Macrolide compound and preparation method thereof

New macrolide compounds prepared through the fermentation of Streptomyces glaciale solve the problems of abamectin's nontoxicity to embryonic eggs and insufficient systemic properties, and achieve efficient killing of a variety of harmful mites and insects. Protected plant and animal crops.

CN101037441AInactive Publication Date: 2007-09-19NORTHEAST AGRICULTURAL UNIVERSITY
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Patent Information

Application Number
CN200710071651.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2007-01-17
Publication Date
2007-09-19
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing abamectin has no toxic effect on first-laid eggs with undeveloped embryos, and has weak systemic effects on adult insects, making it difficult to effectively control a variety of harmful mites and other harmful insects.

Method used

A new macrolide compound was prepared by fermentation of Streptomyces bingchengsis sp.nov, through slant culture, seed culture, fermentation and compound separation processes, using methanol extraction, silica gel column chromatography and RP- 18 Chromatography obtained compounds with strong acaricidal activity.

Benefits of technology

The compound can effectively kill a variety of harmful mites, insects and ectoparasites, including adults and eggs, provide protection for plants, animals and horticultural crops, and significantly improve the killing effect against a variety of harmful mites and insects.

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Abstract

The invention provides a macrolide compound and the producing method thereof. The inventive compound is produced by following steps: cultivating and liquid leavening of Streptomyces bingchengsis sp. nov, filtering the fermentation liquor, extracting by carbinol, EtOAc extraction, concentrating, silica gel column chromatography, RP-18 column chromatography to get the target compound. The inventive new compound has a strong activity to kill acarid and also can be used to control other insects harmful to the plants.
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