Filtering apparatus and mobile phase preparation apparatus

Abstract

The application discloses a suction filtration device and a mobile phase preparation equipment, and relates to the technical field of medicine preparation. The upper portion of the suction filtration main body is respectively inserted with a drainage needle, a negative pressure needle and a liquid suction needle, the liquid suction needle is communicated with a liquid preparation container, and the negative pressure needle can generate negative pressure in a target container. The driving assembly can drive the drainage needle, the negative pressure needle and the liquid suction needle to move towards the direction close to or away from the target container. The first elastic assembly is correspondingly arranged with the drainage needle, the negative pressure needle and the liquid suction needle, and the first elastic assembly can provide the compression force between at least one of the drainage needle, the negative pressure needle and the liquid suction needle and the suction filtration main body. The application can provide the compression force between at least one of the drainage needle, the negative pressure needle and the liquid suction needle and the suction filtration main body through the first elastic assembly, so that the sealing property between the drainage needle, the negative pressure needle, the liquid suction needle and the suction filtration main body is guaranteed, and the air tightness between the suction filtration device and the target container can be improved.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical preparation technology, and more specifically, to a filtration apparatus and a mobile phase preparation device. Background Technology

[0002] In related fields, liquid filtration is a common and crucial preparation step. For example, when preparing a mobile phase, the solvent needs to be filtered to remove impurities and particulate matter. To improve filtration efficiency and safety, a drive mechanism is typically used to move the filtration head and align it with the mouth of the target collection container, and then negative pressure is applied for filtration.

[0003] In practical applications, in order to ensure the negative pressure environment required for filtration, a highly airtight connection must be formed between the outlet of the filtration device and the target container. Traditional automated devices often rely on simple sealing gaskets for sealing. However, during the automatic docking process, slight deviations in equipment positioning can easily lead to incomplete sealing at the docking position, resulting in negative pressure leakage, affecting filtration efficiency, prolonging preparation time, and even affecting the quality of the final product.

[0004] Therefore, how to improve the airtightness between the filtration device and the target container has become a technical problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0005] In view of this, the purpose of this application is to provide a filtration device to improve the airtightness between the filtration device and the target container.

[0006] Another objective of this application is to provide a mobile phase preparation apparatus having the above-described filtration device.

[0007] To achieve the above objectives, this application provides the following technical solution:

[0008] A filtration device, comprising:

[0009] A filtration body is used to filter liquid from a liquid preparation container into a target container. A drainage needle, a negative pressure needle, and a liquid extraction needle are respectively inserted on the top of the filtration body. The liquid extraction needle is connected to the liquid preparation container. The negative pressure needle is used to generate negative pressure in the target container. The target container is located below the filtration body.

[0010] A driving assembly for driving the drainage needle, the negative pressure needle, and the aspiration needle to move toward or away from the target container;

[0011] A first elastic component is provided corresponding to the drainage needle, the negative pressure needle and the aspiration needle respectively. The first elastic component is used to provide a clamping force between the drainage needle, the negative pressure needle and the aspiration needle and the filtration body.

[0012] Optionally, in the above-mentioned filtration device, a linear bearing is sleeved on the outer side of the drainage needle, and the drainage needle can move along the linear bearing;

[0013] The drainage needle is provided with a drainage mounting seat, and the first elastic component of the drainage needle is compressed between the drainage mounting seat and the linear bearing.

[0014] Optionally, in the above-mentioned vacuum filtration device, the driving assembly includes a mounting plate, a slide rail, and a slide base. There are two slide rails, and the two slide rails are arranged parallel to each other on the mounting plate. The slide bases are arranged corresponding to the slide rails. The negative pressure needle and the liquid extraction needle are respectively connected to the two slide bases. A fixing seat is provided on the mounting plate. The first elastic components of the negative pressure needle and the liquid extraction needle are respectively compressed between the corresponding slide base and the fixing seat.

[0015] Optionally, in the above-mentioned filtration device, the mounting plate is further provided with a connector, and the connector can drive the filtration body to move along the mounting plate toward the target container or away from it. The connector is provided with a second elastic component, which is used to allow the drainage needle, the negative pressure needle and the liquid extraction needle to detach from the filtration body when they move toward the target container.

[0016] Optionally, in the above-mentioned filtration device, slots are provided on opposite sides of the filtration body, and the connector includes two protrusions that cooperate with the slots, and the protrusions are provided with mounting parts for installing the second elastic component.

[0017] Optionally, in the above-mentioned filtration device, the lower end of the filtration body is provided with a docking interface for connecting and communicating with the target container, and the upper end face of the filtration body is provided with a first through hole for inserting the liquid extraction needle, a second through hole for inserting the negative pressure needle, and a third through hole for inserting the drainage needle. A filter membrane is provided below the first through hole and the third through hole, and both the first through hole and the third through hole extend into the interior of the filtration body and communicate with the docking interface.

[0018] Optionally, in the above-mentioned filtration device, the filtration body includes a base, a first connecting part, and a second connecting part. The first through hole and the third through hole are disposed on the first connecting part, the second through hole is disposed on the base, the second connecting part is sleeved on the outside of the first connecting part, and the second connecting part is connected to the base, so that the second connecting part presses the first connecting part onto the base.

[0019] Optionally, in the above-described filtration device, the filtration body has a filtration chamber for containing the solution to be filtered, the filtration membrane is located in the filtration chamber, the first connecting part has a first chamber, the base part has a second chamber, the first connecting part is embedded in the second chamber, and the filtration chamber includes at least the first chamber and the second chamber.

[0020] Optionally, in the above-mentioned filtration device, the outer wall of the first connecting part extends in a direction away from the central axis of the first connecting part to form a protrusion, the protrusion being used to press the filter membrane in the filter chamber, and the side wall of the second chamber is provided with a stepped part, the protrusion being provided with a stepped surface that cooperates with the stepped part.

[0021] Optionally, in the above-mentioned suction filtration device, the outer wall of the protrusion is provided with a protrusion, and the side wall of the second cavity is provided with a limiting groove for cooperating with the protrusion, and the limiting groove is provided with an opening to facilitate the protrusion sliding in.

[0022] Optionally, in the above-mentioned vacuum filtration device, the protrusion has a first pressing surface and a second pressing surface disposed opposite to each other. The first pressing surface is used to abut against the filter membrane in the filter cavity, and the second connecting part is used to abut against the second pressing surface. The area of ​​the first pressing surface is smaller than the area of ​​the second pressing surface.

[0023] Optionally, in the above-described filtration device, the second connecting part includes a connecting body and a toothed part located on the connecting body. The outer wall of the connecting body extends in a direction away from the central axis of the connecting body to form a pressing part. The pressing part is used to press the first connecting part, and the pressing part is connected to the base part.

[0024] Optionally, the above-mentioned filtration device further includes a sealing element, wherein a flow channel for communicating with the target container is provided at the center of the interface, the sealing element is snapped onto the outside of the flow channel, and the sealing element has a notch for communicating with the target container, and the second through hole communicates with the notch.

[0025] A mobile phase preparation apparatus includes a filtration device as described in any of the preceding claims, the filtration device being used to filter the solution in the preparation container and extract it into the target container.

[0026] The filtration device provided in this application drives a drainage needle, a negative pressure needle, and a suction needle to move towards the target container via a drive assembly. This allows the drainage needle, negative pressure needle, and suction needle to be inserted into the filtration body from above, so that the liquid in the dispensing container is drawn into the target container under the negative pressure generated by the negative pressure needle. Simultaneously, a first elastic component, corresponding to the drainage needle, negative pressure needle, and suction needle respectively, provides a clamping force between at least one of these needles and the filtration body, thereby ensuring a tight seal between the drainage needle, negative pressure needle, and suction needle and the filtration body. As can be seen from the above example, the filtration device provided in this application, through the first elastic component, provides a clamping force between at least one of the drainage needle, negative pressure needle, and suction needle and the filtration body to ensure a tight seal between the drainage needle, negative pressure needle, and suction needle and the filtration body, thereby improving the airtightness between the filtration device and the target container.

[0027] The technical features mentioned above, those to be mentioned below, and those shown individually in the accompanying drawings can be combined arbitrarily, provided that the combined technical features are not contradictory. All feasible combinations of features are the technical content explicitly described herein. Any one of the multiple sub-features contained in the same statement can be applied independently, without necessarily being applied together with other sub-features. Attached Figure Description

[0028] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this application. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0029] Figure 1 This is a schematic diagram of the structure of the filtration device provided in the embodiments of this application;

[0030] Figure 2 An exploded view of the filtration body provided in the embodiments of this application;

[0031] Figure 3 This is a cross-sectional view of the filtration body provided in an embodiment of this application.

[0032] In this design, 100 is the filtration device, 10 is the filtration body, 101 is the slot, 102 is the interface, 1021 is the flow channel, 103 is the first through hole, 104 is the second through hole, 105 is the third through hole, 106 is the filter membrane, 107 is the base, 1071 is the second cavity, 1071a is the stepped part, 1071b is the limiting groove, 1071c is the opening, 108 is the first connecting part, 1081 is the first cavity, 1082 is the protrusion, 1082a is the stepped surface, 1082b is the protrusion, 1082c is the first pressing surface, 1082d is the second pressing surface, 109 is the second connecting part, and 1091 is the connecting part. Connecting to the main body, 1091a is the toothed part, 1091b is the clamping part, 110 is the filter chamber, 111 is the seal, 1111 is the notch, 20 is the drainage needle, 201 is the linear bearing, 202 is the drainage mounting base, 203 is the connecting base, 30 is the negative pressure needle, 40 is the liquid extraction needle, 41 is the flow meter, 50 is the drive assembly, 501 is the mounting plate, 5011 is the fixing base, 5012 is the fixing part, 5013 is the track, 502 is the slide rail, 503 is the slide block, 504 is the lifting drive component, 60 is the first elastic component, 70 is the second elastic component, 80 is the connecting part, 801 is the protrusion, and 8011 is the mounting part. Detailed Implementation

[0033] The core of this application is to provide a filtration device to improve the airtightness between the filtration device and the target container.

[0034] Another key aspect of this application is to provide a mobile phase preparation apparatus having the aforementioned filtration device.

[0035] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0036] In related fields, especially in the preparation of mobile phases, liquid filtration is a common and crucial step. For example, when preparing a mobile phase, the solvent needs to be filtered to remove impurities and particulate matter. To improve filtration efficiency and safety, a drive mechanism is typically used to move the filtration head and align it with the opening of the target collection container, and then negative pressure is applied for filtration.

[0037] In practical applications, in order to ensure the negative pressure environment required for filtration, a highly airtight connection must be formed between the outlet of the filtration device and the target container. Traditional automated devices often rely on simple sealing gaskets for sealing. However, during the automatic docking process, slight deviations in equipment positioning can easily lead to incomplete sealing at the docking position, resulting in negative pressure leakage, affecting filtration efficiency, prolonging preparation time, and even affecting the quality of the final product.

[0038] Therefore, such as Figure 1 As shown in the figure, this application discloses a filtration device 100, including a filtration body 10, a drive assembly 50, and a first elastic assembly 60. The first elastic assembly 60 provides a clamping force between at least one of the drainage needle 20, the negative pressure needle 30, and the liquid extraction needle 40 and the filtration body 10, thereby ensuring the sealing between the drainage needle 20, the negative pressure needle 30, and the liquid extraction needle 40 and the filtration body 10, and thus improving the airtightness between the filtration device 100 and the target container.

[0039] The following will combine Figures 1 to 3 The filtration apparatus 100 disclosed in the embodiments of this application will be explained and described in detail.

[0040] like Figure 1As shown, the filtration body 10 can filter the liquid in the preparation container into the target container. A drainage needle 20, a negative pressure needle 30, and a suction needle 40 can be inserted above the filtration body 10. The suction needle 40 is connected to the preparation container via a first connecting hose, while the negative pressure needle 30 is connected to a vacuum source via a gas source pipe. This creates a negative pressure in the target container below the filtration body 10, allowing the solution to flow from the preparation container through the suction needle 40, through the filtration body 10, and into the target container under negative pressure. This effectively avoids the risk of the preparation container falling or colliding, ensuring high safety. Furthermore, the drainage needle 20 is connected to the preparation container via a second connecting hose. A drainage drive component, such as a peristaltic pump, can be installed on the second connecting hose. One end of the second connecting hose is connected to the preparation container, and the other end is connected to the peristaltic pump or other drainage drive component, which is then connected to the drainage needle 20. When the solution in the mixing container cannot flow into the filtration body 10 through the suction needle 40 under negative pressure, the vacuum source and peristaltic pump can be activated simultaneously. Driven by these components, the solution can flow into the filtration body 10 through the suction needle 20 and then into the target container after filtration. It should be noted that if the solution overflows from the filtration body 10, it can flow back into the mixing container through the suction needle 40 and the first connecting hose, thus avoiding waste and ensuring the stability of the filtration process. Furthermore, a flow meter 41 can be installed on the first connecting hose to monitor the flow rate of the solution through it in real time, ensuring the reliable operation of the filtration device 100.

[0041] like Figure 1As shown, the driving component 50 can simultaneously drive the drainage needle 20, the negative pressure needle 30, and the suction needle 40 to move towards or away from the target container. That is, the drainage needle 20, the negative pressure needle 30, and the suction needle 40 can share a single driving component 50 for lifting and lowering. To ensure the sealing of the drainage needle 20, the negative pressure needle 30, and the suction needle 40 when inserted into the filtration body 10, and to avoid incomplete insertion during the insertion process, resulting in a poor seal, the first elastic component 60 can be correspondingly provided with each of the drainage needle 20, the negative pressure needle 30, and the suction needle 40. That is, each of the drainage needle 20, the negative pressure needle 30, and the suction needle 40 can be respectively provided with a first elastic component 60, thereby enabling the first elastic component 60 to provide... At least one of the drainage needle 20, negative pressure needle 30, and liquid extraction needle 40 provides clamping force between itself and the filtration body 10. That is, the first elastic component 60 can provide clamping force for one of the drainage needle 20, negative pressure needle 30, and liquid extraction needle 40, or it can provide clamping force for two or three of them simultaneously, so as to ensure that the drainage needle 20, negative pressure needle 30, and liquid extraction needle 40 can all be inserted to the target depth of the filtration body 10 under the elastic force of the first elastic component 60. This ensures the sealing performance of the drainage needle 20, negative pressure needle 30, and liquid extraction needle 40 when inserted into the filtration body 10, prevents leakage of liquid and air, and ensures the reliability and stability of the filtration body 10 in extracting liquid from the liquid preparation container into the target container. It should be noted that, because the drainage needle 20, negative pressure needle 30, and suction needle 40 have a certain taper, they need to be inserted into the filtration body 10 to the target depth to ensure a sealed connection between the drainage needle 20, negative pressure needle 30, and suction needle 40 and the filtration body 10. The first elastic component 60 can be a compression spring, etc.

[0042] In some embodiments, such as Figure 1 As shown, a linear bearing 201 can be sleeved on the outer side of the drainage needle 20, and the linear bearing 201 and the outer peripheral surface of the drainage needle 20 can be clearance-fitted so that the drainage needle 20 can move along the linear bearing 201, thereby providing a guiding effect for the raising and lowering of the drainage needle 20 through the linear bearing 201. Meanwhile, a drainage mounting base 202 can be provided on the drainage needle 20, and the drainage mounting base 202 can be fixedly connected to the drainage needle 20. The first elastic component 60 of the drainage needle 20 is compressed between the drainage mounting base 202 and the linear bearing 201. That is, the first elastic component 60 can be sleeved on the outside of the drainage needle 20, and one end of the first elastic component 60 can abut against the lower end surface of the linear bearing 201, and the other end of the first elastic component 60 can abut against the drainage mounting base 202. Thus, the first elastic component 60 can be compressed between the drainage mounting base 202 and the linear bearing 201, so that the first elastic component 60 can provide a clamping force to the drainage needle 20 through the drainage mounting base 202, ensuring that the drainage needle 20 is inserted in place and preventing leakage.

[0043] In some embodiments, such as Figure 1 As shown, the drive assembly 50 may include a mounting plate 501, a slide rail 502, and a slide block 503. The mounting plate 501 can be connected to a lifting drive component 504, which drives the mounting plate 501 to perform lifting actions. Two slide rails 502 can be used, and the two slide rails 502 can be installed parallel to each other on the mounting plate 501. The slide blocks 503 are correspondingly arranged with the slide rails 502, meaning one slide block 503 can be provided on each slide rail 502. The slide blocks 503 can slide along the slide rails 502. The negative pressure needle 30 and the aspiration needle 40 can be connected to the two slide blocks 503 respectively, thereby providing a more stable guiding effect for the movement of the negative pressure needle 30 and the aspiration needle 40 through the slide rails 502. Furthermore, a fixing seat 5011 can be fixed to the mounting plate 501 with fasteners such as bolts, and the fixing seat 5011 is located on the top of the slide rail 502. The first elastic components 60 of the negative pressure needle 30 and the liquid extraction needle 40 can be compressed between the corresponding slide 503 and the fixing seat 5011, respectively. That is, one end of the first elastic component 60 of the negative pressure needle 30 can abut against the fixing seat 5011, and the other end of the first elastic component 60 of the negative pressure needle 30 can abut against the slide 503 of the negative pressure needle 30. Similarly, one end of the first elastic component 60 of the liquid extraction needle 40 can abut against the fixing seat 5011, and the other end of the first elastic component 60 of the liquid extraction needle 40 can abut against the slide 503 of the liquid extraction needle 40. The two first elastic components 60 can provide clamping force to the negative pressure needle 30 and the liquid extraction needle 40 through the two slides 503 respectively, ensuring that the negative pressure needle 30 and the liquid extraction needle 40 are inserted in place and preventing air and liquid leakage.

[0044] In some embodiments, such as Figure 1 As shown, the drainage needle 20 and the aspiration needle 40 can be mounted on the same slide 503, so that the mounting plate 501 can simultaneously drive the drainage needle 20 to move. The drainage needle 20 can be mounted on the connecting seat 203, and the connecting seat 203 can have at least one vertically oriented slot, i.e., one, two, or more slots. Simultaneously, the slide 503 of the aspiration needle 40 can have a fixing hole that mates with the slot, allowing for locking and fixing by bolts or other fasteners sequentially passing through the slot on the connecting seat 203 and the fixing hole on the slide 503. The vertical height of the drainage needle 20 can be adjusted through the slot on the connecting seat 203, ensuring that the drainage needle 20 and the aspiration needle 40 can be simultaneously inserted into the filtration body 10.

[0045] In some embodiments, such as Figure 1As shown, the lifting drive component 504 can be a screw motor, lifting cylinder, lifting oil cylinder, etc., and the lifting drive component 504 is equipped with a lifting seat that can be raised and lowered. The lifting seat can be connected and fixed to the side of the mounting plate 501 away from the slide rail 502 and slide 503 by bolts or other fasteners through a Z-shaped connecting plate, so that the lifting drive component 504 can drive the lifting seat to rise and fall, thereby realizing the lifting action of the drainage needle 20, negative pressure needle 30 and liquid suction needle 40 through the mounting plate 501, and thus realizing the movement towards or away from the target container.

[0046] In some embodiments, such as Figure 1 As shown, a connector 80 may also be provided on the mounting plate 501, and the connector 80 can drive the filtration body 10 to move along the mounting plate 501 toward or away from the target container. Simultaneously, a second elastic component 70 may be provided on the connector 80, so that under the elastic force of the second elastic component 70, the drainage needle 20, negative pressure needle 30, and suction needle 40 can quickly detach from the filtration body 10 when moving toward the target container. It should be noted that the second elastic component 70 may be a compression spring or the like.

[0047] In some embodiments, such as Figure 1 As shown, slots 101 are provided on opposite sides of the filter body 10, and the connector 80 may include two protrusions 801 that mate with the slots 101. The protrusions 801 can be inserted into the slots 101 to achieve the installation and fixation of the connector 80 to the filter body 10. Simultaneously, a mounting member 8011 for mounting the second elastic component 70 is provided on the protrusion 801, and a fixing member 5012 can be fixed to the mounting plate 501 with bolts or other fasteners. This allows one end of the second elastic component 70 to abut against the mounting member 8011 on the protrusion 801, and the other end of the second elastic component 70 to abut against the fixing member 5012, thereby achieving the installation and fixation of the second elastic component 70.

[0048] In some embodiments, such as Figure 1 As shown, a vertical track 5013 can be provided on the mounting plate 501, and the fixing member 5012 can be located on one side of the track 5013. At the same time, the connecting member 80 can move along the track 5013 to provide guidance for the movement of the filtration body 10. When the drainage needle 20, the negative pressure needle 30, and the liquid extraction needle 40 move in a direction away from the target container, the second elastic component 70 can apply a spring force to the filtration body 10 through the connecting member 80 in the opposite direction to the movement of the drainage needle 20, the negative pressure needle 30, and the liquid extraction needle 40. Thus, under the action of the spring force of the second elastic component 70, the drainage needle 20, the negative pressure needle 30, and the liquid extraction needle 40 can quickly detach from the filtration body 10 when moving in a direction away from the target container.

[0049] The filtration device 100 disclosed in this application uses a drive assembly 50 to drive the drainage needle 20, negative pressure needle 30, and extraction needle 40 to move towards the target container. This allows the drainage needle 20, negative pressure needle 30, and extraction needle 40 to be inserted into the filtration body 10 from above. The negative pressure generated by the negative pressure needle 30 within the target container then draws liquid from the preparation container into the target container. Simultaneously, a first elastic assembly 60, corresponding to the drainage needle 20, negative pressure needle 30, and extraction needle 40 respectively, provides a clamping force between at least one of these needles and the filtration body 10, ensuring a tight seal between them.

[0050] The filtration device 100 disclosed in this application embodiment can provide a clamping force between at least one of the drainage needle 20, negative pressure needle 30 and liquid extraction needle 40 and the filtration body 10 through the first elastic component 60, so as to ensure the sealing between the drainage needle 20, negative pressure needle 30 and liquid extraction needle 40 and the filtration body 10, thereby improving the airtightness between the filtration device 100 and the target container.

[0051] In some embodiments, such as Figure 2 and Figure 3As shown, the lower end of the filtration body 10 may be provided with a connection interface 102. When the filtration body 10 is installed on the target container, the connection interface 102 can be inserted into the target container and communicate with the target container. At the same time, the upper end face of the filtration body 10 may be provided with a first through hole 103 for inserting a suction needle 40, a second through hole 104 for inserting a negative pressure needle 30, and a third through hole 105 for inserting a drainage needle 20. The first through hole 103 extends into the interior of the filtration body 10 and communicates with the interface 102, so that the first through hole 103 can communicate with the target container. The third through hole 105 extends into the interior of the filtration body 10 and communicates with the interface 102, so that the third through hole 105 can communicate with the target container. A filter membrane 106 can be provided below the first through hole 103 and the third through hole 105, so that the solution can flow into the filtration body 10 through the first through hole 103 or the third through hole 105, and after being filtered by the filter membrane 106, flow into the target container through the interface 102. The second through-hole 104 extends into the interior of the filtration body 10 and communicates with the target container. The second through-hole 104 is also connected to a vacuum source, allowing the vacuum source to evacuate the target container through the second through-hole 104. Furthermore, the area below the first through-hole 103 and the third through-hole 105 can be evacuated through the interface 102, creating a negative pressure environment inside the target container and below the first through-hole 103 and the third through-hole 105. Under this negative pressure, the solution flows from the dispensing container into the filtration body 10 through the first through-hole 103 or the third through-hole 105, and after being filtered by the filter membrane 106, flows into the target container through the interface 102. This effectively avoids the risk of the dispensing container falling or colliding, ensuring high safety.

[0052] In some embodiments, the filtration body 10 may use a liquid-permeable and air-permeable filter membrane 106, such as an acrylic copolymer membrane or a polyethersulfone (PES) filter membrane, to ensure that the vacuum source can evacuate the area below the first through hole 103 and the third through hole 105 through the interface 102, thereby creating a negative pressure environment below the first through hole 103 and the third through hole 105, ensuring that the solution can flow from the liquid preparation container into the filtration body 10 through the liquid extraction needle 40.

[0053] In some embodiments, the filtration body 10 may also use a liquid-permeable but air-permeable filter membrane 106, such as a polycarbonate (PC) membrane or a nylon (PA) membrane. In this case, a vacuum source and a peristaltic pump can be activated simultaneously to drive the solution through the flow needle 20 into the filtration body 10. After being filtered by the filter membrane 106 of the filtration body 10, the solution flows into the target container under negative pressure.

[0054] In some embodiments, such as Figure 2As shown, the filtration body 10 may include a base 107, a first connecting part 108, and a second connecting part 109. A first through-hole 103 and a third through-hole 105 are both disposed through the first connecting part 108, allowing the solution in the dispensing container to flow into the cavity enclosed by the first connecting part 108 and the base 107 through a suction needle 40 inserted into the first through-hole 103 or a drainage needle 20 inserted into the third through-hole 105. Simultaneously, a second through-hole 104 is disposed on the base 107 and extends to communicate with the target container. This allows a vacuum to be created in the target container and the cavity enclosed by the first connecting part 108 and the base 107 through a negative pressure needle 30 connected to a vacuum source, thereby evacuating the target container and the cavity enclosed by the first connecting part 108 and the base 107. The cavity enclosed by the connecting part 108 and the base part 107 is in a negative pressure environment. Under the action of negative pressure, the solution can flow from the liquid preparation container into the cavity enclosed by the first connecting part 108 and the base part 107 through the liquid extraction needle 40 of the first through hole 103, and after being filtered by the filter membrane 106, it flows into the target container through the connecting interface 102; or, under the action of the flow driving member, the solution flows from the liquid preparation container into the cavity enclosed by the first connecting part 108 and the base part 107 through the flow extraction needle 20 of the third through hole 105, and after being filtered by the filter membrane 106 under the action of negative pressure in the target container, it flows into the target container through the connecting interface 102. Meanwhile, the second connecting part 109 can be sleeved on the outside of the first connecting part 108, and the second connecting part 109 and the base part 107 can be detachably connected by means of threaded connection, snap-fit, plug-in, etc., so that the second connecting part 109 presses the first connecting part 108 onto the base part 107, thereby facilitating the replacement of the filter membrane 106.

[0055] In some embodiments, such as Figure 3 As shown, the filtration body 10 may have a filtration chamber 110 capable of containing the solution to be filtered, and the filtration membrane 106 may be located within the filtration chamber 110. The first connecting part 108 may have a first cavity 1081, the base part 107 may have a second cavity 1071, and the first connecting part 108 is embedded in the second cavity 1071. At the same time, the filter cavity 110 may include at least the first cavity 1081 and the second cavity 1071, that is, the filter cavity 110 may be formed by the first cavity 1081 and the second cavity 1071. The first through hole 103 and the third through hole 105 may both extend into the filter cavity 110 and communicate with the filter cavity 110, so that the solution can flow from the liquid preparation container into the filter cavity 110 through the liquid extraction needle 40 of the first through hole 103 or the drainage needle 20 of the third through hole 105, and after being filtered by the filter membrane 106 in the filter cavity 110, it flows into the target container through the interface 102.

[0056] In some embodiments, such as Figure 3As shown, the outer wall of the first connecting part 108 may be provided with a protrusion 1082 facing outward. That is, the protrusion 1082 may be formed by extending from the outer wall of the first connecting part 108 in a direction away from the central axis of the first connecting part 108. The protrusion 1082 can press the filter membrane 106 in the filter chamber 110 so that the filter membrane 106 can be reliably installed in the filter chamber 110. At the same time, the side wall of the second chamber 1071 may be provided with a step part 1071a, and the protrusion 1082 is provided with a step surface 1082a that cooperates with the step part 1071a. This allows the protrusion 1082 on the outer wall of the first connecting part 108 to be pressed against the step part 1071a on the side wall of the second chamber 1071 through the step surface 1082a, thereby ensuring the sealing between the first connecting part 108 and the base part 107 and preventing the solution in the filter chamber 110 from leaking out through the gap between the first connecting part 108 and the base part 107.

[0057] In some embodiments, such as Figure 2 and Figure 3 As shown, the cross-sectional shape of the first connecting portion 108 can be circular, and the second cavity 1071 of the base portion 107 can be adapted to the first connecting portion 108 to ensure that the first connecting portion 108 can be inserted into the second cavity 1071, thereby enabling the first cavity 1081 of the first connecting portion 108 and the second cavity 1071 of the base portion 107 to form a filter cavity 110. Simultaneously, the protrusion 1082 can be arranged circumferentially around the first connecting portion 108, and the bottom of the protrusion 1082 can form an annular stepped surface 1082a. Furthermore, the stepped portion 1071a of the sidewall of the second cavity 1071 can adopt an annular structure adapted to the stepped surface 1082a of the protrusion 1082, thereby ensuring the reliability and sealing of the connection between the first connecting portion 108 and the base portion 107.

[0058] In some embodiments, such as Figure 2As shown, a protrusion 1082b may be provided on the outer wall of the protrusion 1082 of the first connecting part 108, and an annular limiting groove 1071b that can cooperate with the protrusion 1082b may be provided on the side wall of the second cavity 1071. At the same time, the limiting groove 1071b may be provided with an opening 1071c to facilitate the protrusion 1082b to slide in. When installing the first connecting part 108 and the base part 107, the protrusion 1082b of the first connecting part 108 can be aligned with the opening 1071c of the limiting groove 1071b and moved towards the base part 107. During the movement, the first connecting part 108 is rotated until the protrusion 1082b of the first connecting part 108 slides into the limiting groove 1071b, thereby realizing the installation and positioning of the relative position between the first connecting part 108 and the base part 107. At this time, the protrusion 1082 of the first connecting part 108 can press the filter membrane 106 in the filter chamber 110. When it is necessary to replace the filter membrane 106, simply rotate the first connecting part 108 and move it away from the base part 107 until the protrusion 1082b of the first connecting part 108 comes out from the opening 1071c. At this time, the filter membrane 106 can be replaced.

[0059] In some embodiments, such as Figure 3 As shown, the protrusion 1082 may have a first pressing surface 1082c and a second pressing surface 1082d disposed opposite to each other. The first pressing surface 1082c may abut against the filter membrane 106 in the filter cavity 110, while the second connecting part 109 may abut against the second pressing surface 1082d, so that the first connecting part 108 is pressed into the second cavity 1071 of the base part 107 by the second connecting part 109, thereby ensuring the reliability of the connection between the first connecting part 108 and the base part 107. Meanwhile, the area of ​​the first pressing surface 1082c can be smaller than the area of ​​the second pressing surface 1082d. That is, the side of the protrusion 1082 away from the second connecting part 109 can have a pressing structure with an inverted trapezoidal cross section, and the first pressing surface 1082c can be located on the side of the pressing structure away from the protrusion 1082, so as to ensure that there is a smaller contact surface between the first connecting part 108 and the filter membrane 106, thereby increasing the effective filtration surface of the filter membrane 106 and improving the filtration efficiency. It should be noted that there can be two, three or more pressing structures distributed at intervals along the circumference of the protrusion 1082, or the pressing structures can be continuously distributed along the circumference of the protrusion 1082.

[0060] In some embodiments, such as Figure 2 and Figure 3As shown, the second connecting portion 109 may include a connecting body 1091 and a toothed portion 1091a located on the connecting body 1091. The outer wall of the connecting body 1091 is provided with a pressing portion 1091b, which extends away from the central axis of the connecting body 1091, such that the pressing portion 1091b can press against the second pressing surface 1082d of the protrusion 1082 of the first connecting portion 108. The pressing portion 1091b is connected to the base portion 107, specifically, it can be a threaded connection. The side wall of the pressing portion 1091b may be provided with an external thread, and the side wall of the second cavity 1071 of the base portion 107 may be provided with an internal thread that mates with the external thread, thereby enabling the pressing portion 1091b of the second connecting portion 109 to be threadedly connected to the base portion 107.

[0061] In some embodiments, such as Figure 2 and Figure 3 As shown, the filtration device 100 may further include a sealing element 111, and a flow channel 1021 capable of communicating with the target container is provided at the center of the interface 102. The flow channel 1021 may be provided on the base 107, and the sealing element 111 may be snapped onto the outside of the flow channel 1021 to achieve a sealed connection between the filtration device 100 and the target container. In addition, the sidewall of the central hole of the sealing element 111 may have a notch 1111 capable of communicating with the inside of the target container, and the second through hole 104 may communicate with the notch 1111, so that the vacuum source can evacuate the target container through the second through hole 104 and the notch 1111, and evacuate the filter chamber 110 through the flow channel 1021, thereby realizing that the solution enters the target container after being filtered through the filter membrane 106 via the first through hole 103.

[0062] In some embodiments, such as Figure 2 As shown, the seal 111 may include a mounting hole, through which the flow channel 1021 is installed. A portion of the mounting hole extends outward to form the notch 1111, thus making the structure simple and easy to install.

[0063] In some embodiments, such as Figure 3 As shown, the bottom wall of the second cavity 1071 can be provided with multiple flow channels, and each flow channel can be radially distributed around the interface 102 and communicate with the interface 102. At the same time, the filter membrane 106 is laid on top of each flow channel, so that the solution can flow into the interface 102 through the flow channel after being filtered by the filter membrane 106, and then flow into the target container through the flow channel 1021. The bottom of the flow channel can be inclined towards the interface 102, that is, the end of the bottom of the flow channel away from the interface 102 is higher than the end of the bottom of the flow channel near the interface 102, so as to facilitate the rapid flow of the filtered solution into the target container and avoid residual liquid remaining in the flow channel.

[0064] In some embodiments, such as Figure 2 As shown, the slots 101 can be located on opposite sides of the base 107, so that the protrusions 801 of the connector 80 can extend into the slots 101 to facilitate the installation and transport of the filter body 10.

[0065] This application also discloses a mobile phase preparation device, including the filtration device 100 disclosed in the above embodiments. Therefore, this mobile phase preparation device has all the technical effects of the filtration device 100, which will not be repeated here. The filtration device 100 can filter the solution in the preparation container and extract it into the target container, thereby effectively avoiding the risk of the preparation container falling or colliding, and improving the safety of solution transfer.

[0066] The terminology used in the above embodiments is for the purpose of describing specific embodiments only and is not intended to be limiting of this application. As used in the specification and appended claims of this application, the singular expressions "a," "an," "the," "the," "the," and "this" are intended to also include expressions such as "one or more," unless the context clearly indicates otherwise. It should also be understood that in the embodiments of this application, "one or more" refers to one, two, or more; "and / or" describes the relationship between related objects, indicating that three relationships may exist; for example, A and / or B can represent: A alone, A and B simultaneously, or B alone, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship.

[0067] References to "one embodiment" or "some embodiments" as described in this specification mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless otherwise specifically emphasized.

[0068] The "multiple" mentioned in the embodiments of this application refers to two or more. It should be noted that in the description of the embodiments of this application, terms such as "first" and "second" are used only for the purpose of distinguishing descriptions and should not be construed as indicating or implying relative importance, nor should they be construed as indicating or implying order.

[0069] The terms "parallel" and "perpendicular" used in this application refer to "basically parallel" and "basically perpendicular" in practical operation. "Basically parallel" can be understood as parallelism with a certain degree of error, and similarly, "basically perpendicular" can be understood as perpendicularity with a certain degree of error.

[0070] The above description of the disclosed embodiments enables those skilled in the art to make or use this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A filtration device, characterized in that, include: A filtration body (10) is used to filter liquid from a liquid preparation container into a target container. A drainage needle (20), a negative pressure needle (30), and a liquid extraction needle (40) are inserted above the filtration body (10). The liquid extraction needle (40) is connected to the liquid preparation container. The negative pressure needle (30) is used to generate negative pressure in the target container, which is located below the filtration body (10). The drainage needle (20) is connected to the liquid preparation container through a second connecting hose, and a drainage drive is provided on the second connecting hose. A drive assembly (50) is used to drive the drainage needle (20), the negative pressure needle (30) and the aspiration needle (40) to move toward or away from the target container; A first elastic component (60) is respectively provided with respect to the drainage needle (20), the negative pressure needle (30) and the aspiration needle (40). The first elastic component (60) is used to provide a clamping force between the drainage needle (20), the negative pressure needle (30) and the aspiration needle (40) and the filtration body (10). The drive assembly (50) includes a mounting plate (501) and a slide (503). A fixing seat (5011) is provided on the mounting plate (501). The first elastic components (60) of the negative pressure needle (30) and the liquid aspiration needle (40) are respectively compressed between the corresponding slide (503) and the fixing seat (5011).

2. The filtration device according to claim 1, characterized in that, A linear bearing (201) is sleeved on the outer side of the drainage needle (20), and the drainage needle (20) can move along the linear bearing (201); The drainage needle (20) is provided with a drainage mounting seat (202), and the first elastic component (60) of the drainage needle (20) is compressed between the drainage mounting seat (202) and the linear bearing (201).

3. The filtration device according to claim 1, characterized in that, The drive assembly (50) further includes two slide rails (502), which are arranged in parallel on the mounting plate (501). The slide base (503) is arranged corresponding to the slide rails (502). The negative pressure needle (30) and the liquid aspiration needle (40) are respectively connected to the two slide bases (503).

4. The filtration device according to claim 3, characterized in that, The mounting plate (501) is also provided with a connector (80), and the connector (80) can drive the filtration body (10) to move along the mounting plate (501) toward the direction of approaching or moving away from the target container. The connector (80) is provided with a second elastic component (70), which is used to enable the drainage needle (20), the negative pressure needle (30) and the liquid extraction needle (40) to detach from the filtration body (10) when they move toward the direction of moving away from the target container.

5. The filtration device according to claim 4, characterized in that, The filter body (10) has slots (101) on its opposite sides. The connector (80) includes two protrusions (801) that cooperate with the slots (101). The protrusions (801) are provided with mounting parts (8011) for installing the second elastic component (70).

6. The filtration apparatus according to claim 1, characterized in that, The lower end of the filtration body (10) is provided with a docking interface (102) for docking and communicating with the target container. The upper end face of the filtration body (10) is provided with a first through hole (103) for inserting the liquid extraction needle (40), a second through hole (104) for inserting the negative pressure needle (30) and a third through hole (105) for inserting the drainage needle (20). A filter membrane (106) is provided below the first through hole (103) and the third through hole (105). The first through hole (103) and the third through hole (105) both extend into the interior of the filtration body (10) and communicate with the docking interface (102).

7. The filtration apparatus according to claim 6, characterized in that, The filtration body (10) includes a base (107), a first connecting part (108), and a second connecting part (109). The first through hole (103) and the third through hole (105) are disposed on the first connecting part (108), and the second through hole (104) is disposed on the base (107). The second connecting part (109) is sleeved on the outside of the first connecting part (108), and the second connecting part (109) is connected to the base (107) so that the second connecting part (109) presses the first connecting part (108) onto the base (107).

8. The filtration apparatus according to claim 7, characterized in that, The filtration body (10) has a filtration chamber (110) for containing the solution to be filtered, the filtration membrane (106) is located in the filtration chamber (110), the first connecting part (108) has a first cavity (1081), the base part (107) has a second cavity (1071), the first connecting part (108) is embedded in the second cavity (1071), and the filtration chamber (110) includes at least the first cavity (1081) and the second cavity (1071).

9. The filtration apparatus according to claim 8, characterized in that, The outer wall of the first connecting part (108) extends toward the direction away from the central axis of the first connecting part (108) to form a protrusion (1082), the protrusion (1082) is used to press the filter membrane (106) in the filter cavity (110), the side wall of the second cavity (1071) is provided with a step part (1071a), and the protrusion (1082) is provided with a step surface (1082a) that cooperates with the step part (1071a).

10. The filtration apparatus according to claim 9, characterized in that, The outer wall of the protrusion (1082) is provided with a protrusion (1082b), and the side wall of the second cavity (1071) is provided with a limiting groove (1071b) for cooperating with the protrusion (1082b). The limiting groove (1071b) is provided with an opening (1071c) to facilitate the sliding of the protrusion (1082b).

11. The filtration apparatus according to claim 9, characterized in that, The protrusion (1082) has a first pressing surface (1082c) and a second pressing surface (1082d) disposed opposite to each other. The first pressing surface (1082c) is used to abut against the filter membrane (106) in the filter cavity (110), and the second connecting part (109) is used to abut against the second pressing surface (1082d). The area of ​​the first pressing surface (1082c) is smaller than the area of ​​the second pressing surface (1082d).

12. The filtration apparatus according to claim 7, characterized in that, The second connecting part (109) includes a connecting body (1091) and a toothed part (1091a) located on the connecting body (1091). The outer wall of the connecting body (1091) extends toward the direction away from the central axis of the connecting body (1091) to form a pressing part (1091b). The pressing part (1091b) is used to press the first connecting part (108), and the pressing part (1091b) is connected to the base part (107).

13. The filtration apparatus according to claim 6, characterized in that, It also includes a seal (111), and a flow channel (1021) for communicating with the target container is provided at the center of the interface (102). The seal (111) is snapped onto the outside of the flow channel (1021), and the seal (111) has a notch (1111) for communicating with the target container. The second through hole (104) communicates with the notch (1111).

14. A mobile phase preparation apparatus, characterized in that, Includes a filtration device (100) as described in any one of claims 1 to 13, the filtration device (100) being used to filter the solution in the dispensing container and extract it into the target container.

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