Mouse rectal administration fixing anesthesia device

Abstract

The utility model discloses a mouse rectal administration fixed anesthesia device, which relates to the technical field of scientific research experiments, and comprises an outer tube and an inner tube, the inner tube is arranged inside the outer tube, the left end of the outer tube is fixedly connected with a first adjustable fan blade ventilation device, and the inside of the outer tube and the left side of the inner tube are fixedly connected with a second adjustable fan blade ventilation device. An anesthetic containing area is formed by the first adjustable fan blade ventilation device, the second adjustable fan blade ventilation device and the interior of the outer pipe, anesthetic cotton balls are arranged in the anesthetic containing area, a first rat tail groove is formed in the right end of the upper side of the outer pipe, and a second rat tail groove is formed in the position, corresponding to the first rat tail groove, of the right end of the upper side of the inner pipe. The device has the advantages that the ventilatory capacity of inhaled anesthetic is controlled in real time according to the anesthesia condition and physiological status of a mouse, the mouse is prevented from escaping through the first mouse tail groove formed in the outer side of the outer tube, the second mouse tail groove formed in the outer side of the inner tube and the limiting clamping bolt, and rectal administration operation is conveniently carried out after the mouse tail is fixed and the anus is exposed.

Description

Technical Field

[0001] The utility model belongs to the field of scientific research experiments, and in particular relates to a mouse rectal drug administration and anesthesia fixing device. Background Art

[0002] Many clinical treatment operations, such as "enema administration", are often easily damaged in the rectum due to factors such as animal resistance when applied to animal models. Some models also require rectal administration, but especially for mice, whose rectum is short and narrow, it is more prone to damage. However, the mouse model undoubtedly has obvious advantages in cost and breeding, so many studies use rectal operations after anesthesia. However, for experiments that require repeated operations, a suitable fixed anesthesia device is needed to reduce rectal damage to mice and facilitate operation. Existing devices often cannot control the depth of anesthesia and the fixed device is not conducive to the exposure of the anus.

[0003] For example, a device that can be used for rectal drug administration or microbiota transplantation in mice is disclosed in Chinese Patent (201920169345.8), including a mouse fixer and a mouse drug administration tube. The mouse fixer is cylindrical and includes a head fixer, a fixer tube body, a tail rubber stopper and an elastic rubber ring. The mouse drug administration tube includes a tube body and a joint. The utility model can efficiently complete the operation of rectal drug administration or microbiota transplantation in mice, reduce drug solution leakage, and avoid mechanical damage such as intestinal bleeding. At the same time, the device can be handheld or placed on a desktop. It is also simple, flexible, easy to operate, low in production cost, and easy to carry.

[0004] However, the above device still has some disadvantages.

[0005] 1. There is no matching simple inhalation anesthesia device. The anus cannot relax without anesthesia. Excessive inhalation anesthesia or intravenous / peritoneal anesthesia is not conducive to multiple operations on mice and is prone to death;

[0006] 2. Existing simple inhalation anesthesia often uses masks and poorly ventilated devices, which cannot control the depth of inhalation anesthesia in many ways;

[0007] 3. The mouse anus was not well exposed during the operation, and there was no appropriate device to fix the mouse tail. Summary of the invention

[0008] The utility model aims to provide a mouse rectal drug administration and fixation anesthesia device which is equipped with an anesthesia device and can control the anesthesia inhalation amount and fix the mouse tail.

[0009] The technical solution is as follows:

[0010] A fixed anesthesia device for rectal drug administration in mice comprises an outer tube and an inner tube, wherein the inner tube is arranged inside the outer tube, a first adjustable fan blade ventilation device is fixedly connected to the left end of the outer tube, a second adjustable fan blade ventilation device is fixedly connected inside the outer tube and to the left side of the inner tube, the first adjustable fan blade ventilation device and the second adjustable fan blade ventilation device form an anesthetic placement area with the inside of the outer tube, an anesthetic cotton ball is arranged inside the anesthetic placement area, a first mouse tail groove is opened at the upper right end of the outer tube, a second mouse tail groove is opened at the upper right end of the inner tube at a position corresponding to the first mouse tail groove, and a square base is fixedly connected to the right side of the outer tube.

[0011] In one embodiment, the square base has a rectangular cross-section and is an integral structure with the outer tube.

[0012] In one of the embodiments, a fastening strip is provided at the right end of the inner tube, the fastening strip is L-shaped, and the fastening strip is fastened to the inside of the square base.

[0013] In one of the embodiments, a ventilation plate is fixedly connected to the left end of the inner tube, and ventilation holes are formed through the surface of the ventilation plate.

[0014] In one of the embodiments, a bolt hole is formed through the top of the square base, and a limit bolt is inserted into the bolt hole.

[0015] In one embodiment, the outer tube and the inner tube are both made of transparent acrylic material.

[0016] In one embodiment, the outer diameter of the fastening strip is greater than the outer diameter of the outer tube.

[0017] In one of the embodiments, rubber anti-slip rings are provided on the outer sides of the first adjustable fan blade ventilation device and the second adjustable fan blade ventilation device.

[0018] In one embodiment, the inner tube is 20 to 25 centimeters long and 10 to 15 centimeters in diameter.

[0019] In one embodiment, the inner tube and the outer tube are clearance-fitted, and the fitting accuracy is two millimeters to five millimeters.

[0020] The technical solution provided by the utility model has the following advantages and effects:

[0021] 1. The utility model controls the flow rate of inhaled anesthetics through the first adjustable fan blade ventilation device and the second adjustable fan blade ventilation device, and at the same time, combines the method in which the inner tube can be pulled outward to control the distance between the mouse's mouth and nose and the anesthetic cotton ball, thereby achieving safe and controllable anesthesia.

[0022] 2. The utility model prevents mice from escaping and conveniently fixes the mouse tail through the first mouse tail groove arranged on the outside of the outer tube, the second mouse tail groove arranged on the outside of the inner tube and the limit bolt, so as to perform rectal drug administration after exposing the anus.

[0023] 3. Control the ventilation volume of inhaled anesthetics in real time according to the anesthesia status and physiological state of the mice.

[0024] 4. The utility model uses a square base. When the device is placed flat on the table, movement is reduced and the device is appropriately raised, which is conducive to the retention of rectal drugs and prevents backflow.

[0025] 5. Both the outer tube and the inner tube are made of transparent acrylic material, which is convenient for observing the status of mice and disinfection, and removable rubber anti-slip rings are added at the two fan blade adjustment devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of an embodiment of the utility model;

[0027] Figure 2 An exploded view of an embodiment of the utility model;

[0028] Figure 3 It is a schematic diagram of the internal structure of an embodiment of the utility model;

[0029] Figure 4 for Figure 3 A partial enlarged view of point A in the middle.

[0030] Description of reference numerals:

[0031] 1. Outer tube; 2. Square base; 3. First adjustable fan blade ventilation device; 4. First rat tail groove; 5. Second adjustable fan blade ventilation device; 6. Anesthetic placement area; 7. Anesthetic cotton ball; 8. Inner tube; 9. Second rat tail groove; 10. Breathable plate; 11. Bolt hole; 12. Limit bolt; 13. Buckle strip; 14. Rubber anti-skid ring. DETAILED DESCRIPTION

[0032] In order to facilitate the understanding of the present invention, specific embodiments of the present invention will be described in more detail below with reference to the accompanying drawings.

[0033] Unless otherwise specified or defined, the "first, second..." used in this article is merely used to distinguish names and does not represent a specific quantity or order.

[0034] Unless specifically stated or defined otherwise, the term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0035] It should be noted that, in this document, “fixed to” or “connected to” may mean directly fixing or connecting to an element, or indirectly fixing or connecting to an element.

[0036] like Figure 1-4 The fixed anesthesia device for rectal drug administration to mice shown in the figure comprises an outer tube 1 and an inner tube 8, wherein the inner tube 8 is arranged inside the outer tube 1, a first adjustable fan blade ventilation device 3 is fixedly connected to the left end of the outer tube 1, a second adjustable fan blade ventilation device 5 is fixedly connected to the inside of the outer tube 1 and the left side of the inner tube 8, the first adjustable fan blade ventilation device 3 and the second adjustable fan blade ventilation device 5 form an anesthetic placement area 6 with the inside of the outer tube 1, an anesthetic cotton ball 7 is arranged inside the anesthetic placement area 6, a first mouse tail groove 4 is opened at the upper right end of the outer tube 1, a second mouse tail groove 9 is opened at the upper right end of the inner tube 8 corresponding to the first mouse tail groove 4, and a square base 2 is fixedly connected to the right side of the outer tube 1.

[0037] Please refer to Figure 1 As shown, the cross section of the square base 2 is rectangular and is an integrated structure with the outer tube 1. The square base 2 reduces the movement of the outer tube 1 after it is placed flat on the table and is appropriately raised, which is conducive to the retention of rectal drugs and prevents them from backflowing.

[0038] Please refer to Figure 4 As shown, a fastening strip 13 is provided at the right end of the inner tube 8 . The fastening strip 13 is L-shaped and fastened to the inside of the square base 2 .

[0039] Please refer to Figure 2 and Figure 3 As shown, the left end of the inner tube 8 is fixedly connected to a breathable plate 10, and breathable holes are opened through the surface of the breathable plate 10. The size and number of the breathable holes can be designed as needed, so that the inflow of the drug can meet specific requirements, ensuring accurate control of the anesthetic effect. Through the breathable holes, the drug can flow evenly over the entire surface of the breathable plate 10, avoiding excessive or insufficient accumulation of the drug in a specific area, thereby improving the uniformity and stability of the anesthetic effect.

[0040] Please refer to Figure 2 As shown, a latch hole 11 is formed on the top of the square base 2 , and a limit latch 12 is inserted into the latch hole 11 .

[0041] Please refer to Figure 2 As shown, the outer tube 1 and the inner tube 8 are both made of fully transparent acrylic material. The transparent material is conducive to observing the state of the mouse, controlling the amount of anesthetic inhaled, and is also convenient for disinfection.

[0042] Please refer to Figure 4 As shown, the outer diameter of the fastening strip 13 is greater than the outer diameter of the outer tube 1, and the fastening strip 13 is wider than the tube body of the outer tube 1, which can prevent the inner tube 8 from sliding into the outer tube 1, making it difficult to pull out the inner tube 8.

[0043] Please refer to Figure 2 As shown, rubber anti-slip rings 14 are provided on the outer sides of the first adjustable fan blade ventilation device 3 and the second adjustable fan blade ventilation device 5, and the first adjustable fan blade ventilation device 3 and the second adjustable fan blade ventilation device 5 are of adjustable and rotatable design.

[0044] Please refer to Figure 2 As shown, the inner tube 8 is 20 to 25 centimeters long and 10 to 15 centimeters in diameter. The size of the inner tube 8 can be customized according to the size of the mouse, and there are no specific restrictions.

[0045] Please refer to Figure 1 and Figure 2 As shown, the inner tube 8 and the outer tube 1 are clearance-fitted, and the fitting accuracy is two to five millimeters. The clearance fit facilitates the pulling of the inner tube 8 inside the outer tube 1, and can reduce friction, making the pulling of the inner tube 8 smoother and easier to operate.

[0046] Working principle: Before the experiment, the first adjustable fan blade ventilation device 3 is disassembled, and the anesthetic cotton ball 7 is placed in the anesthetic placement area 6. Then the inner tube 8 is sleeved on the inside of the outer tube 1 so that the first mouse tail groove 4 and the second mouse tail groove 9 are aligned. Then, the mouse is placed inside the inner tube 8 and the mouse's tail is placed into the first mouse tail groove 4 and the second mouse tail groove 9. Then, the limiting bolt 12 is inserted into the bolt hole 11. The limiting bolt 12 will limit the ends of the first mouse tail groove 4 and the second mouse tail groove 9. Even if the mouse tail is upright, it will not fall down. When the mouse tail stands up, the anus will be exposed. Then, the drug is injected into the mouse rectum through the injection needle.

[0047] The above embodiments are not exhaustive enumerations based on the present invention, and there may be multiple other implementations not listed. Any replacement and improvement made without violating the concept of the present invention shall fall within the protection scope of the present invention.

Claims

1. A fixed anesthesia device for rectal administration of drugs to mice, characterized in that: It comprises an outer tube and an inner tube, the inner tube is arranged inside the outer tube, the left end of the outer tube is fixedly connected with a first adjustable fan blade ventilation device, the inside of the outer tube and the left side of the inner tube are fixedly connected with a second adjustable fan blade ventilation device, the first adjustable fan blade ventilation device and the second adjustable fan blade ventilation device form an anesthetic placement area with the inside of the outer tube, an anesthetic cotton ball is arranged inside the anesthetic placement area, a first rat tail groove is opened at the upper right end of the outer tube, a second rat tail groove is opened at the upper right end of the inner tube and at a position corresponding to the first rat tail groove, and a square base is fixedly connected to the right side of the outer tube.

2. The mouse rectal drug delivery fixed anesthesia device according to claim 1, characterized in that: The square base has a rectangular cross section and is an integral structure with the outer tube.

3. The mouse rectal drug delivery fixed anesthesia device according to claim 1, characterized in that: A buckle strip is arranged at the right end of the inner tube, the buckle strip is L-shaped, and the buckle strip is buckled with the inside of the square base.

4. The mouse rectal drug delivery fixed anesthesia device according to claim 3, characterized in that: The outer diameter of the fastening strip is greater than the outer diameter of the outer tube.

5. The mouse rectal drug delivery fixed anesthesia device according to claim 1, characterized in that: The left end of the inner tube (8) is fixedly connected to a ventilation plate, and ventilation holes are formed through the surface of the ventilation plate.

6. The mouse rectal drug delivery fixed anesthesia device according to any one of claims 1 to 5, characterized in that: A bolt hole is formed on the top of the square base, and a limit bolt is inserted into the bolt hole.

7. The mouse rectal drug delivery fixed anesthesia device according to any one of claims 1 to 5, characterized in that: The outer tube and the inner tube are both made of fully transparent acrylic.

8. The mouse rectal drug delivery fixed anesthesia device according to any one of claims 1 to 5, characterized in that: Rubber anti-slip rings are arranged on the outer sides of the first adjustable fan blade ventilation device and the second adjustable fan blade ventilation device.

9. The mouse rectal drug delivery fixed anesthesia device according to any one of claims 1 to 5, characterized in that: The inner tube is 20 to 25 centimeters long and 10 to 15 centimeters in diameter.

10. The mouse rectal drug delivery fixed anesthesia device according to any one of claims 1 to 5, characterized in that: The inner tube and the outer tube are clearance-matched, and the matching accuracy is two millimeters to five millimeters.

Images