Trans-cinnamic acid ester compounds and their synthesis method and application

A technology of trans-cinnamic acid esters and compounds, applied in the field of compounds, to achieve the effects of low molecular weight, low production cost, and fewer synthesis steps

CN103965048BInactive Publication Date: 2016-02-17NORTHWEST A & F UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2016-02-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a trans cinnamic acid ester compound, as well as a synthetic method and application thereof. At present, a typic miticide has the growing problems, such as drug resistance and environment and ecology, so that a new animal miticide needs to be developed very urgently. The trans cinnamic acid ester compound has the molecular structure shown in the specification, wherein R refers to alkyl radical, R1 and R2 refer to hydrogen, hydroxide radical, alkyl radical, alkoxy, fatty acyloxy, halogen, methylenedioxy or nitro, and are the same or different; the trans cinnamic acid ester compound can be used for preparing miticides for animals and people. The compound serves as a novel miticide, is relatively low in toxicity, small in molecular weight, few in synthetic steps, simple to operate, low in production cost, and suitable for large-scale industrial production; the acaricidal activity is remarkably stronger that of a miticide applied in current all clinics.
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Description

technical field

[0001] The invention relates to a class of compounds, in particular to a trans-cinnamate compound and its synthesis method and application. Background technique

[0002] Acariasis is a kind of ubiquitous ectoparasitic diseases shared by humans and animals. The disease is characterized by contagion, intense itching, and severe skin inflammation. The occurrence of mite disease is very common and quite stubborn. Rabbits, pigs, sheep, dogs, foxes, rats, cattle, chickens and other animals and people can be infected with mites. Mites can cause serious health hazards to humans and animals. For animals, acariasis can cause severe stress reactions in animals, affecting animal feeding, sleep, feed efficiency and animal weight gain, and severe cases can cause animal death. Therefore, the occurrence of animal mite disease will seriously affect the production performance of animals and the quality of livestock products. In addition, mites also play an intermediary rol...

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Embodiment Construction

[0024] The present invention will be described in detail below in combination with specific embodiments.

[0025] The trans-cinnamate compound involved in the present invention has the following molecular structure:

[0026]

[0027] Among them, R is an alkyl group, R 1 , R 2 are the same or different hydrogen, hydroxyl, alkyl, alkoxy, fatty acyloxy, halogen, methylenedioxy, nitro and the like.

[0028] Above-mentioned trans-cinnamate compound is prepared by following synthetic reaction:

[0029]

[0030] Among them, R is an alkyl group, R 1 , R 2 are the same or different hydrogen, hydroxyl, alkyl, alkoxy, fatty acyloxy, halogen, methylenedioxy, nitro and the like.

[0031] All trans-cinnamate compounds are synthesized by Wittig reaction, and the synthesis methods of different compounds are slightly different, mainly reflected in the different molar ratios of the reaction reagent triphenylphosphine ethyl acetate and substituted benzaldehyde, different reaction solv...