A nicotine-containing microcapsule and nicotine slow-release snus

Abstract

This invention belongs to the field of oral cigarettes, specifically disclosing a nicotine-containing microcapsule and a nicotine-slow-release oral cigarette. The nicotine-slow-release oral cigarette comprises the following components by weight percentage: 0.1-40% nicotine-containing microcapsules, 5-50% sweetener, 20-80% cellulose, 0.5-20% flavoring, and 0.5-10% alkali. The oral cigarette of this invention contains microcapsules with nicotine and / or nicotine salts as the core, which effectively solves the problem of nicotine volatilization, greatly extending the shelf life of the oral cigarette. Simultaneously, the controlled release of nicotine through the microcapsules prolongs the flavor retention time during use, better meeting customers' nicotine needs.

Description

Technical Field

[0001] This invention relates to the field of oral cigarettes, specifically to a nicotine-containing microcapsule and a nicotine-suppressed oral cigarette. Background Technology

[0002] Oral cigarettes are a new type of nicotine delivery product. Compared with traditional tobacco, e-cigarettes, and heated tobacco products, they do not produce smoke and are a healthier way to ingest nicotine than the above three tobacco products. Therefore, oral cigarettes are gradually becoming a new generation of smoking cessation products.

[0003] Oral cigarettes are made by mixing fillers, flavoring agents, water, nicotine, humectants, pH adjusters, etc. When classifying the preparation methods of oral cigarettes, products with a moisture content greater than 10% are generally defined as wet-process, and products with a moisture content less than 10% are defined as dry-process. Nicotine is a highly volatile liquid. When nicotine and fillers are mixed, a large amount of nicotine evaporates during storage, resulting in a significant reduction in the nicotine content of the oral cigarette product. When used, the insufficient nicotine content leads to a drastic decrease in flavor, failing to meet usage requirements and greatly impacting the customer's product experience. Furthermore, due to the volatility of nicotine in oral cigarettes, the shelf life of existing nicotine-containing oral cigarettes is generally short, easily resulting in them becoming unusable after expiration. Summary of the Invention

[0004] In order to overcome at least one of the technical problems existing in the prior art, one of the objectives of the present invention is to provide a method for preparing microcapsules.

[0005] The second objective of this invention is to provide a microcapsule.

[0006] The third objective of this invention is to provide a mouth-held smoke.

[0007] The fourth objective of this invention is to provide a method for preparing the above-mentioned microcapsules and / or the application of the microcapsules in the field of tobacco products.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] The first aspect of the present invention provides a method for preparing microcapsules, comprising the following steps:

[0010] The raw materials, including nicotine and / or nicotine salts, emulsifiers, and solvents, are mixed to obtain an emulsion;

[0011] The raw materials, including the emulsion, polyvalent metal salt, and polyphenol, are mixed to obtain a mixture.

[0012] The liquid in the mixture is removed to obtain the microcapsules;

[0013] The polyvalent metal salt includes at least one of divalent, trivalent, and tetravalent metal salts.

[0014] In some embodiments of the present invention, the emulsifier is selected from at least one of Tween 80, Span 60, Span 80, triglycerides, propylene glycol fatty acid esters, glyceryl monolaurate, and sodium stearoyl lactylate.

[0015] In some embodiments of the present invention, the polyphenol is selected from at least one of tannic acid, ellagic acid, gallic acid, anthocyanin, and dopamine.

[0016] In some embodiments of the present invention, the polyvalent metal salt is selected from at least one of FeCl3·6H2O, FeCl3, FeCl2, CaCl2, ZnCl2, AlCl3, and CrCl3.

[0017] In some embodiments of the present invention, each 1 mL of the mixture contains 0.1 to 0.5 mg of a polyvalent metal salt.

[0018] In some embodiments of the present invention, each 1 mL of the mixture contains 0.4 to 1 mg of polyphenols.

[0019] In some embodiments of the present invention, the preparation method further includes the step of adjusting the pH of the mixture to 7-9 using an acid solution.

[0020] In some embodiments of the present invention, the preparation method further includes a water washing step; the water washing step is located after the step of adjusting the pH of the mixture to 7-9 with acid and before the step of removing liquid from the mixture.

[0021] In some embodiments of the present invention, the acid solution is selected from at least one of phosphoric acid, acetic acid, hydrochloric acid, and sulfuric acid.

[0022] In some embodiments of the present invention, the step of removing liquid from the mixture is to remove liquid from the mixture by centrifugation or filtration.

[0023] A second aspect of the present invention provides a microcapsule containing nicotine and / or nicotine salt in its core; the microcapsule is prepared using the preparation method described in the first aspect of the present invention.

[0024] A third aspect of the present invention provides a mouthwash comprising the following components by weight percentage: 0.1-40% of the microcapsules described in the second aspect of the present invention, 5-50% of a sweetener, 20-80% of cellulose, 0.5-20% of a flavoring and fragrance, and 0.5-10% of an alkali.

[0025] In some embodiments of the present invention, the sweetener is selected from at least one of xylitol, maltose, honey, white sugar, brown sugar, glucose, fructose, sucrose, aspartame, sodium saccharin, tripotassium glycyrrhizate, acesulfame potassium, neotame, adventitia, stevia, rhamnose, trehalose, erythritol, lactose, and galactose.

[0026] In some embodiments of the present invention, the fragrance is selected from at least one of blueberry fragrance, banana fragrance, cherry fragrance, peppermint fragrance, strawberry fragrance, grape fragrance, coconut fragrance, apple fragrance, kiwi fragrance, milk fragrance, raspberry fragrance, mango fragrance, lemon fragrance, peppermint essential oil, wintergreen fragrance, jasmine essential oil, sweet orange fragrance, grapefruit essential oil, citrus essential oil, peach essential oil, strawberry essential oil, lavender essential oil, banana essential oil, kiwi essential oil, apple essential oil, and rose essential oil.

[0027] In some embodiments of the present invention, the alkali is selected from at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, and potassium bicarbonate.

[0028] The third aspect of the present invention provides a method for preparing the microcapsules described in the first aspect of the present invention and / or the application of the microcapsules described in the second aspect of the present invention in the field of tobacco products.

[0029] The beneficial effects of this invention are as follows: The microcapsule preparation method of this invention forms a network structure shell through coordination linkage between polyvalent metal salts and polyphenols, thereby encapsulating nicotine and / or nicotine salts, and obtaining microcapsules with a core of nicotine and / or nicotine salts and a shell of coordination compounds of polyvalent metal salts and polyphenols. This effectively solves the problem of nicotine volatilization, and at the same time, the microcapsules enable controlled release of nicotine to better meet customers' needs for nicotine.

[0030] The oral cigarette of the present invention contains microcapsules with nicotine and / or nicotine salt as the core, which can effectively solve the problem of nicotine volatilization and greatly extend the shelf life of the oral cigarette. At the same time, the slow and controlled release of nicotine through microcapsules can prolong the flavor retention time of the oral cigarette during use, so as to better meet the customer's demand for nicotine. Attached Figure Description

[0031] Figure 1 The graph shows the rate of change of nicotine in the smoke in Example 2 and Comparative Example 1 over time. Detailed Implementation

[0032] The specific implementation of the present invention will be further described in detail below with reference to the accompanying drawings and examples, but the implementation and protection of the present invention are not limited thereto. It should be noted that any processes not specifically described in detail below are those that can be implemented or understood by those skilled in the art by referring to the prior art. Reagents or instruments used without specified manufacturers are all conventional products that can be purchased commercially.

[0033] In some embodiments of the present invention, a method for preparing microcapsules is provided, comprising the following steps:

[0034] The raw materials, including nicotine and / or nicotine salts, emulsifiers, and solvents, are mixed to obtain an emulsion;

[0035] The raw materials, including the emulsion, polyvalent metal salt, and polyphenol, are mixed to obtain a mixture.

[0036] The liquid in the mixture is removed to obtain the microcapsules;

[0037] The polyvalent metal salt includes at least one of divalent, trivalent, and tetravalent metal salts.

[0038] In some embodiments of the present invention, the solvent includes water.

[0039] In some embodiments of the present invention, the emulsifier is selected from at least one of Tween 80, Span 60, Span 80, triglycerides, propylene glycol fatty acid esters, glyceryl monolaurate, and sodium stearoyl lactylate.

[0040] In some embodiments of the present invention, the polyphenol is selected from at least one of tannic acid, ellagic acid, gallic acid, anthocyanin, and dopamine.

[0041] In some embodiments of the present invention, the polyvalent metal salt is selected from at least one of FeCl3·6H2O, FeCl3, FeCl2, CaCl2, ZnCl2, AlCl3, and CrCl3. In some embodiments of the present invention, the polyvalent metal salt is selected from at least one of FeCl3·6H2O and FeCl3.

[0042] In some embodiments of the present invention, the mixing step in the preparation method of the microcapsules of the present invention is carried out using a vortex mixer. In some embodiments of the present invention, the mixing step takes 10 to 30 seconds; in some embodiments of the present invention, the mixing step takes 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 seconds.

[0043] In some embodiments of the present invention, each 1 mL of the mixture contains 0.1 to 0.5 mg of a polyvalent metal salt; in some embodiments of the present invention, the content of the polyvalent metal salt in each 1 mL of the mixture can be any value of 0.1 g, 0.2 g, 0.3 g, 0.4 g, 0.5 g, or a range formed by any combination of both.

[0044] In some embodiments of the present invention, each 1 mL of the mixture contains 0.4 to 1 mg of polyphenols; in some embodiments of the present invention, each 1 mL of the mixture contains polyphenols in any value of 0.4 g, 0.5 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1 g, or a range formed by any combination of both.

[0045] In some embodiments of the present invention, the preparation method further includes the step of adjusting the pH of the mixture to 7-9 using an acid solution; the step of adjusting the pH of the mixture to 7-9 using an acid solution is located after the step of preparing the mixture and before the step of removing the liquid from the mixture; in some embodiments of the present invention, the pH of the mixture may be selected from any value of 7, 7.5, 8, 8.5, 9 or a range formed by any combination of both.

[0046] In some embodiments of the present invention, the acid solution is selected from at least one of phosphoric acid, acetic acid, hydrochloric acid, and sulfuric acid; in some embodiments of the present invention, the acid solution is selected from at least one of phosphoric acid and acetic acid.

[0047] In some embodiments of the present invention, the present invention further includes a step of washing away unreacted polyvalent metal salts and polyphenols with water; the step of washing away unreacted polyvalent metal salts and polyphenols with water is located after the step of adjusting the pH of the mixture to 7-9 with acid and before the step of removing liquid from the mixture.

[0048] In some embodiments of the present invention, the step of removing liquid from the mixture is: removing liquid from the mixture by centrifugation or filtration.

[0049] In some embodiments of the present invention, the centrifugation rate is 2000-10000 rpm; in some embodiments of the present invention, the centrifugation rate can be any value or a range formed by any two of 2000 rpm, 3000 rpm, 4000 rpm, 5000 rpm, 6000 rpm, 7000 rpm, 8000 rpm, 9000 rpm, and 10000 rpm.

[0050] In some embodiments of the present invention, a microcapsule is provided, the core of which contains nicotine and / or nicotine salt; the microcapsule is prepared using the above-described microcapsule preparation method. The shell of the microcapsule in the present invention is a coordination compound of a polyvalent metal salt and a polyphenol; the core of the microcapsule contains nicotine and / or nicotine salt. By encapsulating the nicotine and / or nicotine salt with the coordination compound of the polyvalent metal salt and polyphenol, the volatilization or loss of nicotine and / or nicotine salt can be prevented, thus extending the shelf life of the oral cigarette containing the microcapsule.

[0051] In some embodiments of the present invention, the present invention provides a mouthwash comprising the following components by weight percentage: 0.1-40% microcapsules prepared by the above preparation method, 5-50% sweetener, 20-80% cellulose, 0.5-20% flavoring and fragrance, and 0.5-10% alkali.

[0052] In this invention, the mass percentage of the microcapsules is 0.1% to 40%; in some embodiments of this invention, the mass percentage of the microcapsules can be any value or a range formed by any combination of 0.1%, 1%, 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, and 40%.

[0053] In this invention, the mass percentage of the sweetener is 5-50%; in some embodiments of this invention, the mass percentage of the sweetener may be selected from any value or a range formed by any combination of 5%, 8%, 10%, 12%, 15%, 18%, 20%, 32%, 35%, 38%, 40%, 42%, 45%, 48%, and 50%.

[0054] In this invention, the mass percentage of cellulose is 20-80%; in some embodiments of this invention, the mass percentage of cellulose can be any value or a range formed by any combination of 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%.

[0055] In this invention, the mass percentage of the fragrance and flavoring is 0.5% to 20%; in some embodiments of this invention, the mass percentage of the fragrance and flavoring can be any value or a range formed by any combination of 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, and 20%.

[0056] In this invention, the mass percentage of alkali is 0.5% to 10%; in some embodiments of this invention, the mass percentage of alkali can be any value or a range formed by any combination of 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, and 10%.

[0057] In some embodiments of the present invention, the sweetener is selected from at least one of xylitol, maltose, honey, white sugar, brown sugar, glucose, fructose, sucrose, aspartame, sodium saccharin, tripotassium glycyrrhizate, acesulfame potassium, neotame, adventitia, stevia, rhamnose, trehalose, erythritol, lactose, and galactose; in some embodiments of the present invention, the sweetener is selected from at least one of xylitol, maltose, and honey; in some embodiments of the present invention, the sweetener is selected from xylitol.

[0058] In some embodiments of the present invention, the fragrance is selected from at least one of blueberry essence, banana essence, cherry essence, peppermint essence, strawberry essence, grape essence, coconut essence, apple essence, kiwi essence, milk essence, raspberry essence, mango essence, lemon essence, peppermint essential oil, wintergreen essence, jasmine essential oil, sweet orange essence, grapefruit essential oil, citrus essential oil, peach essential oil, strawberry essential oil, lavender essential oil, banana essential oil, kiwi essential oil, apple essential oil, and rose essential oil; in some embodiments of the present invention, the fragrance is selected from at least one of blueberry essence, banana essence, strawberry essence, sweet orange essence, lemon essence, apple essence, peppermint essence, and wintergreen essence.

[0059] In some embodiments of the present invention, the alkali is selected from at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, and potassium bicarbonate; in some embodiments of the present invention, the alkali is selected from at least one of sodium carbonate and potassium carbonate; in some embodiments of the present invention, the alkali is selected from sodium carbonate.

[0060] The specific implementation of the present invention will be further described in detail below with reference to specific embodiments:

[0061] Example 1

[0062] This example provides a method for preparing nicotine-encapsulated microcapsules, which includes the following steps:

[0063] S1: Mix 1g of emulsifier Tween 80, 10g of nicotine, and 100mL of water, and adjust the pH to 9 to obtain an emulsion;

[0064] S2: Add FeCl3·6H2O and tannic acid to the above emulsion to obtain a mixed emulsion. In the mixed emulsion, the concentration of FeCl3·6H2O is 0.5 mg / mL and the concentration of tannic acid is 1 mg / mL.

[0065] S3: Vigorously mix the emulsion obtained in step S2 using a vortex mixer for 30 seconds.

[0066] S4: Add phosphate buffer solution to adjust the pH to 8.

[0067] S5: Wash three times with water to remove excess FeCl3·6H2O and tannic acid.

[0068] S6: The nicotine-encapsulated microcapsules were prepared by centrifugation at a rotation speed of 10,000 rpm, and the microcapsules were obtained as a brown powder.

[0069] Example 2

[0070] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 10g of nicotine-encapsulated microcapsules, 40g of xylitol, 39.5g of cellulose, 0.5g of blueberry flavoring, and 10g of sodium carbonate, as shown in Table 1.

[0071] The oral tobacco in this example is prepared using a method that includes the following steps:

[0072] (1) Take 10g of nicotine-encapsulated microcapsules and 39.5g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0073] (2) Add 40g of xylitol to the mixture in step (1) and mix at a stirring speed of 300 rpm for 30 minutes;

[0074] (3) Take 0.5g of blueberry flavoring and 10g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0075] Example 3

[0076] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 40g of nicotine-encapsulated microcapsules, 30g of xylitol, 20g of cellulose, 5g of strawberry flavoring, and 5g of sodium carbonate, as shown in Table 1.

[0077] The oral tobacco in this example is prepared using a method that includes the following steps:

[0078] (1) Take 40g of nicotine-encapsulated microcapsules and 20g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0079] (2) Take 30g of xylitol and add it to the mixture in step (1). Mix at a stirring speed of 300 rpm for 30 minutes.

[0080] (3) Take 5g of strawberry flavoring and 5g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0081] Example 4

[0082] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 25g of nicotine-encapsulated microcapsules, 20g of xylitol, 20g of cellulose, 20g of banana flavoring, and 5g of sodium carbonate, as shown in Table 1.

[0083] The oral tobacco in this example is prepared using a method that includes the following steps:

[0084] (1) Take 25g of nicotine-encapsulated microcapsules and 20g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0085] (2) Take 20g of xylitol and add it to the mixture in step (1). Mix at a stirring speed of 300 rpm for 30 minutes.

[0086] (3) Take 20g of banana flavoring and 5g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0087] Example 5

[0088] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 20g of nicotine-encapsulated microcapsules, 20g of xylitol, 49.5g of cellulose, 10g of sweet orange flavoring, and 0.5g of sodium carbonate, as shown in Table 1.

[0089] The oral tobacco in this example is prepared using a method that includes the following steps:

[0090] (1) Take 20g of nicotine-coated microcapsules and 49.5g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min;

[0091] (2) Take 20g of xylitol and add it to the mixture in step (1). Mix at a stirring speed of 300 rpm for 30 minutes.

[0092] (3) Take 10g of sweet orange flavoring and 0.5g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0093] Example 6

[0094] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 0.1g of nicotine-encapsulated microcapsules, 5g of xylitol, 80g of cellulose, 10.9g of lemon flavoring, and 4g of sodium carbonate, as shown in Table 1.

[0095] The oral tobacco in this example is prepared using a method that includes the following steps:

[0096] (1) Take 0.1g of nicotine-encapsulated microcapsules and 80g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min;

[0097] (2) Add 5g of xylitol to the mixture in step (1) and mix at a stirring speed of 300 rpm for 30 minutes;

[0098] (3) Take 10.9g of lemon flavoring and 4g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0099] Example 7

[0100] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 5g of nicotine-encapsulated microcapsules, 10g of xylitol, 70g of cellulose, 10g of apple flavoring, and 5g of sodium carbonate, as shown in Table 1.

[0101] The oral tobacco in this example is prepared using a method that includes the following steps:

[0102] (1) Take 5g of nicotine-encapsulated microcapsules and 70g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0103] (2) Add 10g of xylitol to the mixture in step (1) and mix at a stirring speed of 300 rpm for 30 minutes;

[0104] (3) Take 10g of apple flavoring and 5g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0105] Example 8

[0106] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 30g of nicotine-encapsulated microcapsules, 20g of xylitol, 40g of cellulose, 5g of peppermint flavoring, and 5g of sodium carbonate, as shown in Table 1.

[0107] The oral tobacco in this example is prepared using a method that includes the following steps:

[0108] (1) Take 30g of nicotine-encapsulated microcapsules and 40g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0109] (2) Take 20g of xylitol and add it to the mixture in step (1). Mix at a stirring speed of 300 rpm for 30 minutes.

[0110] (3) Take 5g of peppermint flavoring and 5g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0111] Example 9

[0112] This example provides a nicotine sustained-release oral cigarette, comprising the following components: 20g of nicotine-encapsulated microcapsules, 30g of xylitol, 30g of cellulose, 10g of wintergreen flavoring, and 10g of sodium carbonate, as shown in Table 1.

[0113] The oral tobacco in this example is prepared using a method that includes the following steps:

[0114] (1) Take 20g of nicotine-coated microcapsules and 30g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min.

[0115] (2) Take 30g of xylitol and add it to the mixture in step (1). Mix at a stirring speed of 300 rpm for 30 minutes.

[0116] (3) Take 10g of wintergreen essence and 10g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine sustained-release oral cigarette in this example.

[0117] Table 1. Formulations of nicotine sustained-release oral cigarettes in Examples 2-9

[0118]

[0119] Comparative Example 1

[0120] This example provides a nicotine-containing oral cigarette, comprising the following components: 6g nicotine (maintaining the same amount of nicotine as in Example 2), 40g xylitol, 39.5g cellulose, 0.5g blueberry flavoring, and 10g sodium carbonate, as shown in Table 1.

[0121] The oral tobacco in this example is prepared using a method that includes the following steps:

[0122] (1) Take 6g of nicotine and 39.5g of cellulose, and mix them in a reactor at a stirring rate of 300 rpm for 30 min;

[0123] (2) Add 40g of xylitol to the mixture in step (1) and mix at a stirring speed of 300 rpm for 30 minutes;

[0124] (3) Take 0.5g of blueberry flavoring and 10g of sodium carbonate and add them to the mixing vessel in step (2) and mix for 60 minutes to obtain the nicotine-containing oral cigarette in this example.

[0125] The nicotine content in this example is the same as the nicotine content in the oral cigarette in Example 2.

[0126] Performance testing:

[0127] The cigarettes from Example 2 and Comparative Example 1 were placed in room temperature air, and samples were taken at 1, 14, 30, 60, 90, and 120 days to test the nicotine content. The specific testing method was as follows: the cigarette sample was immersed in 30 mL of deionized water for 30 min, and then the liquid was analyzed by GC-MS. The percentage of remaining nicotine mass in the cigarettes from Example 2 and Comparative Example 1 at different placement times, as measured by the above testing method, is shown in Table 2 below. Then, a curve showing the change in the percentage of remaining nicotine mass with placement time was plotted based on Table 2. Figure 1 As shown.

[0128] Table 2. Percentage of residual nicotine mass after smoking for different storage times.

[0129]

[0130] Depend on Figure 1 As shown in Table 2, the nicotine-encapsulated cigarette in Example 2 of this invention uses microcapsules to encapsulate nicotine. During storage, the nicotine evaporation is significantly reduced. After 120 days, the remaining nicotine mass percentage in the cigarette is still as high as 68%. In contrast, the nicotine-encapsulated cigarette in Comparative Example 1 did not undergo nicotine encapsulation treatment, resulting in rapid nicotine evaporation during storage. After 14 days at room temperature, the remaining nicotine mass percentage had reached 30%, and after 120 days, the remaining nicotine mass percentage was only 22%, significantly lower than the nicotine content in the cigarette in Example 1. This demonstrates that the nicotine-encapsulated cigarette of this invention significantly reduces nicotine evaporation, improves the stability of the cigarette, extends its shelf life, and significantly improves the user experience.

[0131] In summary, the oral cigarette of the present invention contains microcapsules with nicotine and / or nicotine salt as the core, which can effectively solve the problem of nicotine volatilization and greatly extend the shelf life of the oral cigarette. At the same time, the slow and controlled release of nicotine through microcapsules can prolong the flavor retention time of the oral cigarette during use, so as to better meet the customer's demand for nicotine.

[0132] The embodiments of the present invention have been described in detail above. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof can be combined with each other unless otherwise specified.

Claims

1. A method for preparing microcapsules, characterized in that: Includes the following steps: The raw materials, including nicotine and / or nicotine salts, emulsifiers, and solvents, are mixed to obtain an emulsion; The raw materials, including the emulsion, polyvalent metal salt, and polyphenol, are mixed to obtain a mixture. The liquid in the mixture is removed to obtain the microcapsules; The polyvalent metal salt includes at least one of divalent, trivalent, and tetravalent metal salts.

2. The method for preparing microcapsules according to claim 1, characterized in that: The emulsifier is selected from at least one of Tween 80, Span 60, Span 80, triglycerides, propylene glycol fatty acid esters, glyceryl monolaurate, and sodium stearoyl lactylate. And / or, the polyphenols are selected from at least one of tannic acid, ellagic acid, gallic acid, anthocyanins, and dopamine; And / or, the polyvalent metal salt is selected from at least one of FeCl3·6H2O, FeCl3, FeCl2, CaCl2, ZnCl2, AlCl3, and CrCl3.

3. The method for preparing microcapsules according to claim 1, characterized in that: Each 1 mL of the mixture contains 0.1–0.5 mg of polyvalent metal salt; And / or, each 1 mL of the mixture contains 0.4 to 1 mg of polyphenols.

4. The method for preparing microcapsules according to claim 1, characterized in that: The preparation method further includes the step of adjusting the pH of the mixture to 7-9 using an acid solution.

5. The method for preparing microcapsules according to claim 4, characterized in that: The preparation method further includes a water washing step; the water washing step is located after the step of adjusting the pH of the mixture to 7-9 with acid and before the step of removing liquid from the mixture.

6. The method for preparing microcapsules according to claim 1, characterized in that: The step of removing liquid from the mixture is to remove the liquid from the mixture by centrifugation or filtration.

7. A microcapsule, characterized in that: The core of the microcapsule contains nicotine and / or nicotine salt; the microcapsule is prepared by the preparation method according to any one of claims 1 to 6.

8. A type of mouth-held tobacco product, characterized in that: The oral tobacco comprises the following components by weight percentage: 0.1-40% of the microcapsules as described in claim 7, 5-50% of sweetener, 20-80% of cellulose, 0.5-20% of flavoring and fragrance, and 0.5-10% of alkali.

9. The oral cigarette according to claim 8, characterized in that: The sweetener is selected from at least one of xylitol, maltose, honey, white sugar, brown sugar, glucose, fructose, sucrose, aspartame, sodium saccharin, tripotassium glycyrrhizate, acesulfame potassium, neotame, advans, stevia, rhamnose, trehalose, erythritol, lactose, and galactose. And / or, the flavoring is selected from at least one of the following: blueberry flavoring, banana flavoring, cherry flavoring, peppermint flavoring, strawberry flavoring, grape flavoring, coconut flavoring, apple flavoring, kiwi flavoring, milk flavoring, raspberry flavoring, mango flavoring, lemon flavoring, peppermint essential oil, wintergreen flavoring, jasmine essential oil, sweet orange flavoring, grapefruit flavoring essential oil, citrus flavoring essential oil, peach flavoring essential oil, strawberry flavoring essential oil, lavender essential oil, banana essential oil, kiwi essential oil, apple essential oil, and rose essential oil; And / or, the base is selected from at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, and potassium bicarbonate.

10. The method for preparing the microcapsules according to any one of claims 1 to 6 and / or the application of the microcapsules according to claim 7 in the field of tobacco products.

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