Visual fractionation recovery aid with temperature control

Abstract

The utility model discloses a kind of visual fraction recovery auxiliary with temperature control, including workbench, the top of workbench is equipped with 96-hole collection plate, for fraction collection. Among them, the bottom of workbench is provided with temperature control area, this part can carry out temperature protection to sample collection container, prevent sample from because temperature anomaly and the case of property change. Among them, it further includes connecting line, connecting line and temperature control area electrically connected. Among them, the bottom of workbench is equipped with locking device, ensure that sample collection container is firmly fixed on workbench. Among them, 96-hole collection plate is provided with color indicating lamp in each hole, and color indicating lamp and connecting line are electrically connected. In the above scheme, the utility model fraction position indication function can effectively reduce the case of "wrong use, wrong take, wrong mix" when post-processing after sample fraction collection, thereby improve work efficiency, reduce the waste of manpower, time, resource etc. of repeated work.

Description

Technical Field

[0001] This invention relates to the field of liquid chromatography technology, and more specifically, to a visual fraction recovery aid with temperature control. Background Technology

[0002] As an important auxiliary module in the field of liquid chromatography, the fraction collector is used to collect the sample effluent from the liquid chromatography system under certain specific conditions.

[0003] In high-flow-rate systems, fraction collection typically utilizes large, relatively fixed containers for fraction recovery. This is common in industrial production, where the fixed containers minimize the risk of misuse, incorrect collection, or incorrect mixing during subsequent production. However, in method development or small-scale laboratory sample preparation, fraction collection containers are often not fixed. Appropriate containers, typically test tubes of varying collection volumes, are chosen based on specific experimental requirements. For smaller volumes, 96-well or 384-well plates may be used. In these scenarios, subsequent operations after sample collection require manual identification of the correct container by referring to the liquid chromatography chromatogram. With a large number of containers, this process is highly susceptible to misuse, incorrect collection, or incorrect mixing. Failure to detect these errors promptly can lead to abnormal experimental results. Even timely detection results in significant time and labor costs associated with repeated collection.

[0004] Furthermore, for certain samples with special properties, preservation at specified temperatures is required. Even with temperature protection during sample collection, the collected sample must be removed from the refrigeration chamber for recovery. At this point, the temperature is no longer maintained under the specified conditions. If operators do not handle this promptly, changes in sample properties may occur, potentially affecting subsequent experimental results. Even if the collection container is immediately removed from the fraction collector and transferred to the cryogenic laboratory for subsequent operations, while this ensures sample stability, it lacks operational flexibility and requires significant financial investment in maintaining the cryogenic laboratory, making it impractical for many users.

[0005] Therefore, a temperature-controlled, visualized fraction recovery aid is proposed to solve the above problems. Utility Model Content

[0006] To overcome the aforementioned deficiencies of the prior art, embodiments of this utility model provide a temperature-controlled visual fraction recovery auxiliary device to solve the problem that, when using existing fraction collectors, the operation is prone to "misuse, mis-collection, and mis-mixing" when there are a large number of sample collection containers.

[0007] To solve the above-mentioned technical problems, this utility model provides the following technical solution: a temperature-controlled visual fraction recovery auxiliary device, including a workbench, on the top of which is a 96-hole collection plate for fraction collection.

[0008] The bottom of the workbench is equipped with a temperature control zone, which can protect the sample collection container from temperature changes and prevent the sample from changing its properties due to abnormal temperature.

[0009] It also includes a connecting wire, which is electrically connected to the temperature control zone and is used for power supply and signal reception.

[0010] The bottom of the workbench is equipped with a locking device to ensure that the sample collection container is securely fixed to the workbench, preventing it from falling off and damaging the sample.

[0011] Each well of the 96-well collection plate is equipped with a color indicator light, which is electrically connected to a connecting wire. When the sample is recovered, the corresponding color indicator light will light up to indicate the location.

[0012] The beneficial effects of the above-mentioned technical solution of this utility model are as follows:

[0013] 1. The fraction position indication function of this utility model can effectively reduce the occurrence of "misuse, mis-collection, and mis-mixing" during the post-processing of sample fractions, thereby improving work efficiency and reducing the waste of manpower, time, and resources in repetitive work;

[0014] 2. The temperature control function of this utility model effectively solves the problem of preserving temperature-sensitive samples, allowing more time for sample processing after collection;

[0015] 3. The offline processing function of this utility model, through the chromatographic spectrum import function, can transfer chromatographic information to a workstation on another computer for offline processing, without conflicting with the current computer or the current collection work, effectively improving work efficiency. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a schematic diagram of the bottom structure of this utility model;

[0018] Figure 3 This is a top view of the structure of this utility model;

[0019] Figure 4 This is a chromatogram of the liquid chromatography preparation results of this utility model and a schematic diagram of the status of the collection indicator light.

[0020] [Figure Labels]

[0021] 1. Workbench; 2. 96-hole collection plate; 3. Temperature control zone; 4. Connecting cable; 5. Locking device; 6. Color indicator light. Detailed Implementation

[0022] To make the technical problems, technical solutions and advantages of this utility model clearer, a detailed description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0023] As attached Figure 1 To be continued Figure 4 An embodiment of this utility model provides a temperature-controlled visual fraction recovery aid, including a workbench 1, on the top of which is a 96-hole collection plate 2 for fraction collection.

[0024] The bottom of the workbench 1 is equipped with a temperature control zone 3, which can protect the sample collection container from temperature changes and prevent the sample from changing its properties due to abnormal temperature.

[0025] It also includes a connecting line 4, which is electrically connected to the temperature control zone 3 for power supply and signal reception.

[0026] The bottom of the workbench 1 is equipped with a locking device 5 to ensure that the sample collection container is securely fixed on the workbench 1, preventing it from falling off and causing damage to the sample.

[0027] Each well of the 96-well collection plate 2 is equipped with a color indicator light 6. The color indicator light 6 is electrically connected to the connecting wire 4. When the sample is recovered, the color indicator light 6 at the corresponding position will light up to indicate the location.

[0028] Among them, temperature control zone 3 uses Peltier temperature control, which has both cooling and heating functions. The temperature can be set according to the user's actual needs to meet the different temperature storage conditions of different samples.

[0029] In this embodiment, the sample collection container and the fraction position indicator are both based on a 96-well collection plate. However, in actual use, the specifications of the sample collection container and the fraction position indicator include, but are not limited to, this.

[0030] This device features offline processing capabilities, allowing it to export spectra from the online acquisition workstation and import them into the corresponding workstation of the auxiliary device. The operation location is flexible, and after importation, indicator lights illuminate at the user-selected location for guidance. Figure 4 exhibit.

[0031] The working process of this utility model is as follows:

[0032] Connect the temperature control zone 3 and the color indicator light 6 to the power supply and workstation equipment via the connecting cable 4. Then, use the locking device 5 to firmly fix the sample collection container to the workbench 1. The temperature control zone 3 can protect the temperature of the sample collection container to prevent the sample from changing its properties due to abnormal temperature. When the sample is recovered, the corresponding color indicator light 6 will light up to indicate the process. The spectrum in the online acquisition workstation can be exported via the connecting cable 4 and then imported into the corresponding workstation of the auxiliary device.

[0033] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0034] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.

[0035] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A visualized fraction recovery aid with temperature control, characterized in that, Includes a workbench (1), the top of which is equipped with a 96-hole collection plate (2) for fraction collection.

2. The visualized fraction recovery aid with temperature control according to claim 1, characterized in that The bottom of the workbench (1) is provided with a temperature control zone (3), which can protect the sample collection container from temperature changes and prevent the sample from changing its properties due to abnormal temperature.

3. The visualized fraction recovery aid with temperature control of claim 1, wherein, It also includes a connecting line (4), which is electrically connected to the temperature control zone (3) for power supply and signal reception.

4. The visualized fractionation recovery aid with temperature control of claim 1, wherein, The bottom of the workbench (1) is equipped with a locking device (5) to ensure that the sample collection container is securely fixed on the workbench (1) to prevent it from falling off and causing the sample to fall off.

5. The visualized fractionation recovery aid with temperature control of claim 1, wherein, Each hole of the 96-well collection plate (2) is equipped with a color indicator light (6), which is electrically connected to the connecting line (4). When the sample is recovered, the color indicator light (6) at the corresponding position will light up to indicate the location.

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