An antibody for detecting total antibody concentration in blood, and a kit and use thereof
By using antibodies with specific amino acid sequences for ELISA detection, the accuracy problem of detecting total antibody concentration of ADC drugs in serum has been solved, achieving high specificity and high sensitivity in monitoring total antibody concentration, and ensuring the assessment of treatment efficacy and safety.
CN121991235BActive Publication Date: 2026-06-23EVOPOINT BIOSCIENCES CO LTD
Patent Information
- Application Number
- CN202610409075.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-31
- Publication Date
- 2026-06-23
- Estimated Expiration
- 2046-03-31
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Figure CN121991235B_ABST
Abstract
The application relates to an antibody for detecting total antibody concentration in blood, a kit and use thereof, and provides the antibody, which comprises: (1) a first antibody comprising a heavy chain variable region VH1 and a light chain variable region VL1, wherein the VH1 comprises three CDRs in a sequence as shown in SEQ ID NO: 41 S ; the VL1 comprises three CDRs in a sequence as shown in SEQ ID NO: 42 S ; and / or (2) a second antibody comprising a heavy chain variable region VH2 and a light chain variable region VL2, wherein the VH2 comprises three CDRs in a sequence as shown in SEQ ID NO: 43 S ; the VL2 comprises three CDRs in a sequence as shown in SEQ ID NO: 44 S . The antibody is used for detecting total antibody concentration in blood, and has the advantages of excellent sensitivity, accuracy and stability, and strong anti-target point interference capability.
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Citation Information
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