Film-forming cool-feeling relieving lotion suitable for relieving itching after bite and bald of infants and preparation method of film-forming cool-feeling relieving lotion

Abstract

The invention provides a film-forming cool feeling relieving lotion suitable for relieving itching after bite and bald of infants and a preparation method thereof, the film-forming cool feeling relieving lotion comprises a film-forming protection system, the film-forming protection system comprises 5.0-15.0% of polyurethane-35, 5.0-10.0% of polyvinyl alcohol and 0.1-0.5% of agarose, and the film-forming protection system is used for constructing a soft-hard interpenetrating network protection film on the skin surface; the cool feeling system is prepared from 5.0 to 10.0 percent of erythritol and 0.1 to 0.5 percent of menthol lactate; the deep soothing system is prepared from the following components in percentage by weight: 0.1 to 5.0 percent of swertia indica extract, 0.1 to 1.0 percent of radix gentianae macrophyllae extract, 0.1 to 1.0 percent of kava pepper root extract and 1.0 to 5.0 percent of bis-diethoxy diethylene glycol cyclohexane 1, 4-dicarboxylate; and the emulsifying and stabilizing system comprises 0.1-1.0% of a compound of acrylic acid (ester) copolymer sodium and lecithin. By compounding the polyurethane-35 and the polyvinyl alcohol, the problems that a pure polyvinyl alcohol film is strong in shrinkage feeling, easy to crack, tight and painful after being dried are solved; meanwhile, the itching relieving effect of'cooling once being smeared 'can be achieved on the premise that delicate skin of infants is not stimulated.

Description

Technical Field

[0001] This invention relates to the field of infant skin care products and topical skin preparations, and in particular to a film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and the method for preparing it. Background Technology

[0002] Insect bites are a common skin problem for infants and young children in summer. Because their skin barrier is weak and their immune system is not yet fully developed, they are very prone to severe inflammatory reactions (redness, swelling, wheals) and unbearable itching after being bitten.

[0003] In existing technologies, there is a core contradiction in care products for mosquito bites: the difficulty in balancing "strong antipruritic / physical protection" with "safety / comfort for infants and young children," specifically manifested as follows:

[0004] 1. Irritation of traditional anti-itch products: Many commercially available products such as floral water and medicated oil rely on high concentrations of ethanol (alcohol) as a solvent and contain high doses of menthol and camphor. While these ingredients provide quick relief from itching, they pose a strong irritant and potential neurotoxic risk to the delicate or broken skin of infants and young children.

[0005] 2. Skin feel defects of physical protective products: In order to prevent infants and young children from scratching and causing secondary infections, some products use film-forming technology (such as liquid bandages); however, most existing film-forming products use nitrocellulose or acrylic resin, which are hard and have a strong contraction after film formation, resulting in tightness and discomfort at the affected area, and poor breathability, which can easily cause skin maceration.

[0006] 3. Limited functionality and penetration challenges: Ordinary creams and ointments are easily rubbed off by clothing and cannot provide long-lasting protection; moreover, they lack effective penetration mechanisms, making it difficult for plant extracts to penetrate the stratum corneum to reach inflamed areas in the superficial dermis, resulting in slow onset of action.

[0007] Developing a physical protective film that can form a breathable, soft, and scratch-resistant membrane while providing instant cooling and itch relief without alcohol or irritation is a pressing technical challenge in the field of infant care. Summary of the Invention

[0008] In view of the shortcomings of the prior art described above, the purpose of this invention is to provide a film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, and its preparation method, to solve the problems of high irritation, poor film-forming comfort, and slow anti-itch effect of existing products.

[0009] To achieve the above and other related objectives, the present invention provides a film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, comprising, by weight percentage of the total composition:

[0010] A film-forming protective system comprising 5.0-15.0% polyurethane-35, 5.0-10.0% polyvinyl alcohol, and 0.1-0.5% agarose, wherein the film-forming protective system is used to construct a soft-hard interpenetrating network protective film on the skin surface.

[0011] The cooling system comprises 5.0-10.0% erythritol and 0.1-0.5% menthol lactate;

[0012] The deep soothing system includes 0.1-5.0% of Indian swert extract, 0.1-1.0% of gentian root extract, 0.1-1.0% of kava root extract, and 1.0-5.0% of bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester.

[0013] The emulsion stabilization system comprises 0.1-1.0% of a complex of sodium acrylate copolymer and lecithin;

[0014] Solvents, including purified water.

[0015] By adopting the above technical solution, a protective film can be formed by the compounding of polyurethane-35 and polyvinyl alcohol. PVA provides high barrier properties, creating a local micro-anaerobic environment to inhibit aerobic bacteria and physically prevent infants from scratching. The soft segment structure of polyurethane-35 gives the film excellent elasticity and flexibility, solving the problems of strong shrinkage, easy cracking, tightness and pain after pure polyvinyl alcohol film dries. At the same time, the high solubility enthalpy of erythritol generates instantaneous physical cooling, combined with the temperature of menthol lactate, which can achieve a "cooling upon application" effect that lasts for 2-3 hours without irritating the delicate skin of infants.

[0016] In one embodiment of the present invention, in the film-forming protection system, polyurethane-35 is an aqueous aliphatic polyurethane dispersion, and polyvinyl alcohol is a partially hydrolyzed polymer with a degree of hydrolysis of 87-89%; the agarose serves as a skeletal support agent to enhance the peel integrity of the film.

[0017] By adopting the above technical solution, agarose, as a neutral polysaccharide backbone, plays a bottom support role in the film formation process, which significantly enhances the cohesion of the film after drying. This allows the soothing lotion to form a complete film after drying, which can be peeled off in pieces when washing or removing, avoiding fragmentation and residue, while reducing the pulling pain when tearing.

[0018] In one embodiment of the present invention, in the deep soothing system, bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester is used as an amphiphilic penetration enhancer to carry the extracts of swertia blakeana and gentiana macrophylla to penetrate the stratum corneum; the swertia blakeana extract is used to inhibit histamine release from mast cells.

[0019] By adopting the above technical solution, the fluidity of stratum corneum lipids can be temporarily increased, allowing hydrophilic plant extracts and lipophilic components to quickly penetrate the barrier and reach the inflamed areas in the superficial dermis, significantly shortening the time for itch relief to take effect.

[0020] In one embodiment of the present invention, the invention further includes an occlusive moisturizer, wherein the occlusive moisturizer is 2.0-5.0% stearyl heptanoate; and a water-soluble emollient, wherein the water-soluble emollient is 0.1-5.0% PEG / PPG-14 / 7 dimethyl ether.

[0021] By adopting the above technical solution, a "lipid-hydration buffer layer" is constructed between the skin and the polymer membrane. This not only prevents the polymer membrane from drying out the skin, but also maintains the water-oil balance of the skin under the membrane after film formation, avoiding skin maceration or aggravation of itching caused by prolonged coverage.

[0022] In one embodiment of the present invention, it further includes 0.1-1.0% lotus water and 0.01-0.5% jasmine flower oil.

[0023] By adopting the above technical solutions, lotus water is rich in alkaloids, which can inhibit nitric oxide synthase and synergistically reduce redness and swelling caused by vasodilation; jasmine oil provides a natural soothing fragrance, which helps to calm the irritability of infants and young children caused by itching, and avoids the potential allergenic risks of artificial fragrances.

[0024] A method for preparing a film-forming cooling and soothing emulsion suitable for relieving itching after bites on infants and young children, as described above, includes the following steps: S1, preparation of the polymer matrix: polyvinyl alcohol, agarose, and a portion of water are mixed and heated to a first temperature of 85°C to 90°C, and stirred until completely dissolved; S2, thickening of the aqueous phase: after cooling, erythritol and a complex of sodium acrylate copolymer and lecithin are added and homogenized to dissolve; S3, emulsification of the oil phase: stearyl heptanoate and menthol lactate are mixed and heated to 70°C to 75°C, and added to the aqueous phase under vacuum for homogenization and emulsification; S4, elastomer compounding and cooling: the emulsion is cooled to a second temperature of 40°C to 45°C, polyurethane-35 aqueous dispersion is added, and stirred at low speed until homogeneous; S5, addition of active ingredients: at 40°C to 45°C, raw materials for the deep soothing system, preservatives, and fragrance components are added and stirred until homogeneous; S6, filtration and discharge: the pH value is adjusted to 5.5-6.5, filtered, and the preparation is complete.

[0025] In one embodiment of the present invention, in step S3, the vacuum level is controlled between -0.6 and -0.1 Bar.

[0026] By adopting the above technical solution, vacuuming during the emulsification process can effectively remove tiny air bubbles in the system.

[0027] In one embodiment of the present invention, in step S5, the bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester in the deep soothing system needs to be mixed with the fat-soluble active ingredient before being added.

[0028] By adopting the above technical solution, bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester is first mixed with the fat-soluble active ingredient to pre-form an "active ingredient-penetration enhancer" micelle or complex. Compared with direct addition, this can improve the dispersion uniformity of the active ingredient in the final emulsion and significantly enhance its transdermal absorption efficiency.

[0029] As described above, the film-forming cooling and soothing lotion of the present invention, suitable for relieving itching after bites on infants and young children, and its preparation method, have the following beneficial effects:

[0030] 1. Achieves comfortable protection through a combination of soft and hard materials: The film formed by modifying polyvinyl alcohol (hard segment) with polyurethane-35 (soft segment) has excellent flexibility and extensibility, moves with the skin texture without being tight, and is painless when torn off.

[0031] 2. Creates a non-irritating, three-dimensional cooling sensation: It abandons alcohol and high concentration of menthol, and uses the high solubility enthalpy of erythritol (endothermic cooling) combined with mild menthyl lactate to achieve immediate cooling and itch relief without irritating the skin of infants and young children.

[0032] 3. Enhanced penetration and efficacy of active ingredients: The introduction of bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester as a penetration enhancer significantly improved the transdermal absorption rate of active ingredients from plants such as Indian swert (antihistamine) and gentian (anti-inflammatory), achieving rapid desquamation. Detailed Implementation

[0033] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification.

[0034] It should be understood that the structures, proportions, sizes, etc., illustrated in this specification are merely for illustrative purposes to aid those skilled in the art and to facilitate understanding and reading. They are not intended to limit the implementation conditions of this invention and therefore have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and objectives of this invention, should still fall within the scope of the technical content disclosed in this invention. Furthermore, the terms such as "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and not intended to limit the scope of this invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of this invention's implementation.

[0035] Example 1:

[0036] This invention provides a film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, comprising, by weight percentage of the total composition:

[0037] The film-forming protective system, comprising 5.0-15.0% polyurethane-35, 5.0-10.0% polyvinyl alcohol, and 0.1-0.5% agarose, is used to construct a soft-hard interpenetrating network protective film on the skin surface.

[0038] The cooling system comprises 5.0-10.0% erythritol and 0.1-0.5% menthol lactate;

[0039] The deep soothing system includes 0.1-5.0% of Indian swert extract, 0.1-1.0% of gentian root extract, 0.1-1.0% of kava root extract, and 1.0-5.0% of bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester.

[0040] The emulsion stabilization system comprises 0.1-1.0% of a complex of sodium acrylate copolymer and lecithin;

[0041] The auxiliary components include 2.0-5.0% stearyl heptanoate, 0.1-5.0% PEG / PPG-14 / 7 dimethyl ether, 0.1-1.0% lotus water, 0.01-0.5% jasmine flower oil, and appropriate amounts of preservatives, pH adjusters and purified water.

[0042] Solvents, including purified water.

[0043] In the film-forming protection system, polyurethane-35 is an aqueous aliphatic polyurethane dispersion, polyvinyl alcohol is a partially hydrolyzed polymer with a degree of hydrolysis of 87-89%, and agarose is used as a skeletal support agent to enhance the peel integrity of the film.

[0044] In the deep soothing system, bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester acts as an amphiphilic penetration enhancer to carry the extracts of swertia blakeana and gentiana macrophylla to penetrate the stratum corneum; the swertia blakeana extract is used to inhibit histamine release from mast cells.

[0045] Example 2:

[0046] A specific formulation of the soothing lotion as described in Example 1, with the following weight percentages of each component:

[0047] Film-forming protection system: 10.0% polyurethane-35, 8.0% polyvinyl alcohol, 0.3% agarose;

[0048] Physical-biological cooling system: 8.0% erythritol, 0.3% menthol lactate;

[0049] Deep Soothing System: 1.0% Indian swert extract, 1.0% Gentiana macrophylla extract, 1.0% Peppermint root extract, 0.5% Bisabolol / ginger root extract, 3.0% bis-diethoxydiethylene glycol cyclohexane 1,4-dicarboxylic acid ester;

[0050] Emulsion stabilizing system: 0.8% sodium acrylate copolymer / lecithin;

[0051] Auxiliary components: 3.0% stearyl heptanoate, 2.0% PEG / PPG-14 / 7 dimethyl ether, 1.0% lotus water, 0.05% jasmine flower oil;

[0052] Solvents and preservatives: 57.5% purified water, 1.5% methyl propylene glycol / octyl glycol / phenylpropanol, 0.8% phenoxyethanol / ethylhexylglycerin.

[0053] Example 3:

[0054] A method for preparing a soothing lotion as described in Example 1 or 2 includes the following steps:

[0055] S1. Preparation of polymer matrix: Polyvinyl alcohol and agarose are added to a portion of water, stirred and homogenized for 30 minutes, then heated to 85-90℃ and stirred until completely dissolved to form a transparent gel.

[0056] S2, Aqueous phase thickening: Cool the adhesive solution obtained in S1 to about 70°C, add erythritol, sodium acrylate copolymer and lecithin, and stir until dissolved and homogeneous.

[0057] S3. Oil phase emulsification: Stearyl heptanoate and menthol lactate are dissolved in the oil phase pot by heating to 70-75℃; the emulsification pot is evacuated to -0.6 to -0.1 Bar, and the oil phase is drawn into the aqueous phase for homogenization emulsification.

[0058] S4. Elastomer Composite and Cooling: Turn on the cooling. When the temperature drops to 40-45℃, add the polyurethane-35 dispersion to the emulsification pot and stir at low speed until uniform. Utilize the film-forming properties of polyurethane to modify polyvinyl alcohol.

[0059] S5. Addition of active ingredients: At 40-45℃, add bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester (premixed bisabolol), Indian swert extract, Gentiana macrophylla extract, Peppermint root extract, PEG / PPG-14 / 7 dimethyl ether, preservative and jasmine oil in sequence, and stir well.

[0060] S6. Filtration and Discharge: Stir and cool to 30-35℃, test pH value (5.5-6.5), degas under vacuum, and discharge after filtration.

[0061] In summary, this invention utilizes the compounding of polyurethane-35 and polyvinyl alcohol to form a protective film. PVA provides high barrier properties, creating a localized micro-anaerobic environment that inhibits aerobic bacteria and physically prevents infants from scratching. The soft segment structure of polyurethane-35 gives the film excellent elasticity and flexibility, solving the problems of strong shrinkage, easy cracking, tightness, and pain after pure polyvinyl alcohol films dry. At the same time, it innovatively utilizes the high solubility enthalpy of erythritol to generate instantaneous physical cooling, combined with the temperature of menthol lactate, to achieve an "instant cooling" and 2-3 hour anti-itch effect without irritating the delicate skin of infants.

[0062] Therefore, this invention effectively overcomes the various shortcomings of the prior art and has high industrial application value.

[0063] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, characterized in that, The composition comprises, by weight percentage of the total composition: A film-forming protective system comprising 5.0-15.0% polyurethane-35, 5.0-10.0% polyvinyl alcohol, and 0.1-0.5% agarose, wherein the film-forming protective system is used to construct a soft-hard interpenetrating network protective film on the skin surface. The cooling system comprises 5.0-10.0% erythritol and 0.1-0.5% menthol lactate; The deep soothing system includes 0.1-5.0% of Indian swert extract, 0.1-1.0% of gentian root extract, 0.1-1.0% of kava root extract, and 1.0-5.0% of bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester. The emulsion stabilization system comprises 0.1-1.0% of a complex of sodium acrylate copolymer and lecithin; Solvents, including purified water.

2. The film-forming cooling and soothing lotion for relieving itching after bites on infants and young children, as described in claim 1, is characterized in that: In the film-forming protection system, polyurethane-35 is an aqueous aliphatic polyurethane dispersion, and polyvinyl alcohol is a partially hydrolyzed polymer with a degree of hydrolysis of 87-89%; agarose serves as a skeletal support agent to enhance the peel integrity of the film.

3. The film-forming cooling and soothing lotion for relieving itching after bites on infants and young children, as described in claim 1, is characterized in that: In the deep soothing system, bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester serves as an amphiphilic penetration enhancer, used to carry the extracts of swertia blakeana and gentiana macrophylla to penetrate the stratum corneum; the swertia blakeana extract is used to inhibit histamine release from mast cells.

4. The film-forming cooling and soothing lotion for relieving itching after bites on infants and young children, as described in claim 1, is characterized in that: It also includes an occlusive moisturizer, wherein the occlusive moisturizer is 2.0-5.0% stearyl heptanoate; and a water-soluble emollient, wherein the water-soluble emollient is 0.1-5.0% PEG / PPG-14 / 7 dimethyl ether.

5. The film-forming cooling and soothing lotion for relieving itching after bites on infants and young children, as described in claim 1, is characterized in that: It also includes 0.1-1.0% lotus water and 0.01-0.5% jasmine flower oil.

6. A method for preparing a film-forming cooling and soothing lotion as described in any one of claims 1-5, suitable for relieving itching after bites on infants and young children, characterized in that... Includes the following steps: S1. Preparation of polymer matrix: Polyvinyl alcohol, agarose and some water are mixed, heated to a first temperature of 85°C to 90°C, and stirred until completely dissolved. S2, after thickening the aqueous phase and cooling, add erythritol and a complex of sodium acrylate copolymer and lecithin, and homogenize to dissolve; S3. Oil phase emulsification: Stearyl heptate and menthol lactate are mixed and heated to 70°C to 75°C. The aqueous phase is then added under vacuum for homogenization and emulsification. S4. Elastomer compounding and cooling: Cool the emulsion to a second temperature of 40°C to 45°C, add polyurethane-35 aqueous dispersion, and stir at low speed until uniform. S5. Add active ingredients: Add the raw materials of the deep soothing system, preservatives and fragrance components at 40℃ to 45℃, and stir well. S6. Filtration and discharge: Adjust the pH value to 5.5-6.5, filter, and the preparation is complete.

7. The preparation method of the film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, as described in claim 6, is characterized in that: In step S3, the vacuum level is controlled between -0.6 and -0.1 Bar.

8. The preparation method of the film-forming cooling and soothing lotion suitable for relieving itching after bites on infants and young children, as described in claim 6, is characterized in that: In step S5, the bis-diethoxydiethylenecyclohexane 1,4-dicarboxylic acid ester in the deep soothing system needs to be mixed with the fat-soluble active ingredient before being added.