Method for extracting artemisinin from artemisia annua L

A technology of wormwood and artemisinin, which is applied in the field of industrial technology, can solve the problems of artemisinin natural resource shortage, low artemisinin content, and many impurities, and achieve good industrial application prospects, good product quality, and high purity high effect

CN104327092AInactive Publication Date: 2015-02-04庞群
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2015-02-04
Estimated Expiration
Not applicable · inactive patent
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Abstract

A method for extracting artemisinin from artemisia annua L comprises: due to the fact that supercritical CO2 has good dissolvability on artemisinin, mixing CO and artemisia annua L in an extraction tank, increasing the pressure intensity and the temperature until liquefaction, performing extraction in the extraction tank, dissolving artemisinin in CO, after reducing pressure, enabling CO2 containing artemisinin to enter a separation tank, separating and precipitating artemisinin (and impurities), sending CO2 to a compressor for cycle usage, and performing simple separation refining on the extractive to obtain pure artemisinin. The method for extracting artemisinin from artemisia annua L is simple in technology and short in period, and has the operation temperature close to normal temperature, artemisinin hardly has thermal cracking and other chemical change, the content of impurities (waxy substances) in the extractive is low, and the method is simple in purification and refining of artemisinin, high in yield, high in purity and good in product quality, and has extremely good industrial application prospect.
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Description

technical field

[0001] The invention relates to a method for extracting artemisinin from Artemisia annua plants, belonging to the technical field of industry. Background technique

[0002] Artemisinin is a colorless needle-like crystal with a molecular formula of C15H2205. In 1976, it was proved to be a new type of sesquiterpene lactone containing peroxy group through chemical reaction, spectral data and X-ray single crystal diffraction method. Due to its special peroxy group, it is unstable to heat and is easily decomposed by moisture, heat and reducing substances. The earliest use of artemisinin as medicine was found in the silk book "Fifty-two Disease Prescriptions" unearthed from the Han Tomb No. 3 in Mawangdui (around 168 BC). Later, it was recorded in "Shen Nong's Materia Medica", "Compendium of Materia Medica" and other books. In 1972, Chinese scientists isolated this active substance from Artemisia annua on the basis of sorting out folk prescriptions and practices....

Examples

Embodiment Construction

[0009] The implementation process of the method for extracting artemisinin from Artemisia annua will be further described below.

[0010] 1. Preparation of raw materials: Dry and harden Artemisia annua (including flower buds) and mechanically grind them into chips. The particle size of the chips is (0.2-2 mm); preparation of the extraction tank: it is recommended to use supercritical fluid produced by Swiss NOVA company Extraction device, the volume of the extraction tank is 4 L. The preparation of the CO tank, the preparation of the separation tank, the connection between the three tanks, the preparation of the pressurization and decompression equipment are complete.

[0011] 2. Put Artemisia annua fragments into a supercritical fluid extraction tank.

[0012] 3. Connect the extraction tank to the CO tank, and input CO into the extraction tank 2 Let the air out.

[0013] 4. Continue to input CO into the extraction tank to reach the temperature (308-333K), the pressure i...