An adapter for a medical dosing pen

Abstract

An adapter (30) for a medical dosing pen (1) is provided. The adapter (30) is configured to connect to a reservoir (10) and to a pen needle hub (40), and wherein the adapter (30) further comprises a septum (350).

Description

[0001] AN ADAPTER FOR A MEDICAL DOSING PEN

[0002] Technical Field

[0003] The present invention relates to an adapter. More specifically, the present invention relates to an adapter for a medical dosing pen, as well as to a medical dosing pen comprising such adapter.

[0004] Background

[0005] Most syringes in use today are of the disposable or single-use type. A typical disposable syringe is made primarily of plastic and has several key components. The largest component, and the one containing the most material, is the plastic barrel. The scale printing on the barrel is a critical and costly manufacturing step that is needed to assure proper dosing by the user. Inside the barrel is typically a rubber stopper acting as a piston that is used to create a hermetic seal and to displace the liquid medication or other fluid into and out from the barrel. The rubber stopper determines the correct dosage upon extracting the liquid from a container. A plastic rod, acting as a piston rod, interfaces with the rubber stopper to move it back and forth by means of the user's control. A metal needle or cannula is usually attached to the distal end of the barrel to allow fluids to be injected into the body, or removed from the body. After a single use the entire syringe is disposed of, and none of the components is reused.

[0006] When it comes to diabetes, disposable plastic syringes are often used to administer liquid insulin to a user several times a day. These single-use syringes typically have transparent plastic barrels with printed scale numbers that allow the user to draw up an accurate dose of insulin from a vial, and fine-gauge metal needles that inject the dose into the body of the patient. Insulin syringes usually have a capacity of 1 ml or less (with 0.3 ml, 0.5 ml and 1.0 ml barrel sizes being common), with scale markings on the barrel representing units of a specific type of insulin (e.g., U-100 or U-500 insulin). Insulin syringes may also be provided with safety features to prevent reuse of the syringe, to shield the used needle, or both. Because insulin syringes are used only once and a user usually requires several of them each day, they are commonly sold in boxes or bags containing multiple syringes.

[0007] The cheapest form of treatment for a variety of chronic diseases where patients should have daily injections is today performed by using a standard disposable syringe as described above, in combination with a vial. Typically, patients who use the cheapest form of treatment will themselves purchase or receive a vial of medication. They will accordingly by themselves arrange the medicine into the syringe and subsequently inject the contents of the syringe.

[0008] This treatment procedure has a number of disadvantages, relating to personal safety and cost, in particular. Firstly, producing the correct amount of dosage has been a known drawback since the introduction of personally injectable medication systems. Individuals suffering from chronic diseases do not necessarily possess the required knowledge behind a correct medication dosage. This may cause severe side effects resulting in hazardous situations, and in worst-case, fatalities. Moreover, today’s injectable medication systems are not very convenient. A user will normally require carrying around several syringes a day, every day, to ensure safety. This of course is a bothersome activity. Another factor of concern is the cost of the disposable syringes. As they are not reusable, the accumulated cost will quickly ramp up causing certain individuals to have their lives economically affected. Finally, one could consider the disposable syringes as being environmentally unfriendly.

[0009] An alternative treatment approach with improved control of dosage and, to some extent, reusability, involves the use of an injection pen device, such as an insulin pen. These devices can be equipped with a medication ampule and are designed for use with single-use pen needle hubs. However, this method has certain drawbacks, primarily related to cost and accessibility.

[0010] Injection pen devices are typically more expensive than traditional singleuse syringes, making them less accessible to patients with lower incomes or those who require ongoing treatment for chronic conditions. The higher cost is due to the complexity of the device's components and the technology involved in their manufacturing. This creates a financial barrier for many patients, potentially limiting their access to necessary medications.

[0011] Moreover, the medication ampules used in these injection pen devices are generally more costly than medications in traditional vials. This can further compound the affordability issues for patients and healthcare systems, leading to a preference for more economical alternatives like single-use syringes. The increased cost of the ampules, coupled with the need for specialized equipment, creates a significant economic burden, particularly for those with chronic conditions requiring long-term or lifelong treatment.

[0012] Consequently, while injection pen devices offer convenience and ease of use, their higher cost can impede equitable access to essential medications. This underlines the need for more affordable and accessible solutions that maintain the benefits of injection pens without the associated financial barriers.

[0013] In W02020152034A1 by the same applicant a solution to address the problems and shortcomings regarding the aforementioned aspects is proposed. This application suggests a medication delivery device which can be used in conjunction with the type of medication vial mentioned above, and allows a precise dose to be administered and a device which is reusable.

[0014] Given the challenges identified with single-use syringes and traditional injection pen devices, there is a need for innovative solutions that allow users to fill a medication reservoir from a medication vial, store the reservoir in a leakproof and sterile manner, and enable easy attachment of a needle hub for subcutaneous injections. Moreover, tamper-proofing the reservoir seal may be of importance to ensure the integrity and security of the medication. A tamper-proof design prevents unauthorized access or tampering, providing patients with greater confidence in the safety and effectiveness of their treatment.

[0015] Reducing the risk of accidental needle pricks during transport and handling is another aspect to consider which protects users from inadvertent contact with needles and enhance overall safety.

[0016] In view of the above drawbacks, there is a need for improvements.

[0017] Summary

[0018] The present inventors have registered and analysed the problems and shortcomings regarding the aforementioned aspects. Accordingly, an object of the present invention is therefore to overcome or at least mitigate one of these problems.

[0019] As will be further explained in the following, the present disclosure is presenting an adapter. The adapter forms an interface between a syringe reservoir and an injection needle, i.e. pen needle hub. The syringe reservoir is thus allowed to be used as a reservoir for a medical dosing pen. Before use of the adapter, the syringe reservoir can be filled with the medication fluid. After mounting the adapter to the syringe reservoir and arranging the syringe reservoir in a medical dosing pen, the pen needle hub can be connected.

[0020] According to one aspect, an adapter for engaging a reservoir for a medical dosing pen is provided. The adapter comprises an inside conic interface engaging an outside conic geometry placed at the front end of the reservoir, and a distal connector configured to engage a pen needle hub. The adapter may further comprise a septum. The adapter may comprise a main body having a proximal connector configured to engage a reservoir connector interface of the reservoir.

[0021] According to one aspect, an adapter for a medical dosing pen is provided. The adapter is configured to connect to a reservoir (of a medical dosing pen) and to a pen needle hub. The adapter may further comprise a septum.

[0022] The adapter may further comprise an inside conical interface configured to engage an outside conical geometry of the reservoir.

[0023] The adapter may further comprise a distal connector configured to engage the pen needle hub.

[0024] The adapter may further comprise a proximal connector configured to engage a reservoir connector interface of a reservoir.

[0025] The adapter may further comprise a main body, said main body comprising the proximal connector and / or the distal connector.

[0026] The adapter enables a reservoir of a syringe suited to be filled from a medication vial to be easily converted to be compatible with a pen needle hub suitable for subcutaneous injections. The adapter enables a reservoir for a medical dosing pen to be filled from a medication vial which is a widely available and cost-effective form to store and distribute medications such as insulin in. The septum of the adapter creates a secure seal of the medication in the reservoir. The septum enables easy transport of the medical dosing pen without risk of contamination or leaks of the medication.

[0027] The main body of the adapter may comprise an outer collar comprising the distal connector. The distal connector may comprise external threads configured to engage with corresponding internal threads of a pen needle hub. Many standard pen needle hubs that are widely available and lower cost include internal threads. As such the external threads of the adapter increases its applicability for connection with standard pen needle hubs. The external threads also ensure a leak-proof and secure connection between the adapter and pen needle hub.

[0028] A proximal end of an inner sidewall of the outer collar may form a fastening means configured to interlock with an external fastening means of the reservoir connector interface. The external fastening means ensures a secure and stable connection between the adapter and the reservoir. The external fastening means may also act as a tamper-evident measure, ensuring that once the system is sealed, it cannot be unintentionally or illicitly opened, thus safeguarding the fluid's sterility and integrity throughout its lifecycle. In an embodiment the fastening means comprise a plurality of teeth configured to engage with corresponding teeth of the reservoir connector interface. A robust fastening means is thereby accomplished.

[0029] The plurality of teeth may form part of a one-way ratchet mechanism preventing disconnection of the adapter from the reservoir. The one-way ratchet mechanism enables easy attachment of the adapter to the reservoir by rotation in one direction, but prevents disconnection of the reservoir by preventing rotation in the opposite direction.

[0030] The main body may further comprises an inner sleeve forming at least part of the proximal connector. The inner sleeve may comprise at least one external protrusion for engaging with the reservoir connector interface. The at least one external protrusion enables a secure and leak-proof connection of the adapter to the reservoir.

[0031] In an embodiment the outer collar and the inner sleeve are integrally formed. This allows for a very simple manufacturing.

[0032] The outer collar and inner sleeve may be connected by at least one radial spacer.

[0033] The septum may be formed with a radial depression along its cylindrical outer surface forming an annular groove and is retained by at least one inner radial ridge of the outer collar whereby it creates a radial seal against whereby it creates a radial seal against an outer sidewall of the inner sleeve. The annular groove of the septum enables the septum to be held securely, preventing axial movement of the septum in both axial directions. The radial seal creates a robust seal that helps prevent leakage and contamination of the medication in the reservoir.

[0034] The outer collar may have at least one inner radial protrusion configured to engage in a snap-fitting with an upper flange of the inner sleeve to connect the outer collar and inner sleeve. A snap-fit connection creates a reliable and durable connection between the outer collar and the inner sleeve.

[0035] In an embodiment the septum is clamped between a radial lip of the outer collar and the upper flange of the inner sleeve to form an axial seal between the outer collar and the inner sleeve. The clamping action creates a secure axial seal that helps prevent leakage or contamination. An axial seal is durable and adds to the reliability of the adapter.

[0036] The septum may be an intact barrier and create a fluid-tight seal of the reservoir when the adapter is attached to the reservoir. The intactness of the septum ensures a secure seal. It also ensures sterility of the medication in the reservoir, preserving medication integrity. The intact septum allows for controlled access to the medication inside the reservoir.

[0037] The septum may be configured to be penetrated by the cannula of the pen needle hub when the adapter and pen needle hub are connected. The penetration creates a fluid channel between the reservoir and the pen needle hub. Said fluid channel enables a medication dose to be administered by the medical dosing pen.

[0038] The thickness, composition and / or position of the septum may enable the septum to be penetrated by the cannula of the pen needle hub when the adapter and pen needle hub are connected. Depending on the specifications of a particular medical dosing pen, the thickness, composition and / or position of the septum can adapt the integrity of the seal and convenience of use of the adapter. For example if a pen needle with a shorter proximal cannula end is preferable the septum may be altered to be thinner or closer to the distal end of the adapter to facilitate easy penetration.

[0039] The septum may be configured to reseal after removal of the pen needle hub from the adapter, creating a liquid-tight seal of the reservoir. The resealing of the septum ensures the adapter may be used in combination with disposable pen needles to administer multiple doses while keeping the reservoir of the medical dosing pen securely sealed. This enables transport of the medical dosing pen without risk of leaks and contamination of the medication, especially between uses. The resealing of the septum also means that the adapter does not need to be exchanged between uses.

[0040] According to a further aspect, a medical dosing pen is provided. The medical dosing pen comprises a dosing assembly, a reservoir and an adapter according to any of the proceeding claims.

[0041] Brief Description of the Drawings

[0042] Embodiments of the invention will now be described, by way of example, with reference to the accompanying schematic drawings, in which

[0043] Fig. 1 A is an isometric view of a medical dosing pen according to prior art.

[0044] Fig. IB is an isometric view of parts of the medical dosing pen shown in Fig. 1A.

[0045] Fig. 2A is a side view of a syringe having a reservoir for use with a medical dosing pen.

[0046] Fig. 2B is a cross-sectional view of the distal end of the syringe reservoir shown in Fig. 2A. Fig. 3 is a side view of a syringe reservoir with an adapter mounted to it, and a pen needle hub to be mounted to the adapter.

[0047] Fig. 4 is a cross-sectional view of the setup shown in Fig. 3.

[0048] Fig. 5 is a cross-sectional view of an adapter forming an interface between a syringe reservoir and a pen needle hub.

[0049] Fig. 6A is a cross-sectional and exploded view of an adapter according to an embodiment.

[0050] Fig. 6B is a cross-sectional view of the adapter shown in Fig. 6A.

[0051] Fig. 7A is an isometric and exploded view of an adapter according to another embodiment.

[0052] Fig. 7B is a cross-sectional view of the adapter shown in Fig. 7A.

[0053] Detailed Description

[0054] For purposes of the description hereinafter, the terms "proximal", "distal", and derivatives thereof relate to the disclosure as it is oriented in the drawings. However, it is to be understood that the disclosure may assume alternative orientations, except where expressly specified to the contrary.

[0055] Starting in Fig. 1, a medical dosing pen 1 is shown. The medical dosing pen 1 is configured to administrate injections by delivering a pre-determined amount of a specific medication to a user. The medication is stored in a cartridge comprising a container in the form of a barrel or reservoir 10.

[0056] The delivery of a medication from the reservoir 10 to a user, is controlled by means of a dosing mechanism 60. The dosing mechanism 60 is loaded with the reservoir, thus forming a medical dosing pen. The exact configuration of the dosing mechanism 60 may vary, as long as it is configured to receive a cartridge (i.e. the reservoir 10) and to allow for controlled injection of a predetermined part of the enclosed volume of medication.

[0057] Embodiments of the present invention will from hereon be described. In particular, the medical dosing pen comprises a medication cartridge and a dosing mechanism configured to hold a medication cartridge. The medication cartridge is provided with a pen needle hub used to penetrate the skin of a user, while the dosing mechanism ensures a proper injection of the medication from the cartridge, via the pen needle hub, to the user. Before the medication cartridge is mounted to the dosing mechanism, the medication cartridge is formed by a syringe reservoir.

[0058] Different parts used to form parts of a medical dosing pen 1 are further shown in Fig. 2 A. A syringe 100 comprises a container in the form of a reservoir 10, in which a piston (not shown) is mounted. The piston is coupled to a piston rod 110. According to the embodiments described herein, while not being described in detail, the piston rod 110 can be released from the piston when the reservoir 10 is sufficiently filled with liquid, which allows the reservoir 10 to be mounted to an associated dosing mechanism after filling from a vial or similar.

[0059] In fact, the dosing mechanism is preferably designed such that it cannot connect to the reservoir 10 when the reservoir 10 is in a state where it is empty and configured to draw liquid from a vial or similar. Instead, the dosing mechanism requires the syringe 100 to transform to another state after it has been filled, in order for it to be properly loaded into the dosing mechanism.

[0060] In FIG. 2 A the syringe 100 may be filled with medicament from a medication vial. For filling purposes a distal end of the reservoir 10 comprises a reservoir connector interface 150. The reservoir connector interface may e.g. be configured to engage with a needle hub 20. The needle hub 20 is preferably a Luer lock or Luer slip needle hub, more preferably a Luer lock needle hub. The internal features of the reservoir connector interface 150 will be described in more detail later.

[0061] The distal end of the reservoir 10 may be open. The open distal end may enable the reservoir 10 to be used together with a standard Luer needle hub 20. This may be important for cost-efficiency as no specialty needle hub is required in order to fill the reservoir. As will be discussed later an open distal end of the reservoir 10 will be specifically advantageous in use with an adapter, as an otherwise open reservoir may present risks of contamination if the reservoir is to be transported or used repeatedly.

[0062] The needle hub 20 comprises a locking insert 208 and a cannula 220. The length and dimensions of the cannula 220 is suitable to penetrate a septum of a medication vial (not shown) and quickly fill the reservoir 10 with medication from the medication vial or the like. The connection between the reservoir connector interface 150 and the needle hub 20 is preferably configured to ensure a leak-proof and sterile transfer process of the medicament from the medication vial to the reservoir 10.

[0063] In Fig. 2B a cross section of the reservoir connector interface 150 and part of the reservoir 10 is shown. The reservoir connector interface 150 comprises a sleeve 155 preferably being provided with internal threads 154 for engaging with one or more corresponding protrusions 210 (see Fig. 2A) on the locking insert 210 of the needle hub 20. A slip connection between the needle hub 20 and sleeve 155 may also be considered an option. In the case of a slip connection the needle hub 20 would connect to the reservoir connector interface 150 by friction between a proximal end of the needle hub and the sleeve 155.

[0064] In the shown example, the needle hub 20 and the reservoir connector interface 150 form a Luer lock connection.

[0065] The reservoir connector interface 150 further comprises an opening through which medication can enter the reservoir 10 from the medication vial. The opening of the reservoir 10 enables the reservoir to be used together with a standard Luer needle hub 20.

[0066] The reservoir connector interface 150 may also comprise an external fastening means 152. The external fastening means 153 is configured to engage with a corresponding fastening means 315 of an adapter 30. The external fastening means 152 may for example comprise a plurality of teeth 152. The external fastening means 152 is configured to engage with the adapter 30 in a manner that prevents disassembly after the initial attachment. The external fastening means 152 may act as a tamper-evident measure, ensuring that once the system is sealed, it cannot be unintentionally or illicitly opened, thus safeguarding the fluid's sterility and integrity throughout its lifecycle. A number of different mechanisms may be used to tamper-proof the reservoir 10 or at least make any accidental or unauthorized openings evident to a user. As an alternative or complement to the plurality of teeth 152 a tear-off tab or break-away ring may be used. The tamper-proofing may be configured to break or deform upon reopening.

[0067] Fig. 3 shows the reservoir 10 with a needleless adapter 30 connected to it. The needleless adapter 30 may be a safer alternative than adapters comprising proximal or distal needles as it reduces the risk of needle pricks or scratches on the user. The adapter 30 comprises main body 3000 having a proximal connector 320 configured to engage the reservoir connector interface 150 of the reservoir 10. The adapter 30 further comprises a septum 350. The septum 350 is arranged inside the main body 3000 of the adapter 30. The septum 350 may be an intact barrier and create a fluid-tight, preferably air-tight, seal of the reservoir 10 when the adapter 30 is attached to the reservoir 10. The adapter 30 further comprises a distal connector 310 configured to engage a pen needle hub 40. The distal connector 310 of the adapter 30 may e.g. comprise external threads configured to engage with corresponding internal threads 410 of the pen needle hub 40. The pen needle hub 40 is preferably in compliance with ISO 11608-2.

[0068] The pen needle hub 40 is further provided with a cannula 420 which is intended to penetrate the skin of a user, and to guide medication during injection. Fig. 4 shows a cross section of the reservoir 10 in connection with the adapter 30 and a cross section of the pen needle hub 40.

[0069] In this embodiment a main body 3000 of the adapter 30 comprises an outer collar 31. The outer collar 31 may comprise the distal connector 310 and said distal connector 310 may comprise external threads 311 configured to engage with corresponding internal threads 410 of the pen needle hub 40. At a proximal end of an inner sidewall 313 of the outer collar 31 a fastening means 315 may be formed. The fastening means 315 is configured to engage with the external fastening means 152 of the reservoir connector interface 150. The fastening means 315 may comprise a plurality of teeth 312 configured to engage with a corresponding external fastening means 152 of the reservoir connector interface 150. The external fastening means 152 of the reservoir connector interface 150 may comprise a plurality of teeth. The plurality of teeth 312 of the fastening means 315 may form part of a one-way ratchet mechanism preventing disconnection of the adapter 30 from the reservoir 10. The one-way ratchet mechanism may prevent disconnection of the adapter 30 from the reservoir without deformation of the plurality of teeth 312 of the fastening means 315 of the outer collar 31 or the external fastening means 152 and / or of the reservoir connector interface 150.

[0070] The main body 3000 of the adapter 30 may further comprise an inner sleeve 32. The inner sleeve 32 may form at least part of the proximal connector 320. Said inner sleeve 32 may comprise one or more external protrusions 324 configured to engage with the reservoir connector interface 150. Said external protrusions 324 may form the at least part of the proximal connector 320. The external protrusions 324 are preferably configured to engage with the internal threads 154 of the sleeve 155 of the reservoir connector interface 150. The external protrusions 324 of the inner sleeve 32 preferably engage with the reservoir connector interface 150 in the same way as the external protrusions 210 of the needle hub 20.

[0071] The adapter 30 further comprises a septum 350. The septum 350 is arranged inside the main body 3000 of the adapter 30. Preferably the septum 350 is arranged near the distal end of the adapter 30. The adapter 30 may, at least in part, be axially aligned with the distal connector 310 of the adapter 30. The septum 350 creates a liquid-tight and / or air-tight seal of the reservoir 10 when the reservoir 10 is connected to the adapter 30. The septum 350 prevents contamination of the medicament in the reservoir 10 and also prevents the medicament from leaking out of the reservoir 10. Suitable materials for the septum 350 may for example include rubber, Silicone, PTFE, etc.

[0072] The septum 350 may allow the adapter to act as a lid to the open end of the reservoir 10. The adapter 30 may be configured to close the open end of the reservoir 10 and thereby enable easy and leak-proof transport of the reservoir 10. The adapter 30 may enable a reservoir 10 suited to be filled by a standard Luer needle to be sealed, transported and used in combination with a standard pen needle hub 40. The adapter 30 may thereby be configured to form part of a more cost-efficient medical dosing pen 1.

[0073] In Fig. 5 an embodiment of the adapter 30 attached to the reservoir 10 and the pen needle hub 40 is shown. The adapter 30 is connected to the reservoir 10 by means of the proximal connector 320 of the adapter 30 engaging the reservoir connector interface 150. The pen needle hub 40 is connected to the adapter 30 by means of the internal threads 410 of the pen needle hub 40 engaging with corresponding external threads of the distal connector 310 of the adapter 30. The septum 350 of the adapter 30 is penetrated by a proximal end 422 of the cannula 420 of the pen needle hub 40. Once the cannula 420 has penetrated the septum 350 a fluid channel is created between the reservoir 10 and the pen needle hub 40. Said fluid channel enables a medication dose to be administered by the delivery system 1. The thickness, composition and / or position of the septum 350 may enable the septum 350 to be penetrated by a proximal end 422 of the cannula 420 of the pen needle hub 40 when the adapter 30 and pen needle hub 40 are connected.

[0074] When the pen needle hub 40 is removed from the adapter 30 the septum 350 preferably reseals. The septum 350 may be made of an elastically deformable material, such as rubber or other elastomeric material as mentioned above. The septum may deform when it is penetrated by the cannula 420. The material of the septum 350 may deform around the puncture site. Once the cannula 420 is removed, the septum 350 returns to its original shape, effectively closing the hole created by the cannula 420. The resealing action helps maintain the integrity of the reservoir 10 and prevents contamination or evaporation of the medication inside. The septum 350 may be made of a material with self-sealing or adhesive properties enabling it to reseal itself. The septum 350 may also be compressed by the main body 3000 of the adapter 30 meaning it has an ability to expand around a cannula puncture to effectively reseal itself.

[0075] Sheet septum Figs. 6A-B show an embodiment of the adapter 30. The septum 350 is formed as a disk. A disk implies a cylindrical shape with a height significantly smaller than its diameter. The height of the septum 30 may be approximately half of the diameter of the septum, preferably smaller. The height should be adapted depending on the penetrability of the material of the septum 30 and the type of pen needle hub 40 it is configured to be penetrated by.

[0076] The main body 3000 of the adapter is formed by two parts. The inner sleeve 32 forms part of the main body 3000 and comprises a flange 322 configured to engage in a snap-fit connection with at least one, preferably two or more, inner radial protrusion 318 of the outer collar 31. The inner sleeve 32 further comprises external protrusions or lugs 324 formed to engage with the reservoir connector interface 150. The external protrusions 324 preferably engage with the inner threads 154 of the sleeve 155 of the reservoir connector interface 150.

[0077] The outer collar 31 forms part of the main body 3000 and comprises the distal connector 310 of the adapter 30. The distal connector 310 may comprise external threads for engaging with corresponding inner threads of a pen needle hub 40. The outer collar 31 further comprises at least one, preferably two, inner radial protrusion 318. The at least one radial protrusion 318 is configured to engage in a snap-fitting with the flange 322 of the inner sleeve 32 to connect the outer collar 31 and inner sleeve 32 to each other. At a proximal end of an inner sidewall 313 of the outer collar 31 a fastening means 315 may be formed. The fastening means 315 is configured to interlock with the external fastening means 152 of the reservoir connector interface 150. The fastening means 315 may comprise a plurality of teeth 312. The plurality of teeth 312 of the fastening means 315 may form part of a one-way ratchet mechanism preventing disconnection of the adapter 30 from the reservoir 10 without deforming the fastening means 315 of the adapter 30.

[0078] A radial lip 316 is formed at a distal end of the outer collar 31. The radial lip 316 extends radially inwards and leaves a passage in the distal end of the outer collar 31. As exemplary shown in Fig. 6B the septum 350 is clamped between the flange 322 of the inner sleeve 32 and the radial lip 316 of the outer collar 31. The outer collar 31 and the inner sleeve 32 are connected by the at least one inner protrusion 318 of the outer collar 31 and the flange 322 of the inner sleeve 32 by means of a snap-fit connection. The septum thus creates an axial seal between the outer collar 31 and the inner sleeve 32. Molded

[0079] Another embodiment of the adapter 30 is exemplary shown in Figs. 7A-B. The main body 3000 is formed in one piece. The main body 3000 of the adapter may comprise an outer collar 31 and an inner sleeve 32. The outer collar 31 and inner sleeve 32 may be integrally formed. The outer collar 31 and inner sleeve 32 may be connected by means of at least one radial spacer 328. Preferably, several spacers 328 are distributed along the inner periphery of the outer collar 31 such that a robust connection between the outer collar 31 and the inner sleeve 32 is accomplished.

[0080] The inner sleeve 32 forms part of the main body 3000. The inner 32 sleeve comprises external protrusions or lugs 324 formed to engage with the reservoir connector interface 150. The external protrusions preferably engage with the inner threads 154 of the sleeve 155 of the reservoir connector interface 150.

[0081] The outer collar 31 forms part of the main body 3000 and comprises the distal connector 310 of the adapter 30. The distal connector 310 may comprise external threads for engaging with corresponding inner threads of a pen needle hub 40. The outer collar 31 further comprises at least one, preferably two, inner radial protrusion 318. At a proximal end of an inner sidewall 313 of the outer collar 31 a fastening means 315 may be formed. The fastening means 315 is configured to engage with the external fastening means 152 of the reservoir connector interface 150. The fastening means 315 may comprise a plurality of teeth 312. The plurality of teeth 312 of the fastening means 315 may form part of a one-way ratchet mechanism preventing disconnection of the adapter 30 from the reservoir 10 without deforming the fastening means 315 of the adapter 30.

[0082] In this embodiment the septum 350 has a disc shape and a radial depression along its cylindrical outer surface forming an annular groove 352. The septum 350 is retained within the main body 3000 of the adapter 30 by means of at least one radial ridge 326 formed on the inner sidewall 313 of the outer collar 31. The septum 30 may be formed with the annular groove 352 such that it surrounds the at least one radial ridge 326 of the main body 3000 of the adapter 30. The annular groove 352 is preferably arranged centrally in an axial direction of the septum 350. The annular groove 352 of the septum 350 enables the septum 350 to be held securely, preventing axial movement of the septum 350 in both axial directions. The septum 350 creates a radial seal against an outer sidewall 327 of the inner sleeve 32.

[0083] For all embodiments described above the adapter 30, with the septum 350, provides for a sealed interface between a reservoir 10 and a pen needle hub 40. The adapter 30 makes it extremely easy to convert the reservoir 10 from a first filling state, where the reservoir 10 is filled using a relatively large cannula, to a dispensing state where the reservoir 10 is configured to inject medication through a relatively small cannula of a pen needle hub using a medical dosing pen. From the description above follows that, although various embodiments of the invention have been described and shown, the invention is not restricted thereto, but may also be embodied in other ways within the scope of the subjectmatter defined in the following claims.

Claims

CLAIMS1. An adapter (30) for a medical dosing pen (1), wherein the adapter (30) is configured to connect to a reservoir (10) and to a pen needle hub (40), and wherein the adapter (30) further comprises a septum (350).

2. The adapter (30) according to claim 1, further comprising an inside conical interface configured to engage an outside conical geometry of the reservoir (10).

3. The adapter (30) according to claim 1 or 2, further comprising a distal connector (310) configured to engage the pen needle hub (40).

4. The adapter (30) according to any of claims 1 to 3, further comprising a proximal connector (320) configured to engage a reservoir connector interface (150) of a reservoir (10).

5. The adapter according to claim 3 or 4, further comprising a main body (3000), said main body (3000) comprising the proximal connector (320) and / or the distal connector (310).

6. The adapter (30) according to claim 5, wherein the main body (3000) further comprises an outer collar (31) comprising the distal connector (310), and wherein the distal connector (310) comprises external threads configured to engage with corresponding internal threads (410) of a pen needle hub (40).

7. The adapter (30) according to claim 6, wherein a proximal end of an inner sidewall (313) of the outer collar (31) forms a fastening means (315) configured to interlock with an external fastening means (152) of the reservoir connector interface (150).

8. The adapter (30) according to claim 7, wherein the fastening means (315) comprises a plurality of teeth (312) configured to engage with a corresponding external fastening means (152) of the reservoir connector interface (150).

9. The adapter (30) according to claim 8, wherein the plurality of teeth (312) forms part of a one-way ratchet mechanism preventing disconnection of the adapter from the reservoir (10).

10. The adapter (30) according to any of claims 6-9, wherein the main body (3000) further comprises an inner sleeve (32) forming at least part of the proximal connector (320), wherein the inner sleeve comprises at least one external protrusion (324) for engaging with the reservoir connector interface (150).

11. The adapter (30) according to claim 10, wherein the outer collar (31) and the inner sleeve (32) are integrally formed.

12. The adapter (30) according to claim 11, wherein the outer collar (31) and inner sleeve (32) are connected by at least one radial spacer (328).

13. The adapter according to claim 10 or 11, wherein the septum (350) is formed with a radial depression along its cylindrical outer surface forming an annular groove (352) and is retained by at least one inner radial ridge (326) of the outer collar (31) whereby it creates a radial seal against an outer sidewall (327) of the inner sleeve (32).

14. The adapter according to claim 10, wherein the outer collar (31) has at least one inner radial protrusion (318) configured to engage in a snap-fitting with a flange (322) of the inner sleeve (32) to connect the outer collar (31) and inner sleeve (32).

15. The adapter according to claim 14, wherein the septum (350) is clamped between a radial lip (316) of the outer collar (31) and the flange (322) of the inner sleeve (32) to form an axial seal between the outer collar (31) and the inner sleeve (32).

16. The adapter (30) according to any preceding claim, wherein the septum (350) is an intact barrier and creates a fluid-tight seal of the reservoir (10) when the adapter (30) is attached to the reservoir (10).

17. The adapter (30) according to any preceding claim, wherein the septum (350) is configured to be penetrated by a proximal end (422) of the cannula (420) of the pen needle hub (40) when the adapter (30) and pen needle hub (40) are connected.

18. The adapter (30) according to any preceding claim, wherein the thickness, composition and / or position of the septum (350) enables the septum (350) to be penetrated by a proximal end (422) of the cannula (420) of the pen needle hub (40) when the adapter (30) and pen needle hub (40) are connected.

19. The adapter (30) according to any preceding claim, wherein the septum (350) is configured to reseal after removal of the pen needle hub (40) from the adapter, creating a liquid-tight seal of the reservoir (10).

20. A medical dosing pen (1) comprising a dosing assembly (60), a reservoir (10) and an adapter (30) according to any of the preceding claims.

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