Tocotrienol derivatives, methods and uses thereof

JP7833472B2Active Publication Date: 2026-03-19GLOBAL SCI
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Patent Information

Application Number
JP2023546573
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-10-08
Filing Date
2021-10-08
Publication Date
2026-03-19
Estimated Expiration
2041-10-08

AI Technical Summary

Technical Problem

Tocotrienols have low stability and poor bioavailability, leading to inefficient delivery and rapid degradation when applied topically, which limits their effectiveness in treating skin conditions such as acne and seborrheic dermatitis.

Method used

Stabilized tocotrienols are modified with nicotinic acid through ester or amide bonds to enhance skin penetration and stability, allowing for effective delivery and conversion back to the original molecules.

Benefits of technology

The modified tocotrienols demonstrate improved skin penetration and stability, effectively treating skin conditions like acne and seborrheic dermatitis while maintaining their antioxidant and anti-inflammatory properties.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present disclosure relates to the use of tocotrienols in pharmaceutical, veterinary and cosmetic applications, namely, by stabilizing tocotrienols without interfering with their function in the skin, particularly in cosmetic formulations. In particular, the disclosure relates to the modification of tocotrienols with nicotinic acid, stabilizing the molecules and their penetration in human skin. The subject compounds and compositions are useful in the medical, veterinary and cosmetic industries, namely, for the prevention, therapy and treatment of skin diseases, skin disorders, or as a therapy or treatment for acne, seborrheic dermatitis, or as anti-aging agents.
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Citation Information

Patent Citations

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    JP1991246222A

  • External preparation for treating skin disease

    JP1997104623A

  • Skin cosmetic

    JP1998130134A

  • Tocotrienol derivative and method for producing the same

    JP2002080475A

  • antioxidant vitamin b6 analogue

    JP2002543209A