pH adjuster to adjust the pH of the system to the range of 4.5 to 6.5, and after standing to remove bubbles, the finished product is obtained.

[0012] Furthermore, the surfactant in S3 is preheated to 40-50°C before being added to reduce its viscosity.

[0013] The application of a scalp care shampoo in scalp care for diabetic patients includes the following steps: a. Apply an appropriate amount of the shampoo to the damp scalp and hair roots; b. Gently massage the scalp with your fingertips for 1-2 minutes to promote the absorption of active ingredients and scalp microcirculation; c. Leave the shampoo on the scalp for 2-5 minutes for deep conditioning; d. Finally, rinse thoroughly with clean water.

[0014] The beneficial effects of this invention are: 1. The natural active ingredients of fragrant wood are scientifically combined with modern dermatological care components, making it suitable for diabetic patients. It can effectively inhibit the growth of harmful bacteria, provide antioxidant protection, and reduce inflammatory symptoms such as scalp redness, swelling, and itching. At the same time, it repairs the scalp barrier and improves microcirculation, providing comprehensive health support for the scalp of diabetic patients. 2. It uses a sulfate-free, mild surfactant system and a weakly acidic pH value, making it suitable for long-term use on sensitive scalps such as those of diabetic patients.

[0015] 3. The product can stay on the scalp like a conditioning mask, prolonging the working time of the active ingredients and solving the problem of insufficient efficacy of traditional shampoos. Detailed Implementation

[0016] To make the objectives, technical solutions, and beneficial effects of the present invention clearer, the preferred embodiments of the present invention will be described in detail below to facilitate understanding by those skilled in the art.

[0017] Weigh each component according to the formula ratio in Table 1 for 100g of product. Table 1. Composition of Scalp Care Shampoo Formula (percentage by weight %) Example 1 S1. Preparation of active ingredients: Preparation of Fragrant Wood Extract (rich in polyphenols and flavonoids) Take 100g of dried leaves of *Pistacia chinensis*, crush them, add 10 times the amount of 75% ethanol solution, reflux extract at 60°C for 2 hours, and filter; add 8 times the amount of 75% ethanol solution to the residue and reflux extract for 1.5 hours, and filter; combine the two filtrates, concentrate under reduced pressure to a thick paste, and spray dry to obtain *Pistacia chinensis* extract powder for later use. Preparation of Fragrant Wood Leaf Essential Oil Using the ultrasonic-assisted hydro-distillation method, 100g of crushed fresh leaves of *Pistacia chinensis* were mixed with 500mL of deionized water and treated with ultrasonic power of 250W for 20 minutes. Then, hydro-distillation was carried out for 3 hours, and the upper oily liquid was collected, which is *Pistacia chinensis* leaf essential oil for later use. S2. Preparation of aqueous gel matrix: Add an appropriate amount of deionized water to the reaction vessel and heat to 75°C. Dry mix 1.0g xanthan gum, 0.5g carbomer 940 and 0.3g sodium hyaluronate evenly beforehand, and slowly sprinkle them into hot water under high speed stirring, continuing to stir until completely hydrated and dissolved to form a transparent and uniform gel matrix; S3. Emulsification and Cooling: Mix 10.0g sodium cocoyl glutamate, 5.0g decyl glucoside and 3.0g cocamidopropyl betaine evenly in another container; while stirring, slowly pump the mixed surfactant into the above gel matrix, stir evenly, turn off the heating and start cooling. S4. Addition of active ingredients: When the system temperature drops below 40°C, add 2.5g of Pistacia chinensis extract, 0.5g of Pistacia chinensis leaf essential oil, 1.0g of panthenol, 0.2g of ceramide NP and 1.0g of nicotinamide in sequence, and stir gently until completely dissolved or evenly dispersed; S5. pH Adjustment and Finished Product: Using a pre-prepared citric acid solution, slowly add it dropwise to adjust the pH of the system to 5.5; finally, add 0.8g of phenoxyethanol, make up the remaining amount of deionized water, stir again until well mixed, and let stand to remove bubbles to obtain a light brown, uniform gel-like shampoo product.

[0018] Examples 2-3 and Comparative Examples 1-3: Each component was weighed according to the formulation ratio in Table 1, and the preparation steps were the same as in Example 1.

[0019] Physicochemical properties and efficacy testing The physicochemical properties and efficacy of Examples 1-3 and Comparative Examples 1-3 were tested, and the test results are shown in Table 2: Table 2: Physicochemical Properties and In Vitro Efficacy Tests Data Analysis: The HET-CAM chorioallantoic membrane irritation score (1.2) of Example 1 was much lower than that of Comparative Example 2 (13.5) which used SLS, indicating that the mild surfactant system of the present invention has extremely low irritation. Compared with Example 1 and Comparative Example 1, the addition of the fragrant wood composite active ingredient endowed the product with significant antibacterial and antioxidant activity. The viscosity (1500 mPa·s) of Comparative Example 3 was much lower than that of Example 1 (8500 mPa·s), indicating poor scalp adhesion.

[0020] Human Effects Evaluation Subjects and Methods: 1. Forty patients with type II diabetes (with symptoms of dry and itchy scalp) were randomly and double-blindly divided into four groups of 10 each. Group A used Example 1, Group B used Example 2, Group C used Example 3, and Group D (control group) used Comparative Example 3. 2. All participants were instructed to apply the product, massage it into their scalp, leave it on for 3 minutes, and then rinse it off. This was continued for 4 weeks. 3. Before the start of the trial and at the end of the fourth week, participants assessed their scalp condition based on their own experience and observation by a dermatologist. Transepidermal water loss (TEWL) and scalp hydration were measured using instruments. Table 3. Improvement of scalp indicators after 4 weeks of human trials. Data Analysis: When using the same "3-minute stay" care method, Group A of Example 1, which uses the thickening and adhesion system of the present invention, showed significantly better results than Group D of Comparative Example 3, which uses the conventional thinning system, in improving scalp itching, erythema, barrier function (reduced TEWL), and moisturizing (increased hydration). This ensures that the active ingredients can work effectively during the stay period, avoiding the problem that traditional shampoos are difficult to exert their effects, and bringing significant improvements to scalp care for special populations such as diabetic patients.

[0021] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made to it in form and detail without departing from the scope defined by the claims of the present invention.

Claims

1. A shampoo containing a fragrant wood extract, characterized in that, The shampoo components, by weight percentage, include: The active ingredients in the Pistacia chinensis complex range from 0.5% to 5.0%, including Pistacia chinensis extract and Pistacia chinensis leaf essential oil. The surfactant system comprises 12%-25% and is selected from at least one of amino acid surfactants, alkyl glucoside surfactants, and betaine surfactants. A biocompatible thickening and adhesion system of 1.0%-5.0% is composed of xanthan gum, carbomer and sodium hyaluronate; The auxiliary care component is 0.5%-3.0%, selected from at least one of panthenol, ceramide, and nicotinamide; Phenoxyethanol 0.8%; Citric acid in appropriate amount; The remaining deionized water; The shampoo has a pH value of 4.5-6.

5.

2. The shampoo containing fragrant wood extract according to claim 1, characterized in that: The surfactant system is composed of sodium cocoyl glutamate, decyl glucoside and cocamidopropyl betaine.

3. The shampoo containing fragrant wood extract according to claim 1, characterized in that: The biocompatible thickening and adhesion system contains xanthan gum at a weight percentage of 0.5%-1.5%, carbomer at a weight percentage of 0.3%-1.0%, and sodium hyaluronate at a weight percentage of 0.2%-0.5%.

4. The shampoo containing fragrant wood extract according to claim 1, characterized in that: The scalp synergistic care component contains 1.0% panthenol, 0.2% ceramide and 1.0% nicotinamide.

5. A method for preparing the scalp care shampoo according to any one of claims 1 to 4, characterized in that, Includes the following steps: S1. Preparation of active ingredients: Fragrant wood extract was prepared by solvent extraction and fragrant wood leaf essential oil was prepared by ultrasound-assisted hydrolysis to obtain the fragrant wood composite active ingredients; S2. Preparation of aqueous gel matrix: Deionized water is heated to 70-80°C, and xanthan gum, carbomer and sodium hyaluronate are added in sequence. The mixture is stirred at high speed to fully hydrate and dissolve the xanthan gum to form a uniform gel matrix. S3. Emulsification and cooling: While stirring, slowly add the mild surfactant system to the gel matrix obtained in step S2, mix evenly, and then begin cooling. S4. Addition of active ingredients: When the system temperature drops below 40°C, add the fragrant wood extract, fragrant wood leaf essential oil and the scalp synergistic care components prepared in step S1 in sequence, and stir gently until completely dispersed and uniform; S5. pH Adjustment and Finished Product: Use a pH adjuster to adjust the pH of the system to the range of 4.5 to 6.5, and after standing to remove bubbles, the finished product is obtained.

6. The method for preparing the shampoo containing fragrant wood extract according to claim 5, characterized in that: The surfactant in S3 is preheated to 40-50°C before addition to reduce viscosity.

7. The application of the scalp care shampoo according to any one of claims 1 to 4 in the scalp care of diabetic patients, characterized in that, Includes the following steps: a. Apply an appropriate amount of the shampoo to the damp scalp and hair roots; b. Gently massage the scalp with your fingertips for 1-2 minutes to promote the absorption of active ingredients and scalp microcirculation; c. Leave the shampoo on the scalp for 2-5 minutes for deep conditioning; d. Finally, rinse thoroughly with clean water.

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