Application of 3-aryl propionate compound in preparation of acaricidal drugs

A technology of aryl propionate and compound, which is applied in the application field of 3-aryl propionate compound as the preparation of acaricide, and achieves the effect of low molecular weight, low production cost and simple operation

CN104304248AActive Publication Date: 2015-01-28NORTHWEST A & F UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2015-01-28

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Abstract

The invention relates to an application of a 3-aryl propionate compound in preparation of acaricidal drugs. Increasing mites have caused increasingly serious drug resistance on existing acaricidal drugs, and reappearance and repeated infection of acaridiasis become increasingly frequent. The invention relates to a 3-aryl propionate compound, which is used for preparing acaricidal drugs of animals and people. The acaricidal activity is significantly stronger than that of all the acaricidal drugs for clinical application at present; the toxicity on people and animals is relatively low; and a plurality of compounds are natural products, and exist in daily food and beverage of people, and therefore, the 3-aryl propionate compound is low in molecular weight, few in synthetic steps, simple in operation, cheap in production ingredients, and suitable for large-scale industrial production.
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Description

technical field

[0001] The invention relates to the pharmaceutical application of a class of compounds, in particular to the application of a class of 3-aryl propionate compounds as preparation of acaricides. Background technique

[0002] Acariasis is a kind of ubiquitous ectoparasitic diseases shared by humans and animals. The disease is characterized by contagion, intense itching, and severe skin inflammation. The occurrence of mite disease is very common and quite stubborn. Rabbits, pigs, sheep, dogs, foxes, rats, cattle, chickens and other animals and people can be infected with mites. Mites can cause serious health hazards to humans and animals. For animals, acariasis can cause severe stress reactions in animals, affecting animal feeding, sleep, feed efficiency and animal weight gain, and severe cases can cause animal death. Therefore, the occurrence of animal mite disease will seriously affect the production performance of animals and the quality of livestock produc...

Examples

Embodiment Construction

[0014] The present invention will be described in detail below in combination with specific embodiments.

[0015] The present invention designs a series of 3-aryl propionate compounds, establishes its synthesis method, and completes its structural identification. Through the determination of biological activity, it is proved that this type of compound has strong acaricidal activity, and is a kind of compound in animal medicine. Drugs with potential application value in human medicine and human medicine, and provide theoretical and technical information for the application and development of such compounds.

[0016] The 3-aryl propionate compounds involved in the present invention have the following molecular structure characteristics:

[0017]

[0018] Wherein, R is an aliphatic hydrocarbon group or an aryl group, and R' and R" are the same or different hydrogen, hydroxyl, hydrocarbon group, alkoxy group, acyl group, acyloxy group, halogen, etc.

[0019] The typical synthe...