Use of benzhexol hydrochloride in withdrawal and treatment of opium poison

Abstract

The invention relates to the application of paralest in the opium drug detoxification abstinence treatment and belongs to the technical field of addiction medicine application. According to the functional characteristics of paralest of selectively breaking the cholinergic nerve tract of striaturn, inhibiting the hyperfunction of acetylcholine, correspondingly improving the effect of brain dopamine, being good for keeping or recovering the balance of two transmitter systems of striaturn dopamine (DA) and acetylcholine (Ach) and causing no drug dependence after long time usage, the paralest is used for the treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome), etc. Experimentation on animals and clinical trial show that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The paralest can be widely applied to the opium drug abstinence treatment.

Description

Technical field:

[0001] The invention relates to the application of trihexyphenidyl hydrochloride in the treatment of opioid drug withdrawal, belonging to the technical field of addiction medicine application. Background technique:

[0002] Benzhexol Hydrochloride, also known as Artane, is traditionally used as a central anticholinergic anti-Parkinson's disease drug. Parkinson's disease is a disease caused by low levels of dopamine in the brain. The goal of drug treatment is to control its symptoms by restoring dopamine levels in the brain. The function of trihexyphenidyl hydrochloride is to selectively block the cholinergic nerve pathway of the striatum, inhibit the hyperactivity of acetylcholine, and have a weak anticholinergic effect on the periphery, thereby increasing the effect of dopamine in the brain accordingly, which is beneficial to maintain or restore striatum. It can directly inhibit the parasympathetic nervous system and relieve muscle spasm. In terms of clin...

Examples

Embodiment 1

[0014] Once the opioid drugs are stopped and acute withdrawal symptoms occur, take trihexyphenidyl hydrochloride three times a day (morning, middle and evening). Take 1-3mg each time on the first day, 4-10mg each time from the second to the fourth day, 3mg each time from the fifth to the sixth day, and 1mg each time on the seventh day.

Embodiment 2

[0016] During the recovery phase, when protracted withdrawal symptoms occur, take trihexyphenidyl hydrochloride three times a day (morning, middle and evening). Take 2 mg each time on the first day, 3-5 mg each time on the second to third day, and 1 mg each time on the fourth day.

Technical field:

[0001] The invention relates to the application of trihexyphenidyl hydrochloride in the treatment of opioid drug withdrawal, belonging to the technical field of addiction medicine application. Background technique:

[0002] Benzhexol Hydrochloride, also known as Artane, is traditionally used as a central anticholinergic anti-Parkinson's disease drug. Parkinson's disease is a disease caused by low levels of dopamine in the brain. The goal of drug treatment is to control its symptoms by restoring dopamine levels in the brain. The function of trihexyphenidyl hydrochloride is to selectively block the cholinergic nerve pathway of the striatum, inhibit the hyperactivity of acetylcholine, and have a weak anticholinergic effect on the periphery, thereby increasing the effect of dopamine in the brain accordingly, which is beneficial to maintain or restore striatum. It can directly inhibit the parasympathetic nervous system and relieve muscle spasm. In terms of clin...

Examples

Embodiment 1

[0014] Once the opioid drugs are stopped and acute withdrawal symptoms occur, take trihexyphenidyl hydrochloride three times a day (morning, middle and evening). Take 1-3mg each time on the first day, 4-10mg each time from the second to the fourth day, 3mg each time from the fifth to the sixth day, and 1mg each time on the seventh day.

Embodiment 2

[0016] During the recovery phase, when protracted withdrawal symptoms occur, take trihexyphenidyl hydrochloride three times a day (morning, middle and evening). Take 2 mg each time on the first day, 3-5 mg each time on the second to third day, and 1 mg each time on the fourth day.

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