Biological sample detection device and scraping piece

Abstract

The biological sample detection device comprises a tube body assembly and a sampling assembly, the tube body assembly comprises a tube body, the scraping piece and a test paper strip, a first opening is formed in the upper part of the tube body, and a main cavity, a communicating cavity and a test paper cavity are formed in the tube body; the scraping piece is integrally made of rubber or silica gel and comprises a mounting ring and a first diaphragm, the mounting ring is of a cylindrical structure, a channel is formed in the mounting ring, the first diaphragm is perpendicular to the axis of the mounting ring and fixed in the mounting ring, a penetrating hole is formed in the middle of the first diaphragm, and the outer wall of the mounting ring is attached to the inner wall of the main cavity in a sealed mode; a test strip is inserted into the test paper cavity, and the lower end of the test strip extends into the communicating cavity; the sampling assembly comprises an upper cover and a sampling rod, the sampling rod extends into the main cavity from the opening, the diameter of the insertion hole is smaller than that of the sampling rod, and the sampling rod penetrates through the insertion hole. The scraping piece can effectively scrape redundant biological samples on the sampling head, so that the accuracy of a detection result is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a biological sample detection device and a scraping piece. Background Art

[0002] With the continuous outbreak and spread of infectious diseases around the world, rapid and accurate detection of pathogens has become a key step in preventing and controlling infectious diseases. However, traditional methods for detecting infectious markers have problems with sample contamination and transmission risks, mainly open lateral flow test cards, which are prone to sample cross-contamination during operation.

[0003] Chinese patent authorization announcement No. CN206523509U discloses an integrated device for stool sampling and occult blood detection. A circular hole is set on the partition layer. When a stool sampling stick passes through, excess stool on the stool sampling stick can be scraped off. However, since the circular hole is fixed, in order to facilitate the passage of the stool sampling stick, the circular hole must be set larger than the diameter of the stool sampling stick. This makes it impossible to effectively scrape off the excess stool on the stool sampling stick, resulting in inaccurate test results. Utility Model Content

[0004] In view of this, the utility model provides a biological sample detection device and a scraper, which can effectively scrape off excess biological samples on the sampling head and improve the accuracy of the detection result.

[0005] The technical solution adopted by the utility model is:

[0006] A biological sample detection device, used for detecting a target in a biological sample, comprises a tube body assembly and a sampling assembly, wherein the tube body assembly comprises a tube body, a scraper and a test paper strip, wherein a first opening is formed at the upper portion of the tube body, wherein a main cavity, a connecting cavity and a test paper cavity are arranged in the tube body, wherein the upper portion of the main cavity is connected to the first opening, wherein the main cavity and the test paper cavity are arranged side by side on the left and right, and wherein the lower portion of the main cavity and the lower portion of the test paper cavity are both connected to the connecting cavity;

[0007] The scraper is made of rubber or silicone in one piece, and includes a mounting ring and a first diaphragm. The mounting ring is a cylindrical structure, a channel is provided in the mounting ring, the first diaphragm is perpendicular to the axis of the mounting ring, the first diaphragm is fixed in the mounting ring, a through hole is provided in the middle of the first diaphragm, and the outer wall of the mounting ring is sealed and fitted with the inner wall of the main cavity;

[0008] A second diaphragm is provided between the main cavity and the communicating cavity, and the second diaphragm separates the main cavity and the communicating cavity;

[0009] The test paper strip is inserted into the test paper cavity, and the lower end of the test paper strip extends into the communicating cavity;

[0010] The sampling assembly includes an upper cover and a sampling rod, the sampling rod is connected to the upper cover, a sampling head is provided at the lower part of the sampling rod, the lower end of the sampling head is sharp, the sampling rod extends from the opening into the main cavity, the diameter of the insertion hole is smaller than the diameter of the sampling rod, the sampling rod passes through the insertion hole, and the sampling head is located between the first diaphragm and the second diaphragm.

[0011] Preferably, the main cavity includes a first cavity and a second cavity connected up and down, the first cavity is located on the upper side of the second cavity, the second cavity is a vertical columnar space, the scraper is installed in the second cavity, and the outer diameter of the mounting ring matches the inner diameter of the second cavity.

[0012] Preferably, an annular sealing ring is provided on the outer wall of the mounting ring along the circumference of the mounting ring.

[0013] Preferably, the number of the sealing rings is two, and the two sealing rings are spaced apart in the axial direction of the mounting ring;

[0014] The first diaphragm is located in the middle of the mounting ring, and the two sealing rings are respectively located on both sides of the first diaphragm, and in the axial direction, the distances between the two sealing rings and the diaphragm are equal.

[0015] Preferably, in the axial direction of the mounting ring, the channel includes a first equal-diameter section, a second equal-diameter section and a third equal-diameter section connected in sequence, the diameter of the first equal-diameter section is equal to the diameter of the third equal-diameter section, the diameter of the second equal-diameter section is smaller than the diameter of the first equal-diameter section, and the first diaphragm is located in the second equal-diameter section.

[0016] Preferably, the channel further comprises a first diameter-reducing section and a second diameter-reducing section, the first constant diameter section and the second constant diameter section are connected via the first diameter-reducing section, the second constant diameter section and the third constant diameter section are connected via the second diameter-reducing section, the diameter of the first diameter-reducing section gradually decreases along the direction from the first constant diameter section to the second constant diameter section, the diameter of the large end of the first diameter-reducing section is equal to the diameter of the first constant diameter section and is connected to the first constant diameter section, the diameter of the small end of the first diameter-reducing section is equal to the diameter of the second constant diameter section and is connected to the second constant diameter section;

[0017] Along the direction from the second equal-diameter section to the third equal-diameter section, the diameter of the second diameter-changing section gradually increases, the diameter of the small end of the second diameter-changing section is equal to the diameter of the second equal-diameter section and is connected to the second equal-diameter section, and the diameter of the large end of the second diameter-changing section is equal to the diameter of the third equal-diameter section and is connected to the third equal-diameter section.

[0018] Preferably, a second opening is formed at the lower portion of the tube body, the communicating cavity is communicated with the second opening, and the tube body assembly further comprises a lower cover, which is sealed and mounted on the second opening from the lower side and closes the second opening from the lower side.

[0019] Preferably, the lower cover is further connected with an auxiliary ring and a support platform, the auxiliary ring is an annular structure, and the support platform is a columnar structure;

[0020] The lower cover includes a cover bottom and a cover wall, the cover wall is connected to the edge of the cover bottom, the auxiliary ring and the support platform are both connected to the cover bottom, the auxiliary ring and the support platform are both located on the inner side of the cover wall, the upper surface of the auxiliary ring is flush with the upper surface of the support platform, the support platform is located on the inner side of the auxiliary ring, the upper surface of the auxiliary ring is in contact with the lower end surface of the inner wall of the main cavity, and the auxiliary ring is provided with a notch for solution circulation.

[0021] The utility model also relates to a scraping member, which is the scraping member in the aforementioned biological sample detection device.

[0022] Beneficial effects of the utility model:

[0023] The biological sample is collected using the sampling head of the sampling assembly, and then the sampling head is extended from the first opening into the main cavity. When the sampling head is inserted into the main cavity, the sampling head must first pass through the scraper, specifically, the sampling head must pass through the insertion hole. Since the diameter of the insertion hole is smaller than the diameter of the sampling rod and also smaller than the diameter of the sampling head, and the scraper is made entirely of silicone or rubber, that is, the first diaphragm can be deformed, when the sampling head passes through the insertion hole, the insertion hole will become larger, and the insertion hole will always be tightly covered on the sampling head, thereby completely scraping the part of the biological tissue outside the gap of the sampling head, and after the sampling head passes through, the insertion hole is covered on the sampling rod, thereby sealing the insertion hole to prevent the biological tissue on the upper side of the first diaphragm from crossing the insertion hole, thereby achieving quantitative biological tissue entry into the solvent and improving the accuracy of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The above and other purposes, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0025] Figure 1 is a schematic diagram of the structure of a biological sample detection device;

[0026] Figure 2 is a cross-sectional view of the biological sample detection device at the first working station;

[0027] Figure 3 is a cross-sectional view of the biological sample detection device at the second station;

[0028] Figure 4 It is a schematic diagram of the structure of the bottom cover;

[0029] Figure 5 is a cross-sectional view of the scraper.

[0030] In the figure: 1. Tube assembly; 2. Sampling assembly;

[0031] 11. Tube body; 12. Scraping member; 13. Test strip; 14. Second diaphragm; 15. Bottom cover; 16. Main cavity; 17. Communication cavity;

[0032] 21. Upper cover; 22. Sampling rod; 23. Sampling head;

[0033] 121. Mounting ring; 122. First diaphragm; 123. Insertion hole; 124. Sealing ring; 125. First equal diameter section; 126. Second equal diameter section; 127. Third equal diameter section; 128. First reduced diameter section; 129. Second reduced diameter section.

[0034] 151. support platform; 152. auxiliary ring; 153. notch;

[0035] 161, first cavity; 162, second cavity; DETAILED DESCRIPTION

[0036] The present invention is described below based on embodiments, but the present invention is not limited to these embodiments. In the following detailed description of the present invention, some specific details are described in detail. In order to avoid confusing the essence of the present invention, known methods, processes, procedures, and components are not described in detail.

[0037] In addition, persons of ordinary skill in the art will appreciate that the drawings provided herein are for illustration purposes and are not necessarily drawn to scale.

[0038] Unless the context clearly requires otherwise, throughout the specification and claims, the words "include", "comprising" and similar words should be interpreted in an inclusive sense rather than an exclusive or exhaustive sense; that is, in the sense of "including but not limited to".

[0039] In the description of the present invention, it should be understood that the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, the meaning of "plurality" is two or more.

[0040] See also Figure 1-Figure 5The utility model provides a biological sample detection device for detecting a target in a biological sample, wherein the biological sample is, for example, feces, respiratory skin tissue or body fluid, and the biological sample detection device comprises a tube body component 1 and a sampling component 2, wherein the tube body component 1 comprises a tube body 11, a scraper 12 and a test strip 13, wherein a first opening is formed at the upper portion of the tube body 11, wherein a main cavity 16, a connecting cavity 17 and a test paper cavity are arranged in the tube body 11, wherein the upper portion of the main cavity 16 is connected to the first opening, wherein the main cavity 16 and the test paper cavity are arranged side by side on the left and right, and the lower portion of the main cavity 16 and the lower portion of the test paper cavity are both connected to the connecting cavity 17.

[0041] The scraper 12 is made of rubber or silicone in one piece, and includes a mounting ring 121 and a first diaphragm 122. The mounting ring 121 is a cylindrical structure, and a channel is provided in the mounting ring 121. The first diaphragm 122 is perpendicular to the axis of the mounting ring 121. The first diaphragm 122 is fixed in the mounting ring 121. A through hole 123 is provided in the middle of the first diaphragm 122. The outer wall of the mounting ring 121 is sealed and fitted with the inner wall of the main cavity 16.

[0042] A second diaphragm 14 is disposed between the main cavity 16 and the communicating cavity 17 , and the second diaphragm 14 separates the main cavity 16 from the communicating cavity 17 .

[0043] The test paper strip 13 is inserted into the test paper cavity, and the lower end of the test paper strip 13 extends into the connecting cavity 17 .

[0044] The sampling assembly 2 includes an upper cover 21 and a sampling rod 22, the sampling rod 22 is connected to the upper cover 21, a sampling head 23 is provided at the lower part of the sampling rod 22, the lower end of the sampling head 23 is sharp, the sampling rod 22 extends from the opening into the main cavity 16, the diameter of the insertion hole 123 is smaller than the diameter of the sampling rod 22, the sampling rod 22 passes through the insertion hole 123, and the sampling head 23 is located between the first diaphragm 122 and the second diaphragm 14.

[0045] When in use, the sampling assembly 2 has a first position and a second position relative to the second diaphragm 14;

[0046] In the first station, the sampling rod 22 is located on the upper side of the second diaphragm 14;

[0047] At the second station, the lower end of the sampling head 23 punctures the second diaphragm 14 .

[0048] Initially, the sampling rod 22 (sampling component 2) is in the first position relative to the sampling tube, and a solvent is pre-stored in the main cavity 16, and the solvent is located between the first diaphragm 122 and the second diaphragm 14. Due to the obstruction of the second diaphragm 14, the solvent cannot flow into the connecting cavity 17. At this time, the sampling head 23 is basically immersed in the solvent of the main cavity 16, and then the sampling component 2 is pulled out, and the biological sample is collected through the sampling component 2. After the collection is completed, the sampling component 2 is reinserted into the main cavity 16 from the first opening. The sampling head 23 needs to pass through the scraper 12 first. Specifically, the sampling head 23 needs to pass through the insertion hole 123. Since the diameter of the insertion hole 123 is smaller than the diameter of the sampling rod 22, it is also smaller than the diameter of the sampling head 23, and the scraper 12 is made of silicone or rubber as a whole, that is, the first diaphragm 122 can be deformed, so the sampling head 23 passes through When the insertion hole 123 is inserted, the insertion hole 123 will become larger, and the insertion hole 123 will always be tightly covered on the sampling head 23, so that the part of the biological tissue outside the gap of the sampling head 23 will be completely scraped, until the sampling head 23 completely passes through the insertion hole 123 and reaches the first station. At this time, the sampling head 23 will be immersed in the solvent again, and the biological sample attached to the sampling head 23 will be dissolved in the solvent, so that only a set amount of the biological sample is dissolved in the solvent, and the sampling component 2 is continued to be pressed down. Since the lower end of the sampling head 23 is sharp, the sampling head 23 will pierce the second diaphragm 14, so that the main cavity 16 is connected with the connecting cavity 17, and the solvent will flow from the main cavity 16 into the connecting cavity 17, and the lower end of the test strip 13 extends into the connecting cavity 17, so that the solvent contacts the lower end of the test strip 13, so that the test strip 13 changes and displays the test result.

[0049] The thickness of the first diaphragm 122 does not exceed 1 mm (for example, 0.1 mm, 0.3 mm, 0.5 mm, 0.8 mm or 1 mm, etc.), and the insertion hole 123 is located in the middle position of the first diaphragm 122. Therefore, when the sampling head 23 passes through the first diaphragm 122, the tip (lower end) of the sampling head 23 first enters the insertion hole 123. As the sampling head 23 moves downward, the sampling head 23 will pull the first diaphragm 122 downward (the first diaphragm 122 is an inverted cone), thereby enlarging the insertion hole 123, thereby enabling the sampling head 23 to pass through the insertion hole 123, and the insertion hole 123 is completely covered on the sampling head 23, thereby scraping off excess biological tissue on the sampling head 23, and after the sampling head 23 passes through, the insertion hole 123 is covered on the sampling rod 22, thereby sealing the insertion hole 123 to prevent the solvent from leaking from the insertion hole 123.

[0050] The main cavity 16 includes a first cavity 161 and a second cavity 162 connected up and down. The first cavity 161 is located on the upper side of the second cavity 162. The second cavity 162 is a vertical columnar space. The scraper 12 is installed in the second cavity 162. The outer diameter of the mounting ring 121 matches the inner diameter of the second cavity 162.

[0051] The columnar second cavity 162 enables the scraper 12 to be better installed in the main cavity 16 , preventing the solvent on the lower side of the scraper 12 from leaking from between the scraper 12 and the inner wall of the second cavity 162 .

[0052] An annular sealing ring 124 is provided on the outer wall of the mounting ring 121 along the circumference of the mounting ring 121 .

[0053] The overall outer diameter of the mounting ring 121 matches the second cavity 162, and a sealing ring 124 is provided on the outer wall of the mounting ring 121, so that when the scraper 12 is installed in the second cavity 162, the inner wall of the second cavity 162 can be squeezed and matched with the scraper 12, thereby improving the sealing between the mounting ring 121 and the inner wall of the second cavity 162.

[0054] There are two sealing rings 124 , and the two sealing rings 124 are spaced apart in the axial direction of the mounting ring 121 .

[0055] The first diaphragm 122 is located in the middle of the mounting ring 121 , and the two sealing rings 124 are respectively located on both sides of the first diaphragm 122 , and in the axial direction, the distances between the two sealing rings 124 and the diaphragm are equal.

[0056] Providing two sealing rings 124 further improves the sealing performance.

[0057] In the axial direction of the mounting ring 121, the channel includes a first equal diameter section 125, a second equal diameter section 126 and a third equal diameter section 127 which are connected in sequence, the diameter of the first equal diameter section 125 is equal to the diameter of the third equal diameter section 127, the diameter of the second equal diameter section 126 is smaller than the diameter of the first equal diameter section 125, and the first diaphragm 122 is located in the second equal diameter section 126.

[0058] In actual application, when the sampling head 23 moves downward, the lower end of the sampling head 23 first enters the larger first equal-diameter section 125. Since the diameter of the first equal-diameter section 125 is larger, it is convenient for the sampling head 23 to enter. Then, under the guidance of the first equal-diameter section 125, the lower end of the sampling head 23 can enter the second equal-diameter section 126, ensuring that the lower end of the sampling head 23 can smoothly contact the through hole 123 on the first diaphragm 122.

[0059] The channel also includes a first reducing section 128 and a second reducing section 129. The first equal diameter section 125 is connected to the second equal diameter section 126 via the first reducing section 128, and the second equal diameter section 126 is connected to the third equal diameter section 127 via the second reducing section 129. Along the direction from the first equal diameter section 125 to the second equal diameter section 126, the diameter of the first reducing section 128 gradually decreases. The diameter of the large end of the first reducing section 128 is equal to the diameter of the first equal diameter section 125 and is connected to the first equal diameter section 125. The diameter of the small end of the first reducing section 128 is equal to the diameter of the second equal diameter section 126 and is connected to the second equal diameter section 126.

[0060] Along the direction from the second equal diameter section 126 to the third equal diameter section 127, the diameter of the second diameter reducing section 129 gradually increases, the diameter of the small end of the second diameter reducing section 129 is equal to the diameter of the second equal diameter section 126 and is connected to the second equal diameter section 126, and the diameter of the large end of the second diameter reducing section 129 is equal to the diameter of the third equal diameter section 127 and is connected to the third equal diameter section 127.

[0061] In particular, the provision of the first reduced diameter section 128 can guide the lower end of the sampling head 23 to enter the second equal diameter section 126 , making it easier for the lower end of the sampling head 23 to enter the insertion hole 123 .

[0062] The lower part of the tube body 11 forms a second opening, and the communicating cavity 17 is communicated with the second opening. The tube body assembly 1 further comprises a lower cover 15, and the lower cover 15 is sealed and installed on the second opening from the lower side and closes the second opening from the lower side.

[0063] The lower cover 15 and the tube body 11 are two independent components, which facilitates the processing of the two. During assembly, the lower cover 15 is inserted into the second opening from the bottom. At the same time, a sealing ring can be provided on the lower cover 15 to seal the second opening and prevent the solvent from leaking from the second opening.

[0064] The lower cover 15 is also connected to an auxiliary ring 152 and a support platform 151, wherein the auxiliary ring 152 is an annular structure and the support platform 151 is a columnar structure;

[0065] The lower cover 15 includes a cover bottom and a cover wall, the cover wall is connected to the edge of the cover bottom, the auxiliary ring 152 and the support platform 151 are both connected to the cover bottom, the auxiliary ring 152 and the support platform 151 are both located on the inner side of the cover wall, the upper surface of the auxiliary ring 152 is flush with the upper surface of the support platform 151, the support platform 151 is located on the inner side of the auxiliary ring 152, the upper surface of the auxiliary ring 152 is in contact with the lower end surface of the inner wall of the main cavity 16, and the auxiliary ring 152 is provided with a notch 153 for solution circulation.

[0066] The support platform 151 is arranged so that when the sampling rod 22 moves downward, the lower end of the sampling rod 22 first contacts the second diaphragm 14, causing the second diaphragm 14 to deform downward until the lower end of the sampling rod 22 contacts the upper end surface of the support platform 151, thereby piercing the second diaphragm 14, and the solvent can flow into the connecting cavity 17 (the space surrounded by the auxiliary ring 152), and then flow out through the notch 153 to contact the lower end of the test strip 13.

[0067] The utility model further provides a scraping member, and the scraping member 12 is the scraping member 12 in the aforementioned biological sample device, and its specific structure and function have been described in the foregoing text, and will not be repeated here.

[0068] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present invention, various obvious or equivalent modifications or substitutions that can be made by technicians in this field to the above details will be included in the scope of the claims of the present invention.

Claims

1. A biological sample detection device for detecting a target in a biological sample, It is characterized in that It comprises a tube body assembly and a sampling assembly, wherein the tube body assembly comprises a tube body, a scraper and a test paper strip, wherein the upper portion of the tube body forms a first opening, wherein the tube body is provided with a main cavity, a connecting cavity and a test paper cavity, wherein the upper portion of the main cavity is connected to the first opening, wherein the main cavity and the test paper cavity are arranged side by side, and wherein the lower portion of the main cavity and the lower portion of the test paper cavity are both connected to the connecting cavity; The scraper is made of rubber or silicone in one piece, and includes a mounting ring and a first diaphragm. The mounting ring is a cylindrical structure, a channel is provided in the mounting ring, the first diaphragm is perpendicular to the axis of the mounting ring, the first diaphragm is fixed in the mounting ring, a through hole is provided in the middle of the first diaphragm, and the outer wall of the mounting ring is sealed and fitted with the inner wall of the main cavity; A second diaphragm is provided between the main cavity and the communicating cavity, and the second diaphragm separates the main cavity and the communicating cavity; The test paper strip is inserted into the test paper cavity, and the lower end of the test paper strip extends into the communicating cavity; The sampling assembly includes an upper cover and a sampling rod, the sampling rod is connected to the upper cover, a sampling head is provided at the lower part of the sampling rod, the lower end of the sampling head is sharp, the sampling rod extends from the opening into the main cavity, the diameter of the insertion hole is smaller than the diameter of the sampling rod, the sampling rod passes through the insertion hole, and the sampling head is located between the first diaphragm and the second diaphragm.

2. The biological sample detection device according to claim 1, It is characterized in that The main cavity includes a first cavity and a second cavity connected up and down, the first cavity is located on the upper side of the second cavity, the second cavity is a vertical columnar space, the scraper is installed in the second cavity, and the outer diameter of the mounting ring matches the inner diameter of the second cavity.

3. The biological sample detection device according to claim 2, It is characterized in that An annular sealing ring is provided on the outer wall of the mounting ring along the circumference of the mounting ring.

4. The biological sample detection device according to claim 3, It is characterized in that The number of the sealing rings is two, and the two sealing rings are arranged at intervals in the axial direction of the mounting ring; The first diaphragm is located in the middle of the mounting ring, and the two sealing rings are respectively located on both sides of the first diaphragm, and in the axial direction, the distances between the two sealing rings and the diaphragm are equal.

5. The biological sample detection device according to claim 4, It is characterized in that In the axial direction of the mounting ring, the channel includes a first equal-diameter section, a second equal-diameter section and a third equal-diameter section connected in sequence, the diameter of the first equal-diameter section is equal to the diameter of the third equal-diameter section, the diameter of the second equal-diameter section is smaller than the diameter of the first equal-diameter section, and the first diaphragm is located in the second equal-diameter section.

6. The biological sample detection device according to claim 5, It is characterized in that The channel further includes a first diameter-reducing section and a second diameter-reducing section, the first constant diameter section and the second constant diameter section are connected via the first diameter-reducing section, the second constant diameter section and the third constant diameter section are connected via the second diameter-reducing section, the diameter of the first diameter-reducing section gradually decreases along the direction from the first constant diameter section to the second constant diameter section, the diameter of the large end of the first diameter-reducing section is equal to the diameter of the first constant diameter section and is connected to the first constant diameter section, the diameter of the small end of the first diameter-reducing section is equal to the diameter of the second constant diameter section and is connected to the second constant diameter section; Along the direction from the second equal-diameter section to the third equal-diameter section, the diameter of the second diameter-changing section gradually increases, the diameter of the small end of the second diameter-changing section is equal to the diameter of the second equal-diameter section and is connected to the second equal-diameter section, and the diameter of the large end of the second diameter-changing section is equal to the diameter of the third equal-diameter section and is connected to the third equal-diameter section.

7. The biological sample detection device according to any one of claims 1 to 6, It is characterized in that A second opening is formed at the lower part of the tube body, and the communicating cavity is communicated with the second opening. The tube body assembly further comprises a lower cover, which is sealed and installed on the second opening from the lower side and closes the second opening from the lower side.

8. The biological sample detection device according to claim 7, It is characterized in that The lower cover is also connected to an auxiliary ring and a support platform, wherein the auxiliary ring is an annular structure and the support platform is a columnar structure; The lower cover includes a cover bottom and a cover wall, the cover wall is connected to the edge of the cover bottom, the auxiliary ring and the support platform are both connected to the cover bottom, the auxiliary ring and the support platform are both located on the inner side of the cover wall, the upper surface of the auxiliary ring is flush with the upper surface of the support platform, the support platform is located on the inner side of the auxiliary ring, the upper surface of the auxiliary ring is in contact with the lower end surface of the inner wall of the main cavity, and the auxiliary ring is provided with a notch for solution circulation.

9. A scraping member, It is characterized in that The scraping member is the scraping member in the biological sample detection device according to any one of claims 1 to 8.

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