Sourness inhibitor and use thereof as additive or raw material

Abstract

To provide a citric acid-derived sourness inhibitor that can inhibit sourness from citric acid.SOLUTION: The present invention provides a citric acid-derived sourness inhibitor for use as an additive or an ingredient in a citric acid-containing liquid oral composition. The citric acid-derived sourness inhibitor contains citric acid and potassium citrate. The pH of the citric acid-containing liquid oral composition containing the citric acid-derived sourness inhibitor is 5-8. The total citric acid content in the citric acid-containing liquid oral composition containing the citric acid-derived sourness inhibitor is 0.05-1.0 mass%. The content of potassium derived from the potassium citrate is 0.4-1.0 pt.mass relative to the total citric acid 1 pt.mass. The citric acid-containing liquid oral composition containing the citric acid-derived sourness inhibitor is free of sweeteners or has a sweetness intensity equivalent to a sucrose solution of 5 mass% or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an acidity suppressant. Specifically, the present invention relates to an acidity suppressant derived from citric acid that suppresses the acidity caused by citric acid. The present invention relates to a food, drink, medicine, or feed containing the citric acid-derived acidity suppressant. The present invention relates to the use of the citric acid-derived acidity suppressant as an additive for citric acid-containing food, drink, medicine, feed, or the like, or as a raw material (including a part thereof). The present invention also relates to a packaged citric acid-containing liquid oral composition (eg, beverage, liquid jelly, slurry, sol-gel, etc.) in which the sour taste due to citric acid is suppressed. [Background technology]

[0002] Citric acid is known to have the effect of reducing fatigue, and is contained in, for example, commercially available sports drinks and soft drinks.

[0003] However, citric acid is irritating to the mouth and throat when consumed and has a strong sour taste, making it difficult to incorporate it in high doses for the purpose of anti-fatigue. Therefore, the incorporation of citric acid may not meet the needs of those who want to quench their thirst by drinking it all at once.

[0004] Patent Document 1 proposes that the sourness of citric acid can be alleviated by adding sodium succinate to a citric acid-containing beverage at a concentration of 1 / 200 to 1 / 10 or sodium fumarate to a citric acid concentration of 1 (by weight). However, the effect is not sufficient, and there is a risk of the flavor of the citric acid-containing beverage being deteriorated.

[0005] Patent Document 2 proposes that in a bottled high citric acid content acidic beverage with a citric acid concentration of 0.4 to 1.5% by weight, potassium citrate is added so that the ratio of the potassium concentration to the citric acid concentration is 0.001 to 0.37, and a large amount of sweetening ingredients is blended, thereby reducing the off-flavor caused by citric acid. However, the effect is not sufficient, and there is a risk that the flavor of the bottled high citric acid content acidic beverage may be deteriorated. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] JP 2005-261395 A [Patent Document 2] JP 2017-46600 A Summary of the Invention [Problem to be solved by the invention]

[0007] In citric acid-containing beverages, the development of technology to suppress the sourness caused by citric acid has not yet been sufficient, and in many cases, commercially available products contain a certain amount of carbohydrates such as high-intensity sweeteners, which have a masking effect to reduce the sourness.

[0008] Therefore, the present invention provides a citric acid-derived sourness suppressant that can suppress the sourness caused by citric acid, and its use as an additive or raw material. The present invention also provides a packaged citric acid-containing liquid oral composition in which the sour taste of citric acid is suppressed. [Means for solving the problem]

[0009] As a result of intensive research, the inventors have discovered that by adjusting the amounts of citric acid and potassium citrate, the sourness caused by citric acid can be suppressed or reduced without relying on the masking effect of a sweetener, and have completed the present invention based on this finding.

[0010] The present invention includes the following aspects.

[0011] The citric acid-derived sourness suppressant of the present disclosure, which suppresses the sourness caused by citric acid, is Citric acid, Potassium citrate, Includes.

[0012] The citric acid-derived sourness suppressant may further contain an additive. The additive may be, for example, a filler, a stabilizer, a sweetener, a flavoring agent, a binder, or a flavoring agent.

[0013] The content of potassium derived from the potassium citrate per part by mass of total citric acid may be 0.4 to 1.0 part by mass.

[0014] A method for using the citric acid-derived sourness suppressant as an additive, comprising: When added to foods (including beverages), medicines (including quasi-drugs), or feed that do not contain citric acid, it creates foods (including beverages), medicines (including quasi-drugs), or feed that have added citric acid with reduced sourness due to citric acid.

[0015] A method for using the citric acid-derived sourness suppressant as a raw material, comprising: By using it as a citric acid raw material in foods (including beverages), medicines (including quasi-drugs), or feed that you want to contain citric acid, you can create citric acid-containing foods (including beverages), citric acid-containing medicines (including quasi-drugs), or citric acid-containing feed that have a reduced sour taste due to citric acid.

[0016] The packaged citric acid-containing liquid oral composition of the present disclosure comprises: Citric acid, Potassium citrate, Including, The pH of the citric acid-containing liquid oral composition is 5 to 8; the total content of citric acid consisting of the citric acid and the citric acid derived from the potassium citrate is 0.05 to 1.0% by mass based on the total amount of the citric acid-containing liquid oral composition; The content of potassium derived from the potassium citrate per part by mass of total citric acid is 0.4 to 1.0 part by mass.

[0017] The citric acid-containing liquid oral composition may contain additives (eg, excipients) when the citric acid-derived sourness suppressant is used as part of a raw material.

[0018] The citric acid-containing liquid oral composition comprises: The citric acid-containing liquid oral composition may contain no sweetener, or may have a sweetness equivalent to that of a sucrose solution at 5% by mass or less based on the total amount of the citric acid-containing liquid oral composition.

[0019] The method for suppressing sourness derived from citric acid according to the present disclosure includes: The citric acid-derived sourness suppressant is used as a part or main component of the ingredients of foods (including beverages), medicines (including quasi-drugs) or feeds in which citric acid is to be contained.

[0020] The method for suppressing the sourness derived from citric acid in a citric acid-containing liquid oral composition according to the present disclosure includes: The citric acid-containing liquid oral composition is Contains citric acid and potassium citrate, The pH of the citric acid-containing liquid oral composition is 5 to 8; the total content of citric acid consisting of the citric acid and citric acid derived from potassium citrate is 0.05 to 1.0% by mass based on the total amount of the citric acid-containing liquid oral composition; The content of potassium derived from the potassium citrate per part by mass of total citric acid is 0.4 to 1.0 part by mass.

[0021] The method for suppressing the sourness derived from citric acid in a citric acid-containing liquid oral composition according to the present disclosure includes: The acidity suppressant derived from citric acid is used as a part or a main part of the raw materials of the citric acid-containing liquid oral composition. Effect of the Invention

[0022] According to the present disclosure, by adjusting the amounts of citric acid and potassium citrate, the sourness derived from citric acid can be suppressed or reduced without relying on the masking effect of a sweetener. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0023] [Citric acid-derived acidity suppressant] The citric acid derived sourness reducer contains citric acid, potassium citrate and additives. In this embodiment, an excipient is used as the additive, and the additive can be in the form of powder, granules, or the like. The citric acid derived acidity reducer may be distributed in single or multi-use packaging. The citric acid-derived sourness suppressant may be in either a solid or liquid form. In this embodiment, it is a solid form. In the case of a liquid form, it may be in a state dissolved in water (corresponding to an additive), in a sol-gel state, or in a jelly state. The citric acid-derived sourness suppressant may contain a quality stabilizer, an antioxidant, etc. as an additive for long-term quality maintenance.

[0024] (Usage: Additive) The above-mentioned citric acid-derived sourness suppressant is added to foods (including beverages), medicines (including quasi-drugs), or feed that do not contain citric acid, thereby producing foods (including beverages), medicines (including quasi-drugs), or feed to which citric acid has been added, in which the sourness due to citric acid is suppressed. As a result, by adding the citric acid-derived sourness suppressant to foods (including beverages), medicines (including quasi-drugs), or feed that do not contain citric acid, it is possible to effectively ingest citric acid with suppressed sourness derived from citric acid along with them. The above-mentioned citric acid-derived sourness suppressant may be added to foods (including beverages), medicines (including quasi-drugs), or feeds that already contain citric acid. This allows the citric acid derived from the citric acid-derived sourness suppressor to be additionally contained without changing the sourness derived from the citric acid already contained. When a solid sourness suppressant derived from citric acid is used as an additive, the above-mentioned food, medicine, and feed are preferably in liquid form. When a liquid sourness suppressant derived from citric acid is used as an additive, the above-mentioned foods, medicines, and feeds may be in either solid or liquid form.

[0025] (How to use: Raw materials) The above-mentioned citric acid-derived sourness suppressant is used as a citric acid raw material for foods (including beverages), medicines (including quasi-drugs), or feed that are desired to contain citric acid, thereby producing citric acid-containing foods (including beverages), citric acid-containing medicines (including quasi-drugs), or citric acid-containing feed in which the sourness caused by citric acid is suppressed. This allows the citric acid in the citric acid-derived acidity suppressor to be used for a portion (meaning 1 to 99 parts by mass) or all (100 parts by mass) of the citric acid raw material in all raw material components, thereby making it possible to produce citric acid-containing foods, medicines, and feeds that effectively suppress the acidity derived from citric acid. When a citric acid-derived sourness suppressant is used as a raw material, it may be in a solid or liquid form.

[0026] (Citric Acid) The citric acid may be, for example, citric acid (crystalline) or citric acid (anhydrous). The content of citric acid in 100 parts by mass of the citric acid-derived sourness suppressor may be 0.5 to 20 parts by mass.

[0027] (Potassium Citrate) The potassium citrate may be a hydrate such as, for example, potassium dihydrogen citrate, tripotassium citrate (monohydrate (C6H5K3O7·H2O)), etc., or a mixture thereof. The content of potassium citrate in 100 parts by mass of the citric acid-derived acidity suppressor may be 20 to 80 parts by mass.

[0028] The content of potassium citrate is not particularly limited, but from the viewpoint of obtaining a greater effect of the present invention, examples of the content include 0.1 parts by mass or more, 1 part by mass or more, 5 parts by mass or more, 10 parts by mass or more, 15 parts by mass or more, 20 parts by mass or more, based on 100 parts by mass of the total amount of the citric acid-derived acidity suppressant.

[0029] In addition, from the viewpoint of obtaining a greater effect of the present invention, the content of potassium citrate may be, for example, 99.99 parts by mass or less, 99 parts by mass or less, 95 parts by mass or less, 90 parts by mass or less, 85 parts by mass or less, 80 parts by mass or less, based on 100 parts by mass of the total amount of the citric acid-derived acidity suppressant.

[0030] From the viewpoint of obtaining a higher effect of the present invention, the content of potassium citrate is, for example, 0.1 to 99.99 parts by mass, 0.1 to 99 parts by mass, 0.1 to 95 parts by mass, 0.1 to 90 parts by mass, 0.1 to 85 parts by mass, 0.1 to 80 parts by mass, 1 to 99.99 parts by mass, 1 to 99 parts by mass, 1 to 95 parts by mass, 1 to 90 parts by mass, 1 to 85 parts by mass, 1 to 80 parts by mass, 5 to 99.99 parts by mass, 5 to 99 parts by mass, 5 to 95 parts by mass, based on 100 parts by mass of the total amount of the citric acid-derived acidity suppressor. , 5-90 parts by mass, 5-85 parts by mass, 5-80 parts by mass, 10-99.99 parts by mass, 10-99 parts by mass, 10-95 parts by mass, 10-90 parts by mass, 10-85 parts by mass, 10-80 parts by mass, 15-99.99 parts by mass, 15-99 parts by mass parts, 15-95 parts by mass, 15-90 parts by mass, 15-85 parts by mass, 15-80 parts by mass, 20-99.99 parts by mass, 20-99 parts by mass, 20-95 parts by mass, 20-90 parts by mass, 20-85 parts by mass, 20-80 parts by mass, and the like.

[0031] (Additives: excipients) The excipient is not particularly limited, but examples thereof include sugar alcohols, dextrins, sucrose, glucose, starches, and the like. As the sugar alcohol, maltitol is preferred. At least one of these may be used, or two or more of them may be used in combination. The content of the additive (or excipient) in 100 parts by mass of the citric acid-derived sourness suppressor may be 20 to 80 parts by mass.

[0032] (pH) The pH may be 5-8 when 3 g of the sourness suppressor derived from citric acid is dissolved in 100 ml to 500 ml of neutral water (pH 7). The pH may be 5 to 8 when the citric acid derived acidity suppressor is dissolved in neutral water (pH 7) at 0.5 to 3 mass %.

[0033] (Total citric acid to potassium mass ratio) The content of potassium derived from the potassium citrate per part by mass of total citric acid is 0.4 to 1.0 part by mass. The total citric acid content of the citric acid-containing liquid oral composition containing a citric acid-derived sourness suppressant is 0.1 to 1.0 mass %, preferably 0.2 to 1.0 mass %, and more preferably 0.25 to 1.0 mass %. The total citric acid content is the sum of citric acid and citric acid from potassium citrate. The mass ratio of citric acid to citric acid derived from potassium citrate is, for example, 10-30:90-70. The mass ratio of citric acid to potassium citrate is, for example, 5-20:95-80. The mass ratio of potassium citrate to the excipient is, for example, 25-60:75-40.

[0034] [Packaged citric acid-containing liquid oral composition] The containerized citric acid-containing liquid oral composition contains citric acid and potassium citrate. The composition contains other ingredients depending on the intended use of the composition. In this embodiment, the citric acid has the same composition as the citric acid of the citric acid-derived sourness suppressant. The potassium citrate has the same composition as the potassium citrate of the citric acid-derived sourness suppressant. The container is not particularly limited and may be made of plastic, paper, or metal.

[0035] (pH) The pH of the containerized citric acid-containing liquid oral composition may be, for example, in the range of 4.3 to 7.8, 4.3 to 7.6, 4.3 to 7.4, 4.4 to 7.8, 4.4 to 7.6, 4.4 to 7.4, 4.5 to 7.8, 4.5 to 7.6, 4.5 to 7.4, 4.6 to 8, 4.6 to 7.8, 4.6 to 7.6, 4.6 to 7.4, 4.8 to 8, 4.8 to 7.8, 4.8 to 7.6, 4.8 to 7.4, 5 to 8, 5 to 7.8, 5 to 7.6, 5 to 7.4, etc. In another embodiment, although not limited thereto, the composition of the present invention preferably does not contain an acidic food with a pH of 4.6 or less, or preferably contains a low-acidity food with a pH of more than 4.6. In another embodiment, but not limited to, the compositions of the present invention can be low acidic to neutral.

[0036] The pH can be measured by a known method, and is not particularly limited. For example, the pH can be measured at 20° C. using a commercially available pH meter (e.g., F-52 (registered trademark) model, manufactured by Horiba, Ltd.).

[0037] (Citric Acid) From the viewpoint of obtaining the effects of the present invention, the total citric acid content in the packaged citric acid-containing liquid oral composition can be 0.05 to 1.0% by mass relative to the total amount of the composition, for example, 0.9% by mass or less, 0.8% by mass or less, 0.7% by mass or less, 0.6% by mass or less, 0.5% by mass or less, etc. The total citric acid content in the packaged citric acid-containing liquid oral composition may be, for example, 0.05% by mass or more, 0.08% by mass or more, 0.09% by mass or more, or 0.1% by mass or more, relative to the total amount of the composition. Total citric acid is the total citric acid in the citric acid-derived sour taste suppressant and the citric acid already contained in the composition (food, medicine, feed). However, it may not be included in the composition. The same definition applies below unless otherwise specified.

[0038] The total citric acid content in the packaged citric acid-containing liquid oral composition is, for example, 0.05 to 0.9 mass%, 0.05 to 0.8 mass%, 0.05 to 0.7 mass%, 0.05 to 0.6 mass%, 0.05 to 0.5 mass%, 0.08 to 1 mass%, 0.08 to 0.9 mass%, 0.08 to 0.8 mass%, 0.08 to 0.7 mass%, 0.08 to 0.7 mass%, 0.08 to 0.9 mass%, 0.08 to 0.8 mass%, 0.08 to 0.7 mass%, 0.08 to 0.9 ... .08~0.6% by mass, 0.08~0.5% by mass, 0.09~1% by mass, 0.09~0.9% by mass, 0.09~0.8% by mass, 0.09~0.7% by mass, 0.09~0.6 % by mass, 0.09-0.5% by mass, 0.1-0.9% by mass, 0.1-0.8% by mass, 0.1-0.7% by mass, 0.1-0.6% by mass, 0.1-0.5% by mass, and the like.

[0039] (Potassium Citrate) In order to obtain the effects of the present invention, the content of potassium citrate in the containerized citric acid-containing liquid oral composition can be 0.1 to 1.5% by mass relative to the total amount of the composition, for example, 1.4% by mass or less, 1.3% by mass or less, 1.2% by mass or less, 1.1% by mass or less, 1.0% by mass or less, etc. The content of potassium citrate in the packaged citric acid-containing liquid oral composition may be, for example, 0.1 mass % or more, 0.2 mass % or more, 0.3 mass % or more, or 0.4 mass % or more, relative to the total amount of the composition.

[0040] The content of potassium citrate in the containerized citric acid-containing liquid oral composition relative to the total amount of the composition may be, for example, 0.1 to 1.4 mass%, 0.1 to 1.3 mass%, 0.1 to 1.2 mass%, 0.1 to 1.1 mass%, 0.1 to 1.0 mass%, 0.2 to 1.5 mass%, 0.2 to 1.4 mass%, 0.2 to 1.3 mass%, 0.2 to 1.2 mass%, 0.2 to 1.1 mass%, 0.2 to 1.0 mass%, 0.3 to 1.5 mass%, 0.3 to 1.4 mass%, 0.3 to 1.3 mass%, 0.3 to 1.2 mass%, 0.3 to 1.1 mass%, or 0.3 to 1.0 mass%.

[0041] The content of potassium derived from the potassium citrate per 1 part by mass of total citric acid in the containerized citric acid-containing liquid oral composition can be 0.4 to 1.0 part by mass from the viewpoint of obtaining the effects of the present invention, for example, 0.9 parts by mass or less, 0.8 parts by mass or less, 0.7 parts by mass or less, 0.6 parts by mass or less, 0.5 parts by mass or less, etc.

[0042] The content of potassium derived from the potassium citrate per 1 part by mass of total citric acid in the packaged citric acid-containing liquid oral composition is, for example, 0.4 parts by mass or more, 0.5 parts by mass or more, 0.6 parts by mass or more, 0.7 parts by mass or more, etc.

[0043] The content of the potassium derived from the potassium citrate per 1 part by mass of total citric acid in the containerized citric acid-containing liquid oral composition can be, for example, 0.4 to 0.9 parts by mass, 0.4 to 0.8 parts by mass, 0.4 to 0.7 parts by mass, 0.4 to 0.6 parts by mass, 0.4 to 0.5 parts by mass, 0.5 to 1 part by mass, 0.5 to 0.9 parts by mass, 0.5 to 0.8 parts by mass, 0.5 to 0.7 parts by mass, 0.5 to 0.6 parts by mass, 0.6 to 1 part by mass, 0.6 to 0.9 parts by mass, 0.6 to 0.8 parts by mass, 0.6 to 0.7 parts by mass, 0.7 to 1 part by mass, 0.7 to 0.9 parts by mass, 0.7 to 0.8 parts by mass, and the like.

[0044] The container-packed citric acid-containing liquid oral composition is not limited, but preferably does not contain sweetener or contains a reduced amount of sweetener. In the examples described below, it has been confirmed that the sweetener has an effect of suppressing sourness depending on the amount of sweetener added. On the other hand, in a citric acid-containing beverage having a sweetness intensity equivalent to a sucrose solution of 5% by mass or less, the sweetener is not easily able to suppress sourness, and the sourness of citric acid is found to be prominent.

[0045] Therefore, even if the packaged citric acid-containing liquid oral composition contains a sweetener, it is preferable that the sweetness of the composition is equivalent to that of a sucrose solution of 5% by mass or less based on the total amount of the composition. The sourness of citric acid can be effectively suppressed without masking with a sweetener.

[0046] The packaged citric acid-containing liquid oral composition may further contain a citrate salt other than the above-mentioned citric acid and potassium citrate. Examples of citrates other than the above citric acid and potassium citrate include sodium citrate, calcium citrate, citric acid derived from fruit juice or salts thereof, and the like.

[0047] As the citrate salt other than the citric acid and potassium citrate, a material containing these may be used, for example, fruits, vegetables, etc., and preferably citrus fruits such as lemon, orange, lime, grapefruit, sudachi, etc. When a material derived from citrus fruits is used, it is preferable to use squeezed juice of citrus fruits or a concentrate thereof. For example, even if the product contains citric acid derived from fruit juice, by using a citric acid-derived sourness suppressor as a raw material or additive, it is possible to additionally contain citric acid derived from the citric acid-derived sourness suppressor without changing the sourness derived from the citric acid already contained.

[0048] <Examples of citric acid-derived acidity suppressant> In the present invention, the form of the citric acid-derived sourness suppressant is not particularly limited, and may be a solid preparation, an aqueous preparation (mainly containing an aqueous or hydrophilic base or carrier), or an oil-based preparation (mainly containing an oil-based or hydrophobic base or carrier).

[0049] In the case of an aqueous formulation, the content of water is, for example, preferably 50 parts by mass or more, more preferably 75 parts by mass or more, and even more preferably 90 parts by mass or more, based on 100 parts by mass of the total amount of the formulation. It may also be 95 parts by mass or more, or 98 parts by mass or more. The base or carrier may consist of only water.

[0050] In the case of an oil-based formulation, the water content is, for example, preferably less than 50 parts by mass, more preferably 30 parts by mass or less, even more preferably 20 parts by mass or less, and particularly preferably 10 parts by mass or less, based on 100 parts by mass of the total formulation.

[0051] <Food, beverages, medicines, or feed> In the present invention, the packaged citric acid-containing liquid oral composition may be a pharmaceutical composition, a quasi-drug, a food and drink composition, or a feed composition for humans or animals. Alternatively, the packaged citric acid-containing liquid oral composition may be first made into a raw material preparation for use in the pharmaceutical composition, the quasi-drug, the food and drink composition, or the feed composition, and then may be mixed therewith.

[0052] <Food and drink composition> The containerized citric acid-containing liquid oral composition is configured as a beverage composition, and may be a functional food (including a food with functional claims), a food for the sick, or a food for specified health uses, or may be any other general food or beverage.

[0053] The form of the food and drink composition may be flavored water, milk drinks, lactic acid bacteria drinks, carbonated drinks, fruit drinks (e.g., fruit juice drinks, soft drinks containing fruit juice, carbonated drinks containing fruit juice, and fruit juice drinks), vegetable drinks, vegetable and fruit drinks, alcoholic drinks such as liqueurs, coffee drinks, powdered drinks, sports drinks, and supplement drinks; Tea beverages such as black tea, green tea, and blended tea (note that beverages and tea beverages are included in "beverages"); Liquid puddings such as custard pudding, milk pudding, and fruit juice pudding, liquid desserts such as jelly, Bavarian cream, and yogurt; Soups such as consommé soup, potage soup, etc. Liquid condiments such as separate dressings, non-oil dressings, ketchup, sauces, and other sauces; Liquid jams such as strawberry jam, blueberry jam, marmalade, apple jam, apricot jam, preserves, syrups, etc.; Fruit wines such as red wine; etc. Examples of the food and drink composition include semi-finished products and intermediate products of these products. Furthermore, nutritional supplement compositions such as drinks and syrups, which are in the same form as pharmaceuticals, are also examples of the food and drink composition.

[0054] The container-packed citric acid-containing liquid oral composition can also contain food additives used in the same way as ordinary food and drink.Particularly, suitable additives include, but are not limited to, high-intensity sweeteners such as acesulfame K, sucralose, aspartame, advantame, saccharin, neotame, thaumatin, monellin, monatin, monk fruit extract, licorice extract, glycyrrhizin, stevia extract, stevia enzyme-treated product, rebaudioside A and stevioside.Other additives can also contain acids, fatty acids, sugars other than those mentioned above, alcohols other than those mentioned above, antioxidants, proteins, peptides, amino acids, vitamins, minerals, thickening stabilizers, auxiliary agents such as chelating agents, flavors, spice extracts, preservatives, preservatives, pH adjusters, stabilizers, surfactants other than those mentioned above, etc.

[0055] The content of the citric acid-derived acidity suppressant used as a raw material or additive in the packaged citric acid-containing liquid oral composition is preferably 0.01 to 100 mass%, more preferably 0.1 to 50 mass%, and even more preferably 0.2 to 30 mass%, relative to the total amount of the packaged citric acid-containing liquid oral composition.

[0056] <Pharmaceutical Composition> The dosage form of the pharmaceutical composition (including quasi-drugs) can be liquid such as a drink or syrup. Examples of "quasi-drugs" include nutritional supplements, various supplements, toothpaste, mouthwash, mouth fresheners, odor control agents, etc.

[0057] In addition, in order to prepare pharmaceutical preparations in such various dosage forms, other pharma- ceutically acceptable excipients, binders, bulking agents, disintegrants, surfactants, lubricants, dispersants, buffers, preservatives, flavoring agents, fragrances, coating agents, carriers, diluents, other medicinal ingredients, etc. can be appropriately combined. Among these administration forms, oral administration is preferred, and oral liquid preparations can be prepared by the usual method by adding flavoring agents, buffers, stabilizers, etc.

[0058] The content of the citric acid-derived acidity suppressant used as a raw material or additive in the pharmaceutical composition is preferably 0.01 to 100 mass%, more preferably 0.1 to 50 mass%, and even more preferably 0.2 to 30 mass%, relative to the total amount of the pharmaceutical composition.

[0059] <Feed> Examples of feed include small animal feed for rabbits, rats, mice, etc., and liquid pet food for dogs, cats, etc., and as long as it is edible by pets, it can be prepared in the same form as the above-mentioned food and drink composition.

[0060] The content of the citric acid-derived acidity suppressant used as a feed ingredient or additive is preferably 0.01 to 100 mass% relative to the total amount of the feed, more preferably 0.1 to 50 mass%, and even more preferably 0.2 to 30 mass%.

[0061] (Method for producing food and beverage composition, pharmaceutical composition, or feed composition) There is no limitation on the method for producing the food / beverage composition, pharmaceutical composition, or feed composition, and they can be produced by any known method.

[0062] [Example] The present invention will be described below with reference to examples, but the scope of the present invention is not limited thereto. Unless otherwise specified, numerical values ​​such as "%" and "parts" represent numerical values ​​based on mass.

[0063] (Citric acid measurement method) 1 mL of 5% by volume perchloric acid was added to 1 g of sample and stirred, and the volume was adjusted to 10 mL with pure water, which was used as the sample solution. The sample solution was filtered, and the citric acid content in the sample was measured by liquid chromatography (HPLC) under the following conditions. In this measurement, trisodium citrate standard was used as the citric acid standard. <Liquid chromatography (HPLC) measurement conditions> Column used: InertSustain AQ-C18 (5 μm, 4.6 id × 150 mm) (GL Sciences Inc.) Mobile phase: 10mM KH2PO4 (adjusted to pH 2.1 with phosphoric acid): isocratic Column temperature: 40℃ Flow rate: 1.0mL / min Detector: UV-Vis Detector (Hitachi High-Tech Corporation) Detection wavelength: 210nm Injection volume: 10μL

[0064] (Potassium measurement method) 10 mL of 10% hydrochloric acid was added to 2-4 g of sample, and the volume was adjusted to 100 mL with pure water and shaken for 30 minutes. The solution after shaking was filtered using No. 5A filter paper. The sample remaining on the filter paper was diluted 1-10 times with 10% hydrochloric acid and the potassium content in the sample was measured using an atomic absorption photometer under the following conditions. (Atomic absorption photometer measurement conditions) Measurement equipment: Agilent 240FS AA (Agilent Technologies, Inc.) Light source: Potassium hollow cathode lamp (Agilent Technologies, Inc.) Measurement wavelength: 766.5nm Frame: Acetylene 2.00L / min, Air 13.50L / min

[0065] [Reference Test Example 1. Confirmation test of the effect of sweeteners in reducing sourness] According to the formulations shown in the following Tables 1 to 3, citric acid-containing beverages containing sweeteners (corresponding to citric acid-containing liquid oral compositions) were prepared (mixed) by a conventional method. The types and contents of each component are as shown in the following tables.

[0066] (Sensory evaluation method 1) The subjects were panelists (6 or 8 people) who had sufficient ability to distinguish sourness. They had undergone training in sensory evaluation of sourness in advance to confirm their ability to distinguish sourness.

[0067] (Evaluation Criteria 1) The panelists were presented with each sample in random order without knowing the details of the samples, and asked to rate the intensity of sourness according to the following evaluation criteria. The average scores are also shown in the table below. A Steel test was also conducted, and the results are also shown in the table below. Very sour: 1 point (Medium acidity): 1.5 points Strong sourness: 2 points (Medium acidity): 2.5 points Moderately sour: 3 points (Medium acidity): 3.5 points Weak sourness: 4 points (Medium acidity): 4.5 points No sourness: 5 points

[0068] [Table 1]

[0069] [Table 2]

[0070] [Table 3]

[0071] As shown in Tables 1 to 3, it was confirmed that the sweetener has an effect of suppressing sourness depending on the amount of sweetener added. Specifically, it was confirmed that the sweetener has a sufficient effect of suppressing sourness in a citric acid-containing beverage having a sweetness intensity equivalent to that of a sucrose solution exceeding 5% by mass.

[0072] [Test Example 1. Confirmation test 1 of the effect of reducing sourness in beverages containing citric acid] As a result of carrying out the above-mentioned Reference Test Example 1, it was found that in a citric acid-containing beverage having a sweetness intensity equivalent to that of a sucrose solution of 5% by mass or less, the effect of the sweetener in suppressing the sourness is not easily achieved, and the sourness of the citric acid becomes prominent.

[0073] Therefore, we investigated a citric acid-derived sourness suppressant that can reduce the sourness caused by the total citric acid in a citric acid-containing beverage that has a sweetness intensity equivalent to that of a sucrose solution of 5% by mass or less.

[0074] The citric acid-derived acidity suppressant and citric acid-containing beverage (corresponding to a citric acid-containing liquid oral composition) shown in Tables 4-1 to 4-3 below were prepared (mixed) by a conventional method. The type and content of each component are as shown in the table below.

[0075] (Sensory evaluation method 2) The subjects were panelists (7 people) who had sufficient ability to distinguish sourness. They had undergone training in sensory evaluation of sourness in advance to confirm their ability to distinguish sourness.

[0076] (Evaluation Criteria 2) Panelists were presented with the samples in random order without knowing the details of the samples, and asked to rate the intensity of sourness according to the following evaluation criteria. A score of 3 or more was deemed to indicate that the addition of potassium citrate had an effect of suppressing sourness, and a score of 4 or more was deemed to indicate that an additional sourness suppressing effect had been observed. The evaluation results are shown in the table below. Same level of sourness as each reference comparison: 1 point (Medium acidity): 2 points The sourness is weaker than the standard comparison: 3 points (Medium acidity): 4 points Very weak acidity compared to each benchmark comparison: 5 points According to the above evaluation criteria, the degree of sourness suppression was evaluated on a 5-point scale, and the average value was calculated. Based on this average degree of sourness suppression, the sourness reduction effect was rated as × (1 to less than 2), △ (2 or more to less than 3), ◯ (3 or more to less than 4), or ⊚ (4 to 5).

[0077] Table 4-1 shows the formulation of the citric acid-derived acidity suppressant.

[0078] [Table 4-1]

[0079] The citric acid-derived acidity suppressants in Table 4-1 contain excipients, but they can also be formulated without excipients, and can also be formulated with additives other than excipients. The excipient has a suppressed sweetness and therefore has almost no effect on the sweetness of a sucrose solution containing 5% by mass or less of the total amount.

[0080] Table 4-2 shows the formulation of a citric acid-containing beverage (a citric acid-containing liquid oral composition). Here, an acidity suppressant derived from citric acid that does not contain an excipient was used as a raw material.

[0081] [Table 4-2]

[0082] Table 4-3 shows the formulation of a citric acid-containing beverage (citric acid-containing liquid oral composition) that contains acesulfame K instead of sucrose. Here, a citric acid-derived sourness suppressant that does not contain an excipient was used as a raw material.

[0083] [Table 4-3]

[0084] As shown in Tables 4-2 and 4-3, in a citric acid-containing beverage having a sweetness intensity equivalent to a sucrose solution of 5% by mass or less, citric acid and potassium citrate are blended as ingredients so that the total citric acid content is 0.1 to 1.0% by mass and the content of potassium derived from potassium citrate per part by mass of total citric acid is 0.2 to 1.0 part by mass at a pH of 4.5 to 8. This reduces the sourness caused by citric acid, and it has been confirmed that the sourness can be significantly reduced preferably at 0.35 parts by mass or more, more preferably at 0.4 parts by mass.

[0085] [Test Example 2. Confirmation test 2 of the effect of reducing sourness in beverages containing citric acid] According to the recipes shown in Tables 5-1 and 5-2 below, citric acid-containing beverages (corresponding to citric acid-containing liquid oral compositions) that do not contain sweeteners such as sucrose were prepared by a conventional method (mixing). The types and contents of each component are as shown in the table below.

[0086] The subjects were panelists (7 people) who had sufficient ability to distinguish sourness. The sensory evaluation method and evaluation criteria were the same as in Test Example 1. For Examples 2-1 to 2-4, the sourness of Comparative Example 2-1 containing only citric acid was used as the standard. For Examples 2-5 to 2-8, the sourness of Comparative Example 2-2 containing only citric acid was used as the standard.

[0087] [Table 5-1]

[0088] [Table 5-2]

[0089] [Test Example 3. Confirmation test 3 of the effect of reducing sourness in beverages containing citric acid] According to the recipes shown in Tables 6-1 and 6-2 below, a citric acid-containing beverage containing a sweetener (a citric acid-containing liquid oral composition) was prepared by a conventional method (mixing). The types and contents of each component are as shown in the table below. Unlike Test Example 2, a citric acid-derived sourness suppressant containing maltitol as an excipient for granulation was used as a raw material. The sweetness of the maltitol used here was 0.75 to 0.85, assuming the sweetness of sucrose to be 1, and the sweetness threshold was 0.5%.

[0090] The subjects were panelists (7 people) who had sufficient ability to distinguish sourness. The sensory evaluation method and evaluation criteria were the same as in Test Example 1. For Examples 3-1 to 3-4, the sourness of Comparative Example 3-1 was used as the standard. For Examples 3-5 to 3-8, the sourness of Comparative Example 3-2 was used as the standard.

[0091] [Table 6-1]

[0092] [Table 6-2]

[0093] According to the recipes shown in Tables 6-3 and 6-4 below, a citric acid-containing beverage (citric acid-containing liquid oral composition) containing a sweetener containing sucrose or acesulfame K instead of sucrose was prepared by a conventional method (mixing). The type and content of each component are as shown in the table below. Here, a citric acid-derived acidity suppressant containing maltitol as an additive (excipient) was used as a raw material. The sweetness of the maltitol used here was 0.75 to 0.85, assuming that the sweetness of sucrose is 1, and the sweetness threshold was 0.5%.

[0094] The subjects were panelists (7 people) who had sufficient ability to distinguish sourness. The sensory evaluation method and evaluation criteria were the same as in Test Example 1. For Examples 3-9 to 3-12, the sourness of Comparative Example 3-3 was used as the standard. For Examples 3-13 to 3-16, the sourness of Comparative Example 3-4 was used as the standard.

[0095] [Table 6-3]

[0096] [Table 6-4]

[0097] [Test Example 4. Flavor test of each beverage containing a citric acid-derived acidity suppressant] A stick-shaped individually packaged sourness reducer (3 g) derived from citric acid was opened and added to each of the following beverages. Here, the citric acid-derived sourness suppressant is a citric acid-derived sourness suppressant containing citric acid, potassium citrate, and reduced malt syrup in a ratio of 0.155:1.36:1.5 parts by mass. By adding 1.1% of the citric acid-derived sourness suppressant to the entire beverage, the final total citric acid concentration in each beverage becomes equal to that of a beverage to which 0.34% by mass of anhydrous citric acid is added to the entire beverage.

[0098] (Sensory evaluation method 3) The subjects were five panelists with sufficient ability to distinguish sourness. They had undergone training in sensory evaluation of sourness in advance to confirm their ability to distinguish sourness.

[0099] (Evaluation Criteria 3) Panelists were presented with the samples in random order without knowing the details of the samples, and asked to rate the intensity of sourness according to the following evaluation criteria. Each additive-free beverage was used as a comparison example, and beverages with the same intensity of sourness as the comparison example were given a score of 3. Very weak acidity compared to the comparative example: 1 point (Medium acidity): 1.5 points Less sour than the comparative example: 2 points (Medium acidity): 2.5 points Same sourness as the comparison example: 3 points (Medium acidity): 3.5 points More sour than the comparative example: 4 points (Medium acidity): 4.5 points Much more sour than the comparative example: 5 points

[0100] [Table 7]

[0101] As shown in Table 7, when total citric acid was added to the same concentration, the beverage with the citric acid-derived acidity suppressant was perceived as less sour than the beverage with anhydrous citric acid, indicating the sourness-reducing effect of the citric acid-derived acidity suppressant. In addition, the beverage with the citric acid-derived acidity suppressant and the beverage without the additive had the same level of sourness.

[0102] The citric acid-derived acidity suppressants in Table 4-1 and those without sweeteners such as sucrose were used as raw materials in fruit juice drinks, sports drinks, and jelly drinks. In all cases, the sourness derived from citric acid was not felt.

Claims

1. A citric acid-derived acidity suppressant for use as a raw material or an additive in a citric acid-containing liquid oral composition, comprising: Citric acid, potassium citrate, The citric acid-containing liquid oral composition containing the citric acid-derived acidity suppressant has a pH of 5 to 8; The total citric acid consists of the citric acid and citric acid derived from potassium citrate; The total citric acid content in the citric acid-containing liquid oral composition containing the citric acid-derived sourness suppressant is 0.05 to 1.0% by mass, The content of potassium derived from the potassium citrate per 1 part by mass of total citric acid is 0.4 to 1.0 parts by mass, The citric acid-containing liquid oral composition containing the citric acid-derived acidity suppressant is characterized in that it does not contain a sweetener or has a sweetness intensity equivalent to that of a sucrose solution of 5% by mass or less.

2. A food, drink, medicine or feed comprising the citric acid-derived sourness suppressant according to claim 1.

3. A method for suppressing sourness derived from citric acid in a citric acid-containing liquid oral composition, comprising: The citric acid-containing liquid oral composition is Contains citric acid and potassium citrate, The pH of the citric acid-containing liquid oral composition is 5 to 8; the total content of citric acid consisting of the citric acid and citric acid derived from potassium citrate is 0.05 to 1.0% by mass based on the total amount of the citric acid-containing liquid oral composition; The content of potassium derived from the potassium citrate per 1 part by mass of total citric acid is 0.4 to 1.0 parts by mass. A method for suppressing sourness derived from citric acid.

4. A packaged citric acid-containing liquid oral composition comprising: Citric acid, Potassium citrate, Including, The pH of the citric acid-containing liquid oral composition is 5 to 8; a total content of citric acid consisting of the citric acid and the citric acid derived from the potassium citrate is 0.05 to 1.0% by mass based on a total amount of the citric acid-containing liquid oral composition; The content of potassium derived from the potassium citrate per 1 part by mass of total citric acid is 0.4 to 1.0 parts by mass. A packaged liquid oral composition containing citric acid.

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