A muscle antagonist drug processing device
Patent Information
- Application Number
- CN202521936486.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-09
- Publication Date
- 2026-09-11
- Estimated Expiration
- 2035-09-09
AI Technical Summary
[0003]传统反应釜在合成肌肉拮抗剂等高附加值原料药时，因其结构单一、搅拌效率低下，常导致反应体系传质传热不均，具体表现为：釜内易出现温度梯度和浓度死角，使反应副产物增多、选择性下降，严重影响中间体纯度和最终收率；尤其对于非均相或高粘度体系，常规桨叶难以实现充分混合，不仅延长反应时间，更可能因局部过热或混合不匀导致药物降解或安全生产事故，成为提升产品质量与合成效率的关键瓶颈，
使用时，启动电机，其输出动力直接驱动中心轴进行旋转，此为主动力的输入；中心轴的转动带动其下部固定连接的搅拌杆随之进行主要的旋转运动，此为主体公转，它负责对釜内物料产生大范围的宏观流动和循环，形成主要的混合基础；与此同时，创新的辅助搅拌件开始发挥关键作用：由于辅助搅拌件通过上部固定的齿轮与静止安装在反应釜上部的齿环相啮合，当中心轴带动整个搅拌杆组件公转时，辅助搅拌件上的齿轮会沿着固定齿环的内齿圈发生啮合滚动；这种机械啮合关系，将搅拌杆的公转运动巧妙地转换为辅助搅拌件绕其自身轴线的自转运动，其转速与公转速度成严格比例关系；最终，装置内部形成了双重强力搅拌场：中心搅拌杆的公转负责主体循环，防止底部沉积；而多个辅助搅拌件的快速自转则如同高速均质器，在公转轨迹的各个点上对物料产生强烈的局部剪切、撕裂和湍流效应，能高效打碎团块、消除温度与浓度死角，确保反应物料在分子级别的均匀混合，极大提升了肌肉拮抗剂合成反应的效率、纯度和一致性。
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Figure CN224736281U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of drug processing technology, and specifically relates to a drug processing device for muscle antagonists. Background Technology
[0002] Muscle antagonists are a class of drugs that inhibit skeletal muscle contraction by blocking the binding of acetylcholine to N-type receptors at the neuromuscular junction. They are mainly divided into depolarizing agents such as succinylcholine and non-depolarizing agents such as rocuronium bromide and vecuronium bromide. Clinically, they are widely used for muscle relaxation during general anesthesia, mechanical ventilation management in intensive care units, and short-term muscle relaxation required for certain diagnostic or therapeutic procedures such as endotracheal intubation and endoscopy.
[0003] Traditional reaction vessels, due to their simple structure and low stirring efficiency, often lead to uneven mass and heat transfer in the reaction system when synthesizing high-value-added active pharmaceutical ingredients such as muscle antagonists. Specifically, this manifests as temperature gradients and concentration dead zones within the vessel, increasing reaction byproducts, reducing selectivity, and severely impacting intermediate purity and final yield. Especially for heterogeneous or high-viscosity systems, conventional impellers struggle to achieve thorough mixing, prolonging reaction time and potentially causing drug degradation or safety accidents due to localized overheating or uneven mixing. This becomes a key bottleneck in improving product quality and synthesis efficiency. Utility Model Content The purpose of this invention is to address the shortcomings of existing technologies by proposing a device for processing muscle antagonist drugs.
[0004] To achieve the above objectives, this utility model provides a muscle antagonist drug processing device, including a reaction vessel and a stirring assembly. The stirring assembly includes a central shaft, with a stirring rod fixedly connected to the lower part of the central shaft. An auxiliary stirring component is rotatably mounted on the upper part of the stirring rod, and a gear is fixedly connected to the upper part of the stirring component, meshing with the gear inside a gear ring fixed on the upper part of the reaction vessel. A motor is also included to drive the central shaft. The central shaft, driven by the motor, causes the stirring rod to revolve around the central shaft and is constrained by the gear ring to cause the auxiliary stirring component to rotate on its own axis. In the above technical solution, further, the stirring rod is provided with multiple stirring rods, and an auxiliary stirring component is rotatably installed on the upper part of each stirring rod.
[0005] In the above technical solution, a lid is fixedly installed on the upper part of the reactor, the input end of the gearbox fixedly installed on the upper part of the lid is fixedly connected to the output shaft of the motor, and the motor is fixed on one side of the gearbox, and the central shaft is fixed on the output end of the gearbox.
[0006] In the above technical solution, further, a plurality of support columns are fixedly installed at the lower part of the reactor, and the plurality of support columns are used to support the reactor. In the above technical solution, the reactor is further provided with a gas channel for transmitting heating gas, and a control valve for discharging material is fixedly installed at the bottom of the reactor. In the above technical solution, the auxiliary stirring component further includes a rotating tube rotatably mounted on the upper part of the stirring rod, and a plurality of mixing plates are uniformly installed on the outer circumference of each rotating tube; In another technical solution, the gear is fixed to the upper part of the rotating tube, a fixed plate is fixedly connected to the outside of the stirring rod, a spring telescopic rod is obliquely installed on the outside of the fixed plate, and a scraper is fixedly connected to the end of the spring telescopic rod away from the fixed plate. The shape of the scraper is movably fitted with the inner wall of the reaction vessel. In use, the rotating tube rotates at high speed, causing the scraper to overcome the tension of the spring telescopic rod and stick to the inner wall of the reactor under the action of centrifugal force to perform a scraping and cleaning action.
[0007] In the above technical solution, the spring telescopic rod further includes a fixed tube fixed to the upper part of the fixed plate, a knob rotatably installed on one side of the fixed tube and rotatably connected to the fixed plate, a screw fixed inside the knob and a slider slidably installed inside the fixed tube are screwed together, the slider is connected to a sliding rod slidably installed inside the fixed tube by a spring, and one end of the sliding rod extends through the fixed tube to the outside and is fixedly connected to the scraper.
[0008] Compared with the prior art, the present invention has the following beneficial effects: During operation, the motor is started, and its output power directly drives the central shaft to rotate, which is the main power input. The rotation of the central shaft drives the stirring rod fixedly connected to its lower part to perform the main rotational motion, which is the main revolution. It is responsible for generating a large-scale macroscopic flow and circulation of the material in the reactor, forming the main mixing basis. At the same time, the innovative auxiliary stirring component begins to play a key role: because the auxiliary stirring component meshes with a gear fixed at the top and a toothed ring stationary on the upper part of the reactor, when the central shaft drives the entire stirring rod assembly to revolve, the gear on the auxiliary stirring component will mesh and roll along the inner toothed ring of the fixed toothed ring. The mechanical meshing relationship cleverly converts the revolution of the stirring rod into the rotation of the auxiliary stirring components around their own axes, with the rotational speed strictly proportional to the revolution speed. Ultimately, a dual-force stirring field is formed inside the device: the revolution of the central stirring rod is responsible for the main circulation and prevents bottom sedimentation; while the rapid rotation of multiple auxiliary stirring components acts like a high-speed homogenizer, generating strong local shearing, tearing, and turbulence effects on the materials at various points along the revolution trajectory. This effectively breaks up clumps, eliminates temperature and concentration dead zones, and ensures uniform mixing of reactants at the molecular level, greatly improving the efficiency, purity, and consistency of the muscle antagonist synthesis reaction. Attached Figure Description
[0009] Figure 1 This is a schematic diagram of the overall structure proposed in this utility model; Figure 2 This is a schematic diagram of the cross-sectional structure of the reaction vessel proposed in this utility model; Figure 3 This is a schematic diagram of the stirring assembly structure proposed in this utility model; Figure 4 The present utility model proposes Figure 3 Schematic diagram of the structure at point A in the middle; Figure 5 This is a schematic diagram of the stirring assembly structure according to another embodiment of the present invention; Figure 6 This is a schematic diagram of the spring telescopic rod structure of this utility model.
[0010] In the diagram: 1. Reactor; 2. Reactor lid; 3. Gearbox; 4. Motor; 5. Stirring assembly; 6. Support column; 7. Control valve; 8. Gas duct; 501. Central shaft; 502. Stirring rod; 503. Rotary tube; 504. Mixing plate; 505. Gear; 506. Gear ring; 507. Fixing plate; 508. Spring telescopic rod; 509. Scraper; 5081, Fixed tube; 5082, Knob; 5083, Lead screw; 5084, Slider; 5085, Slide bar. Detailed Implementation
[0011] To better understand the above-mentioned objectives, features and advantages of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.
[0012] like Figures 1-6 The apparatus shown is a muscle antagonist drug processing device, including a reaction vessel 1 and a stirring assembly 5. The stirring assembly 5 includes a central shaft 501, with a stirring rod 502 fixedly connected to the lower part of the central shaft 501. An auxiliary stirring component is rotatably mounted on the upper part of the stirring rod 502, and a gear 505 is fixedly connected to the upper part of the stirring component. A gear ring 506 fixed on the upper part of the reaction vessel 1 meshes with the gear 505. A motor 4 drives the central shaft 501. The central shaft 501 is driven by the motor 4 to make the stirring rod 502 revolve and is constrained by the gear ring 506 to make the auxiliary stirring component rotate. The core of the aforementioned muscle antagonist drug processing device lies in realizing a composite stirring mode that combines revolution and rotation, so as to completely solve the problem of uneven mixing in the traditional reaction vessel 1. When in use, start motor 4, and its output power directly drives the central shaft 501 to rotate. This is the input of the main power. The rotation of the central shaft 501 drives the stirring rod 502 fixedly connected to its lower part to perform the main rotational motion. This is the main revolution, which is responsible for generating a large-scale macroscopic flow and circulation of the material in the vessel, forming the main mixing basis. At the same time, the innovative auxiliary stirring component begins to play a key role: since the auxiliary stirring component meshes with the gear ring 506 stationary on the upper part of the reactor 1 through the gear 505 fixed at the top, when the central shaft 501 drives the entire stirring rod 502 assembly to revolve, the gear 505 on the auxiliary stirring component will mesh and roll along the inner gear ring of the fixed gear ring 506. This mechanical meshing relationship cleverly converts the revolution of the stirring rod 502 into the rotation of the auxiliary stirring component around its own axis, and its rotation speed is strictly proportional to its revolution speed. Ultimately, a dual-force stirring field is formed inside the device: the revolution of the central stirring rod 502 is responsible for the main circulation and prevents bottom sedimentation, while the rapid rotation of multiple auxiliary stirring components acts like a high-speed homogenizer, generating strong local shearing, tearing and turbulence effects on the materials at various points of the revolution trajectory. This can efficiently break up clumps, eliminate temperature and concentration dead zones, and ensure uniform mixing of reactants at the molecular level, greatly improving the efficiency, purity and consistency of the muscle antagonist synthesis reaction.
[0013] In this embodiment, multiple stirring rods 502 are provided, and an auxiliary stirring component is rotatably installed on the upper part of each stirring rod 502; a lid 2 is fixedly installed on the upper part of the reactor 1, and the input end of the gearbox 3 fixedly installed on the upper part of the lid 2 is fixedly connected to the output shaft of the motor 4, and the motor 4 is fixed on one side of the gearbox 3, and the central shaft 501 is fixed on the output end of the gearbox 3; furthermore, a number of support columns 6 are fixedly installed on the lower part of the reactor 1, and the number of support columns 6 are used to support the reactor 1. After the motor 4 starts, its output shaft transmits power to the input end of the gearbox 3. After the gearbox 3 adjusts the torque and speed, the output end drives the central shaft 501 to rotate under optimal operating conditions. The central shaft 501 drives multiple circumferentially distributed stirring rods 502 to revolve synchronously, forming the main circulation flow. At the same time, the gear 505 on the top of each auxiliary stirring component meshes with the gear ring 506 fixed on the upper part of the reactor 1, and is forced to rotate during the revolution. This compound motion causes the auxiliary stirring components to generate high-intensity local shear on the basis of macroscopic circulation, completely eliminating mixing dead zones and concentration gradients, and ensuring the uniformity of the reaction system. The configuration of the gearbox 3 enables precise control of the stirring intensity to adapt to reaction media of different viscosities. The bottom support column 6 ensures the structural stability and safety of the entire drive system during high-speed operation, thereby significantly improving the efficiency of muscle antagonist synthesis reaction and product purity.
[0014] In this embodiment, the reactor 1 is provided with a gas channel 8 for transmitting heating gas, and a control valve 7 for discharging material is fixedly installed at the lower part of the reactor 1; the auxiliary stirring component includes a rotating tube 503 rotatably installed on the upper part of the stirring rod 502, and several mixing plates 504 are evenly installed on the outer circumference of each rotating tube 503.
[0015] Heating gas is introduced through the pre-set gas channel 8 inside the reactor 1 wall to achieve indirect and uniform temperature control of the materials, ensuring precise and stable temperature of the reaction system. During stirring, the motor 4 drives the central shaft 501 to rotate multiple stirring rods 502. At the same time, the rotating tube 503 of each auxiliary stirring component rotates at high speed due to the meshing of its top gear 505 with the fixed gear ring 506, which drives the circumferentially distributed mixing plate 504 to vigorously stir the materials. This composite motion can generate both macroscopic circulation flow and high-intensity local shear, which greatly improves heat transfer efficiency and reaction uniformity. After the reaction is completed, the materials can be completely and quickly discharged through the control valve 7 below the reactor, effectively avoiding residue. The whole design significantly optimizes the temperature control accuracy, mixing efficiency and operation convenience of the muscle antagonist synthesis process.
[0016] In another embodiment, gear 505 is fixed to the upper part of the rotating tube 503, and a fixing plate 507 is fixedly connected to the outside of the stirring rod 502. A spring telescopic rod 508 is installed obliquely on the outside of the fixing plate 507. A scraper 509 is fixedly connected to the end of the spring telescopic rod 508 away from the fixing plate 507. The shape of the scraper 509 is movably fitted with the inner wall of the reactor 1. When in use, the rotating tube 503 rotates at high speed, driving the scraper 509 to overcome the tension of the spring telescopic rod 508 under the action of centrifugal force and stick to the inner wall of the reactor 1 to perform a scraping and cleaning action.
[0017] When the rotating tube 503 rotates at high speed, the fixed plate 507 fixedly connected to it rotates accordingly, and drives the scraper 509 hinged to it by the spring telescopic rod 508 to make a circular motion. Under the action of centrifugal force, the scraper 509 overcomes the pre-tightening force of the spring telescopic rod 508 and is thrown outward, so that it finally fits tightly against the inner wall of the reactor 1. As the rotating tube 503 continues to rotate, the scraper 509 scrapes circumferentially along the inner wall of the reactor 1, effectively removing reactant crystals, residues or deposits adhering to the wall surface, preventing the heat transfer efficiency from decreasing and avoiding the formation of reaction dead zones. When the rotation speed decreases or stops, the centrifugal force weakens, and the contraction force of the spring telescopic rod 508 pulls the scraper 509 away from the inner wall, avoiding unnecessary frictional wear when stationary. This design enables simultaneous stirring and self-cleaning, making it particularly suitable for the synthesis reaction system of muscle antagonists that are prone to crystallization or have high viscosity, thus ensuring the long-term stable heat transfer and mixing performance of reactor 1.
[0018] In this embodiment, the spring telescopic rod 508 includes a fixed tube 5081 fixed to the upper part of the fixed plate 507, a knob 5082 rotatably mounted on one side of the fixed tube 5081 and rotatably connected to the fixed plate 507, a lead screw 5083 fixed inside the knob 5082 and a slider 5084 slidably mounted inside the fixed tube 5081 are screwed together, the slider 5084 is connected to a slide rod 5085 slidably mounted inside the fixed tube 5081 by a spring, and one end of the slide rod 5085 extends through the fixed tube 5081 to the outside and is fixedly connected to the scraper 509.
[0019] The user rotates the knob 5082 to drive the lead screw 5083, which is fixedly connected to it, to rotate inside the fixed tube 5081. Since the lead screw 5083 and the slider 5084 are screwed together, the rotational motion is converted into the horizontal movement of the slider 5084. When knob 5082 is rotated in the direction that increases the spring preload, slider 5084 moves closer to slide bar 5085, locking the spring and reducing the initial preload tension of the spring on slide bar 5085. At this point, a smaller centrifugal force, i.e., a higher rotation speed, is needed to overcome this tension and allow scraper 509 to be thrown out and contact the inner wall of reactor 1. Conversely, rotating knob 5082 in the opposite direction moves slider 5084 away from slide bar 5085, stretching the spring and increasing the initial preload. At this point, the centrifugal force generated at a higher rotation speed is needed to overcome the spring tension and allow scraper 509 to adhere to the inner wall for scraping. This design enables precise and linear adjustment of the scraper 509's starting speed, allowing the operator to flexibly match the optimal cleaning mode according to the adhesion strength of the reactants, such as easily crystallizing or high-viscosity materials requiring a lower starting speed. This ensures efficient self-cleaning while maximizing adaptability to the process requirements of different synthesis stages and avoiding energy waste.
[0020] Working Principle: During operation, starting motor 4 directly drives the central shaft 501 to rotate, providing the main power input. The rotation of the central shaft 501 causes the stirring rod 502, fixedly connected to its lower part, to rotate accordingly, forming the main revolution. This revolution is responsible for generating a large-scale macroscopic flow and circulation of the materials inside the reactor, forming the main mixing basis. Simultaneously, the innovative auxiliary stirring component begins to play a crucial role: because the auxiliary stirring component meshes with the gear 506 stationary on the upper part of the reactor 1 via a fixed gear 505, when the central shaft 501 drives the entire stirring rod 502 assembly to revolve, the gear 505 on the auxiliary stirring component will move along the fixed gear 506. The internal gear ring of component 6 engages and rolls; this mechanical meshing relationship cleverly converts the revolution of the stirring rod 502 into the rotation of the auxiliary stirring components around their own axis, with the rotation speed being strictly proportional to the revolution speed; ultimately, a dual powerful stirring field is formed inside the device: the revolution of the central stirring rod 502 is responsible for the main circulation and prevents bottom sedimentation, while the rapid rotation of multiple auxiliary stirring components acts like a high-speed homogenizer, generating strong local shearing, tearing, and turbulence effects on the material at various points along the revolution trajectory, which can efficiently break up clumps, eliminate temperature and concentration dead zones, and ensure uniform mixing of reactants at the molecular level, greatly improving the efficiency, purity, and consistency of the muscle antagonist synthesis reaction.
[0021] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.
Claims
1. A muscle antagonist drug processing apparatus comprising a reaction vessel (1), characterized in that, Also includes: The stirring assembly (5) includes a central shaft (501) and a stirring rod (502) is fixedly connected to the lower part of the central shaft (501). Among them, an auxiliary stirring component is rotatably installed on the upper part of the stirring rod (502), and a gear (505) is fixedly connected to the upper part of the stirring component. The gear ring (506) fixed on the upper part of the reactor (1) meshes with the gear (505). The motor (4) is used to drive the central shaft (501). The central shaft (501) is driven by the motor (4) to drive the stirring rod (502) to revolve and is constrained by the gear ring (506) to drive the auxiliary stirring component to rotate.
2. A muscle antagonist drug processing device according to claim 1, characterized in that The stirring rod (502) is provided in multiple ways, and an auxiliary stirring component is rotatably installed on the upper part of each stirring rod (502).
3. A muscle antagonist drug processing device according to claim 1, wherein, The reactor (1) is fixedly mounted with a lid (2) on the upper part. The input end of the gearbox (3) fixedly mounted on the upper part of the lid (2) is fixedly connected to the output shaft of the motor (4). The motor (4) is fixed on one side of the gearbox (3), and the central shaft (501) is fixed at the output end of the gearbox (3).
4. A muscle antagonist drug processing device according to claim 1, wherein, The lower part of the reactor (1) is fixedly equipped with several support columns (6), which are used to support the reactor (1).
5. A muscle antagonist drug processing device according to claim 1, wherein, The reactor (1) has an internal gas channel (8) for transmitting heating gas, and a control valve (7) for discharging material is also fixedly installed at the bottom of the reactor (1).
6. The apparatus for processing a muscle antagonist drug according to claim 1, characterized in that, The auxiliary stirring component includes a rotating tube (503) rotatably mounted on the upper part of the stirring rod (502), and a plurality of mixing plates (504) are uniformly installed on the outer circumference of each rotating tube (503).
7. A muscle antagonist drug processing device according to claim 6, wherein, The gear (505) is fixed on the upper part of the rotating tube (503). A fixing plate (507) is fixedly connected to the outside of the stirring rod (502). A spring telescopic rod (508) is installed obliquely on the outside of the fixing plate (507). A scraper (509) is fixedly connected to the end of the spring telescopic rod (508) away from the fixing plate (507). The shape of the scraper (509) is movably fitted into the inner wall of the reaction vessel (1). When in use, the rotating tube (503) rotates at high speed, driving the scraper (509) to overcome the tension of the spring telescopic rod (508) under the action of centrifugal force and stick to the inner wall of the reactor (1) to perform scraping and cleaning action.
8. A muscle antagonist drug processing device according to claim 7, characterised in that The spring telescopic rod (508) includes a fixed tube (5081) fixed on the upper part of the fixed plate (507), a knob (5082) rotatably mounted on one side of the fixed tube (5081) and rotatably connected to the fixed plate (507), a screw rod (5083) fixed inside the knob (5082) and a slider (5084) slidably mounted inside the fixed tube (5081) are screwed together, the slider (5084) is connected to a slide rod (5085) slidably mounted inside the fixed tube (5081) by a spring, one end of the slide rod (5085) passes through the fixed tube (5081) and extends to the outside to be fixedly connected to the scraper (509).