A lightening and skin lightening composition containing potassium 4-methoxysalicylate and a method for preparing the same

Abstract

The application belongs to the technical field of cosmetics, and specifically discloses a lightening and freckle-removing composition containing 4-methoxyl potassium salicylate and a preparation method thereof, which comprises the following components in parts by mass: 18-41.5 parts of hydrolyzed European plum extract, 20-30 parts of 4-methoxyl potassium salicylate, 5-15 parts of hydroxyethylpiperazine ethane sulfonic acid, 8-15 parts of tranexamic acid, 12-20 parts of Punica granatum extract, 2-5 parts of nonapeptide-1, 1-5 parts of fullerene, and 0.5-2 parts of collagen. The composition described in the application effectively improves the lightening and freckle-removing effect of the composition by synergistic effect of the hydrolyzed European plum extract, 4-methoxyl potassium salicylate and Punica granatum extract on the basis of the addition of hydroxyethylpiperazine ethane sulfonic acid, tranexamic acid, nonapeptide-1, fullerene and collagen.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a brightening and spot-fading composition containing potassium 4-methoxysalicylate and its preparation method. Background Technology

[0002] Skin pigmentation is caused by excessive melanin synthesis, abnormal transport, or slow metabolism of melanin by melanocytes. It manifests as problems such as age spots, dullness, and uneven skin tone, which seriously affect the appearance of the skin and is one of the core skin problems that consumers are concerned about.

[0003] In existing whitening cosmetics, single active ingredients often only act on a single target in the process of melanin production, transport, and metabolism, resulting in limited whitening efficacy.

[0004] Therefore, this application is submitted. Summary of the Invention

[0005] This invention provides a whitening and spot-fading composition containing potassium 4-methoxysalicylate and its preparation method. The composition has excellent whitening and spot-fading effects.

[0006] The present invention solves its technical problem by adopting the following technical solution: A brightening and spot-fading composition containing potassium 4-methoxysalicylate comprises the following components in parts by weight: 18-41.5 parts hydrolyzed European plum extract, 20-30 parts potassium 4-methoxysalicylate, 5-15 parts hydroxyethylpiperazine ethanesulfonic acid, 8-15 parts tranexamic acid, 12-20 parts pomegranate extract, 2-5 parts nonapeptide-1, 1-5 parts fullerene, and 0.5-2 parts collagen.

[0007] The hydrolyzed European plum extract can inhibit the activity of tyrosinase and tyrosinase-related protein-1 (TRP-1), reducing melanin synthesis at the source. At the same time, it can gently accelerate the metabolism of the stratum corneum, promote the shedding of melanin-containing keratinocytes, and improve the skin's penetration rate of subsequent active ingredients.

[0008] The potassium 4-methoxysalicylate can effectively inhibit the migration of melanosomes from melanocytes to keratinocytes; at the same time, it can inhibit ultraviolet-induced melanocyte proliferation, reduce the formation of pigmentation sites, and has anti-inflammatory activity, which can alleviate skin inflammation caused by ultraviolet radiation.

[0009] The pomegranate extract described above has excellent and potent free radical scavenging effects, effectively inhibits UV-induced oxidative stress damage, reduces the inducing factors of melanin synthesis, and at the same time effectively inhibits tyrosinase activity, promotes skin microcirculation, accelerates the excretion of metabolic products, and reduces melanin deposition in the epidermal layer.

[0010] This application combines the above-mentioned raw materials to obtain a composition with excellent whitening and spot-fading effects. The composition, based on the addition of hydroxyethylpiperazine ethanesulfonic acid, tranexamic acid, nonapeptide-1, fullerene, and collagen, effectively improves the whitening and spot-fading effects of the composition through the synergistic effect of hydrolyzed European plum extract, potassium 4-methoxysalicylate, and pomegranate extract.

[0011] The ellagic acid in the hydrolyzed European plum extract and pomegranate extract can synergistically bind to the active site of tyrosinase, enhancing the inhibitory effect on enzyme activity. Potassium 4-methoxysalicylate can indirectly reduce the expression level of tyrosinase by inhibiting the activity of melanocytes. These three components form a direct inhibition and indirect regulation, synergistically reducing the expression level of tyrosinase. The anti-inflammatory activity of potassium 4-methoxysalicylate can alleviate skin inflammation caused by ultraviolet radiation and reduce the induction of melanin synthesis by inflammatory factors. The hydrolyzed European plum extract and pomegranate extract can further scavenge free radicals generated by inflammatory responses. All three components synergistically reduce the risk of post-inflammatory hyperpigmentation. The hydrolyzed European plum extract can improve the permeability of the stratum corneum, promoting the penetration of the active ingredients of potassium 4-methoxysalicylate and pomegranate extract into the deep epidermis, effectively improving the whitening and spot-fading effects.

[0012] As a preferred embodiment of the present invention, the components include the following parts by weight: 25.5-34.2 parts hydrolyzed European plum extract, 23-27 parts potassium 4-methoxysalicylate, 8-12 parts hydroxyethylpiperazine ethanesulfonic acid, 10-12 parts tranexamic acid, 15-18 parts pomegranate extract, 3-4 parts nonapeptide-1, 2-4 parts fullerene, and 0.8-1.5 parts collagen.

[0013] As a preferred embodiment of the present invention, the components include the following parts by weight: 25.5 parts hydrolyzed European plum extract, 27 parts potassium 4-methoxysalicylate, 8 parts hydroxyethylpiperazine ethanesulfonic acid, 12 parts tranexamic acid, 18 parts pomegranate extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0014] As a preferred embodiment of the present invention, the method for preparing the pomegranate extract is as follows: (1) Crush the pomegranate peel to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water, and sonicate to hydrolyze to obtain hydrolysate; (3) Adjust the pH of the enzymatic hydrolysate to 6-6.5, load it onto the macroporous adsorption resin at a rate of 0.5-1.5 BV / h, and elute at a rate of 1-2 BV / h. First wash with deionized water for 1-2 BV, then wash with 40-60 wt% ethanol solution for 1-2 BV. Collect the ethanol wash solution and dry it to obtain pomegranate extract.

[0015] In a preferred embodiment of the present invention, the pomegranate peel powder has a particle size of 50-500 mesh.

[0016] As a preferred embodiment of the present invention, the mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid and water is 1:(0.008~0.02):(0.008~0.02):(0.004~0.01):(0.002~0.005):(4~10).

[0017] In a preferred embodiment of the present invention, the power of the ultrasonic enzymatic hydrolysis is 400~800W.

[0018] In a preferred embodiment of the present invention, the ultrasonic enzymatic hydrolysis is performed at a temperature of 45-50°C for a time of 20-60 minutes.

[0019] In a preferred embodiment of the present invention, the macroporous adsorption resin is D101 macroporous adsorption resin.

[0020] As a preferred embodiment of the present invention, the amount of the brightening and spot-fading composition containing potassium 4-methoxysalicylate added to the cosmetic is 0.1-10%.

[0021] As a preferred embodiment of the present invention, the amount of the brightening and spot-fading composition containing potassium 4-methoxysalicylate added to the cosmetic is 0.2-2%.

[0022] As a preferred embodiment of the present invention, the amount of the brightening and spot-fading composition containing potassium 4-methoxysalicylate added to the cosmetic is 0.5-1%.

[0023] The present invention also provides a method for preparing a brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following steps: weighing raw materials according to the ratio, mixing the raw materials evenly to obtain a brightening and spot-fading composition containing potassium 4-methoxysalicylate.

[0024] The beneficial effects of the present invention are as follows: Based on the addition of hydroxyethylpiperazine ethanesulfonic acid, tranexamic acid, nonapeptide-1, fullerene, and collagen, the composition described in this application effectively improves the whitening and spot-fading effect of the composition through the synergistic effect of hydrolyzed European plum extract, potassium 4-methoxysalicylate, and pomegranate extract. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] In this invention, the technical features described in an open-ended manner include both closed-ended technical solutions composed of the listed features and open-ended technical solutions that include the listed features.

[0027] In this invention, numerical ranges are involved. Unless otherwise specified, the numerical ranges are considered continuous and include the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe features or characteristics, the ranges may be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are included.

[0028] In this invention, there are no particular limitations on the specific dispersion and stirring methods.

[0029] Unless otherwise specified, all reagents or instruments used in this invention are commercially available conventional products. Unless otherwise specified, the raw materials used in each comparative example and the parallel experiments of each embodiment are the same commercially available products.

[0030] The hydrolyzed European plum extracts used in the embodiments and comparative examples of this invention were purchased from Guangzhou Jiufeng Trading Co., Ltd.; trade name: Clairju.

[0031] Potassium 4-methoxysalicylate was purchased from Guangzhou Panhai Fine Chemical Co., Ltd.

[0032] Hydroxyethylpiperazine ethane sulfonic acid was purchased from Shanghai Bilai Chemical Technology Co., Ltd.

[0033] Tranexamic acid was purchased from Guangzhou Pan-Hai Fine Chemical Co., Ltd.

[0034] Nonapeptide-1 was purchased from Guangzhou Xufan Trading Co., Ltd.

[0035] Fullerenes were purchased from Angxing New Carbon Materials Changzhou Co., Ltd.

[0036] The collagen was purchased from Guangzhou Xufan Trading Co., Ltd.

[0037] Example 1 A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 25.5 parts hydrolyzed European plum extract, 27 parts potassium 4-methoxysalicylate, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 18 parts pomegranate extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0038] The preparation method of the pomegranate extract is as follows: (1) Grind the pomegranate peel to 200 mesh to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water and enzymatically hydrolyze for 1.5 h under 500W ultrasound to obtain enzymatic hydrolysate; the mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid and water is 1:0.015:0.012:0.008:0.004:8.

[0039] (3) Adjust the pH of the enzymatic hydrolysate to 6.4, load it onto D101 macroporous adsorption resin at a rate of 1 BV / h, and elute at a rate of 1.5 BV / h. First wash with deionized water for 1.5 BV, then wash with 50 wt% ethanol solution for 1.5 BV. Collect the ethanol wash and dry it to obtain pomegranate extract.

[0040] The preparation method of the brightening and spot-fading composition containing potassium 4-methoxysalicylate includes the following steps: weighing the raw materials according to the ratio, mixing the raw materials evenly, and obtaining the brightening and spot-fading composition containing potassium 4-methoxysalicylate.

[0041] Example 2 A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 34.2 parts hydrolyzed European plum extract, 23 parts potassium 4-methoxysalicylate, 12 parts hydroxyethylpiperazine ethanesulfonic acid, 10 parts tranexamic acid, 15 parts pomegranate extract, 3 parts nonapeptide-1, 2 parts fullerene, and 0.8 parts collagen.

[0042] The preparation method of the pomegranate extract is as follows: (1) Grind the pomegranate peel to 200 mesh to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water and enzymatically hydrolyze for 1.5 h under 500W ultrasound to obtain enzymatic hydrolysate; the mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid and water is 1:0.015:0.012:0.008:0.004:8.

[0043] (3) Adjust the pH of the enzymatic hydrolysate to 6.4, load it onto D101 macroporous adsorption resin at a rate of 1 BV / h, and elute at a rate of 1.5 BV / h. First wash with deionized water for 1.5 BV, then wash with 50 wt% ethanol solution for 1.5 BV. Collect the ethanol wash and dry it to obtain pomegranate extract.

[0044] The preparation method of the brightening and spot-fading composition containing potassium 4-methoxysalicylate includes the following steps: weighing the raw materials according to the ratio, mixing the raw materials evenly, and obtaining the brightening and spot-fading composition containing potassium 4-methoxysalicylate.

[0045] Example 3 A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 41.5 parts hydrolyzed European plum extract, 20 parts potassium 4-methoxysalicylate, 15 parts hydroxyethylpiperazine ethane sulfonic acid, 8 parts tranexamic acid, 12 parts pomegranate extract, 2 parts nonapeptide-1, 1 part fullerene, and 0.5 parts collagen.

[0046] The preparation method of the pomegranate extract is as follows: (1) Grind the pomegranate peel to 200 mesh to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water and enzymatically hydrolyze for 1.5 h under 500W ultrasound to obtain enzymatic hydrolysate; the mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid and water is 1:0.015:0.012:0.008:0.004:8.

[0047] (3) Adjust the pH of the enzymatic hydrolysate to 6.4, load it onto D101 macroporous adsorption resin at a rate of 1 BV / h, and elute at a rate of 1.5 BV / h. First wash with deionized water for 1.5 BV, then wash with 50 wt% ethanol solution for 1.5 BV. Collect the ethanol wash and dry it to obtain pomegranate extract.

[0048] The preparation method of the brightening and spot-fading composition containing potassium 4-methoxysalicylate includes the following steps: weighing the raw materials according to the ratio, mixing the raw materials evenly, and obtaining the brightening and spot-fading composition containing potassium 4-methoxysalicylate.

[0049] Example 4 A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 18 parts hydrolyzed European plum extract, 30 parts potassium 4-methoxysalicylate, 5 parts hydroxyethylpiperazine ethanesulfonic acid, 15 parts tranexamic acid, 20 parts pomegranate extract, 5 parts nonapeptide-1, 5 parts fullerene, and 2 parts collagen.

[0050] The preparation method of the pomegranate extract is as follows: (1) Grind the pomegranate peel to 200 mesh to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water and enzymatically hydrolyze for 1.5 h under 500W ultrasound to obtain enzymatic hydrolysate; the mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid and water is 1:0.015:0.012:0.008:0.004:8.

[0051] (3) Adjust the pH of the enzymatic hydrolysate to 6.4, load it onto D101 macroporous adsorption resin at a rate of 1 BV / h, and elute at a rate of 1.5 BV / h. First wash with deionized water for 1.5 BV, then wash with 50 wt% ethanol solution for 1.5 BV. Collect the ethanol wash and dry it to obtain pomegranate extract.

[0052] The preparation method of the brightening and spot-fading composition containing potassium 4-methoxysalicylate includes the following steps: weighing the raw materials according to the ratio, mixing the raw materials evenly, and obtaining the brightening and spot-fading composition containing potassium 4-methoxysalicylate.

[0053] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the amounts of each raw material are different.

[0054] A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 57.3 parts hydrolyzed European plum extract, 18 parts potassium 4-methoxysalicylate, 10 parts hydroxyethylpiperazine ethane sulfonic acid, 5 parts tranexamic acid, 8 parts pomegranate extract, 1 part nonapeptide-1, 0.5 parts fullerene, and 0.2 parts collagen.

[0055] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the amount of each raw material used is different.

[0056] A brightening and spot-fading composition containing potassium 4-methoxysalicylate comprises the following components in parts by weight: 8 parts hydrolyzed European plum extract, 35 parts potassium 4-methoxysalicylate, 2 parts hydroxyethylpiperazine ethane sulfonic acid, 18 parts tranexamic acid, 22 parts pomegranate extract, 6 parts nonapeptide-1, 6 parts fullerene, and 3 parts collagen.

[0057] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not contain hydrolyzed European plum extract (it is replaced by equal amounts of potassium 4-methoxysalicylate and pomegranate extract).

[0058] A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 40 parts potassium 4-methoxysalicylate, 8 parts hydroxyethylpiperazine ethanesulfonic acid, 12 parts tranexamic acid, 30.5 parts pomegranate extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0059] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 does not contain potassium 4-methoxysalicylate (it is replaced by equal amounts of hydrolyzed European plum extract and pomegranate extract).

[0060] A brightening and spot-fading composition comprising the following components in parts by weight: 39 parts hydrolyzed European plum extract, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 31.5 parts pomegranate extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0061] Comparative Example 5 The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not contain pomegranate extract (it is replaced by an equal amount of hydrolyzed European plum extract and potassium 4-methoxysalicylate).

[0062] A brightening and spot-fading composition containing potassium 4-methoxysalicylate, comprising the following components in parts by weight: 34.5 parts hydrolyzed European plum extract, 36 parts potassium 4-methoxysalicylate, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0063] Comparative Example 6 The difference between Comparative Example 6 and Example 1 is that Comparative Example 6 uses an equal amount of α-arbutin to replace potassium 4-methoxysalicylate and an equal amount of licorice root extract to replace hydrolyzed European plum extract.

[0064] A brightening and spot-fading composition comprising the following components in parts by weight: 25.5 parts hydrolyzed European plum extract, 27 parts α-arbutin, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 18 parts licorice root extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0065] Comparative Example 7 The difference between Comparative Example 7 and Example 1 is that Comparative Example 7 uses an equal amount of α-arbutin to replace potassium 4-methoxysalicylate and an equal amount of mulberry bark extract to replace pomegranate extract.

[0066] A brightening and spot-fading composition comprising the following components in parts by weight: 25.5 parts hydrolyzed European plum extract, 27 parts α-arbutin, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 18 parts mulberry bark extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

[0067] Test case Carbomer 980 from Examples and Comparative Example 1, the whitening and spot-fading composition, butylene glycol, glycerin, and water were mixed evenly in a mass ratio of 0.005:0.5:1:2:6.495 for testing (hereinafter referred to as the test substance).

[0068] Eighty-eight volunteers with normal skin (all female, aged 20-35) were selected and evenly divided into 11 groups of eight people each. The test substances of the example and comparative examples were used in each group.

[0069] Inclusion criteria for volunteers were: female, aged 20-35 years; no use of hormonal drugs or immunosuppressants within the past month; no participation in other clinical trials at the test site within the past 30 days; good cooperation with the trial; ability to read and understand all contents of the informed consent form and voluntarily sign the informed consent form; and agreement not to use any cosmetics, drugs, or health products that may affect the results during the trial. Exclusion criteria included: open wounds or erosions; severe allergies; a history of cosmetic allergies; pregnancy, breastfeeding, or women planning to become pregnant during the test; severe heart, liver, or kidney dysfunction or severe immunodeficiency; mental illness, severe endocrine disorders, or oral contraceptive use; participation in drug clinical trials or other trials within the past 30 days, or systemic use of drugs that may affect the test results within the past week; oral or topical use of cosmetic products that may affect the test results within the past two weeks; or deemed unsuitable for participation by the researchers. Criteria for termination and withdrawal: failure to apply test samples as required or failure to record follow-up information as required during the test; serious illness or serious adverse reaction during use.

[0070] Test Method: Before using the test product, volunteers cleansed their faces. A skin color testing probe (Colorimeter CL400) was used to collect facial brightness (L value), skin tone individual type angle (ITA° value), and melanin (MI value) as initial values. After cleansing their faces in the morning and evening, volunteers used the test product from the example and comparative examples according to their groups for 32 consecutive days. On the evening of the 32nd day, after using the product and cleansing their faces, the skin color testing probe (Colorimeter CL400) was used to collect facial brightness (L value) and skin tone individual type angle (ITA° value) as test values. The rate of change was calculated as: L value / ITA° value / MI change rate = (test value - initial value) / initial value. The test results are shown in Table 1.

[0071] Table 1

[0072] As can be seen from Table 1, the composition described in this application has excellent whitening and spot-fading effects.

[0073] Comparing Examples 1-4 with Comparative Examples 1-2, it can be seen that by controlling the amount of each raw material in this application to be: 18-41.5 parts of hydrolyzed European plum extract, 20-30 parts of potassium 4-methoxysalicylate, 5-15 parts of hydroxyethylpiperazine ethanesulfonic acid, 8-15 parts of tranexamic acid, 12-20 parts of pomegranate extract, 2-5 parts of nonapeptide-1, 1-5 parts of fullerene, and 0.5-2 parts of collagen, the whitening and spot-fading effect of the composition can be significantly improved.

[0074] Comparing Examples 1-2 with Examples 3-4, it can be seen that by controlling the amount of each raw material in this application to be: 25.5-34.2 parts of hydrolyzed European plum extract, 23-27 parts of potassium 4-methoxysalicylate, 8-12 parts of hydroxyethylpiperazine ethanesulfonic acid, 10-12 parts of tranexamic acid, 15-18 parts of pomegranate extract, 3-4 parts of nonapeptide-1, 2-4 parts of fullerene, and 0.8-1.5 parts of collagen, the whitening and spot-fading effect can be further improved.

[0075] Comparing Example 1 with Comparative Examples 3-7, it can be seen that the hydrolyzed European plum extract, potassium 4-methoxysalicylate, and pomegranate extract in the composition described in this application have a significant synergistic effect in whitening and fading spots. The absence of any one of them or the use of other substitutes will result in a significant decrease in the whitening and spot-fading effect.

[0076] Finally, it should be noted that the above embodiments are used to illustrate the technical solutions of the present invention and not to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A brightening and spot-fading composition containing potassium 4-methoxysalicylate, characterized in that, The product comprises the following components in parts by weight: 18-41.5 parts hydrolyzed European plum extract, 20-30 parts potassium 4-methoxysalicylate, 5-15 parts hydroxyethylpiperazine ethane sulfonic acid, 8-15 parts tranexamic acid, 12-20 parts pomegranate extract, 2-5 parts nonapeptide-1, 1-5 parts fullerene, and 0.5-2 parts collagen.

2. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 1, characterized in that, The product comprises the following components in parts by weight: 25.5–34.2 parts hydrolyzed European plum extract, 23–27 parts potassium 4-methoxysalicylate, 8–12 parts hydroxyethylpiperazine ethanesulfonic acid, 10–12 parts tranexamic acid, 15–18 parts pomegranate extract, 3–4 parts nonapeptide-1, 2–4 parts fullerene, and 0.8–1.5 parts collagen.

3. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 1, characterized in that, The product comprises the following components in parts by weight: 25.5 parts hydrolyzed European plum extract, 27 parts potassium 4-methoxysalicylate, 8 parts hydroxyethylpiperazine ethane sulfonic acid, 12 parts tranexamic acid, 18 parts pomegranate extract, 4 parts nonapeptide-1, 4 parts fullerene, and 1.5 parts collagen.

4. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 1, characterized in that, The preparation method of the pomegranate extract is as follows: (1) Crush the pomegranate peel to obtain pomegranate peel powder; (2) Add pomegranate peel powder, cellulase, pectinase, acidic protease and citric acid to water, and sonicate to hydrolyze to obtain hydrolysate; (3) Adjust the pH of the enzymatic hydrolysate to 6-6.5, load it onto the macroporous adsorption resin at a rate of 0.5-1.5 BV / h, and elute at a rate of 1-2 BV / h. First wash with deionized water for 1-2 BV, then wash with 40-60 wt% ethanol solution for 1-2 BV. Collect the ethanol wash solution and dry it to obtain pomegranate extract.

5. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 4, characterized in that, The particle size of the pomegranate peel powder is 50-500 mesh.

6. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 4, characterized in that, The mass ratio of pomegranate peel powder, cellulase, pectinase, acidic protease, citric acid, and water is 1:(0.008~0.02):(0.008~0.02):(0.004~0.01):(0.002~0.005):(4~10).

7. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 4, characterized in that, The power of the ultrasonic enzymatic hydrolysis is 400~800W.

8. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 4, characterized in that, The ultrasonic enzymatic hydrolysis is performed at a temperature of 45-50℃ for 20-60 minutes.

9. The brightening and spot-fading composition containing potassium 4-methoxysalicylate according to claim 4, characterized in that, The macroporous adsorption resin is D101 macroporous adsorption resin.

10. A method for preparing the brightening and spot-fading composition containing potassium 4-methoxysalicylate according to any one of claims 1 to 9, characterized in that, The process includes the following steps: weighing the raw materials according to the specified ratio, mixing the raw materials evenly to obtain a brightening and spot-fading composition containing potassium 4-methoxysalicylate.

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