Penicillin antibiotic for preventing bacterial disease of cattle

Abstract

Disclosed is a penicillin antibiotic for preventing a bacterial disease of cattle. The penicillin antibiotic is penethamate hydriodate, presents in a neutral state, and is slightly soluble in water to form a suspension. After intravenous injection, the penicillin antibiotic can be fast absorbed and enters the blood, and penethamate partially hydrolyzes into penicillin G and diethylaminoethanol. In the blood with a pH value of 7.2, in blood-drug balance, 91.8% of the active medicine turns into a hydrolyzing penicillin G, and the left active medicine maintains the form of penethamate. Compared with a p lactam antibiotic such as amoxicillin or aminoglycoside such as streptomycin, the penicillin antibiotic for preventing the bacterial disease of cattle is easier to diffuse in a breast tissue, and the speed of the penicillin antibiotic penetrating the breast is eight times that of penicillin.

Description

technical field

[0001] The present invention relates to a kind of penicillin antibiotics for the prevention and treatment of bacterial diseases of cattle, specifically a kind of penicillins which are used for the prevention and treatment of bacterial diseases of cattle, especially for clinical mastitis and non-clinical mastitis. antibiotic. Background technique

[0002] Mastitis is a common and frequently-occurring disease of dairy cows, and it is also one of the three common diseases of dairy cows. It seriously affects milk production and quality. Severe acute mastitis can also lead to cow sepsis or udder abandonment. At present, antibiotics or chemical drugs are mainly used to treat dairy cow mastitis, but many years of clinical use have found that the therapeutic effect is not obvious, the treatment cycle is long, and there is a lack of specific drugs. Therefore, in order to improve the therapeutic effect, there is an urgent need for a special antibiotic with good curati...

Examples

Embodiment Construction

[0010] A penicillin antibiotic used for the prevention and treatment of bacterial diseases in cattle, it is a hydroiodide salt of diethylcarbamate of penicillin, it exists in a neutral state, it is slightly soluble in water, and forms a suspension in water, After intravenous injection, the drug is rapidly absorbed and enters the blood. The penicillin G aminoethyl ester is partially hydrolyzed into penicillin G and diethylaminoethanol. When the blood pH (7.2) reaches equilibrium, 91.8% of the active drug becomes the hydrolyzed form of penicillin G. The remainder remained in the penicillin G aminoethyl ester form. Due to the gradient of ph6.6-6.8 in milk and ph7.2 in plasma and the weak alkalinity of the drug itself, the drug easily penetrates the blood-milk barrier and begins to decompose when it diffuses in the breast, releasing a large amount of penicillin G, penicillin G Rapid ionization in the mammary gland (pka=2.8), thus limiting its return to the circulation. In thi...

technical field

[0001] The present invention relates to a kind of penicillin antibiotics for the prevention and treatment of bacterial diseases of cattle, specifically a kind of penicillins which are used for the prevention and treatment of bacterial diseases of cattle, especially for clinical mastitis and non-clinical mastitis. antibiotic. Background technique

[0002] Mastitis is a common and frequently-occurring disease of dairy cows, and it is also one of the three common diseases of dairy cows. It seriously affects milk production and quality. Severe acute mastitis can also lead to cow sepsis or udder abandonment. At present, antibiotics or chemical drugs are mainly used to treat dairy cow mastitis, but many years of clinical use have found that the therapeutic effect is not obvious, the treatment cycle is long, and there is a lack of specific drugs. Therefore, in order to improve the therapeutic effect, there is an urgent need for a special antibiotic with good curati...

Examples

Embodiment Construction

[0010] A penicillin antibiotic used for the prevention and treatment of bacterial diseases in cattle, it is a hydroiodide salt of diethylcarbamate of penicillin, it exists in a neutral state, it is slightly soluble in water, and forms a suspension in water, After intravenous injection, the drug is rapidly absorbed and enters the blood. The penicillin G aminoethyl ester is partially hydrolyzed into penicillin G and diethylaminoethanol. When the blood pH (7.2) reaches equilibrium, 91.8% of the active drug becomes the hydrolyzed form of penicillin G. The remainder remained in the penicillin G aminoethyl ester form. Due to the gradient of ph6.6-6.8 in milk and ph7.2 in plasma and the weak alkalinity of the drug itself, the drug easily penetrates the blood-milk barrier and begins to decompose when it diffuses in the breast, releasing a large amount of penicillin G, penicillin G Rapid ionization in the mammary gland (pka=2.8), thus limiting its return to the circulation. In thi...

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