Natural progesterone proliposome preparation and preparation method and using method thereof

A technology of precursor lipid and progesterone, which is applied in the field of medicine, can solve the problems of high toxicity and side effects of drugs, inconvenient administration, and low bioavailability of progesterone, so as to change the cell barrier, improve absorption and bioavailability, The effect of promoting transmembrane transport

CN102652733AInactive Publication Date: 2012-09-05新疆维吾尔自治区包虫病临床研究所 +3
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2012-09-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a natural progesterone proliposome preparation and a preparation method and a using method thereof. The natural progesterone proliposome preparation contains 1 to 30 percent of progesterone in percentage by weight, and is prepared from progesterone, phosphatide, 1,2-propanediol or / and poly(ethylene glycol)-400 (PEG-400). The natural progesterone proliposome preparation is diluted with water before being taken, or is orally taken into a body, and contacts body fluid, and the phosphatide is hydrated and self-assembled to form liposome. The natural progesterone proliposome preparation avoids metabolizing of progesterone in gastrointestinal tracts and reduces the first pass effect by using a wrapping function of the liposome, and cellular barriers can be changed by using the liposome so as to promote transmembrane transport and inhibit P-glycoprotein to realize slow releasing; and the natural progesterone proliposome preparation has the functions of good cytocompatibility, promotion of lymphatic transport and the like so as to promote gastrointestinal absorption of natural progesterone. Meanwhile, the natural progesterone proliposome preparation can be further modified by chitosan which promotes absorption and has strong adhesivity to further improve the bioavailability of the progesterone. Therefore, the natural progesterone proliposome preparation is a novel preparation which improves the absorption and the bioavailability of the progesterone after oral administration from a variety of mechanism and a plurality of angles.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and relates to a natural progesterone liposome preparation, a preparation method and a use method thereof. Background technique

[0002] Progesterone (Progesterone), also known as progesterone, progestin, and pregnenedione, is a natural progesterone that exists in the body. Natural progesterone is widely used in clinical practice for the treatment of secondary amenorrhea, dysfunctional uterine bleeding, luteal phase support, premature labor, luteal phase insufficiency, premenstrual syndrome, habitual abortion, threatened abortion, etc. And progesterone plays an important role in in vitro fertilization-embryo transfer (IVF) and is essential for maintaining pregnancy. In addition, with the improvement of people's living standards, more and more women supplement estrogen after menopause to improve the quality of life, that is, hormone replacement therapy (Hormone replacement therapy, HRT), in horm...

Examples

Embodiment 1

[0033] Example 1, the natural progesterone proliposome preparation: contains 1% progesterone by weight percentage; 10% phospholipid; the balance is 1,2-propanediol or / and PEG-400.

Embodiment 2

[0034] Example 2, the natural progesterone proliposome preparation: contains 1% progesterone by weight percentage; 30% phospholipid; and 1,2-propanediol or / and PEG-400 in the balance.

Embodiment 3

[0035] Example 3, the natural progesterone proliposome preparation: contains 30% progesterone by weight percentage; 10% phospholipid; the balance is 1,2-propanediol or / and PEG-400.