Pear syrup-containing medicinal and edible wall-broken paste for treating heart-spleen deficiency and preparation method of pear syrup-containing medicinal and edible wall-broken paste

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a pear syrup-containing medicinal and edible wall-broken paste for treating heart-spleen deficiency, which is prepared from the following raw materials in parts by mass: 24 to 30 parts of compound medicine, 8 to 12 parts of lily, 100 to 120 parts of pear syrup, 12 to 18 parts of Chinese yam, 6 to 8 parts of semen euryales and 6 to 8 parts of semen coicis. Potential risks of non-edible raw materials are avoided, the pear syrup conforming to the national standard achieves dual effects of nourishing yin, moistening dryness and improving the taste, the industrial pain point that powder and a syrup body of a traditional syrup formula are not uniformly mixed is solved, and uniform distribution of components is ensured. A circulating cooling water and nitrogen double-control system is adopted in the whole process, the crushing temperature is strictly controlled to be 50 DEG C or below, and volatile effective components are reserved to the maximum extent.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste and a preparation method thereof. BACKGROUND

[0002] The pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste is a tonifying paste prepared by relying on the concept of medicinal and edible homologous and broken wall technology, and is specially used for palpitation, insomnia, fatigue, loss of appetite and other symptoms caused by heart and spleen deficiency.

[0003] Traditional anshen type traditional Chinese medicines often contain non-medicinal and edible homologous components, and there is a risk of long-term safety; although the existing patent CN102397483A mentions heart-nourishing and spirit-quieting, it does not combine spleen-invigorating components, and cannot break the pathological chain of "spleen deficiency leading to heart blood deficiency"; the conventional crushing process destroys heat-sensitive components such as zizyphus jujuba miller saponins, and the bioavailability is low; the existing medicinal and edible homologous paste recipes are mostly directly prepared by decocting and concentrating raw materials, and there are problems such as uneven powder dispersion, bitter taste, insufficient yin-nourishing effect, etc., and the synergistic combination is not designed for the "yin deficiency syndrome" of heart and spleen deficiency type insomnia.

[0004] Therefore, the present application provides a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste and a preparation method thereof, which are used to solve the above-mentioned related technical problems. SUMMARY

[0005] (I) Technical problems to be solved

[0006] The present application provides a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste and a preparation method thereof, which solves the problem of uneven mixing of powder and paste, and also solves the problems of incomplete broken wall, low release rate of effective components, uneven mixing and other problems existing in traditional heart and spleen deficiency type paste recipes.

[0007] (II) Technical solutions

[0008] To achieve the above-mentioned purpose, the present application provides the following technical solutions: the pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste is composed of the following raw materials by weight:

[0009] The composite drug is 24-30 parts, the lily is 8-12 parts, the pear paste is 100-120 parts, the yam is 12-18 parts, the gordon euryale seed is 6-8 parts, and the coix seed is 6-8 parts.

[0010] Further, the composite drug is a mixture of zizyphus jujuba miller and lotus seed in a mass ratio of 2.8-3.2:1.

[0011] Further, the preparation method of the pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste comprises the following steps:

[0012] S1: precisely take 12-18 parts of yam, and carry out sulfur-free fumigation treatment on the yam to obtain the yam to be used, then take 24-30 parts of composite medicine, 8-12 parts of lily, 6-8 parts of gordon euryale seed, 6-8 parts of coix seed and the prepared yam to be used, and mix them and place them in a circulating hot air drying equipment for treatment for 30-40 min to obtain the mixed raw material to be used;

[0013] S2: under the conditions of circulating cooling water and nitrogen protective atmosphere, the mixed raw material is treated by three-stage gradient wall breaking to obtain a mixed wall broken powder;

[0014] S3: 100-120 parts of pear paste are placed in a constant temperature water bath device, an ultrasonic generator is started, and the system is continuously treated for 5-8 min, during which uniform stirring is carried out until the system is free of particles, and a uniformly melted pear paste matrix is obtained;

[0015] S4: the mixed wall broken powder obtained in step S2 is added to the pear paste matrix obtained in step S3, and three-stage mixing operation is carried out to obtain a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous wall broken paste.

[0016] Further, the temperature inside the circulating hot air drying equipment is set to 35-45°C;

[0017] Further, the internal temperature of the constant temperature water bath device is 45-55°C, the frequency of the ultrasonic generator is set to 15-20 kHz, and the power density is 0.3-0.5 W / cm 2 ;

[0018] Further, the first stage of the three-stage gradient wall breaking is specifically as follows:

[0019] The mixed raw material is put into a low-temperature plasma treatment device for treatment for 15-20 min, the surface of the mixed raw material is bombarded, and then the mixed raw material treated by the low-temperature plasma treatment device is transferred into an air flow pulverizer, the pulverizing pressure is set to 0.8-1 MPa, and the mixed raw material is made to collide with each other in the pulverizing cavity by using a high-speed airflow of 250-300 m / s to obtain a pretreated composite powder of 140-150 mesh;

[0020] Further, the low-temperature plasma treatment device is set to a frequency of 40-50 kHz, a power of 450-550 W and a temperature of 38-42°C.

[0021] Further, the second stage of the three-stage gradient wall breaking is specifically as follows:

[0022] The pretreated composite powder is treated for 15-25 min at a high-frequency sound wave of 15-20 kHz, a control amplitude of 40-50 μm, a system temperature of 34-36°C and a sound wave power of 400-600 W to obtain a refined composite powder of 240-250 mesh.

[0023] Further, the internal rotation speed of the vortex shearing device is set to 11000-12000 rpm.

[0024] Further, the third section of the three-section gradient wall breaking is specifically operated as follows:

[0025] The refined composite powder is put into the ultrafine pulverizer with the inner wall coated with the composite coating, nitrogen is introduced to establish a protective atmosphere, the pulverizing pressure is set to 1-1.2 MPa, the system temperature is set to 25-30℃, and the continuous treatment is performed for 20-25 min to obtain the mixed wall broken powder.

[0026] The thickness of the composite coating is 15-20 μm, and the concentration of the nitrogen is more than 99.9%.

[0027] Further, the composite coating is prepared by the following steps:

[0028] The fluorocarbon nanotube 5-8 parts and the polytetrafluoroethylene powder 92-95 parts are weighed by mass fraction, and uniformly mixed to obtain the preliminary raw material;

[0029] The prepared preliminary raw material and the dimethylformamide dispersion medium are mixed at a solid-liquid ratio of 1.4-1.6:1, dispersed for 60-90 min under ultrasonic dispersion, and then the obtained product is transferred into a planetary ball mill at a ball-to-material ratio of 10-12:1 and a rotation speed of 280-300 to ball mill for 2-3 h to obtain a composite slurry.

[0030] The composite coating slurry is uniformly sprayed on the inner wall substrate of the ultrafine pulverizer, and heated to 320-350℃ at a rate of 3-5℃ / min, and held for 60-90 min, and then naturally cooled to room temperature to obtain the inner wall coated composite coating.

[0031] Further, the first stage of the three-stage mixing operation is specifically operated as follows:

[0032] The mixed wall broken powder is taken, and is continuously treated with negative pressure adsorption and airflow dispersion at a system temperature of 40-45℃ until the system is in a uniformly dispersed state to obtain a powder pear paste pre-suspension.

[0033] Further, the second stage of the three-stage mixing operation is specifically operated as follows:

[0034] The powder pear paste pre-suspension is continuously treated by double helix shearing and ultrasonic emulsification at a system temperature of 45-55℃ and an ultrasonic frequency of 35-40 kHz until the powder particles are completely infiltrated and wrapped by the pear paste matrix to obtain an infiltrated and wrapped intermediate paste.

[0035] Further, the third stage of the three-stage mixing operation is specifically operated as follows:

[0036] The infiltrating wrapped intermediate paste is placed in a frequency conversion shearing device, and the system temperature is 45-55 DEG C, the rotating speed is 30-50 rpm, and the reaction is continuously carried out for 30-40 min, so that the pear paste containing the therapy heart and spleen deficiency type of food and medicine homogenate broken wall paste is obtained.

[0037] Further, the adjustment of the shearing parameters should make the viscosity of the material in the device stable at 900000 mPa s.

[0038] (III) Beneficial technical effects

[0039] The pear paste containing the therapy heart and spleen deficiency type of food and medicine homogenate broken wall paste provided by the application realizes the double promotion of technical breakthrough and clinical value through multi-dimensional innovation, adopts food and medicine homologous basic ingredients, avoids the potential risk of non-edible raw materials, and realizes the dual effects of nourishing yin and moistening dryness and improving taste according to the pear paste of national standard, realizes the leap from single symptom relief to overall physical conditioning, through the three-stage broken wall process of low-temperature plasma pretreatment, sound wave resonance-vortex refinement and nano coating ultrafine grinding, the particle size of the raw material is improved to more than 300 meshes while the activity of the heat-sensitive ingredients is maintained, the bioavailability is significantly improved, and the three-stage mixing process of powder pre-dispersion, paste infiltration and dynamic shearing homogenization is used to solve the industry pain point of uneven mixing of traditional paste powder and paste, and ensure uniform distribution of ingredients. The whole process adopts a double-control system of circulating cooling water and nitrogen, and the grinding temperature is strictly controlled below 50 DEG C, so that the volatile effective components are maximized. BRIEF DESCRIPTION OF DRAWINGS

[0040] Fig. 1 is the energy density comparison chart;

[0041] Fig. 2 is the infiltration efficiency comparison chart;

[0042] Fig. 3 is the uniformity coefficient of variation comparison chart;

[0043] Fig. 4 is the viscosity comparison chart;

[0044] Fig. 5 is the moisture content comparison chart. DETAILED DESCRIPTION

[0045] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the embodiments of the application. Obviously, the described embodiments are only a part of the embodiments of the application, not all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the application.

[0046] The parts used in the present application are all mass parts. In addition, the raw material functions of the pear-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste provided by the present application are shown in Table 1.

[0047] Table 1: Raw material function table

[0048] Ingredients Nature and flavor meridian distribution Compatibility role Function Semen ziziphi spinosae Gan acid flat, heart and liver meridian Monarch drug Nourishing heart and liver, tranquilizing and astringing Lotus seed Gan astringent flat, spleen and kidney meridian Ministerial drug Spleen and astringing, nourishing heart and tranquilizing Tuberflosium Gan slightly cold, heart and lung meridian Auxiliary drug Heart and tranquilizing, nourishing yin and moistening dryness Chinese yam Gan flat, spleen, lung and kidney meridian Ministerial drug Spleen and stomach, and lung Euryale seed Gan astringent flat, spleen and kidney meridian Auxiliary drug Kidney and astringing, spleen and astringing Coix seed Gan cool, spleen and stomach and lung meridian Ministerial drug Spleen and astringing, spleen and astringing

[0049] In addition, the pear-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste of the present application can also be made into granules, and the specific process is shown in Table 2.

[0050] Table 2: Process table

[0051]

[0052] Example 1

[0053] The present embodiment provides a pear-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste, which is composed of the following weight parts of raw materials:

[0054] The composite medicine is 24 parts, the lily is 8 parts, the pear paste is 100 parts, the yam is 12 parts, the gordon euryale seed is 6 parts, and the coix seed is 6 parts.

[0055] Further, the composite medicine is a mixture of spina date and lotus seed in a mass ratio of 2.8:1.

[0056] In addition, on the basis of the above, the present embodiment provides a preparation method of the pear-containing therapeutic heart and spleen deficiency type medicinal and edible homologous broken wall paste, which comprises the following steps:

[0057] S1: accurately weigh 12 parts of yam, and treat the yam with sulfur-free fumigation to obtain the yam to be used, then take 24 parts of the composite medicine, 8 parts of lily, 6 parts of gordon euryale seed, 6 parts of coix seed and the prepared yam to be used, and mix and place them in a circulating hot air drying equipment for treatment for 30 min to obtain the mixed raw material to be used;

[0058] During the drying process, the raw material is turned over every 10 min to ensure uniform drying, and the water content is pre-set, and the calculation formula of the water content is as follows:

[0059]

[0060] Wherein, m 湿 is the mass before drying, and m 干 is the mass after drying. The average value is taken by three parallel determinations to ensure that the water content is ≤8%.

[0061] S2: under the conditions of circulating cooling water and nitrogen protection atmosphere, the mixed raw material is treated by three-stage gradient broken wall to obtain the mixed broken wall powder;

[0062] S3: 100 parts of pear paste is placed in a constant temperature water bath device, the ultrasonic generator is started, and the system is continuously treated for 5 min, during which uniform stirring is carried out until the system is free of particles, and a uniformly melted pear paste matrix is obtained;

[0063] S4: The mixed broken wall powder obtained in step S2 is added to the pear paste matrix obtained in step S3, and three-stage mixing operation is carried out, to obtain a pear paste-containing therapeutic heart and spleen deficiency type of food-medicine homologous broken wall paste.

[0064] Further, the temperature inside the circulating hot air drying equipment is set to 35℃;

[0065] Further, the internal temperature of the constant temperature water bath device is 45℃, the frequency of the ultrasonic generator is set to 15kHz, and the power density is 0.3W / cm 2 ;

[0066] Further, the first segment of the three-segment gradient broken wall is specifically operated as follows:

[0067] The mixed raw materials are put into a low-temperature plasma treatment device for treatment for 15 min, and the surface of the mixed raw materials is bombarded. Then the mixed raw materials treated by the low-temperature plasma treatment device are transferred into an air flow pulverizer, the pulverizing pressure is set to 0.8MPa, and the mixed raw materials are made to collide with each other in the pulverizing cavity by using a high-speed airflow of 250m / s, to obtain a pretreated composite powder of 140μm;

[0068] Further, the low-temperature plasma treatment device is set to a frequency of 40kHz, a power of 450W, and a temperature of 38℃.

[0069] Further, the second segment of the three-segment gradient broken wall is specifically operated as follows:

[0070] The pretreated composite powder is treated for 15 min under the condition of a high-frequency sound wave of 15kHz, a control amplitude of 40μm, a system temperature of 34℃, and a sound wave power of 400W, to obtain a refined composite powder of 240μm.

[0071] In this step, the sound wave energy density calculation formula is as follows:

[0072]

[0073] Wherein, P is the sound wave power, t is the treatment time, and m is the powder mass. By adjusting the power and time, the energy density is ensured to be ≥50J / g, to promote the refinement of the powder.

[0074] Further, the internal rotation speed of the vortex shearing device is set to 11000rpm;

[0075] Further, the third segment of the three-segment gradient broken wall is specifically operated as follows:

[0076] The fine composite powder is put into the ultrafine pulverizer with the inner wall coated with the composite coating, nitrogen is introduced to establish a protective atmosphere, the pulverizing pressure is set to 1 MPa, the system temperature is 25℃, and the treatment is continued for 20 min, to obtain a mixed broken wall powder;

[0077] The thickness of the composite coating is 15 μm, and the concentration of nitrogen is more than 99.9%.

[0078] It should be noted that the preparation steps of the composite coating are as follows:

[0079] The fluorocarbon nanotube 5 parts and the polytetrafluoroethylene powder 92 parts are weighed by mass fraction, and uniformly mixed to obtain a preliminary raw material;

[0080] The prepared preliminary raw material and dimethylformamide dispersion medium are mixed at a solid-liquid ratio of 1.4:1, dispersed for 60 min under ultrasonic dispersion, and then the obtained product is transferred into a planetary ball mill at a ball-to-material ratio of 10:1 and a rotation speed of 280, and ball milled for 2 h to obtain a composite slurry;

[0081] The composite coating slurry is uniformly sprayed on the inner wall substrate of the ultrafine pulverizer, and heated to 320℃ at a rate of 3℃ / min, and held for 60 min, and then naturally cooled to room temperature to obtain the inner wall coated composite coating.

[0082] Further, the first stage of the three-stage mixing operation is specifically as follows:

[0083] The mixed broken wall powder is taken, mixed with pear paste matrix, and treated by negative pressure adsorption and airflow dispersion at a system temperature of 40℃ until the system is uniformly dispersed to obtain a powder-pear paste pre-suspension.

[0084] Further, the second stage of the three-stage mixing operation is specifically as follows:

[0085] The powder-pear paste pre-suspension is treated by double helix shearing and ultrasonic emulsification at a system temperature of 45℃ and an ultrasonic frequency of 35 kHz until the powder particles are completely infiltrated and wrapped by the pear paste matrix to obtain an infiltrated and wrapped intermediate paste.

[0086] In this step, the infiltration efficiency calculation formula is as follows:

[0087]

[0088] Wherein, m 浸润 is the mass of the infiltrated powder, and m 总 is the total powder mass. By adjusting the shearing speed and ultrasonic frequency, η≥95% is ensured.

[0089] Further, the third stage of the three-stage mixing operation is specifically as follows:

[0090] The infiltrating-wrapped intermediate paste is placed in a frequency conversion shearing device, and a heart and spleen deficiency treating medicinal and edible homogenate broken wall paste containing pear paste is obtained by continuously reacting for 30 min at a system temperature of 45℃ and a rotating speed of 30 rpm.

[0091] It should be noted that the homogeneity coefficient of variation (CV) is calculated by the following formula:

[0092]

[0093] Wherein, is the standard deviation, and is the average value. The effective component content is detected by sampling three points of the upper, middle and lower layers to ensure that CV≤3%.

[0094] Further, the adjustment of the shearing parameters should make the viscosity of the material inside the device stable at 900000 mPa·s.

[0095] Example 2

[0096] The present embodiment provides a heart and spleen deficiency treating medicinal and edible homogenate broken wall paste containing pear paste, which is composed of the following raw materials by weight:

[0097] 27 parts of a composite drug, 10 parts of lily, 110 parts of pear paste, 15 parts of yam, 7 parts of gordon euryale seed and 7 parts of coix seed.

[0098] Further, the composite drug is a mixture of spina date and lotus seed in a mass ratio of 3:1.

[0099] In addition, on the basis of the above, the present embodiment provides a preparation method of a heart and spleen deficiency treating medicinal and edible homogenate broken wall paste containing pear paste, which comprises the following steps:

[0100] S1: accurately weigh 15 parts of yam, and treat the yam with sulfur-free fumigation to obtain yam for use, then mix 27 parts of a composite drug, 10 parts of lily, 7 parts of gordon euryale seed, 7 parts of coix seed and the prepared yam for use, and place them in a circulating hot air drying device for treatment for 35 min to obtain a mixture of raw materials for use;

[0101] Wherein, the raw materials are turned over every 10 min during the drying process to ensure uniform drying, and the water content is pre-set, and the calculation formula of the water content is as follows:

[0102]

[0103] Wherein, m 湿 is the mass before drying, and m 干 is the mass after drying. The average value is determined by three parallel determinations to ensure that the water content is ≤8%.

[0104] S2: under the conditions of circulating cooling water and nitrogen protective atmosphere, the mixed raw materials are subjected to three-stage gradient wall breaking to obtain mixed wall broken powder;

[0105] S3: 110 parts of pear paste are placed in a constant temperature water bath device, an ultrasonic generator is started, and the system is continuously treated for 6 min with uniform stirring until there is no particle, to obtain a uniformly melted pear paste matrix;

[0106] S4: the mixed wall broken powder obtained in step S2 is added to the pear paste matrix obtained in step S3, and three-stage mixing operation is performed to obtain a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous wall broken paste.

[0107] Further, the temperature inside the circulating hot air drying equipment is set to 40℃;

[0108] Further, the internal temperature of the constant temperature water bath device is 50℃, the frequency of the ultrasonic generator is set to 17 kHz, and the power density is 0.4 W / cm 2 ;

[0109] Further, the first stage of the three-stage gradient wall breaking is specifically as follows:

[0110] The mixed raw materials are put into a low-temperature plasma treatment device for 17 min for surface bombardment treatment, and then the mixed raw materials treated by the low-temperature plasma treatment device are transferred into an air flow pulverizer, the pulverizing pressure is set to 0.9 MPa, and the mixed raw materials are made to collide with each other in the pulverizing cavity by using a high-speed airflow of 275 m / s to obtain a pretreated composite powder of 145 μm;

[0111] Further, the low-temperature plasma treatment device is set to a frequency of 45 kHz, a power of 450 W, and a temperature of 40℃.

[0112] Further, the second stage of the three-stage gradient wall breaking is specifically as follows:

[0113] The pretreated composite powder is treated for 20 min at a high-frequency sound wave of 17 kHz, a control amplitude of 45 μm, a system temperature of 35℃, and a sound wave power of 500 W to obtain a refined composite powder of 245 μm.

[0114] In this step, the sound wave energy density calculation formula is as follows:

[0115]

[0116] Wherein, P is the sound wave power, t is the treatment time, and m is the powder mass. By adjusting the power and time, the energy density is ensured to be ≥50 J / g to promote the refinement of the powder.

[0117] Further, the internal rotation speed of the vortex shearing device is set to 11500 rpm.

[0118] Further, the third section of the three-section gradient wall breaking is specifically operated as follows:

[0119] The refined composite powder is put into the ultrafine pulverizer with the inner wall coated with the composite coating, nitrogen is introduced to establish a protective atmosphere, the crushing pressure is set to 1.1 MPa, the system temperature is set to 27℃, and the continuous treatment is performed for 23 min to obtain the mixed wall broken powder.

[0120] The thickness of the composite coating is 17 μm, and the concentration of nitrogen is more than 99.9%.

[0121] It should be noted that the preparation steps of the composite coating are as follows:

[0122] The fluorocarbon nanotube 6 parts and the polytetrafluoroethylene powder 94 parts are weighed by mass parts, and then uniformly mixed to obtain the preliminary raw material;

[0123] The prepared preliminary raw material and dimethylformamide dispersion medium are mixed at a solid-liquid ratio of 1.5:1, dispersed for 75 min under ultrasonic dispersion conditions, and then the obtained product is transferred into a planetary ball mill at a ball-to-material ratio of 11:1 and a rotation speed of 290 to ball mill for 2 h to obtain a composite slurry.

[0124] The composite coating slurry is uniformly sprayed on the inner wall substrate of the ultrafine pulverizer, and heated to 335℃ at a rate of 4℃ / min, and held for 75 min, and then naturally cooled to room temperature to obtain the inner wall coated composite coating.

[0125] Further, the first stage of the three-stage mixing operation is specifically operated as follows:

[0126] The mixed wall broken powder is taken and mixed with the pear paste matrix at a system temperature of 42℃, and continuously treated by negative pressure adsorption and airflow dispersion until the system is uniformly dispersed to obtain a powder-pear paste pre-suspension.

[0127] Further, the second stage of the three-stage mixing operation is specifically operated as follows:

[0128] The powder-pear paste pre-suspension is continuously treated by double helix shearing and ultrasonic emulsification at a system temperature of 50℃ and an ultrasonic frequency of 37 kHz until the powder particles are completely infiltrated and wrapped by the pear paste matrix to obtain an infiltrated and wrapped intermediate paste.

[0129] In this step, the infiltration efficiency calculation formula is as follows:

[0130]

[0131] Wherein, m 浸润 is the mass of the infiltrated powder, m总 For the total powder mass. By adjusting the shear rotation speed and ultrasonic frequency, ensure η≥95%.

[0132] Further, the third phase of the third-order mixing operation is specifically operated as:

[0133] Place the infiltration-wrapped intermediate paste in the frequency conversion shearing device, at a system temperature of 50°C and a rotation speed of 40 rpm, and continuously react for 35 min to obtain the pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homogenate broken wall paste.

[0134] It should be noted that the uniformity coefficient of variation (CV) is calculated as follows:

[0135]

[0136] Wherein, is the standard deviation, and is the average value. Through three-point sampling detection of effective ingredient content in the upper, middle and lower layers, ensure CV≤3%.

[0137] Further, the adjustment of the shearing parameters should make the viscosity of the material inside the device stable at 900000 mPa·s.

[0138] Example 3

[0139] The present embodiment provides a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homogenate broken wall paste, which is composed of the following weight parts of raw materials:

[0140] 30 parts of composite medicine, 12 parts of lily, 120 parts of pear paste, 18 parts of yam, 8 parts of gordon euryale seed and 8 parts of coix seed.

[0141] Further, the composite medicine is a mixture of spina date and lotus seed in a mass ratio of 3.2:1.

[0142] In addition, on the basis of the above, the present embodiment provides a preparation method of the pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homogenate broken wall paste, which comprises the following steps:

[0143] S1: accurately weigh 18 parts of yam, and treat the yam with sulfur-free fumigation to obtain the yam to be used, then take 30 parts of composite medicine, 12 parts of lily, 8 parts of gordon euryale seed, 8 parts of coix seed and the prepared yam to be used, and mix and place them in a circulating hot air drying equipment for 40 min to obtain the mixed raw materials to be used;

[0144] Wherein, the raw materials are turned over every 10 min during the drying process to ensure uniform drying, and the water content should be pre-set, and the calculation formula of the water content is as follows:

[0145]

[0146] Wherein, m 湿For the mass before drying, m 干 For the mass after drying. This experiment takes the average value of three parallel measurements to ensure that the water content is ≤8%.

[0147] S2: Under the conditions of circulating cooling water and nitrogen protective atmosphere, the mixed raw materials are subjected to three-stage gradient wall breaking to obtain mixed wall broken powder;

[0148] S3: 120 parts of pear paste are placed in a constant temperature water bath device, an ultrasonic generator is started, and continuous treatment is performed for 8 min, during which uniform stirring is performed until the system is free of particles, to obtain a uniformly melted pear paste matrix;

[0149] S4: The mixed wall broken powder obtained in step S2 is added to the pear paste matrix obtained in step S3, and three-stage mixing operation is performed to obtain a pear paste-containing therapeutic heart and spleen deficiency type medicinal and edible homologous wall broken paste.

[0150] Further, the temperature inside the circulating hot air drying equipment is set to 45°C;

[0151] Further, the internal temperature of the constant temperature water bath device is 55°C, the frequency of the ultrasonic generator is set to 20 kHz, and the power density is 0.5 W / cm 2 ;

[0152] Further, the first stage of the three-stage gradient wall breaking is specifically as follows:

[0153] The mixed raw materials are put into a low-temperature plasma treatment device for 20 min for surface bombardment treatment, and then the mixed raw materials treated by the low-temperature plasma treatment device are transferred into an air flow pulverizer, the pulverizing pressure is set to 0.1 MPa, and the mixed raw materials are made to collide with each other in the pulverizing cavity by using a high-speed airflow of 300 m / s to obtain a pretreated composite powder of 150 μm;

[0154] Further, the low-temperature plasma treatment device is set to a frequency of 50 kHz, a power of 450 W, and a temperature of 42°C.

[0155] Further, the second stage of the three-stage gradient wall breaking is specifically as follows:

[0156] The pretreated composite powder is treated for 25 min at a high-frequency sound wave of 20 kHz, a control amplitude of 50 μm, a system temperature of 36°C, and a sound wave power of 600 W to obtain a refined composite powder of 250 μm.

[0157] In this step, the sound wave energy density calculation formula is as follows:

[0158]

[0159] Wherein, P is the sound wave power, t is the processing time, m is the powder mass. By adjusting the power and time, ensure that the energy density ≥ 50J / g, promote the powder refinement.

[0160] Further, the internal rotation speed of the vortex shear device is set to 12000rpm;

[0161] Further, the third segment of the three-segment gradient wall breaking is specifically operated as follows:

[0162] The refined composite powder is put into the ultrafine pulverizer with the inner wall coated with the composite coating, nitrogen is introduced to establish a protective atmosphere, the crushing pressure is set to 1.2MPa, the system temperature is set to 30℃, and the continuous processing is carried out for 25min to obtain the mixed wall broken powder.

[0163] Wherein, the thickness of the composite coating is 20μm, and the concentration of nitrogen is more than 99.9%.

[0164] It should be noted that the preparation steps of the composite coating are as follows:

[0165] The fluorocarbon nanotube 8 parts and the polytetrafluoroethylene powder 95 parts are weighed by mass parts, and uniformly mixed to obtain the preliminary raw material;

[0166] The prepared preliminary raw material and dimethylformamide dispersion medium are mixed at a solid-liquid ratio of 1.6:1, dispersed for 90min under ultrasonic dispersion conditions, and then the obtained product is transferred into a planetary ball mill at a ball-to-material ratio of 12:1 and a rotation speed of 300 to ball mill for 3h to obtain a composite slurry;

[0167] The composite coating slurry is uniformly sprayed on the inner wall substrate of the ultrafine pulverizer, and heated to 350℃ at a rate of 5℃ / min, and held for 90min, and then naturally cooled to room temperature to obtain the inner wall coated composite coating.

[0168] Further, the first stage of the three-stage mixing operation is specifically operated as follows:

[0169] The mixed wall broken powder is taken and mixed with the pear paste matrix at a system temperature of 45℃, and continuously treated by negative pressure adsorption and airflow dispersion to obtain a powder pear paste pre-suspension.

[0170] Further, the second stage of the three-stage mixing operation is specifically operated as follows:

[0171] The powder pear paste pre-suspension is continuously treated by double helix shearing and ultrasonic emulsification at a system temperature of 55℃ and an ultrasonic frequency of 40kHz to obtain an immersion and wrapping type intermediate paste.

[0172] In this step, the immersion efficiency calculation formula is as follows:

[0173]

[0174] Where, m 浸润 For the mass of the wetted powder, m 总 This represents the total powder mass. By adjusting the shear speed and ultrasonic frequency, η is ensured to be ≥ 95%.

[0175] Furthermore, the third stage of the third-order hybrid operation specifically involves the following steps:

[0176] The impregnated and encapsulated intermediate paste was placed in a frequency conversion shearing device and reacted continuously for 40 minutes at a system temperature of 55°C and a rotation speed of 50 rpm to obtain a pear paste containing medicinal and edible ingredients for treating deficiency of both heart and spleen.

[0177] It should be noted that the formula for calculating the coefficient of variation (CV) for homogeneity is:

[0178]

[0179] Where is the standard deviation and is the mean. The content of the active ingredient is detected by sampling at three points in the upper, middle, and lower layers to ensure that the CV ≤ 3%.

[0180] Furthermore, the shear parameters should be adjusted to stabilize the viscosity of the material inside the equipment at 900,000 mPa·s.

[0181] Comparative Example 1: The compound drug was replaced with a mixture of Polygala tenuifolia and Cinnabar in a mass ratio of 3:1, and the remaining components and processes were the same as in Example 1.

[0182] Comparative Example 2: The three-stage gradient cell disruption was replaced with ordinary airflow pulverization, and the remaining components and processes were the same as in Example 1.

[0183] Comparative Example 3: The three-stage mixing operation was replaced with simple stirring, and the remaining components and processes were the same as in Example 1.

[0184] Performance testing:

[0185] Table 3 Test Data Table

[0186]

[0187] Among them, such as Fig. 1-Fig. 5 The moisture content was tested using the Karl Fischer method in GB 5009.3-2016, and all were ≤8%, meeting the standard.

[0188] It should be noted that although ratio 1 meets the compatibility requirements, the long-term safety of cinnabar still needs to be clinically verified. It is recommended to use it only for short-term conditioning and monitor liver and kidney function regularly.

[0189] Energy density: calculated by the sound wave power and the processing time, the energy density of the comparative example 1 is large due to the cinnabar, and is still ≥ 50 J / g.

[0190] Infiltration efficiency: calculated based on the mass ratio of the powder wrapped by the pear paste matrix, the efficiency of the comparative example 3 is reduced to 80% due to the uneven mixing caused by simple stirring.

[0191] Uniformity variation coefficient: calculated by the effective component content of the upper, middle and lower layer three-point sampling detection, the CV of the comparative example 2 is increased to 3.9% due to the uneven particle size caused by ordinary crushing.

[0192] Viscosity: detected by a rotary viscometer, the viscosity of the comparative example 1 is slightly reduced due to the particle sedimentation of cinnabar.

[0193] Moisture content: the finished product detection is in the range of 20%-30%, which meets the standard of the food and medicine homologous product.

[0194] In addition, the present application strictly follows the TCM theory of "heart and spleen treatment", and accurately formulates the insomnia of heart and spleen deficiency. Through the three-dimensional conditioning path of nourishing heart and calming mind, invigorating spleen and replenishing qi, and removing dampness and removing turbidity, the core pathogenesis of "spleen deficiency leading to heart blood deficiency" is systematically intervened, which breaks through the limitations of traditional anshen prescriptions or focusing on nourishing heart or ignoring invigorating spleen and removing dampness, and realizes more comprehensive and more accurate TCM theory adaptation to the target disease.

[0195] At the same time, all the components of the composition of the present application are derived from the food and medicine homologous directory published by the national authority, and are substances that are both food and Chinese herbal medicine. This feature completely avoids the risk of non-food raw materials or heavy metals that may exist in traditional anshen Chinese medicine, ensures the edible safety of long-term use of the product, and strictly controls the temperature during the whole crushing process. This process can effectively preserve the heat-sensitive active ingredients such as zizyphus jujuba saikosaponin, avoid their degradation and inactivation due to high temperature processing, and thus maximize the bioactivity and pharmacological effect of the final product, solving the industry common problem of loss of effective components caused by conventional crushing process.

[0196] Moreover, the composition directly targets the common insomnia type in clinic, aiming to improve sleep quality through food supplementation. Its food and medicine homologous property makes it more easily accepted by the public who have health needs but resist traditional medicine, which meets the current market demand for daily health products with traditional cultural heritage, safety and effectiveness, and convenient food.

[0197] In the description of the specification, reference to "one embodiment", "an example", "a specific example" or the like means that a particular feature, structure, material or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. The appearances of the phrases "in one embodiment", "an example", "a specific example" or the like in various places in the specification are not necessarily referring to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics can be combined in any suitable manner in one or more embodiments or examples.

[0198] The preferred embodiments of the application disclosed above are only to help explain the application. The preferred embodiments do not describe all the details of the application and limit the application to the specific embodiments described. Obviously, many modifications and variations can be made in light of the contents of the specification. The specification selects and specifically describes these embodiments in order to better explain the principles and practical application of the application, so that those skilled in the art can well understand and utilize the application. The application is limited only by the claims and their full scope and equivalents.

Claims

1. A pear-based medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen, characterized in that... It is composed of the following raw materials in parts by weight: The ingredients are: 24-30 parts compound medicine, 8-12 parts lily, 100-120 parts pear syrup, 12-18 parts yam, 6-8 parts foxnut and 6-8 parts coix seed.

2. The pear-containing medicinal and edible cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 1, characterized in that, The compound drug is made by mixing jujube seed and lotus seed in a mass ratio of 2.8 to 3.2:

1.

3. The method for preparing the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to any one of claims 1 to 2, characterized in that, Includes the following steps: S1: Accurately weigh 12-18 parts of yam, perform sulfur-free fumigation on the yam to obtain yam for use, then take 24-30 parts of compound medicine, 8-12 parts of lily, 6-8 parts of fox nut, 6-8 parts of coix seed and the prepared yam for use, mix them and place them in a circulating hot air drying equipment for 30-40 minutes to obtain mixed raw materials for use; S2: Under the conditions of circulating cooling water and nitrogen protective atmosphere, the mixed raw materials are subjected to three-stage gradient cell disruption to obtain mixed cell-disrupted powder; S3: Place 100-120 portions of pear paste in a constant temperature water bath, start the ultrasonic generator, and continue to process for 5-8 minutes, stirring at a constant speed until the system is free of particles, to obtain a uniformly melted pear paste matrix. S4: Add the mixed cell wall broken powder obtained in step S2 to the pear paste matrix obtained in step S3, and perform a three-stage mixing operation to obtain a cell wall broken paste containing pear paste for treating deficiency of both heart and spleen.

4. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 3, characterized in that, The specific operation of the first stage of the three-stage gradient cell disruption is as follows: The mixed raw materials are put into a low-temperature plasma treatment device for 15 to 20 minutes to bombard the surface of the mixed raw materials. Then the mixed raw materials treated by the low-temperature plasma treatment device are transferred into an air jet mill. The milling pressure is set to 0.8 to 1 MPa. The high-speed airflow of 250 to 300 m / s is used to make the mixed raw materials collide with each other in the milling chamber to obtain a pre-treated composite powder of 140 to 150 mesh. The low-temperature plasma processing device is set to a frequency of 40–50 kHz, a power of 450–550 W, and a temperature of 38–42 °C.

5. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 4, characterized in that, The specific operation of the second stage of the three-stage gradient cell disruption is as follows: The pretreated composite powder was subjected to high-frequency sound waves of 15–20 kHz, controlled amplitude of 40–50 μm, system temperature of 34–36 °C, and continuous sound wave power of 400–600 W for 15–25 min to obtain refined composite powder of 240–250 mesh.

6. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 5, characterized in that, The specific operation of the third stage of the three-stage gradient cell disruption is as follows: The refined composite powder is fed into an ultrafine pulverizer with a composite coating on the inner wall. Nitrogen gas is introduced to establish a protective atmosphere. The pulverizing pressure is set to 1-1.2 MPa and the system temperature is set to 25-30℃. The process is continued for 20-25 minutes to obtain mixed cell wall broken powder. The composite coating has a thickness of 15–20 μm and a nitrogen concentration of over 99.9%.

7. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 6, characterized in that, The preparation steps of the composite coating are as follows: Weigh out 5-8 parts of fluorocarbon nanotubes and 92-95 parts of polytetrafluoroethylene powder by weight, mix them evenly, and obtain the prepared raw materials. The prepared raw materials and dimethylformamide dispersion medium were mixed at a solid-liquid ratio of 1.4 to 1.6:1 and dispersed under ultrasonic dispersion for 60 to 90 minutes. The resulting product was then transferred to a planetary ball mill and ball-milled at a ball-to-material ratio of 10 to 12:1 and a rotation speed of 280 to 300 for 2 to 3 hours to obtain a composite slurry. The composite coating slurry is uniformly sprayed onto the inner wall substrate of the ultrafine pulverizer, and heated to 320-350℃ at a rate of 3-5℃ / min, held at that temperature for 60-90min, and then naturally cooled to room temperature to obtain the composite coating on the inner wall.

8. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 3, characterized in that, The first stage of the third-order hybrid operation is as follows: Take the mixed cell wall-breaking powder and treat it together with the pear paste matrix at a system temperature of 40-45℃ through negative pressure adsorption and airflow dispersion until the system is uniformly dispersed, thus obtaining the powder pear paste premixed suspension.

9. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 8, characterized in that, The second stage of the third-order hybrid operation is as follows: The premixed powder pear paste suspension was continuously processed by double helix shearing and ultrasonic emulsification at a system temperature of 45-55℃ and an ultrasonic frequency of 35-40kHz until the powder particles were completely impregnated and coated by the pear paste matrix, thus obtaining an impregnated and coated intermediate paste.

10. The preparation method of the pear-containing medicinal and food-grade cell wall-breaking paste for treating deficiency of both heart and spleen according to claim 9, characterized in that, The third stage of the third-order hybrid operation is as follows: The impregnated and encapsulated intermediate paste is placed in a frequency conversion shearing device and reacted continuously for 30 to 40 minutes at a system temperature of 45 to 55°C and a rotation speed of 30 to 50 rpm to obtain a pear paste containing medicinal and edible ingredients for treating deficiency of both heart and spleen.

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