Double-hole cation covalent organic framework material, preparation method thereof, ratiometric fluorescent probe and application
By designing a dual-pore cationic covalent organic framework material and a ratiometric fluorescent probe, the problem of insufficient selectivity and sensitivity in the detection of fluoroquinolone antibiotics in the prior art has been solved, and high selectivity and high sensitivity detection of FQs have been achieved, especially with good detection stability and accuracy in complex environments.
Patent Information
- Application Number
- CN202610400493.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-30
- Publication Date
- 2026-05-26
AI Technical Summary
Existing fluorescent probes suffer from insufficient selectivity, weak anti-interference ability, and limited sensitivity in the detection of fluoroquinolone antibiotics, making it difficult to achieve effective detection of low concentrations of FQs.
A biporous cationic covalent organic framework material was designed. Utilizing the strong electrostatic interaction between the ion sites on the nanoscale pore walls and fluoroquinolone antibiotics, combined with the spatial matching effect, a ratiometric fluorescent probe was constructed. By controlling the density of ion sites and the type of fluorescent groups in the material framework, a synergistic mechanism of 'ion electrostatic interaction-fluorescence signal response' was established to achieve highly selective recognition and sensitive detection of FQs.
It achieves highly selective recognition and sensitive detection of fluoroquinolone antibiotics, enabling rapid and accurate detection of FQs in complex environments, with a detection limit as low as 2.29 μM, and exhibits good anti-interference ability and detection stability.